cytosine has been researched along with Acquired Immunodeficiency Syndrome in 37 studies
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The safety and efficacy of cidofovir gel for treatment of acyclovir-unresponsive herpes simplex virus infections in AIDS patients was evaluated in a randomized, double-blind, multicenter trial." | 9.08 | A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patients with AIDS. ( Boggs, J; Cheung, T; Corey, L; Drew, WL; Feinberg, J; Gathe, J; Jaffe, HS; Kessler, H; Kramer, F; Lalezari, J; Lee, S; McGuire, B; Safrin, S; Schacker, T, 1997) |
| "Five AIDS patients with cytomegalovirus (CMV) retinitis who had received ganciclovir (GCV) therapy were followed with serial blood sampling to detectchanges both in CMV load and in the genetic composition of genes UL97 and UL54 whilst receiving cidofovir (CDV) therapy." | 7.70 | Quantitative changes in cytomegalovirus DNAemia and genetic analysis of the UL97 and UL54 genes in AIDS patients receiving cidofovir following ganciclovir therapy. ( Bowen, EF; Cherrington, JM; Emery, VC; Griffiths, PD; Johnson, MA; Lamy, PD, 1999) |
| "The safety and efficacy of cidofovir gel for treatment of acyclovir-unresponsive herpes simplex virus infections in AIDS patients was evaluated in a randomized, double-blind, multicenter trial." | 5.08 | A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patients with AIDS. ( Boggs, J; Cheung, T; Corey, L; Drew, WL; Feinberg, J; Gathe, J; Jaffe, HS; Kessler, H; Kramer, F; Lalezari, J; Lee, S; McGuire, B; Safrin, S; Schacker, T, 1997) |
| "Five AIDS patients with cytomegalovirus (CMV) retinitis who had received ganciclovir (GCV) therapy were followed with serial blood sampling to detectchanges both in CMV load and in the genetic composition of genes UL97 and UL54 whilst receiving cidofovir (CDV) therapy." | 3.70 | Quantitative changes in cytomegalovirus DNAemia and genetic analysis of the UL97 and UL54 genes in AIDS patients receiving cidofovir following ganciclovir therapy. ( Bowen, EF; Cherrington, JM; Emery, VC; Griffiths, PD; Johnson, MA; Lamy, PD, 1999) |
| "A patient with AIDS and cytomegalovirus (CMV) retinitis received ganciclovir and foscarnet for 20 and 5 months, respectively, with evidence of periodic disease progression." | 3.70 | A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance. ( Chou, S; Drew, WL; Miner, RC, 2000) |
| "To evaluate the decrease in intraocular pressure associated with cidofovir (1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate; HPMPC) intravitreal injections." | 3.69 | Intraocular pressure and aqueous humor dynamics in patients with AIDS treated with intravitreal cidofovir (HPMPC) for cytomegalovirus retinitis. ( Arevalo, JF; Banker, AS; Berry, C; De Clercq, E; Freeman, WR; Ishimoto, B; Munguia, D; Ochabski, R; Rahhal, FM; Taskintuna, I, 1997) |
| " Treatment was well tolerated with most common adverse events being mild to moderate affecting lesional skin: pain/burning/irritation (25 patients) and ulceration (13 patients)." | 2.78 | Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. ( Aboulafia, D; Berry, JM; Da Costa, M; Darragh, TM; Einstein, MH; Goldstone, SE; Jay, N; Lee, JY; Palefsky, JM; Panther, L; Stier, EA; Wilkin, T, 2013) |
| "Eligible patients with acquired immune deficiency syndrome had active CMV retinitis in at least one eye and no evidence of extraocular CMV disease." | 2.68 | Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. ( Arevalo, JF; Chavez de la Paz, E; de Clercq, E; Freeman, WR; Kirsch, LS; Munguia, D, 1995) |
| "Patients with acquired immunodeficiency syndrome (AIDS) can develop severe uveitis." | 1.37 | Drug-induced uveitis in aids patients: two case reports. ( Bazewicz, M; Caspers, L; Fikri, J; Frippiat, F; Libois, A; Martin, CH; Meunier, A; Willermain, F, 2011) |
| "Late AIDS diagnosis was established during a neurological complication, 13 years after a neonatal transmission." | 1.31 | [Progressive multifocal leukoencephalopathy revealing AIDS in a 13-year-old girl]. ( Chabrol, B; Chambost, H; Hugonenq, C; Lethel, V; Mancini, J; Michel, G, 2002) |
| "Eleven AIDS patients receiving HAART with healed CMV retinitis in whom CMV-specific maintenance therapy was discontinued were studied." | 1.30 | Lack of reactivation of cytomegalovirus (CMV) retinitis after stopping CMV maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy. ( Freeman, WR; Karavellas, MP; Macdonald, JC; Morse, LS; Reed, JB; Torriani, FJ, 1998) |
| " A pretreatment regimen consisting of prednisone, H1 and H2 blockers was administered before the dosing of probenecid in order for the patient to continue with the antiviral therapy." | 1.30 | Probenecid hypersensitivity in AIDS: a case report. ( Engler, RJ; Katial, RK; Myers, KW, 1998) |
| "Some advances in AIDS research have been limited by this lack of urgency in implementation, optimization, or equitable delivery to the broad patient community." | 1.29 | Advances, challenges and growing frustration. ( , 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (45.95) | 18.2507 |
| 2000's | 18 (48.65) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bazewicz, M | 1 |
| Fikri, J | 1 |
| Martin, CH | 1 |
| Libois, A | 1 |
| Meunier, A | 1 |
| Frippiat, F | 1 |
| Caspers, L | 1 |
| Willermain, F | 1 |
| Stier, EA | 1 |
| Goldstone, SE | 1 |
| Einstein, MH | 1 |
| Jay, N | 1 |
| Berry, JM | 1 |
| Wilkin, T | 1 |
| Lee, JY | 1 |
| Darragh, TM | 1 |
| Da Costa, M | 1 |
| Panther, L | 1 |
| Aboulafia, D | 1 |
| Palefsky, JM | 1 |
| Kimberlin, DW | 1 |
| Zambarakji, HJ | 1 |
| Obi, AA | 1 |
| Mitchell, SM | 1 |
| Tacconelli, E | 1 |
| Tumbarello, M | 2 |
| Rabagliati, R | 1 |
| Scoppettuolo, G | 2 |
| Minnella, A | 1 |
| Ventura, G | 1 |
| Cauda, R | 3 |
| Check, E | 1 |
| Ramos, C | 1 |
| Lajusticia, J | 1 |
| Baldanti, F | 1 |
| Lurain, N | 1 |
| Gerna, G | 1 |
| Wyen, C | 1 |
| Hoffmann, C | 1 |
| Schmeisser, N | 1 |
| Wöhrmann, A | 1 |
| Qurishi, N | 1 |
| Rockstroh, J | 1 |
| Esser, S | 1 |
| Rieke, A | 1 |
| Ross, B | 1 |
| Lorenzen, T | 1 |
| Schmitz, K | 1 |
| Stenzel, W | 1 |
| Salzberger, B | 1 |
| Fätkenheuer, G | 1 |
| Di Giambenedetto, S | 1 |
| Vago, G | 1 |
| Pompucci, A | 1 |
| Cingolani, A | 2 |
| Marzocchetti, A | 1 |
| De Luca, A | 2 |
| Kirsch, LS | 1 |
| Arevalo, JF | 2 |
| Chavez de la Paz, E | 1 |
| Munguia, D | 2 |
| de Clercq, E | 4 |
| Freeman, WR | 4 |
| Sadler, M | 1 |
| Morris-Jones, S | 1 |
| Nelson, M | 1 |
| Gazzard, BG | 1 |
| Banker, AS | 1 |
| Rahhal, FM | 2 |
| Ishimoto, B | 1 |
| Berry, C | 1 |
| Ochabski, R | 1 |
| Taskintuna, I | 2 |
| Lalezari, J | 1 |
| Schacker, T | 1 |
| Feinberg, J | 1 |
| Gathe, J | 1 |
| Lee, S | 1 |
| Cheung, T | 1 |
| Kramer, F | 1 |
| Kessler, H | 1 |
| Corey, L | 1 |
| Drew, WL | 2 |
| Boggs, J | 1 |
| McGuire, B | 1 |
| Jaffe, HS | 1 |
| Safrin, S | 1 |
| Capparelli, EV | 1 |
| Cundy, KC | 1 |
| Macdonald, JC | 1 |
| Torriani, FJ | 1 |
| Morse, LS | 1 |
| Karavellas, MP | 1 |
| Reed, JB | 1 |
| Myers, KW | 1 |
| Katial, RK | 1 |
| Engler, RJ | 1 |
| Vogel, JU | 1 |
| Scholz, M | 1 |
| Cinatl, J | 1 |
| Lateef, F | 1 |
| Don, PC | 1 |
| Kaufmann, M | 1 |
| White, SM | 1 |
| Weinberg, JM | 1 |
| Bowen, EF | 1 |
| Cherrington, JM | 1 |
| Lamy, PD | 1 |
| Griffiths, PD | 1 |
| Johnson, MA | 1 |
| Emery, VC | 1 |
| Chou, S | 1 |
| Miner, RC | 1 |
| Sparling, JD | 1 |
| Norwood, CW | 1 |
| Turiansky, GW | 1 |
| Oster, CN | 1 |
| Hocqueloux, L | 1 |
| Agbalika, F | 1 |
| Oksenhendler, E | 1 |
| Molina, JM | 1 |
| Torres, G | 1 |
| Herrero-Romero, M | 1 |
| Cordero, E | 1 |
| López-Cortés, LF | 1 |
| de Alarcón, A | 1 |
| Pachón, J | 1 |
| Cinque, P | 1 |
| Pierotti, C | 1 |
| Viganò, MG | 1 |
| Bestetti, A | 1 |
| Fausti, C | 1 |
| Bertelli, D | 1 |
| Lazzarin, A | 1 |
| Giancola, ML | 1 |
| Ammassari, A | 1 |
| Grisetti, S | 1 |
| Larussa, D | 1 |
| Alba, L | 1 |
| Murri, R | 1 |
| Ippolito, G | 1 |
| Monforte, A | 1 |
| Antinori, A | 1 |
| Gasnault, J | 1 |
| Kousignian, P | 1 |
| Kahraman, M | 1 |
| Rahoiljaon, J | 1 |
| Matheron, S | 1 |
| Delfraissy, JF | 1 |
| Taoufik, Y | 1 |
| Snoeck, R | 1 |
| Van Laethem, Y | 1 |
| De Maubeuge, J | 1 |
| Clumeck, N | 1 |
| Razonable, RR | 1 |
| Aksamit, AJ | 1 |
| Wright, AJ | 1 |
| Wilson, JW | 1 |
| Hugonenq, C | 1 |
| Lethel, V | 1 |
| Chambost, H | 1 |
| Michel, G | 1 |
| Chabrol, B | 1 |
| Mancini, J | 1 |
| Warren, RP | 1 |
| Morrey, JD | 1 |
| Burger, RA | 1 |
| Okleberry, KM | 1 |
| Sidwell, RW | 1 |
| Rooke, R | 1 |
| Parniak, MA | 1 |
| Tremblay, M | 1 |
| Soudeyns, H | 1 |
| Li, XG | 1 |
| Gao, Q | 1 |
| Yao, XJ | 1 |
| Wainberg, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase IIA Trial of 1% Topical Cidofovir for Treatment of High-Grade Perianal Squamous Intraepithelial Lesions in HIV-Infected Men and Women[NCT00550589] | Phase 2 | 33 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Refractory Mucocutaneous Herpes Simplex Disease in Patients With AIDS[NCT00002116] | Phase 1 | 30 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of patients who cleared HPV among those who had a complete or partial response (NCT00550589)
Timeframe: 6 weeks after treatment discontinuation
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 2 |
Number of patients with HPV16 at baseline in perianal HSIL and normal perianal tissue (NCT00550589)
Timeframe: Baseline
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 16 |
Number of patients with HPV16 type present in the anus from anal swab or cytobrush at baseline (NCT00550589)
Timeframe: Baseline
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 14 |
(NCT00550589)
Timeframe: 6 weeks after treatment discontinuation
| Intervention | proportion of participants (Number) |
|---|---|
| Cidofovir | 0.515 |
Number of study patients who had a serious adverse event (NCT00550589)
Timeframe: Every 2 weeks on study, 6 weeks after treatment discontinuation
| Intervention | participants (Number) |
|---|---|
| Cidofovir | 3 |
3 reviews available for cytosine and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs.
Topics: Acquired Immunodeficiency Syndrome; Antiretroviral Therapy, Highly Active; Cidofovir; Cytomegaloviru | 2004 |
Treatment of cytomegalovirus diseases.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosin | 1997 |
Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA, Viral; Huma | 1991 |
6 trials available for cytosine and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women.
Topics: Acquired Immunodeficiency Syndrome; Administration, Cutaneous; Adult; Aged; Antiviral Agents; Anus N | 2013 |
Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; | 1995 |
A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Animals; Antiviral Agents; Cells, Cultured; Ch | 1997 |
Cidofovir added to highly active antiretroviral therapy in AIDS-associated progressive multifocal leukoencephalopathy.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; C | 2001 |
Potent anti-retroviral therapy with or without cidofovir for AIDS-associated progressive multifocal leukoencephalopathy: extended follow-up of an observational study.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiretroviral The | 2001 |
Cidofovir in AIDS-associated progressive multifocal leukoencephalopathy: a monocenter observational study with clinical and JC virus load monitoring.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiretroviral The | 2001 |
28 other studies available for cytosine and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Drug-induced uveitis in aids patients: two case reports.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; C | 2011 |
Antiviral therapy for cytomegalovirus infections in pediatric patients.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adolescent; Adult; AIDS-Related Opportunis | 2002 |
Successful treatment of varicella zoster virus retinitis with aggressive intravitreal and systemic antiviral therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Comb | 2002 |
Correlation between cidofovir-associated uveitis and failing immunorestoration during HAART.
Topics: Acquired Immunodeficiency Syndrome; Adult; Analysis of Variance; Antiretroviral Therapy, Highly Acti | 2003 |
Boom, or bust?
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Animals; Bacterial Vaccines; Biomedical Re | 2003 |
[Infection due to acyclovir-resistant varicella-zoster herpes virus in a patient with AIDS].
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Cidofovir; Cytosine; Drug Re | 2004 |
Progressive multifocal leukencephalopathy in patients on highly active antiretroviral therapy: survival and risk factors of death.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; C | 2004 |
Fatal inflammatory AIDS-associated PML with high CD4 counts on HAART: a new clinical entity?
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiretroviral Therapy, Highly Active; Antiviral Agents; | 2004 |
Successful treatment of cytomegalovirus encephalitis in an AIDS patient using cidofovir.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; | 1997 |
Intraocular pressure and aqueous humor dynamics in patients with AIDS treated with intravitreal cidofovir (HPMPC) for cytomegalovirus retinitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anterior Chamber; Antiviral Agents; Aqueous Humor; Cidofo | 1997 |
Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cidofovir; Cohort Studies; Cytomegalovi | 1998 |
Lack of reactivation of cytomegalovirus (CMV) retinitis after stopping CMV maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; A | 1998 |
Probenecid hypersensitivity in AIDS: a case report.
Topics: Acquired Immunodeficiency Syndrome; Cidofovir; Cytosine; Drug Hypersensitivity; Herpes Simplex; Huma | 1998 |
Treatment of acyclovir-resistant, foscarnet-unresponsive HSV infection with topical cidofovir in a child with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Anti-HIV Agents; Child, Preschool; Cidofovir; Cytosin | 1998 |
Quantitative changes in cytomegalovirus DNAemia and genetic analysis of the UL97 and UL54 genes in AIDS patients receiving cidofovir following ganciclovir therapy.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus In | 1999 |
A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Re | 2000 |
Diagnostic and therapeutic dilemmas of a large scrotal lesion in an AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Biopsy; Cidofovir; Cytosine; Diagnosis, Differ | 2001 |
Long-term remission of an AIDS-related primary effusion lymphoma with antiviral therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antineoplastic Age | 2001 |
Black-bordered warning box for cidofovir.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cidofovir; Cytosine; Drug Labeling; Humans; In | 1997 |
Second National Retrovirus conference: a further report.
Topics: Acetamides; Acetophenones; Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cause of Dea | 1995 |
Advances, challenges and growing frustration.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cachexia; Cidofovir; Cytomegalovirus Infection | 1995 |
Acyclovir-resistant herpes: expanded access available for cidofovir gel (Forvade).
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cidofovir; Cytosine; Drug Approval; | 1997 |
The good and evil of HAART in HIV-related progressive multifocal leukoencephalopathy.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; A | 2001 |
Treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Adult; Antiviral Agents; Bowen's Diseas | 2001 |
Cidofovir treatment of progressive multifocal leukoencephalopathy in a patient receiving highly active antiretroviral therapy.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, H | 2001 |
[Progressive multifocal leukoencephalopathy revealing AIDS in a 13-year-old girl].
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Age Factors; Anti-HIV Agents; Antiretroviral Therapy | 2002 |
Murine retroviral disease-enhancing effects of a pyrimidinone immunomodulator.
Topics: Acquired Immunodeficiency Syndrome; Adjuvants, Immunologic; Administration, Oral; Animals; Antineopl | 1992 |
Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytosine; Drug Resistance, Microbial; HIV-1; H | 1991 |