cytosine has been researched along with Benign Neoplasms, Brain in 20 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells." | 7.80 | 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. ( Akiyama, T; Ino, Y; Katou, Y; Koyama-Nasu, R; Kozuka-Hata, H; Masuda, K; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Ogawa, H; Oyama, M; Saito, N; Sakaguchi, Y; Sato, T; Shirahige, K; Suzuki, T; Takai, H; Todo, T; Toyoshima, C, 2014) |
| "Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature." | 5.72 | Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. ( Burgess, ER; Crake, RLI; Dachs, GU; Das, AB; Magon, NJ; Morrin, HR; Phillips, E; Robinson, BA; Royds, JA; Slatter, TL; Vissers, MCM; Wiggins, GAR, 2022) |
| " Here, we show that TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells." | 3.80 | 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. ( Akiyama, T; Ino, Y; Katou, Y; Koyama-Nasu, R; Kozuka-Hata, H; Masuda, K; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Ogawa, H; Oyama, M; Saito, N; Sakaguchi, Y; Sato, T; Shirahige, K; Suzuki, T; Takai, H; Todo, T; Toyoshima, C, 2014) |
| "Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature." | 1.72 | Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. ( Burgess, ER; Crake, RLI; Dachs, GU; Das, AB; Magon, NJ; Morrin, HR; Phillips, E; Robinson, BA; Royds, JA; Slatter, TL; Vissers, MCM; Wiggins, GAR, 2022) |
| "In squamous cell lung cancers, levels of 5hmdC were depleted substantially with up to 5-fold reduction compared with normal lung tissue." | 1.37 | 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. ( Jiang, Y; Jin, SG; Krex, D; Lu, Q; Pfeifer, GP; Qiu, R; Rauch, TA; Schackert, G; Wang, Y, 2011) |
| " In vitro studies showed that 5-FC combined with CDase induced significant growth-inhibitory effects on the cultured glioma cells." | 1.27 | Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules. ( Ito, T; Katsuragi, T; Kawamoto, K; Kawamura, Y; Matsumura, H; Nishiyama, T; Ohyama, A; Sakai, T; Yamamoto, N, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crake, RLI | 1 |
| Burgess, ER | 1 |
| Wiggins, GAR | 1 |
| Magon, NJ | 1 |
| Das, AB | 1 |
| Vissers, MCM | 1 |
| Morrin, HR | 1 |
| Royds, JA | 1 |
| Slatter, TL | 1 |
| Robinson, BA | 1 |
| Phillips, E | 1 |
| Dachs, GU | 1 |
| Galardi, S | 1 |
| Michienzi, A | 1 |
| Ciafrè, SA | 1 |
| Kazlauskas, A | 1 |
| Darinskas, A | 1 |
| Meškys, R | 1 |
| Tamašauskas, A | 1 |
| Urbonavičius, J | 1 |
| Hadaczek, P | 1 |
| Ozawa, T | 1 |
| Soroceanu, L | 1 |
| Yoshida, Y | 1 |
| Matlaf, L | 1 |
| Singer, E | 1 |
| Fiallos, E | 1 |
| James, CD | 1 |
| Cobbs, CS | 1 |
| Ye, C | 1 |
| Li, L | 1 |
| Takai, H | 1 |
| Masuda, K | 1 |
| Sato, T | 1 |
| Sakaguchi, Y | 1 |
| Suzuki, T | 2 |
| Koyama-Nasu, R | 1 |
| Nasu-Nishimura, Y | 1 |
| Katou, Y | 1 |
| Ogawa, H | 1 |
| Morishita, Y | 1 |
| Kozuka-Hata, H | 1 |
| Oyama, M | 1 |
| Todo, T | 1 |
| Ino, Y | 1 |
| Mukasa, A | 1 |
| Saito, N | 1 |
| Toyoshima, C | 1 |
| Shirahige, K | 1 |
| Akiyama, T | 1 |
| Ramsawhook, A | 1 |
| Lewis, L | 1 |
| Coyle, B | 1 |
| Ruzov, A | 1 |
| Tasca, G | 1 |
| Iorio, R | 1 |
| Basile, U | 1 |
| Lauriola, L | 1 |
| Tartaglione, R | 1 |
| Mirabella, M | 1 |
| Ricci, E | 1 |
| Sabatelli, M | 1 |
| Jin, SG | 1 |
| Jiang, Y | 1 |
| Qiu, R | 1 |
| Rauch, TA | 1 |
| Wang, Y | 1 |
| Schackert, G | 1 |
| Krex, D | 1 |
| Lu, Q | 1 |
| Pfeifer, GP | 1 |
| Kraus, TF | 1 |
| Globisch, D | 1 |
| Wagner, M | 1 |
| Eigenbrod, S | 1 |
| Widmann, D | 1 |
| Münzel, M | 1 |
| Müller, M | 1 |
| Pfaffeneder, T | 1 |
| Hackner, B | 1 |
| Feiden, W | 1 |
| Schüller, U | 1 |
| Carell, T | 1 |
| Kretzschmar, HA | 1 |
| Müller, T | 1 |
| Gessi, M | 1 |
| Waha, A | 2 |
| Isselstein, LJ | 1 |
| Luxen, D | 1 |
| Freihoff, D | 1 |
| Freihoff, J | 1 |
| Becker, A | 1 |
| Simon, M | 1 |
| Hammes, J | 1 |
| Denkhaus, D | 1 |
| zur Mühlen, A | 1 |
| Pietsch, T | 1 |
| Kaliberov, SA | 1 |
| Market, JM | 1 |
| Gillespie, GY | 1 |
| Krendelchtchikova, V | 1 |
| Della Manna, D | 1 |
| Sellers, JC | 1 |
| Kaliberova, LN | 1 |
| Black, ME | 1 |
| Buchsbaum, DJ | 1 |
| Nishiyama, T | 2 |
| Kawamura, Y | 2 |
| Kawamoto, K | 2 |
| Matsumura, H | 2 |
| Yamamoto, N | 2 |
| Ito, T | 2 |
| Ohyama, A | 2 |
| Katsuragi, T | 2 |
| Sakai, T | 2 |
| Woodcock, DM | 1 |
| Adams, JK | 1 |
| Allan, RG | 1 |
| Cooper, IA | 1 |
| Merlo, A | 1 |
| Herman, JG | 1 |
| Mao, L | 1 |
| Lee, DJ | 1 |
| Gabrielson, E | 1 |
| Burger, PC | 1 |
| Baylin, SB | 1 |
| Sidransky, D | 1 |
| Liekens, S | 3 |
| Andrei, G | 1 |
| Vandeputte, M | 1 |
| De Clercq, E | 3 |
| Neyts, J | 3 |
| al-Ghamdi, H | 1 |
| Sabbah, R | 1 |
| Martin, J | 1 |
| Patay, Z | 1 |
| Verbeken, E | 2 |
| Ribatti, D | 1 |
| Presta, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft Tissue Sarcoma After Pre-treatment Failure: an Open-label, Multicenter Phase II Study[NCT01136499] | Phase 2 | 53 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cytosine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Insights into the Regulatory Role of m
Topics: Adenosine; Brain Neoplasms; Cytosine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expressio | 2020 |
5-hydroxymethylcytosine: a new insight into epigenetics in cancer.
Topics: 5-Methylcytosine; Animals; Brain Neoplasms; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Pro | 2014 |
18 other studies available for cytosine and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine.
Topics: Brain Neoplasms; Cytosine; DNA Methylation; Glioma; Humans; Neoplasm Grading; O(6)-Methylguanine-DNA | 2022 |
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Caco-2 Cells; Cell Line, | 2019 |
Cidofovir: a novel antitumor agent for glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cidofov | 2013 |
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
Topics: 5-Methylcytosine; Acetylation; Brain Neoplasms; Carcinogenesis; Chromatin; Cytosine; DNA-Binding Pro | 2014 |
Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated
Topics: 5-Methylcytosine; Brain Neoplasms; Cell Line, Tumor; Cerebellar Neoplasms; Child; Cytosine; Ependymo | 2017 |
Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia.
Topics: Adenocarcinoma; Agammaglobulinemia; Aged; Antiviral Agents; Brain; Brain Neoplasms; Cidofovir; Cytos | 2009 |
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations.
Topics: 5-Methylcytosine; Animals; Base Sequence; Brain; Brain Neoplasms; Carcinoma, Squamous Cell; Cell Lin | 2011 |
Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Anaplasia; Astrocytoma; Brain; Brain N | 2012 |
Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas.
Topics: 5-Methylcytosine; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cytosine; Dioxygenases; DNA Methy | 2012 |
Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma.
Topics: Adenoviridae; Animals; Antimetabolites; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy | 2007 |
[Antineoplastic effect of 5-fluorocytosine and cytosine deaminase on brain tumor (author's transl)].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cytosine; Cytosine Deaminase; Drug Therapy, Combina | 1982 |
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; C | 1983 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lu | 1995 |
Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir.
Topics: Animals; Antiviral Agents; Body Weight; Brain Neoplasms; Cidofovir; Cytosine; Hemangioma; Incidence; | 1998 |
Primary T-cell lymphoma of the brain in children: a case report and literature review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arabinose; Asparaginase; Brain Neoplasms; Child; Com | 2000 |
Potent inhibition of hemangiosarcoma development in mice by cidofovir.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Cell Line, Transformed; C | 2001 |
Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Apoptosis; Brain Neoplasms; Cell Division; Chick E | 2001 |
Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules.
Topics: Animals; Brain Neoplasms; Capsules; Cytosine; Cytosine Deaminase; Drug Evaluation, Preclinical; Drug | 1985 |