cytochrome-c-t has been researched along with MELAS-Syndrome* in 2 studies
1 trial(s) available for cytochrome-c-t and MELAS-Syndrome
Article | Year |
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Treatment of mitochondrial encephalomyopathy with a combination of cytochrome C and vitamins B1 and B2.
The therapeutic efficacy of a regimen consisting of intravenous injection of Cardiocrome, containing cytochrome c, flavin mononucleotide and thiamine diphosphate for mitochondrial encephalomyopathy (MEM) was examined. This combined therapy was applied to nine patients with MEM, including four with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. For the standard regimen, Cardiocrome was first injected daily, usually for 4 weeks, and later by means of intermittent injections for maintenance treatment. Clinical improvement was obtained in eight of the patients. Improvement was observed in the muscle symptoms of easy fatigability, motor disability and severity of stroke-like episodes, as well as in various other symptoms such as phosphate, tinnitus, headache, corneal edema, chilblains, thalamic pain, respiratory failure, and nystagmus. This clinical improvement was maintained for more than 1 year by additional intermittent injections. In conclusion, this therapy was fairly effective for the management of patients with MEM. Topics: Adolescent; Adult; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Cytochrome c Group; Cytochrome-c Oxidase Deficiency; Cytochromes c; Drug Combinations; Female; Flavin Mononucleotide; Humans; Kearns-Sayre Syndrome; Lactates; Male; MELAS Syndrome; MERRF Syndrome; Mitochondrial Encephalomyopathies; Riboflavin; Thiamine; Thiamine Pyrophosphate | 1997 |
1 other study(ies) available for cytochrome-c-t and MELAS-Syndrome
Article | Year |
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Platelet mitochondrial evaluation during cytochrome c and dichloroacetate treatments of MELAS.
We hypothesized that serial changes in platelet (PLT) mitochondrial enzyme (ME) activities might correspond to the effects of medications for mitochondrial encephalomyopathy and stroke-like episodes (MELAS). Cytochrome c and sodium dichloroacetate (DCA) were given to a 7-year-old girl with MELAS who had an A3243G mitochondrial DNA mutation. The effects were evaluated with whole PLT-ME assays, developed by our group, using a microplate-reader. During cytochrome c treatment, complex II+III (II+III), complex IV (IV) and citrate synthase (CS) activities showed gradual but statistically significant decrease. II+III activity dropped below normal. II+III/CS activity was initially below normal, followed by a transient improvement, then decreased again before the appearance of central nervous system symptoms. II+III, IV, II+III/CS and IV/CS activities reached their lowest levels in association with a stroke-like episode, then increased with DCA treatment. Our results suggest that progressive mitochondrial dysfunction may occur before the stroke-like episodes in MELAS and that DCA treatment may increase mitochondrial activities. Our whole PLT-ME assay system may be useful for serially evaluating mitochondrial functions in relation to clinical symptoms. Topics: Blood Platelets; Child; Child, Preschool; Cytochromes c; Dichloroacetic Acid; Female; Humans; Male; MELAS Syndrome; Mitochondria | 2005 |