cytidylyl-3--5--guanosine and Hypersensitivity

cytidylyl-3--5--guanosine has been researched along with Hypersensitivity* in 2 studies

Other Studies

2 other study(ies) available for cytidylyl-3--5--guanosine and Hypersensitivity

Article	Year
Respiratory syncytial virus(RSV)-induced allergy may be controlled by IL-4 and CX3C fractalkine antagonists and CpG ODN as adjuvant: hypothesis and implications for treatment. Virus genes, 2006, Volume: 33, Issue:2 Based on the hypothesis that respiratory syncytial virus (RSV) sG protein causes allergy in patients, it is suggested that treatment of RSV patients with antagonists of IL-4 and FKN early in infection will prevent the increased level of IL-4 in the serum. Together with CpG ODNs that induce Toll-like receptor 9(+) (TLR9(+)) plasmacytoid dendritic cells to release type I IFN-alpha and -beta will reactivate the inhibited Th1 cells and the antiviral cytotoxic T leukocytes. In addition, binding of CpG ODNs to TLR9(+) B cells will stop IgE synthesis and antiviral IgG and IgA will continue. Together, the IL-4 and FKN antagonists and CpG ODNs reactivate the adaptive immune response to clear the virus and protect the patient from a second RSV infection. It is also suggested that the less-pathogenic RSV strain Long may be a candidate for vaccine development after deletion of the FKN and superantigen domains from the G gene. Topics: Adjuvants, Immunologic; Allergens; Amino Acid Sequence; Animals; Chemokine CX3CL1; Chemokines, CX3C; Dinucleoside Phosphates; Humans; Hypersensitivity; Interleukin-4; Membrane Proteins; Molecular Sequence Data; Oligonucleotides; Protein Structure, Tertiary; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Viral Fusion Proteins	2006
The role of CpG motifs in innate immunity. Current opinion in immunology, 2000, Volume: 12, Issue:1 Pattern recognition receptors of the innate immune system are able to distinguish certain prokaryotic DNAs from vertebrate DNAs by detecting unmethylated CpG dinucleotides in particular base contexts ('CpG motifs'). Recent studies have begun to define the molecular mechanisms of actions of CpG motifs and have demonstrated their stimulatory effects on leukocytes from humans and vertebrates other than mice. Oligodeoxynucleotides containing CpG motifs are highly effective Th1-like vaccine adjuvants through multiple routes of immunization and show promise as immunotherapeutic agents for cancer and allergic diseases. Topics: Adjuvants, Immunologic; Animals; Dinucleoside Phosphates; Hypersensitivity; Immunity, Innate; Neoplasms; Oligodeoxyribonucleotides; Th1 Cells; Vaccines, DNA; Vertebrates	2000

Article

Year

Respiratory syncytial virus(RSV)-induced allergy may be controlled by IL-4 and CX3C fractalkine antagonists and CpG ODN as adjuvant: hypothesis and implications for treatment.

Virus genes, 2006, Volume: 33, Issue:2

Based on the hypothesis that respiratory syncytial virus (RSV) sG protein causes allergy in patients, it is suggested that treatment of RSV patients with antagonists of IL-4 and FKN early in infection will prevent the increased level of IL-4 in the serum. Together with CpG ODNs that induce Toll-like receptor 9(+) (TLR9(+)) plasmacytoid dendritic cells to release type I IFN-alpha and -beta will reactivate the inhibited Th1 cells and the antiviral cytotoxic T leukocytes. In addition, binding of CpG ODNs to TLR9(+) B cells will stop IgE synthesis and antiviral IgG and IgA will continue. Together, the IL-4 and FKN antagonists and CpG ODNs reactivate the adaptive immune response to clear the virus and protect the patient from a second RSV infection. It is also suggested that the less-pathogenic RSV strain Long may be a candidate for vaccine development after deletion of the FKN and superantigen domains from the G gene.

Topics: Adjuvants, Immunologic; Allergens; Amino Acid Sequence; Animals; Chemokine CX3CL1; Chemokines, CX3C; Dinucleoside Phosphates; Humans; Hypersensitivity; Interleukin-4; Membrane Proteins; Molecular Sequence Data; Oligonucleotides; Protein Structure, Tertiary; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Viral Fusion Proteins

2006

The role of CpG motifs in innate immunity.

Current opinion in immunology, 2000, Volume: 12, Issue:1

Pattern recognition receptors of the innate immune system are able to distinguish certain prokaryotic DNAs from vertebrate DNAs by detecting unmethylated CpG dinucleotides in particular base contexts ('CpG motifs'). Recent studies have begun to define the molecular mechanisms of actions of CpG motifs and have demonstrated their stimulatory effects on leukocytes from humans and vertebrates other than mice. Oligodeoxynucleotides containing CpG motifs are highly effective Th1-like vaccine adjuvants through multiple routes of immunization and show promise as immunotherapeutic agents for cancer and allergic diseases.

Topics: Adjuvants, Immunologic; Animals; Dinucleoside Phosphates; Hypersensitivity; Immunity, Innate; Neoplasms; Oligodeoxyribonucleotides; Th1 Cells; Vaccines, DNA; Vertebrates

2000