cytidylyl-3--5--guanosine and Neurilemmoma

cytidylyl-3--5--guanosine has been researched along with Neurilemmoma* in 1 studies

Other Studies

1 other study(ies) available for cytidylyl-3--5--guanosine and Neurilemmoma

Article	Year
CpG island methylation in sporadic and neurofibromatis type 2-associated schwannomas. Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Nov-15, Volume: 9, Issue:15 The purpose of this research was to examine the DNA methylation profile of schwannomas.. We examined the DNA methylation status of 12 tumor-related genes (NF2, RB1, p14(ARF), p16(INK4a), p73, TIMP-3, MGMT, DAPK, THBS1, caspase-8, TP53, and GSTP1) in 44 sporadic and/or NF2-associated schwannomas using methylation-specific PCR.. The most frequently methylated genes were THBS1 (36%), p73 (27%), MGMT (20%), NF2 (18%), and TIMP-3 (18%). The RB1/p16INK4a gene pair displayed aberrant methylayed alleles in 15% of cases, whereas methylation was relatively rare in the other genes (<5%). Methylation was tumor specific because it was absent in two nonneoplastic nerve sheath samples and two nonneoplastic brain samples studied as controls.. Our findings indicate that aberrant methylation seems to be a mechanism for NF2 gene inactivation, considered an early step in schwannoma tumorigenesis, and as well, aberrant hypermethylation of other tumor-related genes might represent secondary events that also contribute to the development of these tumors. Topics: Adult; Aged; Dinucleoside Phosphates; DNA Methylation; Female; Genes, Neoplasm; Humans; Male; Middle Aged; Neurilemmoma; Neurofibromatosis 2; Polymerase Chain Reaction	2003

Article

Year

CpG island methylation in sporadic and neurofibromatis type 2-associated schwannomas.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Nov-15, Volume: 9, Issue:15

The purpose of this research was to examine the DNA methylation profile of schwannomas.. We examined the DNA methylation status of 12 tumor-related genes (NF2, RB1, p14(ARF), p16(INK4a), p73, TIMP-3, MGMT, DAPK, THBS1, caspase-8, TP53, and GSTP1) in 44 sporadic and/or NF2-associated schwannomas using methylation-specific PCR.. The most frequently methylated genes were THBS1 (36%), p73 (27%), MGMT (20%), NF2 (18%), and TIMP-3 (18%). The RB1/p16INK4a gene pair displayed aberrant methylayed alleles in 15% of cases, whereas methylation was relatively rare in the other genes (<5%). Methylation was tumor specific because it was absent in two nonneoplastic nerve sheath samples and two nonneoplastic brain samples studied as controls.. Our findings indicate that aberrant methylation seems to be a mechanism for NF2 gene inactivation, considered an early step in schwannoma tumorigenesis, and as well, aberrant hypermethylation of other tumor-related genes might represent secondary events that also contribute to the development of these tumors.

Topics: Adult; Aged; Dinucleoside Phosphates; DNA Methylation; Female; Genes, Neoplasm; Humans; Male; Middle Aged; Neurilemmoma; Neurofibromatosis 2; Polymerase Chain Reaction

2003