cytidine diphosphate choline and Disease Models, Animal

cytidine diphosphate choline has been researched along with Disease Models, Animal in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.49)	18.7374
1990's	2 (2.99)	18.2507
2000's	24 (35.82)	29.6817
2010's	32 (47.76)	24.3611
2020's	8 (11.94)	2.80

Authors

Authors	Studies
Bakulin, DA; Kovalenko, AL; Kurkin, DV; Kuznetsova, EV; Lycheva, NA; Morkovin, EI; Myagkova, IA; Robertus, AI; Shmidt, MV; Tarasov, AS	1
Chen, Q; Gao, Y; Guo, L; Jiang, H; Xu, M; Zhang, F; Zhou, F	1
Chen, J; Chen, Y; Fang, M; Feng, X; Xiao, C; Zhang, M	1
Jasielski, P; Petit, V; Piędel, F; Piwek, M; Rejdak, K; Rocka, A	1
Candiotti, KA; Gitlin, MC; Sevilla, A; Wang, S; Weller, R; Zhang, Y	1
Amin, SN; El Gazzar, WB; Hussein, UK; Khashaba, AS; Latif, NSA	1
Khakpai, F; Ramezanikhah, M; Valizadegan, F; Zarrindast, MR	1
Partadiredja, G; Yuliani, S	1
Choi, BY; Choi, MG; Hong, DK; Jeong, JH; Kho, AR; Kim, JH; Lee, SH; Ryu, OH; Sohn, M; Suh, SW	1
Aranda-Frausto, A; Bojalil, R; Buelna-Chontal, M; Correa, F; Galvan Arzate, S; González-Pacheco, H; Macías-López, A; Pavón, N; Román-Anguiano, NG; Silva-Palacios, A; Springall, R; Velázquez-Espejel, R; Zazueta, C	1
Akhondzadeh, S; Nejatisafa, AA; Roohi-Azizi, M; Sadat-Shirazi, MS; Torkaman-Boutorabi, A; Zarrindast, MR	1
Baba, T; Bikbova, G; Kitamura, Y; Oshitari, T; Yamamoto, S	1
Fukunaga, K; Hishida, Y; Izumi, H; Kamimura, A; Nakazaki, E; Shinoda, Y; Watanabe, F; Yabuki, Y	1
Beaumont, E; Rouleau, DM; Wang, L	1
Canpolat, FE; Cansev, M; Cekmez, F; Cetinkaya, M; Kafa, IM; Sarici, SU; Tayman, C; Tunc, T	1
Centofanti, M; Manni, G; Parisi, V; Roberti, G; Sampalmieri, M; Tanga, L	1
Borlongan, CV; Coll-Andreu, M; Costa-Miserachs, D; Jacotte-Simancas, A; Portell-Cortés, I; Torras-Garcia, M	1
Choi, BY; Choi, HC; Kim, JH; Lee, DW; Lee, SH; Sohn, M; Song, HK; Suh, SW	1
Brenner, T; Doerr, M; Hernekamp, JF; Hofer, S; Schmidt, K; Walther, A; Weigand, MA; Zivkovic, AR	1
Karpova, MN; Klishina, NV; Kuznetsova, LV; Zin'kovskii, KA	1
Fu, C; Liu, S; Mao, J	1
Bulte, JW; Cao, S; Chen, H; Jablonska, A; Janowski, M; Li, Y; Liu, D; Liu, G; Liu, H; Van Zijl, PC; Walczak, P	1
Fiedorowicz, M; Grieb, P; Makarewicz, D; Stańczak-Mrozek, KI	1
Eisenach, JC; Gurun, MS; Parker, R; Vincler, M	1
Cox, GA; Sher, RB; Vance, DE; Wu, G	1
Alkan, T; Korfali, E; Sahin, S; Temel, SG; Tolunay, S; Tureyen, K	1
Menku, A; Ogden, M; Saraymen, R	1
Botsina, AIu; Shamalov, NA; Shetova, IM	1
Díez-Tejedor, E; Frank-García, A; García-Cobos, R; Gutiérrez-Fernández, M	1
Das, N; Dungdung, SR; Ghosh, S; Mandal, AK; Sarkar, S	1
Agulla, J; Argibay, B; Castillo, J; Pérez-Mato, M; Ramos-Cabrer, P	1
Fujikawa, R; Fujiwara, M; Iwasaki, K; Katsurabayashi, S; Kawasaki, C; Kubota, K; Mishima, K; Morishita, K; Morita, M; Nakamura, K; Nogami, A; Takasaki, K; Uchida, K; Yamaguchi, K	1
Chaba, T; Jacobs, RL; Niebergall, LJ; Vance, DE	1
Aslan, E; Bekar, A; Kocaeli, H; Tolunay, S; Ulus, IH	1
Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA	1
Bekar, A; Caner, B; Cansev, M; Kafa, MI; Karli, N; Kurt, MA; Ulus, IH	1
Altach, E; Diederich, K; Eggert, V; Frauenknecht, K; Minnerup, J; Schäbitz, WR; Schmidt, A; Schneider, BK; Sommer, CJ	1
Díez-Tejedor, E; Gutiérrez-Fernández, M; Leciñana, MA; Ramos-Cejudo, J; Roda, JM; Rodríguez-Frutos, B	1
Bustamante, A; Campos, M; Garcia-Bonilla, L; Giralt, D; Montaner, J; Rosell, A	1
Canpolat, FE; Cansev, M; Cekmez, F; Cetinkaya, M; Kafa, IM; Sarici, SU; Tayman, C; Tunc, T; Uysal, S	1
Dengler, R; Gudi, V; Knippenberg, S; Körner, S; Petri, S; Pul, R; Rath, KJ; Skripuletz, T; Stangel, M; Thau, N	1
Adibhatla, RM; Hatcher, JF	1
Dempsey, RJ; Raghavendra Rao, VL	1
Teather, LA; Wurtman, RJ	1
Ataus, SA; Balkan, S; Locke, KW; Onal, MZ; Ozdem, SS	1
Cárdenas, A; Castillo, J; Dávalos, A; Fernández-Tomé, P; Hurtado, O; Leza, JC; Lizasoain, I; Lorenzo, P; Lozano, R; Moro, MA; Sánchez, V; Secades, JJ	1
Adibhatla, RM; Hatcher, JF; Tureyen, K	1
Alver, A; Baykal, S; Cakir, E; Kuzeyli, K; Peksoylu, B; Sayin, OC; Topbas, M; Usul, H	1
Alonso de Leciñana, M; Carceller, F; Díez Tejedor, E; Fuentes, B; Gutiérrez, M; Roda, JM	1
Meden, P; Overgaard, K	1
Alonso de Leciñana, M; Carceller, F; Díez-Tejedor, E; Gutiérrez, M; Roda, JM	1
Bolz, S; Grieb, P; Junemann, A; Lehaci, C; Mankowska, A; Rejdak, R; Schuettauf, F; Thaler, S; Zagorski, Z; Zarnowski, T; Zrenner, E	1
Gurun, MS; Hamurtekin, E	1
Blum, D; Brotchi, J; Ledent, C; Levivier, M; Mievis, S; Vassart, G	1
Bagdas, D; Gurun, MS; Hamurtekin, E	1
Deutsch, SI; Gaskins, BL; Long, KD; Mastropaolo, J; Rosse, RB; Schooler, NR; Schwartz, BL	1
Alborch, E; Castillo, J; Fernández-López, D; Hurtado, O; Lizasoain, I; Morales, JR; Moro, MA; Pradillo, JM; Sobrino, T	1
Bekar, A; Filiz, G; Karlı, N; Kocaeli, H; Özay, R; Ulus, IH	1
Cansev, M; Hamurtekin, E; Ilcol, YO; Ulus, IH; Yilmaz, MS	1
Di Giacomo, C; Fresta, M; Puglisi, G; Russo, A	1
Fisher, M; Locke, KW; Sandage, BW; Schäbitz, WR; Takano, K; Weber, J	1
Blusztajn, JK; Farber, SA; Slack, BE	1
Dempsey, RJ; Hatcher, JF; Rao, AM	1
Adibhatla, RM; Dempsey, RJ; Hatcher, JF	1
Dodd, RC; Havener, LJ; Spargo, BH; Toback, FG	1
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1

Reviews

7 review(s) available for cytidine diphosphate choline and Disease Models, Animal

Article	Year
Application of Citicoline in Neurological Disorders: A Systematic Review. Nutrients, 2020, Oct-12, Volume: 12, Issue:10 Topics: Animals; Brain Injuries, Traumatic; Cognition; Cytidine Diphosphate Choline; Dementia; Disease Models, Animal; Humans; Meta-Analysis as Topic; Nervous System Diseases; Neuralgia; Neurotransmitter Agents; Peripheral Nervous System; Stroke	2020
Most effective adjuvant treatments after surgery in peripheral nerve laceration: Systematic review of the literature on rodent models. Restorative neurology and neuroscience, 2013, Volume: 31, Issue:3 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Humans; Lacerations; Nerve Growth Factors; Nitric Oxide Synthase; Peripheral Nerves; Rodentia; Treatment Outcome	2013
[The use of citicoline in the acute cerebral stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2009, Volume: 109, Issue:12 Suppl 2 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Humans; Neuroprotective Agents; Stroke	2009
Citicoline, use in cognitive decline: vascular and degenerative. Journal of the neurological sciences, 2010, Dec-15, Volume: 299, Issue:1-2 Topics: Animals; Cognition Disorders; Cytidine Diphosphate Choline; Dementia; Disease Models, Animal; Humans; Nootropic Agents	2010
Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial. Journal of neurochemistry, 2012, Volume: 123, Issue:2 Topics: Animals; Clinical Trials as Topic; Cytidine Diphosphate Choline; Disease Models, Animal; Humans; Neuroprotective Agents; Nootropic Agents; Stroke	2012
Citicoline mechanisms and clinical efficacy in cerebral ischemia. Journal of neuroscience research, 2002, Oct-15, Volume: 70, Issue:2 Topics: Animals; Arachidonic Acid; Brain Ischemia; Clinical Trials as Topic; Cytidine Diphosphate Choline; Disease Models, Animal; Humans; Ischemic Attack, Transient; Neuroprotective Agents; Phosphatidylcholines; Phospholipases A; Rats; Treatment Outcome	2002
Citicoline--the first effective neuroprotectant to be combined with thrombolysis in acute ischemic stroke? Journal of the neurological sciences, 2006, Sep-25, Volume: 247, Issue:2 Topics: Animals; Clinical Trials as Topic; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combination; Humans; Neuroprotective Agents; Stroke; Thrombolytic Therapy	2006

Other Studies

60 other study(ies) available for cytidine diphosphate choline and Disease Models, Animal

Article	Year
[Study of the effect of Unifuzol on cognitive impairment and damage to the hippocampus and cerebral cortex during course administration to rats with bilateral stenosis of the common carotid arteries, causing chronic circulatory failure]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2023, Volume: 123, Issue:3 Topics: Animals; Brain Ischemia; Carotid Artery, Common; Carotid Stenosis; Cognitive Dysfunction; Constriction, Pathologic; Cytidine Diphosphate Choline; Disease Models, Animal; Hippocampus; Male; Nicergoline; Rats; Shock	2023
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease. Biochemical pharmacology, 2023, Volume: 217 Topics: Acetylcholine; Acetylcholinesterase; Animals; Choline; Colitis; Colon; Cytidine Diphosphate Choline; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Inflammation; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Nicotinic Antagonists	2023
Protective effect of citicoline on random flap survival in a rat mode. International immunopharmacology, 2020, Volume: 83 Topics: Animals; Anti-Inflammatory Agents; Cytidine Diphosphate Choline; Cytokines; Disease Models, Animal; Graft Survival; Humans; Inflammation Mediators; Male; NF-kappa B; Plastic Surgery Procedures; Rats; Rats, Sprague-Dawley; Signal Transduction; Skin Transplantation; Surgical Flaps; Toll-Like Receptor 4; Vascular Endothelial Growth Factor A	2020
The role of α7-nicotinic acetylcholine receptor in a rat model of chronic nicotine-induced mechanical hypersensitivity. Neuroscience letters, 2021, 01-19, Volume: 743 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Chronic Pain; Cytidine Diphosphate Choline; Disease Models, Animal; Hyperalgesia; Male; Nicotine; Nootropic Agents; Rats; Rats, Sprague-Dawley; Spinal Cord; Touch	2021
Citicoline improved cardiovascular function in animal model of dysautonomia. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2021, Volume: 72, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Blood Pressure; Cardiovascular Diseases; Cytidine Diphosphate Choline; Disease Models, Animal; Echocardiography; Electrocardiography; Male; Mitochondria; Primary Dysautonomias; Rats	2021
Synergistic effect between imipramine and citicoline upon induction of analgesic and antidepressant effects in mice. Neuroscience letters, 2021, 08-24, Volume: 760 Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Cytidine Diphosphate Choline; Depression; Disease Models, Animal; Drug Synergism; Humans; Imipramine; Injections, Intraperitoneal; Male; Mice; Nociception; Pain	2021
Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats. Drug and chemical toxicology, 2018, Volume: 41, Issue:1 Topics: Animals; Behavior, Animal; Curcuma; Cytidine Diphosphate Choline; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory Disorders; Nerve Degeneration; Neuroprotective Agents; Nootropic Agents; Phytotherapy; Plant Extracts; Plants, Medicinal; Pyramidal Cells; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species; Rhizome; Spatial Memory; Time Factors; Trimethyltin Compounds	2018
Acetylcholine precursor, citicoline (cytidine 5'-diphosphocholine), reduces hypoglycaemia-induced neuronal death in rats. Journal of neuroendocrinology, 2018, Volume: 30, Issue:1 Topics: Animals; Cell Death; Cytidine Diphosphate Choline; Disease Models, Animal; Hypoglycemia; Insulin; Male; Microglia; Neurons; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley	2018
Cytidine-5'-Diphosphocholine Protects the Liver From Ischemia/Reperfusion Injury Preserving Mitochondrial Function and Reducing Oxidative Stress. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2018, Volume: 24, Issue:8 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Humans; Liver; Liver Function Tests; Liver Transplantation; Male; Mitochondria; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury	2018
Influence of citicoline on citalopram-induced antidepressant activity in depressive-like symptoms in male mice. Physiology & behavior, 2018, 10-15, Volume: 195 Topics: Animals; Antidepressive Agents; Chemotherapy, Adjuvant; Citalopram; Cytidine Diphosphate Choline; Depression; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Feeding Behavior; Male; Mice; Motor Activity; Random Allocation; Stress, Psychological	2018
In vivo effects of single or combined topical neuroprotective and regenerative agents on degeneration of retinal ganglion cells in rat optic nerve crush model. Scientific reports, 2019, 01-14, Volume: 9, Issue:1 Topics: Administration, Topical; Animals; Cell Count; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combination; Histocytochemistry; Immunohistochemistry; Nerve Growth Factors; Neuroprotective Agents; Optic Nerve Injuries; Rats, Sprague-Dawley; Retinal Ganglion Cells; Taurochenodeoxycholic Acid; Treatment Outcome	2019
Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia. Journal of pharmacological sciences, 2019, Volume: 139, Issue:4 Topics: Animals; Avoidance Learning; Brain Ischemia; CA1 Region, Hippocampal; Cell Survival; Cognitive Dysfunction; Cytidine Diphosphate Choline; Disease Models, Animal; Docosahexaenoic Acids; Drug Therapy, Combination; Learning; Male; Memory; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Recognition, Psychology; Treatment Outcome	2019
Cytidine 5'-diphosphocholine ameliorates hyperoxic lung injury in a neonatal rat model. Pediatric research, 2013, Volume: 74, Issue:1 Topics: Animals; Animals, Newborn; Cytidine Diphosphate Choline; Disease Models, Animal; Hyperoxia; Lung Injury; Rats	2013
A preliminary study of the neuroprotective role of citicoline eye drops in glaucomatous optic neuropathy. Indian journal of ophthalmology, 2014, Volume: 62, Issue:5 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Electroretinography; Glaucoma, Open-Angle; Mice; Nootropic Agents; Ophthalmic Solutions; Optic Nerve Diseases; Retinal Ganglion Cells	2014
Effects of voluntary physical exercise, citicoline, and combined treatment on object recognition memory, neurogenesis, and neuroprotection after traumatic brain injury in rats. Journal of neurotrauma, 2015, May-15, Volume: 32, Issue:10 Topics: Animals; Behavior, Animal; Brain Injuries; Combined Modality Therapy; Cytidine Diphosphate Choline; Disease Models, Animal; Male; Memory, Long-Term; Memory, Short-Term; Motor Activity; Neurogenesis; Neuroprotection; Nootropic Agents; Rats; Rats, Sprague-Dawley; Recognition, Psychology	2015
Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death. Brain research, 2015, Jan-21, Volume: 1595 Topics: Animals; Blood-Brain Barrier; CD11b Antigen; Cell Death; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluoresceins; Hippocampus; Kainic Acid; Male; Microglia; Neurons; Nootropic Agents; Pilocarpine; Rats; Rats, Sprague-Dawley	2015
Cytidine-5-diphosphocholine reduces microvascular permeability during experimental endotoxemia. BMC anesthesiology, 2015, Aug-01, Volume: 15 Topics: Animals; Capillary Permeability; Cell Adhesion; Cytidine Diphosphate Choline; Disease Models, Animal; Endotoxemia; Leukocytes; Lipopolysaccharides; Male; Nootropic Agents; Rats; Rats, Wistar; Sepsis	2015
Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats. Bulletin of experimental biology and medicine, 2016, Volume: 160, Issue:4 Topics: Animals; Anticonvulsants; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combination; Male; Nootropic Agents; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid	2016
Citicoline retards myopia progression following form deprivation in guinea pigs. Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:11 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Dopamine; Guinea Pigs; Myopia; Nootropic Agents; Retina; Sensory Deprivation	2016
Label-free CEST MRI Detection of Citicoline-Liposome Drug Delivery in Ischemic Stroke. Theranostics, 2016, Volume: 6, Issue:10 Topics: Animals; Brain; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Carriers; Injections, Intra-Articular; Liposomes; Magnetic Resonance Imaging; Nootropic Agents; Rats; Stroke	2016
CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia. Acta neurobiologiae experimentalis, 2008, Volume: 68, Issue:3 Topics: Animals; Animals, Newborn; Apoptosis; Asphyxia Neonatorum; Carrier Proteins; Caspase 3; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Female; HSP70 Heat-Shock Proteins; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Microfilament Proteins; Neuroprotective Agents; Nootropic Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar	2008
The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor. Anesthesia and analgesia, 2009, Volume: 108, Issue:5 Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Inflammation; Injections; Male; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Time Factors; Tumor Necrosis Factor-alpha	2009
Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse. Biochimica et biophysica acta, 2010, Volume: 1801, Issue:4 Topics: Animals; Cardiotoxins; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Disease Models, Animal; Forelimb; Hindlimb; Homeostasis; Isoenzymes; Mice; Mice, Knockout; Mitochondria; Muscle, Skeletal; Muscular Dystrophy, Animal; Phenotype; Phosphatidylcholines; Regeneration	2010
Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2010, Volume: 17, Issue:2 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Brain; Brain Infarction; Brain Ischemia; Combined Modality Therapy; Cytidine Diphosphate Choline; Disease Models, Animal; Hypothermia, Induced; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Nootropic Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome	2010
The protective effects of propofol and citicoline combination in experimental head injury in rats. Turkish neurosurgery, 2010, Volume: 20, Issue:1 Topics: Animals; Blood Pressure; Craniocerebral Trauma; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combination; Heart Rate; Lipid Peroxidation; Neuroprotective Agents; Nootropic Agents; Propofol; Rats; Superoxide Dismutase	2010
Mannosylated liposomal cytidine 5' diphosphocholine prevent age related global moderate cerebral ischemia reperfusion induced mitochondrial cytochrome c release in aged rat brain. Neuroscience, 2010, Dec-29, Volume: 171, Issue:4 Topics: Aging; Analysis of Variance; Animals; Brain; Brain Ischemia; Catalase; Cytidine Diphosphate Choline; Cytochromes c; Disease Models, Animal; Glutathione; Lipid Peroxidation; Liposomes; Male; Mannose; Microscopy, Electron, Transmission; Mitochondria; Nootropic Agents; Rats; Rats, Wistar; Reperfusion; Statistics as Topic; Superoxide Dismutase	2010
Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia. International journal of pharmaceutics, 2011, Feb-28, Volume: 405, Issue:1-2 Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Injections, Intravenous; Liposomes; Magnetic Resonance Imaging; Male; Nootropic Agents; Rats; Rats, Sprague-Dawley; Stroke	2011
Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia. Journal of pharmacological sciences, 2011, Volume: 116, Issue:2 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Rats; Rats, Wistar	2011
Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. Biochimica et biophysica acta, 2011, Volume: 1811, Issue:12 Topics: Adenoviridae; Animals; Betaine; Ceramides; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Female; Genetic Predisposition to Disease; Genetic Vectors; Lipotropic Agents; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; Triglycerides	2011
CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves. Neurological research, 2011, Volume: 33, Issue:7 Topics: Administration, Cutaneous; Animals; Choline; Cytidine; Cytidine Diphosphate Choline; Disease Models, Animal; Female; Nerve Regeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Sciatic Neuropathy; Trauma Severity Indices	2011
The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. Behavioural pharmacology, 2011, Volume: 22, Issue:5-6 Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Choline; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Male; Neuralgia; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Receptors, Nicotinic; Receptors, Opioid; Time Factors	2011
Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury. Neurological research, 2012, Volume: 34, Issue:3 Topics: Animals; Axotomy; Choline; Cytidine; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combination; Female; Injections, Intraperitoneal; Nerve Regeneration; Nootropic Agents; Rats; Rats, Sprague-Dawley; Recovery of Function; Sciatic Nerve; Sciatic Neuropathy	2012
Citicoline enhances neuroregenerative processes after experimental stroke in rats. Stroke, 2012, Volume: 43, Issue:7 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Male; Neurogenesis; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar; Stroke	2012
CDP-choline at high doses is as effective as i.v. thrombolysis in experimental animal stroke. Neurological research, 2012, Volume: 34, Issue:7 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Infusions, Intravenous; Male; Nootropic Agents; Random Allocation; Rats; Rats, Long-Evans; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome	2012
CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis. The Journal of surgical research, 2013, Volume: 183, Issue:1 Topics: Animals; Animals, Newborn; Apoptosis; Cytidine Diphosphate Choline; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Enterocolitis, Necrotizing; Intestines; Nootropic Agents; Rats	2013
CDP-choline is not protective in the SOD1-G93A mouse model of ALS. Amyotrophic lateral sclerosis & frontotemporal degeneration, 2013, Volume: 14, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Random Allocation; Superoxide Dismutase	2013
Cytidinediphosphocholine treatment to decrease traumatic brain injury-induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction in rats. Journal of neurosurgery, 2003, Volume: 98, Issue:4 Topics: Animals; Brain Injuries; Cell Death; Cytidine Diphosphate Choline; Disease Models, Animal; Hippocampus; Male; Neurons; Nootropic Agents; Phospholipases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2003
Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats. Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:4 Topics: Administration, Oral; Aging; Animals; Cytidine Diphosphate Choline; Diet; Disease Models, Animal; Female; Hippocampus; Memory Disorders; Nootropic Agents; Rats; Rats, Sprague-Dawley	2003
The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats. The International journal of neuroscience, 2004, Volume: 114, Issue:2 Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Brain Ischemia; Cerebral Infarction; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Lamotrigine; Male; Neurologic Examination; Random Allocation; Rats; Rats, Wistar; Statistics, Nonparametric; Tetrazolium Salts; Treatment Outcome; Triazines	2004
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiology of disease, 2005, Volume: 18, Issue:2 Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Biological Transport; Brain; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Infarction; Coculture Techniques; Cytidine Diphosphate Choline; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Rats, Wistar; Symporters	2005
CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. Brain research, 2005, Oct-05, Volume: 1058, Issue:1-2 Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cholesterol; Choline; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Combinations; Drug Synergism; G(M1) Ganglioside; Liposomes; Male; Phagocytosis; Phosphatidylcholines; Rats; Rats, Inbred SHR; Reperfusion Injury; Stroke; Treatment Outcome	2005
Effects of citicoline on experimental spinal cord injury. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2005, Volume: 12, Issue:8 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Lipid Peroxidation; Malondialdehyde; Motor Activity; Nootropic Agents; Rats; Rats, Wistar; Recovery of Function; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances	2005
Thrombolysis and neuroprotection in cerebral ischemia. Cerebrovascular diseases (Basel, Switzerland), 2006, Volume: 21 Suppl 2 Topics: Animals; Brain; Brain Ischemia; Clinical Trials as Topic; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Neuroprotective Agents; Rats; Recombinant Proteins; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator	2006
Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke. Journal of the neurological sciences, 2006, Sep-25, Volume: 247, Issue:2 Topics: Animals; Brain Infarction; Cell Death; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Fibrinolytic Agents; Immunohistochemistry; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Interleukin-6; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Long-Evans; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha	2006
Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat. Experimental eye research, 2006, Volume: 83, Issue:5 Topics: Animals; Apoptosis; Cell Count; Cytidine Diphosphate Choline; Disease Models, Animal; Female; Immunohistochemistry; Lithium; Microscopy, Fluorescence; Neuroprotective Agents; Optic Nerve Injuries; Pharmaceutical Vehicles; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred BN; Retinal Ganglion Cells	2006
The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system. Brain research, 2006, Oct-30, Volume: 1117, Issue:1 Topics: Acetylcholine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Brain; Cholinergic Fibers; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Male; Neurotransmitter Uptake Inhibitors; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission	2006
Citicoline is not protective in experimental models of Huntington's disease. Neurobiology of aging, 2007, Volume: 28, Issue:12 Topics: Animals; Behavior, Animal; Cytidine Diphosphate Choline; Disease Models, Animal; Huntington Disease; Neuroprotective Agents; Nootropic Agents; Rats; Treatment Outcome	2007
Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. Neuroscience letters, 2007, Jun-13, Volume: 420, Issue:2 Topics: Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Animals; Brain; Cytidine Diphosphate Choline; Disease Models, Animal; Efferent Pathways; GABA Antagonists; Injections, Intraventricular; Male; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, GABA; Receptors, GABA-B; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists	2007
Effects of CDP-choline and the combination of CDP-choline and galantamine differ in an animal model of schizophrenia: development of a selective alpha7 nicotinic acetylcholine receptor agonist strategy. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2008, Volume: 18, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Cytidine Diphosphate Choline; Disease Models, Animal; Dizocilpine Maleate; Drug Interactions; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Male; Mice; Nootropic Agents; Schizophrenia	2008
Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke. Neurobiology of disease, 2008, Volume: 29, Issue:1 Topics: Animals; Cell Fractionation; Cytidine Diphosphate Choline; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Membrane Microdomains; Neuroprotective Agents; Rats; Rats, Inbred F344; Time Factors	2008
Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats. Surgical neurology, 2007, Volume: 68, Issue:6 Topics: Animals; Axons; Cicatrix; Connective Tissue; Cytidine Diphosphate Choline; Disease Models, Animal; Electromyography; Female; Nerve Regeneration; Nootropic Agents; Postoperative Complications; Rats; Rats, Sprague-Dawley; Recovery of Function; Sciatic Nerve	2007
Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. Autonomic & autacoid pharmacology, 2008, Volume: 28, Issue:1 Topics: Adrenal Glands; Animals; Atropine Derivatives; Autonomic Nervous System; Central Nervous System; Choline; Cytidine; Cytidine Diphosphate Choline; Cytidine Monophosphate; Disease Models, Animal; Dose-Response Relationship, Drug; Epinephrine; Female; Hemorrhage; Hexamethonium; Injections, Intraperitoneal; Injections, Intraventricular; Mecamylamine; Nicotinic Antagonists; Norepinephrine; Phosphorylcholine; Rats; Rats, Wistar; Time Factors	2008
Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:12 Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Cortex; Cholesterol; Chromatography, High Pressure Liquid; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Evaluation; Lactates; Lactic Acid; Lipid Peroxidation; Liposomes; Male; Phosphatidylserines; Rats; Rats, Wistar; Reperfusion Injury; Survival Rate	1994
The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. Journal of the neurological sciences, 1996, Volume: 138, Issue:1-2 Topics: Animals; Arterial Occlusive Diseases; Brain Diseases; Cerebral Arteries; Cerebral Infarction; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Ischemic Attack, Transient; Male; Nootropic Agents; Rats; Rats, Sprague-Dawley; Survival Rate; Treatment Outcome	1996
Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2000, Volume: 14, Issue:14 Topics: Alzheimer Disease; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Choline; Cytidine Diphosphate Choline; Dinitrophenols; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycerylphosphorylcholine; Membranes; Mitochondria; Neurons; PC12 Cells; Phosphatidylcholines; Phosphorylcholine; Rats; Sodium Azide; Time Factors; Uncoupling Agents	2000
Does CDP-choline modulate phospholipase activities after transient forebrain ischemia? Brain research, 2001, Mar-02, Volume: 893, Issue:1-2 Topics: Animals; Arachidonic Acid; Cardiolipins; Cytidine Diphosphate Choline; Disease Models, Animal; Enzyme Activation; Fatty Acids; Gerbillinae; Hippocampus; Injections, Intraperitoneal; Ischemic Attack, Transient; Isoenzymes; Male; Nootropic Agents; Phosphatidylcholines; Phosphatidylinositols; Phospholipase D; Phospholipases; Phospholipases A; Prosencephalon; Type C Phospholipases	2001
Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia. Stroke, 2001, Volume: 32, Issue:10 Topics: Animals; Cytidine Diphosphate Choline; Disease Models, Animal; Fatty Acids; Gerbillinae; Glutathione; Glutathione Reductase; Hippocampus; Ischemic Attack, Transient; Male; Phospholipids; Prosencephalon; Reperfusion	2001
Phospholipid metabolism during renal regeneration after acute tubular necrosis. The American journal of physiology, 1977, Volume: 232, Issue:2 Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cell Membrane; Choline; Cytidine Diphosphate Choline; Disease Models, Animal; Kidney; Kidney Tubular Necrosis, Acute; Male; Mercury; Phosphatidylcholines; Phospholipids; Rats; Regeneration	1977
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries	2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020