Page last updated: 2024-10-17

cytosine and Aging

cytosine has been researched along with Aging in 70 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Here we showed that the zebrafish genome gradually and clearly lost methylcytosine in somatic cells, but not in male germ cells during aging, and that age-dependent hypomethylation preferentially occurred at a particular domain called the CpG island shore, which is associated with vertebrates' genes and has been shown to be hypomethylated in humans with age."7.80Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging. ( Hashimoto, N; Izawa, T; Kikuchi, Y; Shimoda, N; Yokoi, H; Yoshizawa, A, 2014)
"Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes."7.78Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. ( Chen, H; Dzitoyeva, S; Manev, H, 2012)
" In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease."4.88Dynamics of DNA methylation in aging and Alzheimer's disease. ( Irier, HA; Jin, P, 2012)
"We propose a laboratory tool that allows the quantification of DNA methylation in cytosines underlying four different clocks, thus providing broad information on epigenetic aging while maintaining a reasonable number of CpG markers, opening the way to a wide range of applications in forensics, medicine, and healthcare."4.31Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks. ( Boroń, M; Branicki, W; Dowejko, J; Kobus, M; Lisman, D; Masny, A; Migacz-Gruszka, K; Noroozi, R; Ossowski, A; Pisarek, A; Pośpiech, E; Pruszkowska-Przybylska, P; Rudnicka, J; Sitek, A; Spólnicka, M; Stanisz, K; Szargut, M; Wysocka, B; Zacharczuk, J; Zieliński, P, 2023)
"These results suggest that the location of hydroxymethylcytosine in the genome is site specific and not random, and that changes in hydroxymethylation may play a role in the liver's response to aging and alcohol."3.85Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging. ( Ausman, LM; Choi, SW; Dolnikowski, GG; Friso, S; Park, LK; Tammen, SA, 2017)
"A gradual loss of the correct patterning of 5-methyl cytosine marks in gene promoter regions has been implicated in aging and age-related diseases, most notably cancer."3.79High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice. ( Dollé, ME; Gravina, S; Hasty, P; Hoeijmakers, J; van Steeg, H; Vijg, J; Wang, T, 2013)
"Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes."3.78Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. ( Chen, H; Dzitoyeva, S; Manev, H, 2012)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199015 (21.43)18.7374
1990's8 (11.43)18.2507
2000's8 (11.43)29.6817
2010's33 (47.14)24.3611
2020's6 (8.57)2.80

Authors

AuthorsStudies
Finesso, GE1
McDevitt, RA1
Roy, R1
Brinster, LR1
Di Francesco, A1
Meade, T1
de Cabo, R1
Ferrucci, L1
Perdue, KA1
de Sena Brandine, G1
Aston, KI2
Jenkins, TG2
Smith, AD1
Pośpiech, E1
Pisarek, A1
Rudnicka, J1
Noroozi, R1
Boroń, M1
Masny, A1
Wysocka, B1
Migacz-Gruszka, K1
Lisman, D1
Pruszkowska-Przybylska, P1
Kobus, M1
Szargut, M1
Dowejko, J1
Stanisz, K1
Zacharczuk, J1
Zieliński, P1
Sitek, A1
Ossowski, A1
Spólnicka, M1
Branicki, W1
Mei, X1
Blanchard, J1
Luellen, C1
Conboy, MJ1
Conboy, IM1
Hearn, J1
Plenderleith, F1
Little, TJ1
Oh, ES3
Petronis, A3
López, V1
Fernández, AF1
Fraga, MF1
Oh, G2
Ebrahimi, S2
Carlucci, M2
Zhang, A2
Nair, A2
Groot, DE2
Labrie, V2
Jia, P2
Jeremian, RH1
Susic, M2
Shrestha, TC1
Ralph, MR1
Gordevičius, J2
Koncevičius, K2
Kriščiūnas, A1
Wong, AHC1
Cencioni, C1
Gaetano, C1
Spallotta, F1
Shimoda, N1
Izawa, T1
Yoshizawa, A1
Yokoi, H1
Kikuchi, Y1
Hashimoto, N1
Cairns, BR1
Carrell, DT1
De Jonge, CJ1
Gravina, S1
Dollé, ME1
Wang, T1
van Steeg, H1
Hasty, P1
Hoeijmakers, J1
Vijg, J1
de Keyser, CE1
Peters, BJ1
Becker, ML1
Visser, LE1
Uitterlinden, AG1
Klungel, OH1
Verstuyft, C1
Hofman, A1
Maitland-van der Zee, AH1
Stricker, BH1
Gebhard, D1
Mahler, B1
Matt, K1
Burger, K1
Bergemann, J1
Cadena-del-Castillo, C1
Valdes-Quezada, C1
Carmona-Aldana, F1
Arias, C1
Bermúdez-Rattoni, F1
Recillas-Targa, F1
Niederberger, C1
Irier, H2
Street, RC1
Dave, R1
Lin, L1
Cai, C1
Davis, TH1
Yao, B1
Cheng, Y1
Jin, P3
Sun, W1
Zang, L1
Shu, Q1
Li, X2
Kraus, TF2
Guibourt, V2
Kretzschmar, HA2
Qian, Y1
Tu, J1
Tang, NL1
Kong, GW1
Chung, JP1
Chan, WY1
Lee, TL1
Bachman, M1
Uribe-Lewis, S1
Yang, X2
Burgess, HE1
Iurlaro, M1
Reik, W1
Murrell, A1
Balasubramanian, S1
Lardenoije, R1
van den Hove, DLA1
Vaessen, TSJ1
Iatrou, A1
Meuwissen, KPV1
van Hagen, BTJ1
Kenis, G1
Steinbusch, HWM1
Schmitz, C1
Rutten, BPF1
Kilinc, S1
Steinmaurer, M1
Stieglitz, M1
Tammen, SA1
Park, LK1
Dolnikowski, GG1
Ausman, LM1
Friso, S1
Choi, SW1
Vyhlidal, CA1
Bi, C1
Ye, SQ1
Leeder, JS1
Gong, P1
Li, K1
Huang, F1
Cheng, F1
Pan, G1
Mäkivuokko, H1
Tiihonen, K1
Tynkkynen, S1
Paulin, L1
Rautonen, N1
Fenech, M1
Thompson, RF1
Atzmon, G1
Gheorghe, C1
Liang, HQ1
Lowes, C1
Greally, JM1
Barzilai, N1
Schiepers, OJ1
van Boxtel, MP1
de Groot, RH1
Jolles, J1
Kok, FJ1
Verhoef, P1
Durga, J1
King, GD1
Rosene, DL1
Abraham, CR1
Szulwach, KE1
Li, Y1
Song, CX1
Wu, H1
Dai, Q1
Upadhyay, AK1
Gearing, M1
Levey, AI1
Vasanthakumar, A1
Godley, LA1
Chang, Q1
Cheng, X1
He, C1
Flax, JD1
Soloway, PD1
van den Hove, DL1
Chouliaras, L1
Rutten, BP1
Irier, HA1
Chen, H2
Dzitoyeva, S2
Manev, H2
Nguyen, TV1
Esteban, LM1
White, CP1
Grant, SF1
Center, JR1
Gardiner, EM1
Eisman, JA1
Travison, TG1
Morley, JE1
Araujo, AB1
O'Donnell, AB1
McKinlay, JB1
Lehmann, G1
Budovsky, A1
Muradian, KK1
Fraifeld, VE1
Berletch, JB1
Phipps, SM1
Walthall, SL1
Andrews, LG1
Tollefsbol, TO1
Akintola, AD1
Crislip, ZL1
Catania, JM1
Chen, G1
Zimmer, WE1
Burghardt, RC1
Parrish, AR1
Adams, RL1
Burdon, RH1
Kunnath, L1
Locker, J1
Holliday, R1
Wilson, VL1
Jones, PA1
Dainat, J1
Sellinger, OZ1
Jue, K1
Benoit, G1
Alcivar-Warren, AA1
Trasler, JM1
Murru, S1
Pischedda, MC1
Cao, A1
Rosatelli, MC1
Pirastu, M1
Sciarratta, GV1
Manca, L1
Gallisai, D1
Toffoli, C1
Counts, JL1
Kaznowski, JM1
McClain, RM1
Goodman, JI1
Tohgi, H4
Utsugisawa, K4
Nagane, Y4
Yoshimura, M3
Ukitsu, M3
Genda, Y3
Stuart, GR1
Glickman, BW1
Jubb, AM1
Bell, SM1
Quirke, P1
Romanov, GA1
Zin'kovskaia, GG2
Berbyshev, GD1
Vaniushin, BF3
Berdyshev, GD1
Loo, LS1
Cauchi, MN1
Tawa, R1
Ono, T1
Kurishita, A1
Okada, S1
Hirose, S1
Lotzová, E1
Savary, CA1
Lowlachi, M1
Murasko, DM1
Drinkwater, RD1
Blake, TJ1
Morley, AA1
Turner, DR1
Zhavoronkova, EN1
Simpson, VJ1
Johnson, TE1
Hammen, RF1
Gedda, L1
Brenci, G1
Vanyushin, BF1
Nemirovsky, LE1
Klimenko, VV1
Vasiliev, VK1
Belozersky, AN1
Yajima, A1
Ringborg, U1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects[NCT03353597]Phase 1/Phase 22,120 participants (Anticipated)Interventional2018-05-15Not yet recruiting
The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial[NCT00110604]835 participants Interventional2000-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for cytosine and Aging

ArticleYear
Origins of human disease: the chrono-epigenetic perspective.
    Nature reviews. Genetics, 2021, Volume: 22, Issue:8

    Topics: Aging; Animals; Biological Clocks; Chronology as Topic; Cytosine; Disease; DNA; Epigenomics; Humans

2021
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
    Ageing research reviews, 2017, Volume: 37

    Topics: 5-Methylcytosine; Aging; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genet

2017
The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study.
    Pharmacogenetics and genomics, 2014, Volume: 24, Issue:1

    Topics: Aged; Aging; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cytosine; Databases, Factual; Dose

2014
From development to diseases: the role of 5hmC in brain.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genet

2014
Folate, DNA damage and the aging brain.
    Mechanisms of ageing and development, 2010, Volume: 131, Issue:4

    Topics: Aging; Animals; Brain; Cell Nucleus; Cytosine; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; M

2010
Dynamics of DNA methylation in aging and Alzheimer's disease.
    DNA and cell biology, 2012, Volume: 31 Suppl 1

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; DNA; DNA Methylation; Humans; Neurode

2012
A method to study the expression of DNA methyltransferases in aging systems in vitro.
    Methods in molecular biology (Clifton, N.J.), 2007, Volume: 371

    Topics: Aging; Animals; Cell Culture Techniques; Cells, Cultured; Cellular Senescence; CpG Islands; Cytosine

2007
DNA methylation in eukaryotes.
    CRC critical reviews in biochemistry, 1982, Volume: 13, Issue:4

    Topics: 5-Methylcytosine; Aging; Animals; Azacitidine; Base Sequence; Chromatin; Cytosine; Deoxyribonuclease

1982
Methylation and colorectal cancer.
    The Journal of pathology, 2001, Volume: 195, Issue:1

    Topics: Adenocarcinoma; Adenoma; Aged; Aging; Biomarkers, Tumor; Chromatin; Colorectal Neoplasms; CpG Island

2001

Trials

1 trial available for cytosine and Aging

ArticleYear
DNA methylation and cognitive functioning in healthy older adults.
    The British journal of nutrition, 2012, Volume: 107, Issue:5

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Aging; Cognitive Dysfunction; Cross-Sectiona

2012

Other Studies

60 other studies available for cytosine and Aging

ArticleYear
Impact of Large Granular Lymphocyte Leukemia on Blood DNA Methylation and Epigenetic Clock Modeling in Fischer 344 Rats.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2022, 05-05, Volume: 77, Issue:5

    Topics: Aging; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Leukemia, Large Granular Lymphocytic

2022
Global effects of identity and aging on the human sperm methylome.
    Clinical epigenetics, 2023, 08-07, Volume: 15, Issue:1

    Topics: Adult; Aging; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenome; Humans; Longitudinal Studie

2023
Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks.
    Clinical epigenetics, 2023, 08-10, Volume: 15, Issue:1

    Topics: Aging; Child, Preschool; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Genomics; High

2023
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.
    Aging, 2023, 09-12, Volume: 15, Issue:17

    Topics: Aging; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Longevity

2023
DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna.
    Epigenetics & chromatin, 2021, 01-06, Volume: 14, Issue:1

    Topics: Aging; Animals; CpG Islands; Cytosine; Daphnia; DNA Methylation; Epigenesis, Genetic; Epigenomics; H

2021
Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.
    Nature communications, 2018, 02-13, Volume: 9, Issue:1

    Topics: Aging; Animals; Circadian Rhythm; Cytosine; DNA Methylation; Epigenesis, Genetic; Genetic Variation;

2018
Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease.
    Genome biology, 2019, 01-03, Volume: 20, Issue:1

    Topics: Aging; Circadian Rhythm; Cytosine; Epigenesis, Genetic; Humans; Leukemia, Lymphocytic, Chronic, B-Ce

2019
Dissecting cytosine methylation mechanics of dysmetabolism.
    Aging, 2019, 01-23, Volume: 11, Issue:3

    Topics: Aging; Animals; Cytosine; DNA Methylation; Humans

2019
Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging.
    Age (Dordrecht, Netherlands), 2014, Volume: 36, Issue:1

    Topics: Aging; Animals; Apoptosis; CpG Islands; Cytosine; DNA Fragmentation; DNA Methylation; Embryo, Nonmam

2014
Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
    Fertility and sterility, 2013, Volume: 100, Issue:4

    Topics: 5-Methylcytosine; Adult; Age Factors; Aging; Cytosine; DNA; DNA Methylation; Enzyme-Linked Immunosor

2013
Paternal age and sperm methylation status.
    Fertility and sterility, 2013, Volume: 100, Issue:4

    Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa

2013
High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Aging; Animals; Brain; CpG Islands; Cytosine; DNA Methylation; DNA Repair; Genetic Loci; Genomic Imp

2013
Mitochondrial DNA copy number - but not a mitochondrial tandem CC to TT transition - is increased in sun-exposed skin.
    Experimental dermatology, 2014, Volume: 23, Issue:3

    Topics: Abdomen; Aged; Aging; Base Sequence; Biomarkers; Cytosine; DNA Copy Number Variations; DNA, Mitochon

2014
Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:3

    Topics: 5-Methylcytosine; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein

2014
Re: paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
    The Journal of urology, 2014, Volume: 191, Issue:5

    Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa

2014
Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; Gene Expression Regulation; Gene-Enviro

2014
5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:7

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Animals;

2015
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
    The international journal of biochemistry & cell biology, 2015, Volume: 67

    Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Met

2015
5-Formylcytosine can be a stable DNA modification in mammals.
    Nature chemical biology, 2015, Volume: 11, Issue:8

    Topics: 5-Methylcytosine; Aging; Animals; Animals, Newborn; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltr

2015
Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine.
    Neurobiology of aging, 2015, Volume: 36, Issue:11

    Topics: 5-Methylcytosine; Aging; Animals; Caloric Restriction; Cytosine; DNA Methylation; Epigenesis, Geneti

2015
Profiling of methylation and demethylation pathways during brain development and ageing.
    Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:3

    Topics: 5-Methylcytosine; Aging; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Imm

2016
Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging.
    European journal of nutrition, 2017, Volume: 56, Issue:2

    Topics: Aging; Alcohol Drinking; Alcoholism; Animals; Cytosine; DNA; DNA Methylation; Fatty Liver; Gene Regu

2017
Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7

    Topics: Adolescent; Age Factors; Aging; Child; Child, Preschool; Cytochrome P-450 CYP3A; Cytosine; DNA Methy

2016
A single cytosine deletion in the OsPLS1 gene encoding vacuolar-type H+-ATPase subunit A1 leads to premature leaf senescence and seed dormancy in rice.
    Journal of experimental botany, 2016, Volume: 67, Issue:9

    Topics: Aging; Chromosome Mapping; Cloning, Molecular; Cytosine; Genes, Plant; Oryza; Plant Dormancy; Plant

2016
The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition.
    The British journal of nutrition, 2010, Volume: 103, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cytosine;

2010
Tissue-specific dysregulation of DNA methylation in aging.
    Aging cell, 2010, Volume: 9, Issue:4

    Topics: Aging; Animals; Biological Assay; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Pr

2010
Promoter methylation and age-related downregulation of Klotho in rhesus monkey.
    Age (Dordrecht, Netherlands), 2012, Volume: 34, Issue:6

    Topics: 5-Methylcytosine; Aging; Animals; Brain; Cell Line; Cytosine; DNA Methylation; Down-Regulation; Epig

2012
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
    Nature neuroscience, 2011, Oct-30, Volume: 14, Issue:12

    Topics: 5-Methylcytosine; Aging; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Chromosome Del

2011
Methylation on the mind.
    Nature neuroscience, 2011, Nov-23, Volume: 14, Issue:12

    Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cytosine; Epigenomics; Gene Expression Regulation, Dev

2011
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
    Current Alzheimer research, 2012, Volume: 9, Issue:5

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; Disease Models, Animal; DNA Methylati

2012
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
    Restorative neurology and neuroscience, 2012, Volume: 30, Issue:3

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Arachidonate 5-Lipoxygenase; Cytosine; Disease

2012
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.
    Neurobiology of aging, 2012, Volume: 33, Issue:12

    Topics: 5-Methylcytosine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cells,

2012
Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:12

    Topics: Aged; Aged, 80 and over; Aging; Bone Density; Cohort Studies; Collagen Type I; Collagen Type I, alph

2005
The relationship between libido and testosterone levels in aging men.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:7

    Topics: Adenine; Adult; Aged; Aging; Cytosine; Follow-Up Studies; Guanine; Humans; Libido; Longitudinal Stud

2006
Mitochondrial genome anatomy and species-specific lifespan.
    Rejuvenation research, 2006,Summer, Volume: 9, Issue:2

    Topics: Aging; Animals; Cytosine; DNA, Mitochondrial; Eukaryotic Cells; Longevity; Species Specificity; Thym

2006
Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:1

    Topics: Aging; Animals; Azacitidine; Base Sequence; Cadherins; Cells, Cultured; Cytosine; Decitabine; DNA; D

2008
Characterization of DNA methylation in the rat.
    Biochimica et biophysica acta, 1982, Dec-31, Volume: 699, Issue:3

    Topics: 5-Methylcytosine; Aging; Animals; Base Composition; Base Sequence; Cell Differentiation; Cell Line;

1982
The biological significance of meiosis.
    Symposia of the Society for Experimental Biology, 1984, Volume: 38

    Topics: 5-Methylcytosine; Aging; Base Sequence; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Repair;

1984
DNA methylation decreases in aging but not in immortal cells.
    Science (New York, N.Y.), 1983, Jun-03, Volume: 220, Issue:4601

    Topics: 5-Methylcytosine; Aging; Animals; Cell Division; Cell Line; Cricetinae; Cytosine; DNA; Fibroblasts;

1983
Cerebellar tRNA methyltransferases: a developmental study.
    Brain research, 1980, Feb-03, Volume: 183, Issue:1

    Topics: Aging; Animals; Cerebellum; Cytosine; Guanine; Kinetics; Male; Methylation; Purkinje Cells; Rats; tR

1980
Developmental and hormonal regulation of DNA methyltransferase in the rat testis.
    Biology of reproduction, 1995, Volume: 52, Issue:6

    Topics: Aging; Animals; Cytosine; DNA (Cytosine-5-)-Methyltransferases; Gene Expression; Hypophysectomy; Mal

1995
A promoter mutation of the beta-globin gene (-101 C-->T) has an age-related expression pattern.
    Blood, 1993, May-15, Volume: 81, Issue:10

    Topics: Adult; Aging; Base Sequence; Cytosine; Female; Fetal Hemoglobin; Fetus; Gene Expression Regulation;

1993
5-methylcytosine is present in the 5' flanking region of Ha-ras in mouse liver and increases with ageing.
    International journal of cancer, 1997, Jul-29, Volume: 72, Issue:3

    Topics: 5-Methylcytosine; Aging; Animals; Cytosine; Deoxyribonucleases, Type II Site-Specific; DNA Methylati

1997
Decrease with age in methylcytosines in the promoter region of receptor for advanced glycated end products (RAGE) gene in autopsy human cortex.
    Brain research. Molecular brain research, 1999, Feb-19, Volume: 65, Issue:1

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Aging; Base Sequence; Brain Chemistry; Cerebral Co

1999
Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex.
    Brain research. Molecular brain research, 1999, Jul-05, Volume: 70, Issue:2

    Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Aging; Amyloid beta-Protein Precursor; Autopsy; Ba

1999
The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex.
    Neuroscience letters, 1999, Nov-12, Volume: 275, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Autopsy; Base Sequence; Cerebral Cortex; Cytosine; DNA Methyl

1999
PCR amplification in bisulfite methylcytosine mapping in the GC-rich promoter region of amyloid precursor protein gene in autopsy human brain.
    Brain research. Brain research protocols, 2000, Volume: 5, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Amyloid beta-Protein Precursor; Base Sequence; Cadaver; Cerebral Cor

2000
Through a glass, darkly: reflections of mutation from lacI transgenic mice.
    Genetics, 2000, Volume: 155, Issue:3

    Topics: 5-Methylcytosine; Aging; Animals; Bacterial Proteins; Brain; Cell Division; CpG Islands; Cytosine; D

2000
[Age- and tissue-specific differences in intragenome distribution of 5'-methylcytosine in cow's DNA].
    Biokhimiia (Moscow, Russia), 1979, Volume: 44, Issue:9

    Topics: Aging; Animals; Cattle; Cytosine; DNA; Embryo, Mammalian; Female; Heart; Myocardium; Pregnancy; Thym

1979
[Tissue-specific decrease and change in the character of DNA methylation in cattle with aging].
    Biokhimiia (Moscow, Russia), 1978, Volume: 43, Issue:10

    Topics: Aging; Animals; Brain Chemistry; Cattle; Chemical Phenomena; Chemistry; Cytosine; DNA; Kidney; Liver

1978
DNA methylation patterns of the gamma delta beta-globin genes in human fetal and adult erythroid tissues.
    American journal of hematology, 1992, Volume: 39, Issue:4

    Topics: Adult; Aging; Autoradiography; Cytosine; DNA; DNA Restriction Enzymes; Erythroid Precursor Cells; Fe

1992
Changes of DNA methylation level during pre- and postnatal periods in mice.
    Differentiation; research in biological diversity, 1990, Volume: 45, Issue:1

    Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; Liver; Lu

1990
Cytotoxic and morphologic profile of endogenous and pyrimidinone-activated murine NK cells.
    Journal of immunology (Baltimore, Md. : 1950), 1986, Volume: 136, Issue:2

    Topics: Adjuvants, Immunologic; Aging; Animals; Cell Separation; Cytosine; Cytotoxicity, Immunologic; Female

1986
Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA.
    Mutation research, 1989, Volume: 219, Issue:1

    Topics: 5-Methylcytosine; Adult; Aged; Aging; Cytosine; DNA; Genes; Humans; Lymphocytes; Methylation; Transc

1989
[DNA methylation and interaction with glucocorticoid receptor complexes in the rat liver].
    Biokhimiia (Moscow, Russia), 1987, Volume: 52, Issue:5

    Topics: 5-Methylcytosine; Adrenalectomy; Aging; Animals; Cytosine; DNA; Female; Hydrocortisone; Liver; Methy

1987
Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging.
    Nucleic acids research, 1986, Aug-26, Volume: 14, Issue:16

    Topics: 5-Methylcytosine; Aging; Animals; Caenorhabditis; Chromatography, High Pressure Liquid; Crosses, Gen

1986
Mechanisms of ageing.
    Lancet (London, England), 1970, Nov-07, Volume: 2, Issue:7680

    Topics: Adenine; Aging; Cytosine; Genetic Code; Genetics, Medical; Guanine; Humans; Thymine

1970
The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents.
    Gerontologia, 1973, Volume: 19, Issue:3

    Topics: Aging; Animals; Brain Chemistry; Cytosine; DNA; DNA, Mitochondrial; Genetics; Hydrocortisone; Kidney

1973
The decrepitude of the rat brain with special reference to changes in nucleic acid.
    The Tohoku journal of experimental medicine, 1966, Jul-25, Volume: 89, Issue:3

    Topics: Adenine; Aging; Animals; Brain Chemistry; Brain Stem; Cerebellum; Chromatography; Cytosine; Dienceph

1966
Composition and content of RNA in neurons of rat hippocampus at different ages.
    Brain research, 1966, Volume: 2, Issue:3

    Topics: Adenine; Aging; Animals; Animals, Newborn; Chemical Phenomena; Chemistry; Cytosine; Electrophoresis;

1966