cytosine has been researched along with Anal Cancer in 9 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment was well tolerated with most common adverse events being mild to moderate affecting lesional skin: pain/burning/irritation (25 patients) and ulceration (13 patients)." | 2.78 | Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. ( Aboulafia, D; Berry, JM; Da Costa, M; Darragh, TM; Einstein, MH; Goldstone, SE; Jay, N; Lee, JY; Palefsky, JM; Panther, L; Stier, EA; Wilkin, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nambudiri, VE | 1 |
| Mutyambizi, K | 1 |
| Walls, AC | 1 |
| Fisher, DC | 1 |
| Bleday, R | 1 |
| Saavedra, AP | 1 |
| Sendagorta, E | 1 |
| Bernardino, JI | 1 |
| Álvarez-Gallego, M | 1 |
| Feíto, M | 1 |
| Feltes, R | 1 |
| Beato, MJ | 1 |
| Pérez-Molina, JA | 1 |
| Yllescas, M | 1 |
| Díaz-Almirón, M | 1 |
| Arribas, JR | 1 |
| González-García, J | 1 |
| Herranz, P | 1 |
| Coremans, G | 1 |
| Snoeck, R | 1 |
| Collette, DC | 1 |
| Zechel, MA | 1 |
| Gormley, RH | 1 |
| Kovarik, CL | 1 |
| Fox, PA | 1 |
| Stier, EA | 1 |
| Goldstone, SE | 1 |
| Einstein, MH | 1 |
| Jay, N | 1 |
| Berry, JM | 1 |
| Wilkin, T | 1 |
| Lee, JY | 1 |
| Darragh, TM | 1 |
| Da Costa, M | 1 |
| Panther, L | 1 |
| Aboulafia, D | 1 |
| Palefsky, JM | 1 |
| Nathan, M | 1 |
| Descamps, V | 1 |
| Duval, X | 1 |
| Grossin, M | 1 |
| Crickx, B | 1 |
| Leport, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, With One Site, Open-label Not Controled Trial, for the Observation of Treatment With CIDOFOVIR 1%, 3 Nights Per Week, During 4 Weeks, of Anal Intraepithelial Neoplasia, High Level, in HIV+ Patients[NCT01946009] | 20 participants (Actual) | Interventional | 2013-09-30 | Completed | |||
| Efficacy and Safety of Topical Trichloroacetic Acid vs. Electrocautery for the Treatment of Anal Intraepithelial Neoplasia in HIV-positive Patients (TECAIN) - a Randomized Controlled Trial[NCT02615860] | 560 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| Phase IIA Trial of 1% Topical Cidofovir for Treatment of High-Grade Perianal Squamous Intraepithelial Lesions in HIV-Infected Men and Women[NCT00550589] | Phase 2 | 33 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of patients who cleared HPV among those who had a complete or partial response (NCT00550589)
Timeframe: 6 weeks after treatment discontinuation
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 2 |
Number of patients with HPV16 at baseline in perianal HSIL and normal perianal tissue (NCT00550589)
Timeframe: Baseline
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 16 |
Number of patients with HPV16 type present in the anus from anal swab or cytobrush at baseline (NCT00550589)
Timeframe: Baseline
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 14 |
(NCT00550589)
Timeframe: 6 weeks after treatment discontinuation
| Intervention | proportion of participants (Number) |
|---|---|
| Cidofovir | 0.515 |
Number of study patients who had a serious adverse event (NCT00550589)
Timeframe: Every 2 weeks on study, 6 weeks after treatment discontinuation
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 3 |
4 reviews available for cytosine and Anal Cancer
| Article | Year |
|---|---|
Cidofovir: clinical experience and future perspectives on an acyclic nucleoside phosphonate analog of cytosine in the treatment of refractory and premalignant HPV-associated anal lesions.
Topics: Antiviral Agents; Anus Neoplasms; Cidofovir; Cytosine; Humans; Organophosphonates; Papillomaviridae; | 2009 |
Novel treatment of atypical human papillomavirus-associated epithelial hyperplasia with cidofovir.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Anus Neoplasms; Cidofovir; Cytosine; Epithe | 2011 |
Human papillomavirus-related genital disease in the immunocompromised host: Part II.
Topics: Adjuvants, Immunologic; Alphapapillomavirus; Aminoquinolines; Antineoplastic Agents, Phytogenic; Ant | 2012 |
Treatment options for anal intraepithelial neoplasia and evidence for their effectiveness.
Topics: Adult; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Anus Neoplasms; Cido | 2012 |
2 trials available for cytosine and Anal Cancer
| Article | Year |
|---|---|
Topical cidofovir to treat high-grade anal intraepithelial neoplasia in HIV-infected patients: a pilot clinical trial.
Topics: Administration, Topical; Adult; Antiviral Agents; Anus Neoplasms; Biopsy; Carcinoma in Situ; Cidofov | 2016 |
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women.
Topics: Acquired Immunodeficiency Syndrome; Administration, Cutaneous; Adult; Aged; Antiviral Agents; Anus N | 2013 |
3 other studies available for cytosine and Anal Cancer
| Article | Year |
|---|---|
Successful treatment of perianal giant condyloma acuminatum in an immunocompromised host with systemic interleukin 2 and topical cidofovir.
Topics: Administration, Topical; Antineoplastic Agents; Antiviral Agents; Anus Neoplasms; Buschke-Lowenstein | 2013 |
Treatment of anal intraepithelial neoplasia: has it come of age?
Topics: Antiviral Agents; Anus Neoplasms; Carcinoma in Situ; Cidofovir; Cytosine; Female; HIV Infections; Hu | 2013 |
Topical cidofovir for bowenoid papulosis in an HIV-infected patient.
Topics: Adult; Antineoplastic Agents; Antiviral Agents; Anus Neoplasms; Carcinoma in Situ; Carcinoma, Squamo | 2001 |