cytellin and Typhoid-Fever

In this article, we aim to examine the novel effects of β-sitosterol on murine experimental colitis. β-Sitosterol significantly reduces the weight loss, colon length, and alleviated microscopic appearances of colitis induced by dextran sulfate sodium. This compound also decreases the levels of TNF-α, IL-6, and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner. β-Sitosterol treatment to intestinal epithelial cells significantly increases expression of antimicrobial peptides and reduces survival of intracellular Salmonella typhimurium. These results showed the multiple effects of β-sitosterol against pathogenic bacteria for a novel approach to the treatment of colonic inflammation.

Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Hypolipidemic Agents; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Salmonella typhimurium; Sitosterols; Typhoid Fever