cytochalasin-b and Neoplasm-Seeding

Cytochalasin B pretreatment of tumor cells alters the distribution pattern of metastases after i.v. injection. We now have studied Cytochalasin B cell pretreatment affects the i.v. distribution and elimination of 125IUDR-labeled TA3-Ha tumor cells. We found no differences between control and CB-treated cells in their initial distribution. but 4-8 hours after the injection, in the redistribution phase, there were more CB cells than control cells extrapulmonally. Rather than a consequence of CB paralysis, we interpret the results in terms of altered surface properties of CB cells during their recovery.

Topics: Animals; Cell Movement; Cytochalasin B; Female; Male; Mice; Neoplasm Metastasis; Neoplasm Seeding; Neoplasms, Experimental; Surface Properties; Time Factors