cytochalasin-e and Adenoma--Islet-Cell

Tumoral pancreatic islet cells of the RINm5F line are equipped with two classes of [3H]cytochalasin B binding sites with respective Kd of 0.4 and 7 microM. The binding of the fungal metabolite and its dissociation from the binding sites display rapid time courses. The binding is inhibited by D-glucose, more than by L-glucose, by phlorizin and by cytochalasin E. These findings are considered in the light of the dual action of cytochalasin B upon hexose transport and motile activity in islet cells.

Topics: Adenoma, Islet Cell; Binding Sites; Cytochalasin B; Cytochalasins; Glucose; Islets of Langerhans; Kinetics; Pancreatic Neoplasms; Phlorhizin; Tumor Cells, Cultured