cytellin has been researched along with Biliary-Fistula* in 2 studies
2 other study(ies) available for cytellin and Biliary-Fistula
| Article | Year |
|---|---|
The presence of 5 alpha-sitostanol in the serum of a patient with phytosterolemia, and its biosynthesis from plant steroids in rats with bile fistula.
The presence of 5 alpha-sitostanol (24-ethyl-5 alpha-cholestan-3 beta-ol) in serum of a patient with the rare genetic disease phytosterolemia was confirmed. This study aimed at clarifying the pathway(s) for the formation of 5 alpha-sitostanol, by use of rats with bile fistula. 5 alpha-Sitostanol was formed only slowly from sitosterol, but readily from 24-ethyl-4-cholesten-3-one. Some conversion was also obtained with 7 alpha-hydroxysitosterol as precursor. In view of the low rate of 7 alpha-hydroxylation of sitosterol, however, a pathway from sitosterol to 5 alpha-sitostanol involving 7 alpha-hydroxysitosterol as intermediate is probably of small physiological importance. Intestinal microorganisms are not essential for the above conversions, since the 5 alpha-sitostanol was found in bile from bile fistula rats. 5 alpha-Sitostanol was converted to water soluble metabolites (bile acids) much more slowly than was cholestanol (5 alpha-cholestan-3 beta-ol), and was accumulated serum to a much larger extent. Topics: Adolescent; Animals; Bile; Biliary Fistula; Carbon Radioisotopes; Female; Humans; Kinetics; Lipid Metabolism, Inborn Errors; Liver; Mass Spectrometry; Plants; Rats; Rats, Inbred Strains; Sitosterols; Steroids; Tritium | 1985 |
Studies on the formation of C7-oxygenated cholesterol and beta-sitosterol metabolites in cell-free preparations of rat liver.
The microsomal fraction and the 18,000 g supernatant fluid obtained from livers from normal rats, cholestyraminetreated rats, or from rats with a bile fistula have been used to compare the 7alpha-hydroxylation of [4-(14)C]cholesterol and beta-[4-(14)C]sitosterol (24alpha-ethyl-cholesterol). It was not possible to increase the specific formation of 7alpha-hydroxy-beta-sitosterol above 0.05% with any of the preparations. This conversion was less than 1% of that found for cholesterol. The inhibitory effect of added 7-oxo- and 7beta-hydroxy-beta-sitosterol on the 7alpha-hydroxylation of cholesterol was found to be much less than that of the corresponding cholesterol compounds. 7alpha-Hydroxy-beta-sitosterol was without effect. It is concluded that the activity of the cholesterol 7alpha-hydroxylase is dependent upon the structure of the steroid side chain. Topics: Animals; Biliary Fistula; Carbon Isotopes; Cell-Free System; Cholesterol; Cholestyramine Resin; Chromatography, Gas; Chromatography, Ion Exchange; Chromatography, Thin Layer; Circadian Rhythm; Hydroxylation; Liver; Male; Mass Spectrometry; Microsomes, Liver; Phenobarbital; Phytosterols; Rats; Sitosterols; Steroid Hydroxylases; Time Factors; Triolein | 1973 |