cytosine has been researched along with Aging in 70 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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" Here we showed that the zebrafish genome gradually and clearly lost methylcytosine in somatic cells, but not in male germ cells during aging, and that age-dependent hypomethylation preferentially occurred at a particular domain called the CpG island shore, which is associated with vertebrates' genes and has been shown to be hypomethylated in humans with age." | 7.80 | Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging. ( Hashimoto, N; Izawa, T; Kikuchi, Y; Shimoda, N; Yokoi, H; Yoshizawa, A, 2014) |
"Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes." | 7.78 | Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. ( Chen, H; Dzitoyeva, S; Manev, H, 2012) |
" In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease." | 4.88 | Dynamics of DNA methylation in aging and Alzheimer's disease. ( Irier, HA; Jin, P, 2012) |
"We propose a laboratory tool that allows the quantification of DNA methylation in cytosines underlying four different clocks, thus providing broad information on epigenetic aging while maintaining a reasonable number of CpG markers, opening the way to a wide range of applications in forensics, medicine, and healthcare." | 4.31 | Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks. ( Boroń, M; Branicki, W; Dowejko, J; Kobus, M; Lisman, D; Masny, A; Migacz-Gruszka, K; Noroozi, R; Ossowski, A; Pisarek, A; Pośpiech, E; Pruszkowska-Przybylska, P; Rudnicka, J; Sitek, A; Spólnicka, M; Stanisz, K; Szargut, M; Wysocka, B; Zacharczuk, J; Zieliński, P, 2023) |
"These results suggest that the location of hydroxymethylcytosine in the genome is site specific and not random, and that changes in hydroxymethylation may play a role in the liver's response to aging and alcohol." | 3.85 | Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging. ( Ausman, LM; Choi, SW; Dolnikowski, GG; Friso, S; Park, LK; Tammen, SA, 2017) |
"A gradual loss of the correct patterning of 5-methyl cytosine marks in gene promoter regions has been implicated in aging and age-related diseases, most notably cancer." | 3.79 | High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice. ( Dollé, ME; Gravina, S; Hasty, P; Hoeijmakers, J; van Steeg, H; Vijg, J; Wang, T, 2013) |
"Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes." | 3.78 | Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. ( Chen, H; Dzitoyeva, S; Manev, H, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (21.43) | 18.7374 |
1990's | 8 (11.43) | 18.2507 |
2000's | 8 (11.43) | 29.6817 |
2010's | 33 (47.14) | 24.3611 |
2020's | 6 (8.57) | 2.80 |
Authors | Studies |
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Finesso, GE | 1 |
McDevitt, RA | 1 |
Roy, R | 1 |
Brinster, LR | 1 |
Di Francesco, A | 1 |
Meade, T | 1 |
de Cabo, R | 1 |
Ferrucci, L | 1 |
Perdue, KA | 1 |
de Sena Brandine, G | 1 |
Aston, KI | 2 |
Jenkins, TG | 2 |
Smith, AD | 1 |
Pośpiech, E | 1 |
Pisarek, A | 1 |
Rudnicka, J | 1 |
Noroozi, R | 1 |
Boroń, M | 1 |
Masny, A | 1 |
Wysocka, B | 1 |
Migacz-Gruszka, K | 1 |
Lisman, D | 1 |
Pruszkowska-Przybylska, P | 1 |
Kobus, M | 1 |
Szargut, M | 1 |
Dowejko, J | 1 |
Stanisz, K | 1 |
Zacharczuk, J | 1 |
Zieliński, P | 1 |
Sitek, A | 1 |
Ossowski, A | 1 |
Spólnicka, M | 1 |
Branicki, W | 1 |
Mei, X | 1 |
Blanchard, J | 1 |
Luellen, C | 1 |
Conboy, MJ | 1 |
Conboy, IM | 1 |
Hearn, J | 1 |
Plenderleith, F | 1 |
Little, TJ | 1 |
Oh, ES | 3 |
Petronis, A | 3 |
López, V | 1 |
Fernández, AF | 1 |
Fraga, MF | 1 |
Oh, G | 2 |
Ebrahimi, S | 2 |
Carlucci, M | 2 |
Zhang, A | 2 |
Nair, A | 2 |
Groot, DE | 2 |
Labrie, V | 2 |
Jia, P | 2 |
Jeremian, RH | 1 |
Susic, M | 2 |
Shrestha, TC | 1 |
Ralph, MR | 1 |
Gordevičius, J | 2 |
Koncevičius, K | 2 |
Kriščiūnas, A | 1 |
Wong, AHC | 1 |
Cencioni, C | 1 |
Gaetano, C | 1 |
Spallotta, F | 1 |
Shimoda, N | 1 |
Izawa, T | 1 |
Yoshizawa, A | 1 |
Yokoi, H | 1 |
Kikuchi, Y | 1 |
Hashimoto, N | 1 |
Cairns, BR | 1 |
Carrell, DT | 1 |
De Jonge, CJ | 1 |
Gravina, S | 1 |
Dollé, ME | 1 |
Wang, T | 1 |
van Steeg, H | 1 |
Hasty, P | 1 |
Hoeijmakers, J | 1 |
Vijg, J | 1 |
de Keyser, CE | 1 |
Peters, BJ | 1 |
Becker, ML | 1 |
Visser, LE | 1 |
Uitterlinden, AG | 1 |
Klungel, OH | 1 |
Verstuyft, C | 1 |
Hofman, A | 1 |
Maitland-van der Zee, AH | 1 |
Stricker, BH | 1 |
Gebhard, D | 1 |
Mahler, B | 1 |
Matt, K | 1 |
Burger, K | 1 |
Bergemann, J | 1 |
Cadena-del-Castillo, C | 1 |
Valdes-Quezada, C | 1 |
Carmona-Aldana, F | 1 |
Arias, C | 1 |
Bermúdez-Rattoni, F | 1 |
Recillas-Targa, F | 1 |
Niederberger, C | 1 |
Irier, H | 2 |
Street, RC | 1 |
Dave, R | 1 |
Lin, L | 1 |
Cai, C | 1 |
Davis, TH | 1 |
Yao, B | 1 |
Cheng, Y | 1 |
Jin, P | 3 |
Sun, W | 1 |
Zang, L | 1 |
Shu, Q | 1 |
Li, X | 2 |
Kraus, TF | 2 |
Guibourt, V | 2 |
Kretzschmar, HA | 2 |
Qian, Y | 1 |
Tu, J | 1 |
Tang, NL | 1 |
Kong, GW | 1 |
Chung, JP | 1 |
Chan, WY | 1 |
Lee, TL | 1 |
Bachman, M | 1 |
Uribe-Lewis, S | 1 |
Yang, X | 2 |
Burgess, HE | 1 |
Iurlaro, M | 1 |
Reik, W | 1 |
Murrell, A | 1 |
Balasubramanian, S | 1 |
Lardenoije, R | 1 |
van den Hove, DLA | 1 |
Vaessen, TSJ | 1 |
Iatrou, A | 1 |
Meuwissen, KPV | 1 |
van Hagen, BTJ | 1 |
Kenis, G | 1 |
Steinbusch, HWM | 1 |
Schmitz, C | 1 |
Rutten, BPF | 1 |
Kilinc, S | 1 |
Steinmaurer, M | 1 |
Stieglitz, M | 1 |
Tammen, SA | 1 |
Park, LK | 1 |
Dolnikowski, GG | 1 |
Ausman, LM | 1 |
Friso, S | 1 |
Choi, SW | 1 |
Vyhlidal, CA | 1 |
Bi, C | 1 |
Ye, SQ | 1 |
Leeder, JS | 1 |
Gong, P | 1 |
Li, K | 1 |
Huang, F | 1 |
Cheng, F | 1 |
Pan, G | 1 |
Mäkivuokko, H | 1 |
Tiihonen, K | 1 |
Tynkkynen, S | 1 |
Paulin, L | 1 |
Rautonen, N | 1 |
Fenech, M | 1 |
Thompson, RF | 1 |
Atzmon, G | 1 |
Gheorghe, C | 1 |
Liang, HQ | 1 |
Lowes, C | 1 |
Greally, JM | 1 |
Barzilai, N | 1 |
Schiepers, OJ | 1 |
van Boxtel, MP | 1 |
de Groot, RH | 1 |
Jolles, J | 1 |
Kok, FJ | 1 |
Verhoef, P | 1 |
Durga, J | 1 |
King, GD | 1 |
Rosene, DL | 1 |
Abraham, CR | 1 |
Szulwach, KE | 1 |
Li, Y | 1 |
Song, CX | 1 |
Wu, H | 1 |
Dai, Q | 1 |
Upadhyay, AK | 1 |
Gearing, M | 1 |
Levey, AI | 1 |
Vasanthakumar, A | 1 |
Godley, LA | 1 |
Chang, Q | 1 |
Cheng, X | 1 |
He, C | 1 |
Flax, JD | 1 |
Soloway, PD | 1 |
van den Hove, DL | 1 |
Chouliaras, L | 1 |
Rutten, BP | 1 |
Irier, HA | 1 |
Chen, H | 2 |
Dzitoyeva, S | 2 |
Manev, H | 2 |
Nguyen, TV | 1 |
Esteban, LM | 1 |
White, CP | 1 |
Grant, SF | 1 |
Center, JR | 1 |
Gardiner, EM | 1 |
Eisman, JA | 1 |
Travison, TG | 1 |
Morley, JE | 1 |
Araujo, AB | 1 |
O'Donnell, AB | 1 |
McKinlay, JB | 1 |
Lehmann, G | 1 |
Budovsky, A | 1 |
Muradian, KK | 1 |
Fraifeld, VE | 1 |
Berletch, JB | 1 |
Phipps, SM | 1 |
Walthall, SL | 1 |
Andrews, LG | 1 |
Tollefsbol, TO | 1 |
Akintola, AD | 1 |
Crislip, ZL | 1 |
Catania, JM | 1 |
Chen, G | 1 |
Zimmer, WE | 1 |
Burghardt, RC | 1 |
Parrish, AR | 1 |
Adams, RL | 1 |
Burdon, RH | 1 |
Kunnath, L | 1 |
Locker, J | 1 |
Holliday, R | 1 |
Wilson, VL | 1 |
Jones, PA | 1 |
Dainat, J | 1 |
Sellinger, OZ | 1 |
Jue, K | 1 |
Benoit, G | 1 |
Alcivar-Warren, AA | 1 |
Trasler, JM | 1 |
Murru, S | 1 |
Pischedda, MC | 1 |
Cao, A | 1 |
Rosatelli, MC | 1 |
Pirastu, M | 1 |
Sciarratta, GV | 1 |
Manca, L | 1 |
Gallisai, D | 1 |
Toffoli, C | 1 |
Counts, JL | 1 |
Kaznowski, JM | 1 |
McClain, RM | 1 |
Goodman, JI | 1 |
Tohgi, H | 4 |
Utsugisawa, K | 4 |
Nagane, Y | 4 |
Yoshimura, M | 3 |
Ukitsu, M | 3 |
Genda, Y | 3 |
Stuart, GR | 1 |
Glickman, BW | 1 |
Jubb, AM | 1 |
Bell, SM | 1 |
Quirke, P | 1 |
Romanov, GA | 1 |
Zin'kovskaia, GG | 2 |
Berbyshev, GD | 1 |
Vaniushin, BF | 3 |
Berdyshev, GD | 1 |
Loo, LS | 1 |
Cauchi, MN | 1 |
Tawa, R | 1 |
Ono, T | 1 |
Kurishita, A | 1 |
Okada, S | 1 |
Hirose, S | 1 |
Lotzová, E | 1 |
Savary, CA | 1 |
Lowlachi, M | 1 |
Murasko, DM | 1 |
Drinkwater, RD | 1 |
Blake, TJ | 1 |
Morley, AA | 1 |
Turner, DR | 1 |
Zhavoronkova, EN | 1 |
Simpson, VJ | 1 |
Johnson, TE | 1 |
Hammen, RF | 1 |
Gedda, L | 1 |
Brenci, G | 1 |
Vanyushin, BF | 1 |
Nemirovsky, LE | 1 |
Klimenko, VV | 1 |
Vasiliev, VK | 1 |
Belozersky, AN | 1 |
Yajima, A | 1 |
Ringborg, U | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects[NCT03353597] | Phase 1/Phase 2 | 2,120 participants (Anticipated) | Interventional | 2018-05-15 | Not yet recruiting | ||
The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial[NCT00110604] | 835 participants | Interventional | 2000-09-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
9 reviews available for cytosine and Aging
Article | Year |
---|---|
Origins of human disease: the chrono-epigenetic perspective.
Topics: Aging; Animals; Biological Clocks; Chronology as Topic; Cytosine; Disease; DNA; Epigenomics; Humans | 2021 |
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
Topics: 5-Methylcytosine; Aging; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genet | 2017 |
The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study.
Topics: Aged; Aging; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cytosine; Databases, Factual; Dose | 2014 |
From development to diseases: the role of 5hmC in brain.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genet | 2014 |
Folate, DNA damage and the aging brain.
Topics: Aging; Animals; Brain; Cell Nucleus; Cytosine; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; M | 2010 |
Dynamics of DNA methylation in aging and Alzheimer's disease.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; DNA; DNA Methylation; Humans; Neurode | 2012 |
A method to study the expression of DNA methyltransferases in aging systems in vitro.
Topics: Aging; Animals; Cell Culture Techniques; Cells, Cultured; Cellular Senescence; CpG Islands; Cytosine | 2007 |
DNA methylation in eukaryotes.
Topics: 5-Methylcytosine; Aging; Animals; Azacitidine; Base Sequence; Chromatin; Cytosine; Deoxyribonuclease | 1982 |
Methylation and colorectal cancer.
Topics: Adenocarcinoma; Adenoma; Aged; Aging; Biomarkers, Tumor; Chromatin; Colorectal Neoplasms; CpG Island | 2001 |
1 trial available for cytosine and Aging
Article | Year |
---|---|
DNA methylation and cognitive functioning in healthy older adults.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Aging; Cognitive Dysfunction; Cross-Sectiona | 2012 |
60 other studies available for cytosine and Aging
Article | Year |
---|---|
Impact of Large Granular Lymphocyte Leukemia on Blood DNA Methylation and Epigenetic Clock Modeling in Fischer 344 Rats.
Topics: Aging; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Leukemia, Large Granular Lymphocytic | 2022 |
Global effects of identity and aging on the human sperm methylome.
Topics: Adult; Aging; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenome; Humans; Longitudinal Studie | 2023 |
Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks.
Topics: Aging; Child, Preschool; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Genomics; High | 2023 |
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.
Topics: Aging; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Longevity | 2023 |
DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna.
Topics: Aging; Animals; CpG Islands; Cytosine; Daphnia; DNA Methylation; Epigenesis, Genetic; Epigenomics; H | 2021 |
Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.
Topics: Aging; Animals; Circadian Rhythm; Cytosine; DNA Methylation; Epigenesis, Genetic; Genetic Variation; | 2018 |
Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease.
Topics: Aging; Circadian Rhythm; Cytosine; Epigenesis, Genetic; Humans; Leukemia, Lymphocytic, Chronic, B-Ce | 2019 |
Dissecting cytosine methylation mechanics of dysmetabolism.
Topics: Aging; Animals; Cytosine; DNA Methylation; Humans | 2019 |
Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging.
Topics: Aging; Animals; Apoptosis; CpG Islands; Cytosine; DNA Fragmentation; DNA Methylation; Embryo, Nonmam | 2014 |
Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
Topics: 5-Methylcytosine; Adult; Age Factors; Aging; Cytosine; DNA; DNA Methylation; Enzyme-Linked Immunosor | 2013 |
Paternal age and sperm methylation status.
Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa | 2013 |
High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice.
Topics: Aging; Animals; Brain; CpG Islands; Cytosine; DNA Methylation; DNA Repair; Genetic Loci; Genomic Imp | 2013 |
Mitochondrial DNA copy number - but not a mitochondrial tandem CC to TT transition - is increased in sun-exposed skin.
Topics: Abdomen; Aged; Aging; Base Sequence; Biomarkers; Cytosine; DNA Copy Number Variations; DNA, Mitochon | 2014 |
Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.
Topics: 5-Methylcytosine; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein | 2014 |
Re: paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa | 2014 |
Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; Gene Expression Regulation; Gene-Enviro | 2014 |
5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Animals; | 2015 |
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Met | 2015 |
5-Formylcytosine can be a stable DNA modification in mammals.
Topics: 5-Methylcytosine; Aging; Animals; Animals, Newborn; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltr | 2015 |
Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Aging; Animals; Caloric Restriction; Cytosine; DNA Methylation; Epigenesis, Geneti | 2015 |
Profiling of methylation and demethylation pathways during brain development and ageing.
Topics: 5-Methylcytosine; Aging; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Imm | 2016 |
Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging.
Topics: Aging; Alcohol Drinking; Alcoholism; Animals; Cytosine; DNA; DNA Methylation; Fatty Liver; Gene Regu | 2017 |
Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Topics: Adolescent; Age Factors; Aging; Child; Child, Preschool; Cytochrome P-450 CYP3A; Cytosine; DNA Methy | 2016 |
A single cytosine deletion in the OsPLS1 gene encoding vacuolar-type H+-ATPase subunit A1 leads to premature leaf senescence and seed dormancy in rice.
Topics: Aging; Chromosome Mapping; Cloning, Molecular; Cytosine; Genes, Plant; Oryza; Plant Dormancy; Plant | 2016 |
The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cytosine; | 2010 |
Tissue-specific dysregulation of DNA methylation in aging.
Topics: Aging; Animals; Biological Assay; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Pr | 2010 |
Promoter methylation and age-related downregulation of Klotho in rhesus monkey.
Topics: 5-Methylcytosine; Aging; Animals; Brain; Cell Line; Cytosine; DNA Methylation; Down-Regulation; Epig | 2012 |
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
Topics: 5-Methylcytosine; Aging; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Chromosome Del | 2011 |
Methylation on the mind.
Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cytosine; Epigenomics; Gene Expression Regulation, Dev | 2011 |
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; Disease Models, Animal; DNA Methylati | 2012 |
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Arachidonate 5-Lipoxygenase; Cytosine; Disease | 2012 |
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.
Topics: 5-Methylcytosine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, | 2012 |
Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women.
Topics: Aged; Aged, 80 and over; Aging; Bone Density; Cohort Studies; Collagen Type I; Collagen Type I, alph | 2005 |
The relationship between libido and testosterone levels in aging men.
Topics: Adenine; Adult; Aged; Aging; Cytosine; Follow-Up Studies; Guanine; Humans; Libido; Longitudinal Stud | 2006 |
Mitochondrial genome anatomy and species-specific lifespan.
Topics: Aging; Animals; Cytosine; DNA, Mitochondrial; Eukaryotic Cells; Longevity; Species Specificity; Thym | 2006 |
Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney.
Topics: Aging; Animals; Azacitidine; Base Sequence; Cadherins; Cells, Cultured; Cytosine; Decitabine; DNA; D | 2008 |
Characterization of DNA methylation in the rat.
Topics: 5-Methylcytosine; Aging; Animals; Base Composition; Base Sequence; Cell Differentiation; Cell Line; | 1982 |
The biological significance of meiosis.
Topics: 5-Methylcytosine; Aging; Base Sequence; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; | 1984 |
DNA methylation decreases in aging but not in immortal cells.
Topics: 5-Methylcytosine; Aging; Animals; Cell Division; Cell Line; Cricetinae; Cytosine; DNA; Fibroblasts; | 1983 |
Cerebellar tRNA methyltransferases: a developmental study.
Topics: Aging; Animals; Cerebellum; Cytosine; Guanine; Kinetics; Male; Methylation; Purkinje Cells; Rats; tR | 1980 |
Developmental and hormonal regulation of DNA methyltransferase in the rat testis.
Topics: Aging; Animals; Cytosine; DNA (Cytosine-5-)-Methyltransferases; Gene Expression; Hypophysectomy; Mal | 1995 |
A promoter mutation of the beta-globin gene (-101 C-->T) has an age-related expression pattern.
Topics: Adult; Aging; Base Sequence; Cytosine; Female; Fetal Hemoglobin; Fetus; Gene Expression Regulation; | 1993 |
5-methylcytosine is present in the 5' flanking region of Ha-ras in mouse liver and increases with ageing.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; Deoxyribonucleases, Type II Site-Specific; DNA Methylati | 1997 |
Decrease with age in methylcytosines in the promoter region of receptor for advanced glycated end products (RAGE) gene in autopsy human cortex.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Aging; Base Sequence; Brain Chemistry; Cerebral Co | 1999 |
Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Aging; Amyloid beta-Protein Precursor; Autopsy; Ba | 1999 |
The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex.
Topics: Adult; Aged; Aged, 80 and over; Aging; Autopsy; Base Sequence; Cerebral Cortex; Cytosine; DNA Methyl | 1999 |
PCR amplification in bisulfite methylcytosine mapping in the GC-rich promoter region of amyloid precursor protein gene in autopsy human brain.
Topics: Aged; Aged, 80 and over; Aging; Amyloid beta-Protein Precursor; Base Sequence; Cadaver; Cerebral Cor | 2000 |
Through a glass, darkly: reflections of mutation from lacI transgenic mice.
Topics: 5-Methylcytosine; Aging; Animals; Bacterial Proteins; Brain; Cell Division; CpG Islands; Cytosine; D | 2000 |
[Age- and tissue-specific differences in intragenome distribution of 5'-methylcytosine in cow's DNA].
Topics: Aging; Animals; Cattle; Cytosine; DNA; Embryo, Mammalian; Female; Heart; Myocardium; Pregnancy; Thym | 1979 |
[Tissue-specific decrease and change in the character of DNA methylation in cattle with aging].
Topics: Aging; Animals; Brain Chemistry; Cattle; Chemical Phenomena; Chemistry; Cytosine; DNA; Kidney; Liver | 1978 |
DNA methylation patterns of the gamma delta beta-globin genes in human fetal and adult erythroid tissues.
Topics: Adult; Aging; Autoradiography; Cytosine; DNA; DNA Restriction Enzymes; Erythroid Precursor Cells; Fe | 1992 |
Changes of DNA methylation level during pre- and postnatal periods in mice.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; Liver; Lu | 1990 |
Cytotoxic and morphologic profile of endogenous and pyrimidinone-activated murine NK cells.
Topics: Adjuvants, Immunologic; Aging; Animals; Cell Separation; Cytosine; Cytotoxicity, Immunologic; Female | 1986 |
Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA.
Topics: 5-Methylcytosine; Adult; Aged; Aging; Cytosine; DNA; Genes; Humans; Lymphocytes; Methylation; Transc | 1989 |
[DNA methylation and interaction with glucocorticoid receptor complexes in the rat liver].
Topics: 5-Methylcytosine; Adrenalectomy; Aging; Animals; Cytosine; DNA; Female; Hydrocortisone; Liver; Methy | 1987 |
Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging.
Topics: 5-Methylcytosine; Aging; Animals; Caenorhabditis; Chromatography, High Pressure Liquid; Crosses, Gen | 1986 |
Mechanisms of ageing.
Topics: Adenine; Aging; Cytosine; Genetic Code; Genetics, Medical; Guanine; Humans; Thymine | 1970 |
The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents.
Topics: Aging; Animals; Brain Chemistry; Cytosine; DNA; DNA, Mitochondrial; Genetics; Hydrocortisone; Kidney | 1973 |
The decrepitude of the rat brain with special reference to changes in nucleic acid.
Topics: Adenine; Aging; Animals; Brain Chemistry; Brain Stem; Cerebellum; Chromatography; Cytosine; Dienceph | 1966 |
Composition and content of RNA in neurons of rat hippocampus at different ages.
Topics: Adenine; Aging; Animals; Animals, Newborn; Chemical Phenomena; Chemistry; Cytosine; Electrophoresis; | 1966 |