cytochrome-c-t has been researched along with Meningitis--Pneumococcal* in 1 studies
1 other study(ies) available for cytochrome-c-t and Meningitis--Pneumococcal
| Article | Year |
|---|---|
Examining the use of ceftaroline in the treatment of Streptococcus pneumoniae meningitis with reference to human cathelicidin LL-37.
Five cases of bacterial meningitis treated with ceftaroline (4 Streptococcus pneumoniae and 1 Staphylococcus aureus) are summarized here. The pharmacodynamics of human cathelicidin LL-37 and ceftaroline were evaluated against S. pneumoniae. Patients who received ceftaroline 600 mg every 8 h (q8h) (1 S. aureus and 3 S. pneumoniae) were successfully treated; treatment failed in 1 patient with S. pneumoniae who received 600 mg q12h. Ceftaroline increased the negative surface charge and sensitized S. pneumoniae to killing by LL-37, a peptide implicated in blood-brain barrier defense. Topics: Adult; Aged; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cathelicidins; Ceftaroline; Cephalosporins; Cytochromes c; Drug Interactions; Female; Humans; Male; Meningitis, Pneumococcal; Microbial Sensitivity Tests; Middle Aged; Streptococcus pneumoniae; Survival Analysis | 2015 |