cytosine has been researched along with Aging in 70 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we showed that the zebrafish genome gradually and clearly lost methylcytosine in somatic cells, but not in male germ cells during aging, and that age-dependent hypomethylation preferentially occurred at a particular domain called the CpG island shore, which is associated with vertebrates' genes and has been shown to be hypomethylated in humans with age." | 7.80 | Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging. ( Hashimoto, N; Izawa, T; Kikuchi, Y; Shimoda, N; Yokoi, H; Yoshizawa, A, 2014) |
| "Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes." | 7.78 | Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. ( Chen, H; Dzitoyeva, S; Manev, H, 2012) |
| " In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease." | 4.88 | Dynamics of DNA methylation in aging and Alzheimer's disease. ( Irier, HA; Jin, P, 2012) |
| "We propose a laboratory tool that allows the quantification of DNA methylation in cytosines underlying four different clocks, thus providing broad information on epigenetic aging while maintaining a reasonable number of CpG markers, opening the way to a wide range of applications in forensics, medicine, and healthcare." | 4.31 | Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks. ( Boroń, M; Branicki, W; Dowejko, J; Kobus, M; Lisman, D; Masny, A; Migacz-Gruszka, K; Noroozi, R; Ossowski, A; Pisarek, A; Pośpiech, E; Pruszkowska-Przybylska, P; Rudnicka, J; Sitek, A; Spólnicka, M; Stanisz, K; Szargut, M; Wysocka, B; Zacharczuk, J; Zieliński, P, 2023) |
| "These results suggest that the location of hydroxymethylcytosine in the genome is site specific and not random, and that changes in hydroxymethylation may play a role in the liver's response to aging and alcohol." | 3.85 | Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging. ( Ausman, LM; Choi, SW; Dolnikowski, GG; Friso, S; Park, LK; Tammen, SA, 2017) |
| "A gradual loss of the correct patterning of 5-methyl cytosine marks in gene promoter regions has been implicated in aging and age-related diseases, most notably cancer." | 3.79 | High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice. ( Dollé, ME; Gravina, S; Hasty, P; Hoeijmakers, J; van Steeg, H; Vijg, J; Wang, T, 2013) |
| "Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes." | 3.78 | Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus. ( Chen, H; Dzitoyeva, S; Manev, H, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (21.43) | 18.7374 |
| 1990's | 8 (11.43) | 18.2507 |
| 2000's | 8 (11.43) | 29.6817 |
| 2010's | 33 (47.14) | 24.3611 |
| 2020's | 6 (8.57) | 2.80 |
| Authors | Studies |
|---|---|
| Finesso, GE | 1 |
| McDevitt, RA | 1 |
| Roy, R | 1 |
| Brinster, LR | 1 |
| Di Francesco, A | 1 |
| Meade, T | 1 |
| de Cabo, R | 1 |
| Ferrucci, L | 1 |
| Perdue, KA | 1 |
| de Sena Brandine, G | 1 |
| Aston, KI | 2 |
| Jenkins, TG | 2 |
| Smith, AD | 1 |
| Pośpiech, E | 1 |
| Pisarek, A | 1 |
| Rudnicka, J | 1 |
| Noroozi, R | 1 |
| Boroń, M | 1 |
| Masny, A | 1 |
| Wysocka, B | 1 |
| Migacz-Gruszka, K | 1 |
| Lisman, D | 1 |
| Pruszkowska-Przybylska, P | 1 |
| Kobus, M | 1 |
| Szargut, M | 1 |
| Dowejko, J | 1 |
| Stanisz, K | 1 |
| Zacharczuk, J | 1 |
| Zieliński, P | 1 |
| Sitek, A | 1 |
| Ossowski, A | 1 |
| Spólnicka, M | 1 |
| Branicki, W | 1 |
| Mei, X | 1 |
| Blanchard, J | 1 |
| Luellen, C | 1 |
| Conboy, MJ | 1 |
| Conboy, IM | 1 |
| Hearn, J | 1 |
| Plenderleith, F | 1 |
| Little, TJ | 1 |
| Oh, ES | 3 |
| Petronis, A | 3 |
| López, V | 1 |
| Fernández, AF | 1 |
| Fraga, MF | 1 |
| Oh, G | 2 |
| Ebrahimi, S | 2 |
| Carlucci, M | 2 |
| Zhang, A | 2 |
| Nair, A | 2 |
| Groot, DE | 2 |
| Labrie, V | 2 |
| Jia, P | 2 |
| Jeremian, RH | 1 |
| Susic, M | 2 |
| Shrestha, TC | 1 |
| Ralph, MR | 1 |
| Gordevičius, J | 2 |
| Koncevičius, K | 2 |
| Kriščiūnas, A | 1 |
| Wong, AHC | 1 |
| Cencioni, C | 1 |
| Gaetano, C | 1 |
| Spallotta, F | 1 |
| Shimoda, N | 1 |
| Izawa, T | 1 |
| Yoshizawa, A | 1 |
| Yokoi, H | 1 |
| Kikuchi, Y | 1 |
| Hashimoto, N | 1 |
| Cairns, BR | 1 |
| Carrell, DT | 1 |
| De Jonge, CJ | 1 |
| Gravina, S | 1 |
| Dollé, ME | 1 |
| Wang, T | 1 |
| van Steeg, H | 1 |
| Hasty, P | 1 |
| Hoeijmakers, J | 1 |
| Vijg, J | 1 |
| de Keyser, CE | 1 |
| Peters, BJ | 1 |
| Becker, ML | 1 |
| Visser, LE | 1 |
| Uitterlinden, AG | 1 |
| Klungel, OH | 1 |
| Verstuyft, C | 1 |
| Hofman, A | 1 |
| Maitland-van der Zee, AH | 1 |
| Stricker, BH | 1 |
| Gebhard, D | 1 |
| Mahler, B | 1 |
| Matt, K | 1 |
| Burger, K | 1 |
| Bergemann, J | 1 |
| Cadena-del-Castillo, C | 1 |
| Valdes-Quezada, C | 1 |
| Carmona-Aldana, F | 1 |
| Arias, C | 1 |
| Bermúdez-Rattoni, F | 1 |
| Recillas-Targa, F | 1 |
| Niederberger, C | 1 |
| Irier, H | 2 |
| Street, RC | 1 |
| Dave, R | 1 |
| Lin, L | 1 |
| Cai, C | 1 |
| Davis, TH | 1 |
| Yao, B | 1 |
| Cheng, Y | 1 |
| Jin, P | 3 |
| Sun, W | 1 |
| Zang, L | 1 |
| Shu, Q | 1 |
| Li, X | 2 |
| Kraus, TF | 2 |
| Guibourt, V | 2 |
| Kretzschmar, HA | 2 |
| Qian, Y | 1 |
| Tu, J | 1 |
| Tang, NL | 1 |
| Kong, GW | 1 |
| Chung, JP | 1 |
| Chan, WY | 1 |
| Lee, TL | 1 |
| Bachman, M | 1 |
| Uribe-Lewis, S | 1 |
| Yang, X | 2 |
| Burgess, HE | 1 |
| Iurlaro, M | 1 |
| Reik, W | 1 |
| Murrell, A | 1 |
| Balasubramanian, S | 1 |
| Lardenoije, R | 1 |
| van den Hove, DLA | 1 |
| Vaessen, TSJ | 1 |
| Iatrou, A | 1 |
| Meuwissen, KPV | 1 |
| van Hagen, BTJ | 1 |
| Kenis, G | 1 |
| Steinbusch, HWM | 1 |
| Schmitz, C | 1 |
| Rutten, BPF | 1 |
| Kilinc, S | 1 |
| Steinmaurer, M | 1 |
| Stieglitz, M | 1 |
| Tammen, SA | 1 |
| Park, LK | 1 |
| Dolnikowski, GG | 1 |
| Ausman, LM | 1 |
| Friso, S | 1 |
| Choi, SW | 1 |
| Vyhlidal, CA | 1 |
| Bi, C | 1 |
| Ye, SQ | 1 |
| Leeder, JS | 1 |
| Gong, P | 1 |
| Li, K | 1 |
| Huang, F | 1 |
| Cheng, F | 1 |
| Pan, G | 1 |
| Mäkivuokko, H | 1 |
| Tiihonen, K | 1 |
| Tynkkynen, S | 1 |
| Paulin, L | 1 |
| Rautonen, N | 1 |
| Fenech, M | 1 |
| Thompson, RF | 1 |
| Atzmon, G | 1 |
| Gheorghe, C | 1 |
| Liang, HQ | 1 |
| Lowes, C | 1 |
| Greally, JM | 1 |
| Barzilai, N | 1 |
| Schiepers, OJ | 1 |
| van Boxtel, MP | 1 |
| de Groot, RH | 1 |
| Jolles, J | 1 |
| Kok, FJ | 1 |
| Verhoef, P | 1 |
| Durga, J | 1 |
| King, GD | 1 |
| Rosene, DL | 1 |
| Abraham, CR | 1 |
| Szulwach, KE | 1 |
| Li, Y | 1 |
| Song, CX | 1 |
| Wu, H | 1 |
| Dai, Q | 1 |
| Upadhyay, AK | 1 |
| Gearing, M | 1 |
| Levey, AI | 1 |
| Vasanthakumar, A | 1 |
| Godley, LA | 1 |
| Chang, Q | 1 |
| Cheng, X | 1 |
| He, C | 1 |
| Flax, JD | 1 |
| Soloway, PD | 1 |
| van den Hove, DL | 1 |
| Chouliaras, L | 1 |
| Rutten, BP | 1 |
| Irier, HA | 1 |
| Chen, H | 2 |
| Dzitoyeva, S | 2 |
| Manev, H | 2 |
| Nguyen, TV | 1 |
| Esteban, LM | 1 |
| White, CP | 1 |
| Grant, SF | 1 |
| Center, JR | 1 |
| Gardiner, EM | 1 |
| Eisman, JA | 1 |
| Travison, TG | 1 |
| Morley, JE | 1 |
| Araujo, AB | 1 |
| O'Donnell, AB | 1 |
| McKinlay, JB | 1 |
| Lehmann, G | 1 |
| Budovsky, A | 1 |
| Muradian, KK | 1 |
| Fraifeld, VE | 1 |
| Berletch, JB | 1 |
| Phipps, SM | 1 |
| Walthall, SL | 1 |
| Andrews, LG | 1 |
| Tollefsbol, TO | 1 |
| Akintola, AD | 1 |
| Crislip, ZL | 1 |
| Catania, JM | 1 |
| Chen, G | 1 |
| Zimmer, WE | 1 |
| Burghardt, RC | 1 |
| Parrish, AR | 1 |
| Adams, RL | 1 |
| Burdon, RH | 1 |
| Kunnath, L | 1 |
| Locker, J | 1 |
| Holliday, R | 1 |
| Wilson, VL | 1 |
| Jones, PA | 1 |
| Dainat, J | 1 |
| Sellinger, OZ | 1 |
| Jue, K | 1 |
| Benoit, G | 1 |
| Alcivar-Warren, AA | 1 |
| Trasler, JM | 1 |
| Murru, S | 1 |
| Pischedda, MC | 1 |
| Cao, A | 1 |
| Rosatelli, MC | 1 |
| Pirastu, M | 1 |
| Sciarratta, GV | 1 |
| Manca, L | 1 |
| Gallisai, D | 1 |
| Toffoli, C | 1 |
| Counts, JL | 1 |
| Kaznowski, JM | 1 |
| McClain, RM | 1 |
| Goodman, JI | 1 |
| Tohgi, H | 4 |
| Utsugisawa, K | 4 |
| Nagane, Y | 4 |
| Yoshimura, M | 3 |
| Ukitsu, M | 3 |
| Genda, Y | 3 |
| Stuart, GR | 1 |
| Glickman, BW | 1 |
| Jubb, AM | 1 |
| Bell, SM | 1 |
| Quirke, P | 1 |
| Romanov, GA | 1 |
| Zin'kovskaia, GG | 2 |
| Berbyshev, GD | 1 |
| Vaniushin, BF | 3 |
| Berdyshev, GD | 1 |
| Loo, LS | 1 |
| Cauchi, MN | 1 |
| Tawa, R | 1 |
| Ono, T | 1 |
| Kurishita, A | 1 |
| Okada, S | 1 |
| Hirose, S | 1 |
| Lotzová, E | 1 |
| Savary, CA | 1 |
| Lowlachi, M | 1 |
| Murasko, DM | 1 |
| Drinkwater, RD | 1 |
| Blake, TJ | 1 |
| Morley, AA | 1 |
| Turner, DR | 1 |
| Zhavoronkova, EN | 1 |
| Simpson, VJ | 1 |
| Johnson, TE | 1 |
| Hammen, RF | 1 |
| Gedda, L | 1 |
| Brenci, G | 1 |
| Vanyushin, BF | 1 |
| Nemirovsky, LE | 1 |
| Klimenko, VV | 1 |
| Vasiliev, VK | 1 |
| Belozersky, AN | 1 |
| Yajima, A | 1 |
| Ringborg, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects[NCT03353597] | Phase 1/Phase 2 | 2,120 participants (Anticipated) | Interventional | 2018-05-15 | Not yet recruiting | ||
| The Folic Acid and Carotid Intima-Media Thickness (FACIT) Study: A Randomized Controlled Trial[NCT00110604] | 835 participants | Interventional | 2000-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for cytosine and Aging
| Article | Year |
|---|---|
Origins of human disease: the chrono-epigenetic perspective.
Topics: Aging; Animals; Biological Clocks; Chronology as Topic; Cytosine; Disease; DNA; Epigenomics; Humans | 2021 |
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
Topics: 5-Methylcytosine; Aging; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genet | 2017 |
The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study.
Topics: Aged; Aging; Anticholesteremic Agents; Atorvastatin; Cholesterol; Cytosine; Databases, Factual; Dose | 2014 |
From development to diseases: the role of 5hmC in brain.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genet | 2014 |
Folate, DNA damage and the aging brain.
Topics: Aging; Animals; Brain; Cell Nucleus; Cytosine; DNA; DNA Damage; Folic Acid; Folic Acid Deficiency; M | 2010 |
Dynamics of DNA methylation in aging and Alzheimer's disease.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; DNA; DNA Methylation; Humans; Neurode | 2012 |
A method to study the expression of DNA methyltransferases in aging systems in vitro.
Topics: Aging; Animals; Cell Culture Techniques; Cells, Cultured; Cellular Senescence; CpG Islands; Cytosine | 2007 |
DNA methylation in eukaryotes.
Topics: 5-Methylcytosine; Aging; Animals; Azacitidine; Base Sequence; Chromatin; Cytosine; Deoxyribonuclease | 1982 |
Methylation and colorectal cancer.
Topics: Adenocarcinoma; Adenoma; Aged; Aging; Biomarkers, Tumor; Chromatin; Colorectal Neoplasms; CpG Island | 2001 |
1 trial available for cytosine and Aging
| Article | Year |
|---|---|
DNA methylation and cognitive functioning in healthy older adults.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Aging; Cognitive Dysfunction; Cross-Sectiona | 2012 |
60 other studies available for cytosine and Aging
| Article | Year |
|---|---|
Impact of Large Granular Lymphocyte Leukemia on Blood DNA Methylation and Epigenetic Clock Modeling in Fischer 344 Rats.
Topics: Aging; Animals; Cytosine; DNA Methylation; Epigenesis, Genetic; Leukemia, Large Granular Lymphocytic | 2022 |
Global effects of identity and aging on the human sperm methylome.
Topics: Adult; Aging; Cytosine; DNA Methylation; Epigenesis, Genetic; Epigenome; Humans; Longitudinal Studie | 2023 |
Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks.
Topics: Aging; Child, Preschool; CpG Islands; Cytosine; DNA Methylation; Epigenesis, Genetic; Genomics; High | 2023 |
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.
Topics: Aging; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Longevity | 2023 |
DNA methylation differs extensively between strains of the same geographical origin and changes with age in Daphnia magna.
Topics: Aging; Animals; CpG Islands; Cytosine; Daphnia; DNA Methylation; Epigenesis, Genetic; Epigenomics; H | 2021 |
Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.
Topics: Aging; Animals; Circadian Rhythm; Cytosine; DNA Methylation; Epigenesis, Genetic; Genetic Variation; | 2018 |
Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease.
Topics: Aging; Circadian Rhythm; Cytosine; Epigenesis, Genetic; Humans; Leukemia, Lymphocytic, Chronic, B-Ce | 2019 |
Dissecting cytosine methylation mechanics of dysmetabolism.
Topics: Aging; Animals; Cytosine; DNA Methylation; Humans | 2019 |
Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging.
Topics: Aging; Animals; Apoptosis; CpG Islands; Cytosine; DNA Fragmentation; DNA Methylation; Embryo, Nonmam | 2014 |
Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
Topics: 5-Methylcytosine; Adult; Age Factors; Aging; Cytosine; DNA; DNA Methylation; Enzyme-Linked Immunosor | 2013 |
Paternal age and sperm methylation status.
Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa | 2013 |
High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice.
Topics: Aging; Animals; Brain; CpG Islands; Cytosine; DNA Methylation; DNA Repair; Genetic Loci; Genomic Imp | 2013 |
Mitochondrial DNA copy number - but not a mitochondrial tandem CC to TT transition - is increased in sun-exposed skin.
Topics: Abdomen; Aged; Aging; Base Sequence; Biomarkers; Cytosine; DNA Copy Number Variations; DNA, Mitochon | 2014 |
Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.
Topics: 5-Methylcytosine; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein | 2014 |
Re: paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa | 2014 |
Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; Gene Expression Regulation; Gene-Enviro | 2014 |
5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.
Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Animals; | 2015 |
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Met | 2015 |
5-Formylcytosine can be a stable DNA modification in mammals.
Topics: 5-Methylcytosine; Aging; Animals; Animals, Newborn; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltr | 2015 |
Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine.
Topics: 5-Methylcytosine; Aging; Animals; Caloric Restriction; Cytosine; DNA Methylation; Epigenesis, Geneti | 2015 |
Profiling of methylation and demethylation pathways during brain development and ageing.
Topics: 5-Methylcytosine; Aging; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Imm | 2016 |
Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging.
Topics: Aging; Alcohol Drinking; Alcoholism; Animals; Cytosine; DNA; DNA Methylation; Fatty Liver; Gene Regu | 2017 |
Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
Topics: Adolescent; Age Factors; Aging; Child; Child, Preschool; Cytochrome P-450 CYP3A; Cytosine; DNA Methy | 2016 |
A single cytosine deletion in the OsPLS1 gene encoding vacuolar-type H+-ATPase subunit A1 leads to premature leaf senescence and seed dormancy in rice.
Topics: Aging; Chromosome Mapping; Cloning, Molecular; Cytosine; Genes, Plant; Oryza; Plant Dormancy; Plant | 2016 |
The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cytosine; | 2010 |
Tissue-specific dysregulation of DNA methylation in aging.
Topics: Aging; Animals; Biological Assay; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression Pr | 2010 |
Promoter methylation and age-related downregulation of Klotho in rhesus monkey.
Topics: 5-Methylcytosine; Aging; Animals; Brain; Cell Line; Cytosine; DNA Methylation; Down-Regulation; Epig | 2012 |
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
Topics: 5-Methylcytosine; Aging; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Chromosome Del | 2011 |
Methylation on the mind.
Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cytosine; Epigenomics; Gene Expression Regulation, Dev | 2011 |
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; Disease Models, Animal; DNA Methylati | 2012 |
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Arachidonate 5-Lipoxygenase; Cytosine; Disease | 2012 |
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.
Topics: 5-Methylcytosine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, | 2012 |
Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women.
Topics: Aged; Aged, 80 and over; Aging; Bone Density; Cohort Studies; Collagen Type I; Collagen Type I, alph | 2005 |
The relationship between libido and testosterone levels in aging men.
Topics: Adenine; Adult; Aged; Aging; Cytosine; Follow-Up Studies; Guanine; Humans; Libido; Longitudinal Stud | 2006 |
Mitochondrial genome anatomy and species-specific lifespan.
Topics: Aging; Animals; Cytosine; DNA, Mitochondrial; Eukaryotic Cells; Longevity; Species Specificity; Thym | 2006 |
Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney.
Topics: Aging; Animals; Azacitidine; Base Sequence; Cadherins; Cells, Cultured; Cytosine; Decitabine; DNA; D | 2008 |
Characterization of DNA methylation in the rat.
Topics: 5-Methylcytosine; Aging; Animals; Base Composition; Base Sequence; Cell Differentiation; Cell Line; | 1982 |
The biological significance of meiosis.
Topics: 5-Methylcytosine; Aging; Base Sequence; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; | 1984 |
DNA methylation decreases in aging but not in immortal cells.
Topics: 5-Methylcytosine; Aging; Animals; Cell Division; Cell Line; Cricetinae; Cytosine; DNA; Fibroblasts; | 1983 |
Cerebellar tRNA methyltransferases: a developmental study.
Topics: Aging; Animals; Cerebellum; Cytosine; Guanine; Kinetics; Male; Methylation; Purkinje Cells; Rats; tR | 1980 |
Developmental and hormonal regulation of DNA methyltransferase in the rat testis.
Topics: Aging; Animals; Cytosine; DNA (Cytosine-5-)-Methyltransferases; Gene Expression; Hypophysectomy; Mal | 1995 |
A promoter mutation of the beta-globin gene (-101 C-->T) has an age-related expression pattern.
Topics: Adult; Aging; Base Sequence; Cytosine; Female; Fetal Hemoglobin; Fetus; Gene Expression Regulation; | 1993 |
5-methylcytosine is present in the 5' flanking region of Ha-ras in mouse liver and increases with ageing.
Topics: 5-Methylcytosine; Aging; Animals; Cytosine; Deoxyribonucleases, Type II Site-Specific; DNA Methylati | 1997 |
Decrease with age in methylcytosines in the promoter region of receptor for advanced glycated end products (RAGE) gene in autopsy human cortex.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Aging; Base Sequence; Brain Chemistry; Cerebral Co | 1999 |
Reduction with age in methylcytosine in the promoter region -224 approximately -101 of the amyloid precursor protein gene in autopsy human cortex.
Topics: 5-Methylcytosine; Adult; Aged; Aged, 80 and over; Aging; Amyloid beta-Protein Precursor; Autopsy; Ba | 1999 |
The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex.
Topics: Adult; Aged; Aged, 80 and over; Aging; Autopsy; Base Sequence; Cerebral Cortex; Cytosine; DNA Methyl | 1999 |
PCR amplification in bisulfite methylcytosine mapping in the GC-rich promoter region of amyloid precursor protein gene in autopsy human brain.
Topics: Aged; Aged, 80 and over; Aging; Amyloid beta-Protein Precursor; Base Sequence; Cadaver; Cerebral Cor | 2000 |
Through a glass, darkly: reflections of mutation from lacI transgenic mice.
Topics: 5-Methylcytosine; Aging; Animals; Bacterial Proteins; Brain; Cell Division; CpG Islands; Cytosine; D | 2000 |
[Age- and tissue-specific differences in intragenome distribution of 5'-methylcytosine in cow's DNA].
Topics: Aging; Animals; Cattle; Cytosine; DNA; Embryo, Mammalian; Female; Heart; Myocardium; Pregnancy; Thym | 1979 |
[Tissue-specific decrease and change in the character of DNA methylation in cattle with aging].
Topics: Aging; Animals; Brain Chemistry; Cattle; Chemical Phenomena; Chemistry; Cytosine; DNA; Kidney; Liver | 1978 |
DNA methylation patterns of the gamma delta beta-globin genes in human fetal and adult erythroid tissues.
Topics: Adult; Aging; Autoradiography; Cytosine; DNA; DNA Restriction Enzymes; Erythroid Precursor Cells; Fe | 1992 |
Changes of DNA methylation level during pre- and postnatal periods in mice.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Cytosine; Deoxycytidine; DNA; Liver; Lu | 1990 |
Cytotoxic and morphologic profile of endogenous and pyrimidinone-activated murine NK cells.
Topics: Adjuvants, Immunologic; Aging; Animals; Cell Separation; Cytosine; Cytotoxicity, Immunologic; Female | 1986 |
Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA.
Topics: 5-Methylcytosine; Adult; Aged; Aging; Cytosine; DNA; Genes; Humans; Lymphocytes; Methylation; Transc | 1989 |
[DNA methylation and interaction with glucocorticoid receptor complexes in the rat liver].
Topics: 5-Methylcytosine; Adrenalectomy; Aging; Animals; Cytosine; DNA; Female; Hydrocortisone; Liver; Methy | 1987 |
Caenorhabditis elegans DNA does not contain 5-methylcytosine at any time during development or aging.
Topics: 5-Methylcytosine; Aging; Animals; Caenorhabditis; Chromatography, High Pressure Liquid; Crosses, Gen | 1986 |
Mechanisms of ageing.
Topics: Adenine; Aging; Cytosine; Genetic Code; Genetics, Medical; Guanine; Humans; Thymine | 1970 |
The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents.
Topics: Aging; Animals; Brain Chemistry; Cytosine; DNA; DNA, Mitochondrial; Genetics; Hydrocortisone; Kidney | 1973 |
The decrepitude of the rat brain with special reference to changes in nucleic acid.
Topics: Adenine; Aging; Animals; Brain Chemistry; Brain Stem; Cerebellum; Chromatography; Cytosine; Dienceph | 1966 |
Composition and content of RNA in neurons of rat hippocampus at different ages.
Topics: Adenine; Aging; Animals; Animals, Newborn; Chemical Phenomena; Chemistry; Cytosine; Electrophoresis; | 1966 |