cytochalasin-a and Carcinoma--Ehrlich-Tumor

cytochalasin-a has been researched along with Carcinoma--Ehrlich-Tumor* in 1 studies

Other Studies

1 other study(ies) available for cytochalasin-a and Carcinoma--Ehrlich-Tumor

Article	Year
The role of the conjugated carbonyl of cytochalasin A in contractility inhibitions. Life sciences, 1982, May-31, Volume: 30, Issue:22 A study of the mechanism of action of cytochalasin A (CA) in relation to its structural features and to its selective inhibition of certain contractile processes has been initiated. Quantitative structure-function analyses with several CA-related cytochalasins - including synthetic 21,22-dihydro-CA (DHCA), the 22-beta mercaptoethanol CA-adduct, (CA-2ME), and the 22-dithiothreitol CA-adduct (CA-DTT) - have been carried out in a temperature sensitive gel-sol extract from Ehrlich ascites tumor cells. Each drug congener was purified to homogeneity by HPLC prior to biological testing. The undiminished inhibitory indices of DHCA and CA-2ME (ID50 congruent to 3.7 x 10(-7) M) overrules the prior circumstantial evidence accumulated for the obligatory electrophilic interaction of this drug, at its alpha-beta-unsaturated ketone region, with presumptive receptor nucleophiles. Topics: Animals; Carcinoma, Ehrlich Tumor; Colchicine; Cytochalasin B; Cytochalasins; Dithiothreitol; Dose-Response Relationship, Drug; Mercaptoethanol; Mice; Structure-Activity Relationship	1982

Article

Year

The role of the conjugated carbonyl of cytochalasin A in contractility inhibitions.

Life sciences, 1982, May-31, Volume: 30, Issue:22

A study of the mechanism of action of cytochalasin A (CA) in relation to its structural features and to its selective inhibition of certain contractile processes has been initiated. Quantitative structure-function analyses with several CA-related cytochalasins - including synthetic 21,22-dihydro-CA (DHCA), the 22-beta mercaptoethanol CA-adduct, (CA-2ME), and the 22-dithiothreitol CA-adduct (CA-DTT) - have been carried out in a temperature sensitive gel-sol extract from Ehrlich ascites tumor cells. Each drug congener was purified to homogeneity by HPLC prior to biological testing. The undiminished inhibitory indices of DHCA and CA-2ME (ID50 congruent to 3.7 x 10(-7) M) overrules the prior circumstantial evidence accumulated for the obligatory electrophilic interaction of this drug, at its alpha-beta-unsaturated ketone region, with presumptive receptor nucleophiles.

Topics: Animals; Carcinoma, Ehrlich Tumor; Colchicine; Cytochalasin B; Cytochalasins; Dithiothreitol; Dose-Response Relationship, Drug; Mercaptoethanol; Mice; Structure-Activity Relationship

1982