cytidine diphosphate choline and Cerebral Ischemia

cytidine diphosphate choline has been researched along with Cerebral Ischemia in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (12.50)	18.7374
1990's	8 (11.11)	18.2507
2000's	20 (27.78)	29.6817
2010's	26 (36.11)	24.3611
2020's	9 (12.50)	2.80

Authors

Authors	Studies
Agarwal, A; Bhatia, R; Dwivedi, S; Garg, A; Goyal, V; Gupta, A; Rajan, R; Sharma, J; Singh, MB; Srivastava, MVP; Upadhyay, A; Vishnu, VY	1
Bakulin, DA; Kovalenko, AL; Kurkin, DV; Kuznetsova, EV; Lycheva, NA; Morkovin, EI; Myagkova, IA; Robertus, AI; Shmidt, MV; Tarasov, AS	1
Khlestkina, MS; Maslov, LN; Mukhomedzyanov, AV; Shapkin, AG; Sufianov, AA; Sufianova, GZ; Voronkov, NS	1
Karimulin, R; Semenenko, A	1
Putilina, MV	1
Bonfill Cosp, X; Martí-Amarista, CE; Martí-Carvajal, AJ; Martí-Fàbregas, J; Solà, I; Valli, C	1
Gromova, OA; Putilina, MV; Rudakov, KV; Semenov, VA; Torshin, IY	1
El Amrousy, D; Faheem, A; Mehrez, M; Salamah, A	1
Bogacheva, TE; Demidov, VI; Grishina, TR; Gromova, OA; Torshin, IY	1
Fukunaga, K; Hishida, Y; Izumi, H; Kamimura, A; Nakazaki, E; Shinoda, Y; Watanabe, F; Yabuki, Y	1
Ballesteros, I; Camarero, G; Cuartero, MI; Hernández-Jiménez, M; Hurtado, O; Lizasoain, I; Moraga, A; Moro, MA; Pradillo, JM; Zarruk, JG	1
Bansal, KK; Goel, D; Mitta, M; Puri, P	1
Kamal, AK; Nomani, F	1
Grieb, P	1
Overgaard, K	1
Minnerup, J; Schmidt, A	1
Alvarez-Sabín, J; Jacas, C; Maisterra, O; Molina, C; Quintana, M; Santamarina, E	1
Chipova, DT; Farrahova, KI; Karneev, AN; Solovieva, EY	1
Alvarez-Sabín, J; Castillo, J; Díez-Tejedor, E; Martínez-Vila, E; Oudovenko, N; Ríos, J; Secades, JJ	1
Minnerup, J; Schäbitz, WR	1
Cho, HJ; Kim, YJ	1
Alkan, T; Korfali, E; Sahin, S; Temel, SG; Tolunay, S; Tureyen, K	1
Andrade-Ramos, MA; Cantu, C; Chiquete, E; Leon-Jimenez, C; Miramontes-Saldana, MJ; Ruiz-Sandoval, JL	1
Das, N; Dungdung, SR; Ghosh, S; Mandal, AK; Sarkar, S	1
Dávalos, A; Secades, J	1
Alvarez-Sabín, J; Román, GC	1
Agulla, J; Argibay, B; Castillo, J; Pérez-Mato, M; Ramos-Cabrer, P	1
Chen, H; Han, H; Hou, C; Li, W; Xia, Z	1
Secades, JJ	1
Sahota, P; Savitz, SI	1
Blanco, M; Brea, D; Castillo, J; Leira, R; Pérez-Mato, M; Rodríguez-González, R; Rodríguez-Yáñez, M; Sobrino, T	1
Alvarez-Grech, J; Díez-Tejedor, E; Expósito-Alcaide, M; Fuentes, B; Gutiérrez-Fernández, M; Rodríguez-Frutos, B; Vallejo-Cremades, MT	1
Galkin, AS; Gusev, AO; Koval'chuk, VV	1
Alifirova, VM; Vaizova, OE; Vengerovskiĭ, AI; Zautner, NA	1
Hankey, GJ	1
Alvarez-Sabín, J; Castillo, J; Cobo, E; Cruz, VT; Dávalos, A; Díez-Tejedor, E; Ferro, J; Martínez-Vila, E; Masjuan, J; Secades, JJ; Segura, T; Serena, J	1
Hubenia, OV	1
Adibhatla, RM; Hatcher, JF	1
Alvarez-Sabín, J; Castillo, J; Clark, WM; Cobo, E; Dávalos, A; López, S; Lozano, R; Mercadal, J; Secades, JJ; Sherman, D; Warach, S	1
Aledo, R; Argemí, J; Casals, N; Cervós-Navarro, J; Clotet, J; Durany, N; Lozano, R; Mir, C	1
Carceller, F; García, AG; López, MG; Roda, JM; Sobrado, M	1
Ataus, SA; Balkan, S; Locke, KW; Onal, MZ; Ozdem, SS	1
Cárdenas, A; Castillo, J; Dávalos, A; Fernández-Tomé, P; Hurtado, O; Leza, JC; Lizasoain, I; Lorenzo, P; Lozano, R; Moro, MA; Sánchez, V; Secades, JJ	1
Adibhatla, RM; Hatcher, JF; Tureyen, K	1
Badimon, L; Krupinski, J; Slevin, M	1
Adibhatla, RM; Chen, X; Hatcher, JF; Larsen, EC; Sun, D; Tsao, FH	1
Cárdenas, A; Castillo, J; Hurtado, O; Lizasoain, I; Lorenzo, P; Mallolas, J; Moro, MA; Romera, C	1
Alonso de Leciñana, M; Carceller, F; Díez Tejedor, E; Fuentes, B; Gutiérrez, M; Roda, JM	1
Brunetti, M; De Medio, GE; Dorman, RV; Droz, B; Horrocks, LA; Porcellati, G; Souyri, F; Trovarelli, G	1
Dabrowiecki, Z; Dorman, RV; Horrocks, LA	1
De Medio, GE; Montanini, I; Trovarelli, G	1
Dabrowiecki, Z; Dorman, RV; Goracci, G; Horrocks, LA; Porcellati, G	1
D'Orlando, KJ; Sandage, BW	1
Di Giacomo, C; Fresta, M; Puglisi, G; Russo, A	1
Fresta, M; Puglisi, G; Wehrli, E	1
Aronowski, J; Grotta, JC; Strong, R	1
Clark, WM; Gammans, RE; Pettigrew, LC; Sabounjian, LA; Warach, SJ	1
Fresta, M; Puglisi, G	2
Dashe, JF; Gammans, R; Harnett, K; Lefkowitz, DM; Pettigrew, LC; Pullicino, P; Sabounjian, L; Schwiderski, U; Warach, S	1
Fisher, M; Schaebitz, W	1
Grieb, P; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z	1
Clark, WM; Sabounjian, LA; Schwiderski, UE; Wechsler, LR	1
Alkan, T; Goren, B; Kahveci, N; Korfali, E; Ozluk, K	1
Adibhatla, RM; Dempsey, RJ; Hatcher, JF	1
Alexandrov, AV	1
Okamiya, H; Shimizu, M; Yamamoto, M	1
Dabrowiecki, Z; Dorman, RV; Goldberg, WJ; Horrocks, LA	1
Araki, T; Kogure, K; Nishioka, K	1
Fukuda, N; Kakihana, M; Nagaoka, A; Suno, M	1
Calicchio, G; Centrone, G; Ragno, G	1
Duterte, D; Lageron, A; Le Poncin-Lafitte, M; Rapin, JR	1

Reviews

18 review(s) available for cytidine diphosphate choline and Cerebral Ischemia

Article	Year
Citicoline for treating people with acute ischemic stroke. The Cochrane database of systematic reviews, 2020, 08-29, Volume: 8 Topics: Activities of Daily Living; Acute Disease; Aged; Aged, 80 and over; Bias; Brain Ischemia; Cause of Death; Cytidine Diphosphate Choline; Humans; Middle Aged; Nootropic Agents; Randomized Controlled Trials as Topic; Recovery of Function; Stroke	2020
Neuroprotective properties of citicoline: facts, doubts and unresolved issues. CNS drugs, 2014, Volume: 28, Issue:3 Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Clinical Trials as Topic; Cytidine Diphosphate Choline; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Stroke	2014
The effects of citicoline on acute ischemic stroke: a review. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:7 Topics: Brain Ischemia; Clinical Trials, Phase III as Topic; Cytidine Diphosphate Choline; Humans; Nootropic Agents; Stroke	2014
Promoting recovery from ischemic stroke. Expert review of neurotherapeutics, 2016, Volume: 16, Issue:2 Topics: Axons; Brain; Brain Ischemia; Cytidine Diphosphate Choline; Erythropoietin; Granulocyte Colony-Stimulating Factor; Humans; Myelin Proteins; Neovascularization, Physiologic; Neurogenesis; Neurological Rehabilitation; Neuronal Plasticity; Nogo Proteins; Nootropic Agents; Phosphodiesterase 5 Inhibitors; Recovery of Function; Regeneration; Selective Serotonin Reuptake Inhibitors; Stem Cell Transplantation; Stroke; Stroke Rehabilitation	2016
[Phospholipids metabolism disorders in acute stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2016, Volume: 116, Issue:1 Topics: Brain Ischemia; Cell Membrane; Cerebrovascular Circulation; Cytidine Diphosphate Choline; Free Radicals; Humans; Lipid Peroxidation; Lipolysis; Neuroprotective Agents; Phosphatidylcholines; Phospholipids; Stroke	2016
Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Trials. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:8 Topics: Brain Ischemia; Cytidine Diphosphate Choline; Double-Blind Method; Female; Humans; Male; Nootropic Agents; Randomized Controlled Trials as Topic; Stroke	2016
Multifunctional actions of approved and candidate stroke drugs. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2009, Volume: 6, Issue:1 Topics: Albumins; Animals; Antihypertensive Agents; Aspirin; Brain Ischemia; Clopidogrel; Cytidine Diphosphate Choline; Dipyridamole; Erythropoietin; Granulocyte Colony-Stimulating Factor; Humans; Hypolipidemic Agents; Neuroprotective Agents; Platelet Aggregation Inhibitors; Stroke; Ticlopidine	2009
Citicoline preclinical and clinical update 2009-2010. Stroke, 2011, Volume: 42, Issue:1 Suppl Topics: Acute Disease; Animals; Brain Ischemia; Cytidine Diphosphate Choline; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Nootropic Agents; Recovery of Function; Stroke	2011
Citicoline in vascular cognitive impairment and vascular dementia after stroke. Stroke, 2011, Volume: 42, Issue:1 Suppl Topics: Alzheimer Disease; Brain Ischemia; Clinical Trials as Topic; Cognition; Cytidine Diphosphate Choline; Dementia, Vascular; Humans; Neuroprotective Agents; Nootropic Agents; Recovery of Function; Stroke	2011
Citicoline: pharmacological and clinical review, 2010 update. Revista de neurologia, 2011, Mar-14, Volume: 52 Suppl 2 Topics: Brain Injuries; Brain Ischemia; Cerebrovascular Disorders; Clinical Trials as Topic; Cognition Disorders; Cytidine Diphosphate Choline; Humans; Learning; Memory; Stroke; Synaptic Transmission	2011
Investigational therapies for ischemic stroke: neuroprotection and neurorecovery. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2011, Volume: 8, Issue:3 Topics: Albumins; Animals; Brain Ischemia; Cell- and Tissue-Based Therapy; Clinical Trials as Topic; Cytidine Diphosphate Choline; Embryonic Stem Cells; Granulocyte Colony-Stimulating Factor; Humans; Hypothermia, Induced; Neural Stem Cells; Neuroprotective Agents; Stroke	2011
Citicoline mechanisms and clinical efficacy in cerebral ischemia. Journal of neuroscience research, 2002, Oct-15, Volume: 70, Issue:2 Topics: Animals; Arachidonic Acid; Brain Ischemia; Clinical Trials as Topic; Cytidine Diphosphate Choline; Disease Models, Animal; Humans; Ischemic Attack, Transient; Neuroprotective Agents; Phosphatidylcholines; Phospholipases A; Rats; Treatment Outcome	2002
Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials. Stroke, 2002, Volume: 33, Issue:12 Topics: Acute Disease; Administration, Oral; Aged; Brain Ischemia; Cytidine Diphosphate Choline; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Neuroprotective Agents; Odds Ratio; Prospective Studies; Randomized Controlled Trials as Topic; Recovery of Function; Severity of Illness Index; Stroke; Time Factors; Treatment Outcome	2002
Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. Neurological research, 1995, Volume: 17, Issue:4 Topics: Animals; Brain Ischemia; Cell Membrane; Clinical Trials as Topic; Cytidine Diphosphate Choline; Fatty Acids, Nonesterified; Humans; Membrane Lipids; Neurons; United States	1995
An overview of acute stroke therapy: past, present, and future. Archives of internal medicine, 2000, Nov-27, Volume: 160, Issue:21 Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; Calcium Channel Blockers; Cardiovascular Agents; Cell Adhesion Molecules; Clinical Trials as Topic; Cytidine Diphosphate Choline; Cytokines; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; gamma-Aminobutyric Acid; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Piperidines; Stroke; Thiazoles; Thrombolytic Therapy	2000
Citicoline: neuroprotective mechanisms in cerebral ischemia. Journal of neurochemistry, 2002, Volume: 80, Issue:1 Topics: Animals; Brain Ischemia; Cytidine Diphosphate Choline; Humans; Neuroprotective Agents	2002
Citicoline. Ferrer Internacional. Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:12 Topics: Alzheimer Disease; Animals; Brain Ischemia; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cytidine Diphosphate Choline; Humans; Multiple Sclerosis; Nootropic Agents; Structure-Activity Relationship	2001
[Inhibition of ischemic brain cell death by cell membrane lipid synthesis enhancers]. Nihon rinsho. Japanese journal of clinical medicine, 1988, Volume: 46, Issue:12 Topics: Animals; Brain; Brain Ischemia; Cell Survival; Cytidine Diphosphate Choline; Gerbillinae; Membrane Lipids; Rats; S-Adenosylmethionine; Stimulation, Chemical	1988

Trials

10 trial(s) available for cytidine diphosphate choline and Cerebral Ischemia

Article	Year
Citicoline in acute ischemic stroke: A randomized controlled trial. PloS one, 2022, Volume: 17, Issue:5 Topics: Brain Ischemia; Cytidine Diphosphate Choline; Double-Blind Method; Humans; Ischemia; Ischemic Stroke; Stroke	2022
Efficacy of Citicoline as a Neuroprotector in children with post cardiac arrest: a randomized controlled clinical trial. European journal of pediatrics, 2021, Volume: 180, Issue:4 Topics: Adult; Brain Injuries; Brain Ischemia; Child; Cytidine Diphosphate Choline; Heart Arrest; Humans; Stroke	2021
Edaravone - citicoline comparative study in acute ischemic stroke (ECCS-AIS). The Journal of the Association of Physicians of India, 2012, Volume: 60 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antipyrine; Brain Ischemia; Cytidine Diphosphate Choline; Edaravone; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Treatment Outcome; Young Adult	2012
Citicoline in the treatment of acute ischaemic stroke: an international, randomized, multicentre, placebo-controlled study (ICTUS trial) is the use of Citicoline is beneficial for acute ischaemic stroke? JPMA. The Journal of the Pakistan Medical Association, 2013, Volume: 63, Issue:11 Topics: Brain Ischemia; Cytidine Diphosphate Choline; Humans; Nootropic Agents; Stroke; Treatment Failure	2013
Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases. Methods and findings in experimental and clinical pharmacology, 2009, Volume: 31, Issue:3 Topics: Administration, Oral; Aged; Brain Ischemia; Cytidine Diphosphate Choline; Drug Evaluation; Female; Humans; Korea; Male; Stroke; Time Factors	2009
[Influence of neuroprotectors with choline-positive action on the level of brain-injury markers during acute ischemic stroke]. Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:3 Topics: Biomarkers; Blood-Brain Barrier; Brain Ischemia; Cytidine Diphosphate Choline; Glycerylphosphorylcholine; Humans; Nootropic Agents; Phosphopyruvate Hydratase; S100 Proteins; Stroke	2012
Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet (London, England), 2012, Jul-28, Volume: 380, Issue:9839 Topics: Acute Disease; Administration, Oral; Aged; Brain Ischemia; Cytidine Diphosphate Choline; Double-Blind Method; Female; Humans; Injections, Intravenous; Ischemia; Male; Nootropic Agents; Treatment Outcome	2012
A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group. Neurology, 1997, Volume: 49, Issue:3 Topics: Acute Disease; Aged; Brain Ischemia; Cerebrovascular Disorders; Cytidine Diphosphate Choline; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Placebos; Severity of Illness Index; Treatment Outcome	1997
Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators. Annals of neurology, 2000, Volume: 48, Issue:5 Topics: Aged; Brain; Brain Ischemia; Cytidine Diphosphate Choline; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging; Male; Prognosis; Stroke	2000
A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology, 2001, Nov-13, Volume: 57, Issue:9 Topics: Acute Disease; Aged; Brain Ischemia; Cytidine Diphosphate Choline; Female; Humans; Male; Nootropic Agents; Stroke; Treatment Outcome	2001

Other Studies

44 other study(ies) available for cytidine diphosphate choline and Cerebral Ischemia

Article	Year
[Study of the effect of Unifuzol on cognitive impairment and damage to the hippocampus and cerebral cortex during course administration to rats with bilateral stenosis of the common carotid arteries, causing chronic circulatory failure]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2023, Volume: 123, Issue:3 Topics: Animals; Brain Ischemia; Carotid Artery, Common; Carotid Stenosis; Cognitive Dysfunction; Constriction, Pathologic; Cytidine Diphosphate Choline; Disease Models, Animal; Hippocampus; Male; Nicergoline; Rats; Shock	2023
The Role of P Bulletin of experimental biology and medicine, 2023, Volume: 175, Issue:1 Topics: Animals; Brain; Brain Ischemia; Cytidine Diphosphate Choline; Mice; Neuroprotective Agents	2023
EFFECT OF INVESTIGATIONAL COMBINATIONS OF NEUROPROTECTANTS ON THE LEVEL OF S 100 AND NSE PROTEIN IN THE BLOOD SERUM OF PATIENTS WITH MODERATE AND SEVERE ISCHEMIC STROKE. Georgian medical news, 2023, Issue:342 Topics: Brain Ischemia; Cytidine Diphosphate Choline; Humans; Ischemic Stroke; Neuroprotective Agents; Phosphopyruvate Hydratase; S100 Proteins; Serum; Stroke	2023
[A personalized selection of choline precursors in evidence - based medicine]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:6 Topics: Brain Ischemia; Choline; Cytidine Diphosphate Choline; Humans; Neuroprotective Agents; Nootropic Agents	2020
[Choice of neuroprotective therapy regimens in patients with chronic cerebral ischemia, taking into account the synergy of drug interactions]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:8 Topics: Brain Ischemia; Cytidine Diphosphate Choline; Drug Interactions; Humans; Neuroprotective Agents; Proteomics	2020
[Molecular and clinical aspects of the effect of cytidyndiphosphocholine on cognitive functions]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2021, Volume: 121, Issue:5 Topics: Brain Ischemia; Cognition; Cognition Disorders; Cytidine Diphosphate Choline; Humans; Nootropic Agents	2021
Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia. Journal of pharmacological sciences, 2019, Volume: 139, Issue:4 Topics: Animals; Avoidance Learning; Brain Ischemia; CA1 Region, Hippocampal; Cell Survival; Cognitive Dysfunction; Cytidine Diphosphate Choline; Disease Models, Animal; Docosahexaenoic Acids; Drug Therapy, Combination; Learning; Male; Memory; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Recognition, Psychology; Treatment Outcome	2019
Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. Journal of neurochemistry, 2013, Volume: 126, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Blotting, Western; Brain Ischemia; Cells, Cultured; Cytidine Diphosphate Choline; Drug Synergism; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; Monocytes; Naphthols; Neurons; Neuroprotective Agents; Nootropic Agents; Rats; Rats, Inbred F344; Resveratrol; Sirtuin 1; Stilbenes; Stroke	2013
Long-Term Treatment with Citicoline Prevents Cognitive Decline and Predicts a Better Quality of Life after a First Ischemic Stroke. International journal of molecular sciences, 2016, Mar-16, Volume: 17, Issue:3 Topics: Aged; Brain Ischemia; Cognitive Dysfunction; Cytidine Diphosphate Choline; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Quality of Life; Random Allocation; Stroke	2016
Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2010, Volume: 17, Issue:2 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Brain; Brain Infarction; Brain Ischemia; Combined Modality Therapy; Cytidine Diphosphate Choline; Disease Models, Animal; Hypothermia, Induced; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Nootropic Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome	2010
Citicoline for acute ischemic stroke in Mexican hospitals: a retrospective postmarketing analysis. Methods and findings in experimental and clinical pharmacology, 2010, Volume: 32, Issue:5 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Case-Control Studies; Cytidine Diphosphate Choline; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Product Surveillance, Postmarketing; Retrospective Studies; Stroke	2010
Mannosylated liposomal cytidine 5' diphosphocholine prevent age related global moderate cerebral ischemia reperfusion induced mitochondrial cytochrome c release in aged rat brain. Neuroscience, 2010, Dec-29, Volume: 171, Issue:4 Topics: Aging; Analysis of Variance; Animals; Brain; Brain Ischemia; Catalase; Cytidine Diphosphate Choline; Cytochromes c; Disease Models, Animal; Glutathione; Lipid Peroxidation; Liposomes; Male; Mannose; Microscopy, Electron, Transmission; Mitochondria; Nootropic Agents; Rats; Rats, Wistar; Reperfusion; Statistics as Topic; Superoxide Dismutase	2010
Serial MRI study of the enhanced therapeutic effects of liposome-encapsulated citicoline in cerebral ischemia. International journal of pharmaceutics, 2011, Feb-28, Volume: 405, Issue:1-2 Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Injections, Intravenous; Liposomes; Magnetic Resonance Imaging; Male; Nootropic Agents; Rats; Rats, Sprague-Dawley; Stroke	2011
Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia. Science China. Life sciences, 2011, Volume: 54, Issue:3 Topics: Animals; Brain Ischemia; Cytidine Diphosphate Choline; Diffusion; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Nootropic Agents; Rats; Rats, Sprague-Dawley	2011
CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke. Neurological research, 2011, Volume: 33, Issue:6 Topics: Aged; Aged, 80 and over; Brain Ischemia; Cell Count; Cells, Cultured; Cytidine Diphosphate Choline; Endothelial Cells; Female; Humans; Male; Middle Aged; Prospective Studies; Stem Cells; Stroke; Treatment Outcome	2011
CDP-choline treatment induces brain plasticity markers expression in experimental animal stroke. Neurochemistry international, 2012, Volume: 60, Issue:3 Topics: Animals; Apoptosis; Biomarkers; Blotting, Western; Brain Chemistry; Brain Ischemia; Cell Proliferation; Cytidine Diphosphate Choline; Glial Fibrillary Acidic Protein; Immunohistochemistry; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Neuronal Plasticity; Nootropic Agents; Rats; Rats, Sprague-Dawley; Stroke; Synaptophysin; Vascular Endothelial Growth Factor A	2012
[Comparison of efficacy of different neurometabolic and vasoactive medicines in ischemic stroke patients's rehabilitation]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:10 Pt 1 Topics: Adult; Aged; Brain Ischemia; Cytidine Diphosphate Choline; Female; Humans; Male; Middle Aged; Neurotransmitter Agents; Stroke; Stroke Rehabilitation	2011
How effective is citicoline for acute ischaemic stroke? Lancet (London, England), 2012, Jul-28, Volume: 380, Issue:9839 Topics: Brain Ischemia; Cytidine Diphosphate Choline; Female; Humans; Ischemia; Male; Nootropic Agents	2012
[The role of neuroprotection in complex rehabilitation of patients with ischemic stroke]. Likars'ka sprava, 2012, Issue:7 Topics: Brain Ischemia; Clinical Trials as Topic; Cognition; Cytidine Diphosphate Choline; Drug Therapy, Combination; Humans; Neuroprotective Agents; Nootropic Agents; Stroke; Stroke Rehabilitation	2012
CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons. Journal of molecular neuroscience : MN, 2003, Volume: 20, Issue:1 Topics: Animals; Animals, Newborn; Apoptosis; Brain Ischemia; Cells, Cultured; Cerebellar Cortex; Cytidine Diphosphate Choline; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Time Factors; Trypan Blue	2003
Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia. Neuroscience, 2003, Volume: 118, Issue:1 Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channel Blockers; Cerebral Cortex; Cerebral Infarction; Cytidine Diphosphate Choline; Drug Therapy, Combination; In Situ Nick-End Labeling; Male; Nerve Degeneration; Neurons; Nimodipine; Nootropic Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome; Up-Regulation	2003
The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats. The International journal of neuroscience, 2004, Volume: 114, Issue:2 Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Brain Ischemia; Cerebral Infarction; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Lamotrigine; Male; Neurologic Examination; Random Allocation; Rats; Rats, Wistar; Statistics, Nonparametric; Tetrazolium Salts; Treatment Outcome; Triazines	2004
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiology of disease, 2005, Volume: 18, Issue:2 Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Biological Transport; Brain; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Infarction; Coculture Techniques; Cytidine Diphosphate Choline; Cytoprotection; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Rats, Wistar; Symporters	2005
CDP-choline liposomes provide significant reduction in infarction over free CDP-choline in stroke. Brain research, 2005, Oct-05, Volume: 1058, Issue:1-2 Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Cholesterol; Choline; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Combinations; Drug Synergism; G(M1) Ganglioside; Liposomes; Male; Phagocytosis; Phosphatidylcholines; Rats; Rats, Inbred SHR; Reperfusion Injury; Stroke; Treatment Outcome	2005
Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia. Neurochemical research, 2005, Volume: 30, Issue:8 Topics: Animals; Brain Ischemia; Cytidine Diphosphate Choline; Enzyme Activation; Female; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nootropic Agents; Phosphorylation; Rats; Rats, Sprague-Dawley	2005
CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. The Journal of biological chemistry, 2006, Mar-10, Volume: 281, Issue:10 Topics: Animals; Brain Ischemia; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Gene Expression Regulation; Male; Phosphatidylcholines; Phospholipase D; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; RNA, Messenger	2006
Targets of cytoprotection in acute ischemic stroke: present and future. Cerebrovascular diseases (Basel, Switzerland), 2006, Volume: 21 Suppl 2 Topics: Animals; Brain; Brain Ischemia; Cytidine Diphosphate Choline; Cytoprotection; Drug Evaluation, Preclinical; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Ischemic Preconditioning; Meta-Analysis as Topic; Neuropharmacology; Neuroprotective Agents; Polymorphism, Genetic; Promoter Regions, Genetic; Randomized Controlled Trials as Topic; Stroke	2006
Thrombolysis and neuroprotection in cerebral ischemia. Cerebrovascular diseases (Basel, Switzerland), 2006, Volume: 21 Suppl 2 Topics: Animals; Brain; Brain Ischemia; Clinical Trials as Topic; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Neuroprotective Agents; Rats; Recombinant Proteins; Stroke; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator	2006
Phospholipid metabolism during central and peripheral damage and recovery in nervous tissue. Birth defects original article series, 1983, Volume: 19, Issue:4 Topics: Animals; Axonal Transport; Axons; Brain; Brain Ischemia; Cerebrovascular Circulation; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Fatty Acids, Nonesterified; Gerbillinae; Lipid Metabolism; Membrane Lipids; Nerve Degeneration; Nerve Regeneration; Peripheral Nerves; Phospholipids	1983
Effects of CDPcholine and CDPethanolamine on the alterations in rat brain lipid metabolism induced by global ischemia. Journal of neurochemistry, 1983, Volume: 40, Issue:1 Topics: Acetates; Animals; Brain; Brain Ischemia; Choline; Cytidine Diphosphate; Cytidine Diphosphate Choline; Cytosine Nucleotides; Ethanolamines; Fatty Acids, Nonesterified; Kinetics; Lipid Metabolism; Male; Rats; Rats, Inbred Strains	1983
The influence of CDP-choline on brain lipid metabolism during ischemia. Il Farmaco; edizione scientifica, 1982, Volume: 37, Issue:10 Topics: Animals; Brain; Brain Ischemia; Choline; Cytidine Diphosphate Choline; Diglycerides; Fatty Acids, Nonesterified; Gerbillinae; Lipid Metabolism	1982
CDPcholine and CDPethanolamine prevent the release of free fatty acids during brain ischemia. Progress in lipid research, 1981, Volume: 20 Topics: Animals; Brain; Brain Ischemia; Choline; Cytidine Diphosphate; Cytidine Diphosphate Choline; Cytosine Nucleotides; Ethanolamines; Fatty Acids, Nonesterified; Male; Rats	1981
Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:12 Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Cortex; Cholesterol; Chromatography, High Pressure Liquid; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Evaluation; Lactates; Lactic Acid; Lipid Peroxidation; Liposomes; Male; Phosphatidylserines; Rats; Rats, Wistar; Reperfusion Injury; Survival Rate	1994
Enhanced therapeutic effect of cytidine-5'-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model. Pharmaceutical research, 1995, Volume: 12, Issue:11 Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Cytidine Diphosphate Choline; Drug Carriers; G(M1) Ganglioside; Liposomes; Magnetic Resonance Spectroscopy; Male; Nootropic Agents; Particle Size; Rats; Rats, Wistar; Reperfusion Injury	1995
Citicoline for treatment of experimental focal ischemia: histologic and behavioral outcome. Neurological research, 1996, Volume: 18, Issue:6 Topics: Animals; Arterial Occlusive Diseases; Atrophy; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Cytidine Diphosphate Choline; Male; Neuroprotective Agents; Nootropic Agents; Rats; Rats, Inbred SHR; Reperfusion Injury	1996
Survival rate improvement in a rat ischemia model by long circulating liposomes containing cytidine-5I-diphosphate choline. Life sciences, 1997, Volume: 61, Issue:13 Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Brain Ischemia; Carotid Artery, Common; Cholesterol; Constriction; Cytidine Diphosphate Choline; G(M1) Ganglioside; Liposomes; Male; Phosphatidylserines; Rats; Rats, Wistar; Survival Rate	1997
Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes. Pharmaceutical research, 1999, Volume: 16, Issue:12 Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Chemical Phenomena; Chemistry, Physical; Cytidine Diphosphate Choline; Drug Carriers; Electroencephalography; Freeze Fracturing; G(M1) Ganglioside; Lactates; Lipid Peroxidation; Liposomes; Male; Nootropic Agents; Rats; Rats, Wistar; Survival Analysis	1999
The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2001, Volume: 11, Issue:5 Topics: Animals; Behavior, Animal; Brain Ischemia; Cytidine Diphosphate Choline; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperglycemia; Hypoxia; Male; Mice; Motor Activity; Nervous System	2001
Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of citicoline. Archives of physiology and biochemistry, 2001, Volume: 109, Issue:2 Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Cytidine Diphosphate Choline; Edema; Female; Neuroprotective Agents; Nootropic Agents; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Survival; Vertebrobasilar Insufficiency	2001
Pharmacological actions of a new TRH analogue, YM-14673, in rats subjected to cerebral ischemia and anoxia. European journal of pharmacology, 1990, Jun-08, Volume: 181, Issue:3 Topics: Animals; Azetidines; Azetines; Body Water; Brain; Brain Chemistry; Brain Ischemia; Carbon Dioxide; Cytidine Diphosphate Choline; Dipeptides; Hypoxia, Brain; Injections, Intraperitoneal; Male; Naloxone; Nervous System; Oxygen Consumption; Rats; Rats, Inbred Strains	1990
The effects of ischemia and CDPamines on Na+, K+-ATPase and acetylcholinesterase activities in rat brain. Neurochemical pathology, 1985,Winter, Volume: 3, Issue:4 Topics: Acetylcholinesterase; Animals; Brain Ischemia; Cerebral Cortex; Choline; Corpus Striatum; Cytidine Diphosphate; Cytidine Diphosphate Choline; Cytosine Nucleotides; Ethanolamines; Male; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase	1985
Effects of CDP-choline on neurologic deficits and cerebral glucose metabolism in a rat model of cerebral ischemia. Stroke, 1988, Volume: 19, Issue:2 Topics: Animals; Brain; Brain Ischemia; Carbon Radioisotopes; Cerebral Cortex; Choline; Cytidine Diphosphate Choline; Glucose; Male; Motor Activity; Posture; Rats; Rats, Inbred Strains; Reflex	1988
[Use of citicoline in high dosages in acute cerebrovascular disease]. Minerva medica, 1986, Mar-17, Volume: 77, Issue:11 Topics: Acute Disease; Aged; Brain Ischemia; Cerebral Hemorrhage; Choline; Coma; Consciousness; Cytidine Diphosphate Choline; Electroencephalography; Female; Humans; Language Disorders; Male; Middle Aged; Paralysis	1986
[CDP choline and experimental cerebrovascular disorder]. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1986, Volume: 27, Issue:5 Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Choline; Cytidine Diphosphate Choline; Drug Evaluation, Preclinical; Histocytochemistry; Male; Rats; Rats, Inbred Strains	1986