cytidylyl-3--5--guanosine and Tularemia

cytidylyl-3--5--guanosine has been researched along with Tularemia* in 1 studies

Other Studies

1 other study(ies) available for cytidylyl-3--5--guanosine and Tularemia

Article	Year
Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infection and immunity, 1999, Volume: 67, Issue:11 Synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate an innate immune response characterized by the production of polyreactive immunoglobulin M antibodies and immunomodulatory cytokines. This immune response has been shown to protect mice from challenge by Listeria monocytogenes and Francisella tularensis for up to 2 weeks. By repeatedly administering CpG ODN two to four times/month, we found that this protection could be maintained indefinitely. Protection was associated with a significant increase in the number of spleen cells that could be triggered by subsequent pathogen exposure to secrete gamma interferon and interleukin-6 in vivo (P < 0.01). ODN-treated animals remained healthy and developed neither macroscopic nor microscopic evidence of tissue damage or inflammation. Thus, repeated administration of CpG ODN may provide a safe means of conferring long-term protection against infectious pathogens. Topics: Adjuvants, Immunologic; Animals; Dinucleoside Phosphates; Interferon-gamma; Interleukin-6; Listeriosis; Male; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Tularemia	1999

Article

Year

Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection.

Infection and immunity, 1999, Volume: 67, Issue:11

Synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate an innate immune response characterized by the production of polyreactive immunoglobulin M antibodies and immunomodulatory cytokines. This immune response has been shown to protect mice from challenge by Listeria monocytogenes and Francisella tularensis for up to 2 weeks. By repeatedly administering CpG ODN two to four times/month, we found that this protection could be maintained indefinitely. Protection was associated with a significant increase in the number of spleen cells that could be triggered by subsequent pathogen exposure to secrete gamma interferon and interleukin-6 in vivo (P < 0.01). ODN-treated animals remained healthy and developed neither macroscopic nor microscopic evidence of tissue damage or inflammation. Thus, repeated administration of CpG ODN may provide a safe means of conferring long-term protection against infectious pathogens.

Topics: Adjuvants, Immunologic; Animals; Dinucleoside Phosphates; Interferon-gamma; Interleukin-6; Listeriosis; Male; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Tularemia

1999