cytochrome-c-t has been researched along with Critical-Illness* in 2 studies
1 review(s) available for cytochrome-c-t and Critical-Illness
| Article | Year |
|---|---|
Cytochrome c oxidase dysfunction in sepsis.
Sepsis, the principal cause of death in critically ill patients, is associated with impaired oxygen extraction by tissues. One possible explanation is the development of mitochondrial dysfunction and ineffective oxygen utilization. This abnormality has been termed cytopathic hypoxia. This may be caused by an abnormality in the transport of electrons down the cytochrome chain on the mitochondrial inner membrane. In this article we review our studies on abnormalities in the function of complex IV (cytochrome oxidase), the final electron acceptor in this chain. In addition, we provide evidence that administration of cytochrome c may overcome these abnormalities and provide a novel therapeutic alternative. Topics: Animals; Critical Illness; Cytochromes c; Electron Transport Complex IV; Humans; Mitochondria, Heart; Muscle Relaxation; Myocardial Contraction; Myocardium; Sepsis | 2007 |
1 trial(s) available for cytochrome-c-t and Critical-Illness
| Article | Year |
|---|---|
Melatonin Pharmacological Blood Levels Increase Total Antioxidant Capacity in Critically Ill Patients.
In this study, the aim was to test the biochemical effects of melatonin supplementation in Intensive Care Unit (ICU) patients, since their blood levels are decreased. Sixty-four patients were enrolled in the study. From the evening of the 3rd ICU day, patients were randomized to receive oral melatonin (3 mg, group M) or placebo (group P) twice daily, at 20:00 and 24:00, until discharged. Blood was taken (at 00:00 and 14:00), on the 3rd ICU day to assess basal nocturnal melatonin values, and then during the treatment period on the 4th and 8th ICU days. Melatonin, total antioxidant capacity, and oxidative stress were evaluated in serum. Melatonin circadian rhythm before treatment was similar in the two groups, with a partial preservation of the cycle. Four hours from the 1st administration (4th ICU day, 00:00), melatonin levels increased to 2514 (982.3; 7148) pg·mL Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Circadian Rhythm; Critical Illness; Cytochromes c; Double-Blind Method; Drug Administration Schedule; Female; Humans; Intensive Care Units; Lymphocytes; Male; Melatonin; Microscopy, Confocal; Middle Aged; Nitric Oxide Synthase Type II; Oxidative Stress; Time Factors; Treatment Outcome; Young Adult | 2017 |