cytarabine has been researched along with Leukemia L 1210 in 378 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 318 (84.13) | 18.7374 |
| 1990's | 53 (14.02) | 18.2507 |
| 2000's | 7 (1.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abbasi, MM; Beisler, JA; Driscoll, JS | 2 |
| Hong, CI; Nechaev, A; West, CR | 3 |
| Hamamura, EK; Moffatt, JG; Prystasz, M; Verheyden, JP | 3 |
| Allen, LB; Khwaja, TA; Long, RA; Mian, AM; Robins, RK; Sidwell, RW | 1 |
| Gibbons, AJ; Gish, DT; Gray, GD; Gray, LG; Greig, ME; Griffin, RL; Kuentzel, SL; Moxley, TE; Neil, GL; Wechter, WJ | 1 |
| Birnbaum, GI; Cheng, YC; Clarke-Katzenburg, RH; Gabe, EJ; Giziewicz, J; Lin, TS; Liu, MC; Luo, MZ; Mancini, WR; Prusoff, WH | 1 |
| Dorr, RT; Iyengar, BS; Remers, WA | 1 |
| Barchi, JJ; Driscoll, JS; Kelley, JA; Liu, PS; Marquez, VE; Plowman, J | 1 |
| Matsuda, A; Sasaki, T; Takenuki, K; Ueda, T | 1 |
| Corbett, TH; Court, BA; Kessel, D; Phadtare, S; Renis, HE; Zimlicka, J | 1 |
| Birnbaum, GI; Brankovan, V; Cheng, YC; Ghazzouli, I; Giziewicz, J; Lin, TS; Liu, MC; Prusoff, WH; Shen, ZY; Yang, JH | 1 |
| Matsuda, A; Sasaki, T; Takenuki, K; Tanaka, M; Ueda, T | 1 |
| Buchheit, DJ; Hong, CI; Kirisits, AJ; Nechaev, A; West, CR | 4 |
| Hansch, C; Khwaja, TA; Selassie, CD | 1 |
| An, SH; Bernacki, RJ; Bobek, M; De Clercq, E; Skrincosky, D | 1 |
| Arbiser, J; Kalman, TI; Lee, JJ; Prusoff, WH; Schinazi, RF | 1 |
| An, SH; Buchheit, DJ; Hong, CI; Kirisits, AJ; Nechaev, A; Schliselfeld, L; West, CR | 1 |
| Bordoni, T; Cristalli, G; Franchetti, P; Geroni, C; Grifantini, M; Vittori, S | 1 |
| An, SH; Berdel, WE; Buchheit, DJ; Hong, CI; Kirisits, AJ; Nechaev, A; West, CR | 1 |
| Cook, PD; McNamara, DJ | 1 |
| Phadtare, S; Zemlicka, J | 1 |
| Avery, TL; Chwang, TL; Fridland, A | 1 |
| Kim, SH; Rosowsky, A; Ross, J; Wick, MM | 1 |
| Hong, CI; MacCoss, M; Matsushita, T; Ross, RJ; Ryu, EK; West, CR | 1 |
| Bussolari, JC; Chen, SF; Panzica, RP; Ramesh, K; Stoeckler, JD | 1 |
| Azuma, A; Hanaoka, K; Kobayashi, T; Matsuda, A; Minakawa, N; Nakajima, Y; Nishizono, N; Sasaki, T; Suzuki, M; Tanaka, M | 1 |
| Dan, A; Matsuda, A; Minakawa, N; Okazaki, S; Sasaki, T; Sugimoto, Y; Tregear, SJ | 1 |
| Hong, CI; Kirisits, AJ; Nechaev, A; Vig, R; West, CR | 1 |
| Gang, M; Goldin, A; Kline, I; Sirica, A; Venditti, JM; Woodman, RJ | 1 |
| Balajthy, Z | 1 |
| Ooi, K | 1 |
| Cha, MC; Meckling, KA; Stewart, C | 1 |
| BOSTWICK, L; EVANS, JS; MENGEL, GD | 1 |
| BOSTWICK, L; EVANS, JS; MENGEL, GD; MUSSER, EA | 1 |
| KENSLER, CJ; WODINSKY, I | 1 |
| Mego, M; Novotny, L; Rauko, P; Saiko, P; Schott, H; Szekeres, T | 1 |
| Cheon, EP; Han, HK | 1 |
| Cipak, L; Miadokova, E; Nadova, S | 1 |
| Goldin, A; Kline, I; Tyrer, DD; Venditti, JM | 2 |
| Hall, TC; Kessel, D; Wodinsky, I | 1 |
| Burchenal, JH; Dollinger, MR; Fox, JJ; Kreis, W | 1 |
| Burchenal, JH; Butterbaugh, J; Dollinger, M; Giner-Sorolla, A; Stoll, D | 1 |
| Schabel, FM; Skipper, HE; Wilcox, WS | 1 |
| Burdeshaw, JA; Dixon, GJ; Dulmadge, EA; Wilcox, WS; Wilkoff, LJ | 1 |
| Skipper, HE | 2 |
| Momparler, LF; Momparler, RL; Samson, J | 1 |
| Afonin, NI; Ermakova, LN; Oksinoĭd, OE | 1 |
| Lee, MH; Sartorelli, AC | 1 |
| Cesario, T; Slater, LM; Wetzel, MW | 1 |
| Coulter, DM; Presant, CA; Valeriote, F; Vietti, TJ | 1 |
| Cadman, E; Rauscher, F | 1 |
| Chou, TC; Feinberg, A; Han, J; Philips, FS; Schmid, FA | 1 |
| Campbell, J; Li, ZR; Rustum, YM | 1 |
| Fukushima, H; Hara, T; Kato, Y; Saito, M; Takeda, Y | 1 |
| Afonin, NI; Ermakov, LN; Fertukova, NM; Oksinoĭd, OE; Reshchikov, VP | 1 |
| Kerrigan, D; Minford, J; Nichols, M; Shackney, S; Zwelling, LA | 1 |
| Chabot, GG; Momparler, RL | 1 |
| Cadman, E; Grant, S | 1 |
| Allaudeen, HS; Chang, PK; Chu, MY; Itoh, YH; Sartorelli, AC | 1 |
| Balzarini, J; De Clercq, E | 1 |
| Prakash, NJ; Sunkara, PS | 1 |
| Araki, T; Ninomiya, K; Sekido, S | 1 |
| Egan, E; Herrick, D; Kufe, DW; Munroe, D; Spriggs, D | 1 |
| Fram, RJ; Kufe, DW | 2 |
| Ali-Osman, F; Maurer, HR | 1 |
| An, SH; Buchheit, DJ; Hong, CI; Kirisits, AJ; MacCoss, M; Nechaev, A; Ryu, EK; West, CR | 1 |
| Lin, TS; Mancini, WR | 1 |
| Pauly, JE | 1 |
| Perez, DJ; Tattersall, MH | 1 |
| Acharya, RS; Sundareshan, MK | 1 |
| Li, ZR; Rustum, YM; Slocum, HK | 1 |
| Hori, K; Naganuma, K; Sakurai, Y; Tsukagoshi, S; Tsuruo, T | 1 |
| Fietkau, R; Friede, H; Maurer-Schultze, B | 1 |
| Howell, SB; King, ME; Naporn, A; Young, B | 1 |
| Hacker, B; Medon, PJ | 1 |
| Fang, WD; Muzyka, TG; Warrington, RC | 1 |
| Hemmi, H | 1 |
| Brouwer, M; Jongsma, AP; Smets, LA | 1 |
| Egan, EM; Fram, RJ; Kufe, DW | 1 |
| Cysyk, RL; Hoerauf, RM; Karle, JM | 1 |
| Kagawa, D; Nakamura, T; Sasada, M; Uchida, M; Uchino, H; Ueda, T; Yamamoto, K | 1 |
| Burke, PJ; Karp, JE; Vaughan, WP | 1 |
| Capizzi, RL; Cheng, YC | 1 |
| Bertino, JR | 1 |
| Mitchell, MS; Murahata, RI | 1 |
| Harrap, KR; Renshaw, J | 1 |
| Mihich, E | 2 |
| Au, JL; Danhauser, L; Luccioni, C; Rustum, YM | 1 |
| Kimura, K | 1 |
| Burchenal, JH; Chou, TC; Fox, JJ; Lokys, L; Smith, RS; Su, TL; Watanabe, KA | 1 |
| Braun, TJ; Burchenal, JH; Chou, TC; Fox, JJ; Philips, FS; Schmid, FA; Su, TL; Watanabe, KA | 1 |
| Golenko, OD; Kudriavtsev, IA; Miasishcheva, NV; Paramonova, TD | 1 |
| Bernal, SD; Chen, LB; Shapiro, HM | 1 |
| Egan, EM; Herrick, DJ; Kufe, DW; Major, PP | 1 |
| Brockman, RW; Corbett, TH; Griswold, DP; Laster, WR; Schabel, FM; Skipper, HE; Trader, MW | 1 |
| Valeriote, F | 1 |
| Blechman, WJ; Kim, K; Pardee, AB; Riddle, VG | 1 |
| Campbell, J; Mayhew, E; Rustum, YM; Szoka, F | 1 |
| Egan, EM; Herrick, D; Kufe, DW; Major, PP | 1 |
| Kataoka, T; Kobayashi, H; Oh-ishi, J; Sakurai, Y; Shibukawa, M; Tsukagoshi, S | 1 |
| Hong, CI; MacCoss, M; Matsushita, T; Ryu, EK | 1 |
| Balázová, E; Koza, I; Ujházy, V | 1 |
| Egan, EM; Kufe, DW; Major, PP; Sargent, L | 1 |
| Kataoka, T; Sakurai, Y | 1 |
| Cadman, E; Grant, S; Lehman, C | 1 |
| Moran, RE; Straus, MJ | 2 |
| Maas, E; Mattern, J; Volm, M | 1 |
| Beardsley, GP; Egan, EM; Kufe, DW; Major, PP | 1 |
| Agarwal, RP; Craig, RW; Walsh, CT | 1 |
| Hromas, RA; Markel, DE; Scholes, VE | 1 |
| Grindey, GB; Kinahan, JJ; Kowal, EP | 1 |
| Peck, C; Roberts, D | 1 |
| Hilliard, S; Peck, C; Roberts, D | 1 |
| Ganapathi, R; Krishan, A; Lesko, LJ; Wodinsky, I; Zubrod, CG | 1 |
| Iwasaki, H; Nakamura, T; Takauji, R; Tohyama, K; Ueda, T; Yoshida, A | 1 |
| Hong, CI; Hui, SW; Kirisits, AJ; Nechaev, A; Vig, R; West, CR | 1 |
| Chorvath, B; Duraj, J; Hunakova, L; Novotny, L; Sedlak, J | 1 |
| Cory, AH; Cory, JG | 1 |
| Kawai, Y; Nakamura, T; Ueda, T | 1 |
| Kalman, TI; Kerr, SG | 1 |
| An, SH; Hong, CI; Kirisits, AJ; Nechaev, A; Vig, R; West, CR | 1 |
| Higashigawa, M; Inagaki, S; Kagawa, Y; Kakitoh, H; Kawasaki, H; Kuwabara, H; Ohkubo, T; Ooi, K; Sakurai, M; Sumida, K | 1 |
| Chalovich, JM; Cory, AH; Cory, JG; Shibley, IA | 1 |
| Tsukagoshi, S | 1 |
| Malmberg, M; Minderman, H; Raymakers, RA; Rustum, YM; Slocum, HK | 1 |
| Horber, DH; Odermatt, B; Schott, H; Schwendener, RA | 1 |
| Schott, H; Schwendener, RA | 3 |
| Higashigawa, M; Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M | 1 |
| Capizzi, RL | 1 |
| Iwasaki, H; Kamiya, K; Kawai, Y; Nakamura, T; Takauji, R; Tohyama, K; Ueda, T; Yamauchi, T | 1 |
| Cory, AH; Cory, JG; Nelson, TO; Somerville, L | 1 |
| Bergman, AM; Brouwer, M; Eriksson, S; Jongsma, AP; Leyva, A; Peters, GJ; Pinedo, HM; Ruiz van Haperen, VW; Veerman, G | 1 |
| Balzarini, J; Breistøl, K; De Clercq, E; Fodstad, O; Martinsen, M; Myhren, F; Sandvold, ML | 1 |
| Beauséjour, CM; Momparler, RL; Tremblay, G | 1 |
| Horváth, M; Hudecz, F; Szekerke, M | 1 |
| Buchman, VM; Lichinitser, MR; Mkheidze, DM; Svet-Moldavsky, GJ | 1 |
| Burchenal, JH; Chisholm, J; Kalaher, K; O'Toole, T | 1 |
| Gregoriadis, G | 1 |
| Bhuyan, BK; Day, KJ; Fraser, TJ | 2 |
| Brockman, RW; Nelson, JA; Rose, LM; Schabel, FM; Shaddix, SC; Williams, M | 1 |
| Dave, C; Mayhew, E; Papahadjopoulos, D; Rustum, YM | 3 |
| Atkins, LM; Glae, GR; Meischen, SJ; Smith, AB; Walker, EM | 1 |
| Rustum, YM | 1 |
| Abe, I; Sato, H; Sato, S; Watanabe, M | 2 |
| Belch, AW; Lauzon, GJ; Paterson, AR | 1 |
| Bukhman, VM; Lichinitser, MR; Mkheidze, DM; Svet-Moldavskiĭ, GIa | 1 |
| Bloch, A; Bobek, M; Cheng, YC | 1 |
| Kataoka, T; Kobayashi, T | 1 |
| Cadman, E; Eiferman, F | 1 |
| O'Dell, CA; Shealy, YF | 1 |
| Khwaja, TA; Kigwana, LJ; Mian, AM | 1 |
| Arai, Y; Inoue, I; Kondo, K; Nagura, T | 1 |
| Hilliard, S; Peck, C; Roberts, D; Wingo, W | 1 |
| Cornelissen, G; Good, RA; Halberg, F; Haus, E; Nelson, W; Scheving, LE | 1 |
| Maass, E; Volm, M | 1 |
| Barkhotkina, MF; Belyanchikova, NI; Buchman, VM; Lichinitser, MR; Litovchenko, TA; Mkheidze, DM; Svet-Moldavsky, GJ | 1 |
| Bhuyan, BK; Blowers, CL; Bono, VH; Day, KJ; Neil, GL | 1 |
| Chu, CK; Fox, JJ; Reichman, U; Watanabe, KA | 1 |
| Cummings, L; Elshire, D; Fu, JC; Khwaja, T; Moyer, DL; Varvan, J | 1 |
| Hoshi, A; Kuretani, K; Yoshida, M | 1 |
| Edelstein, M; Valeriote, F; Vietti, T | 5 |
| Hilliard, SL; Roberts, D | 1 |
| Laster, WR; Rose, WC; Schabel, FM; Trader, MW | 1 |
| Adwankar, MK; Alate, AD; Amonkar, AJ; Khandalekar, DD; Sahasrabudhe, MB | 1 |
| Hashida, M; Kojima, T; Muranishi, S; Sezaki, H | 1 |
| Stupfel, M | 1 |
| Bekesi, JG; Corey, RW; Cuttner, J; Ellison, RR; Glidewell, O; Hoagland, HC; Holland, JF; Rai, K; Schwartz, J; Wallace, HJ; Wiernik, P | 1 |
| Ho, DH; Neil, GL | 1 |
| Aoshima, M; Ishida, T; Oh-ishi, JI; Sakurai, Y; Tsukagoshi, S | 1 |
| Caron, N; Kimball, AP; Lee, SH | 1 |
| Burns, ER; Halberg, F; Haus, E; Pauly, JE; Scheving, LE | 1 |
| Buchman, VM; Lichinitser, MR; Mkheidze, DM; Svet-Maoldavsky, GJ | 1 |
| Dombernowsky, P; Nissen, NI | 1 |
| Kimball, AP; LePage, GA; Worth, LS | 1 |
| Helfman, D; Zucker, RM | 1 |
| Hutchison, DJ; Otter, GM; Schmid, FA; Stock, CC | 1 |
| Aroesty, J; Carter, G; Lincoln, T; Morrison, P | 1 |
| Bichel, P; Dombernowsky, P; Hartmann, NR | 1 |
| Baguley, BC; Falkenhaug, EM | 1 |
| Burchenal, JH; Currie, VE; Dowling, MD; Fox, JJ; Krakoff, IH | 1 |
| Chou, TC; Hutchison, DJ; Philips, FS; Schmid, FA | 1 |
| Asseburg, U; Barlogie, B; Büchner, T; Hiddemann, W; Hofschröer, J; Kamanabroo, D; Metz, U; Ortheil, NB | 1 |
| Burchenal, JH | 1 |
| Chou, TC; Hutchinson, DJ; Philips, FS; Schmid, FA | 1 |
| Cass, CE; Muzik, H; Paterson, AR | 1 |
| Berger, AE; Gish, DT; Hall, CM; Johnson, MA; Neil, GL; Warner, DT; Wechter, WJ; Wenzel, AH | 1 |
| Doty, C; Hacker, B; McDermott-Sheedy, BJ; Westin, E | 1 |
| Harrap, KR; Mulder, JH | 1 |
| Doty, C; Hacker, B; McDermott-Sheedy, BJ | 1 |
| Atassi, G; Schaus, C; Tagnon, HJ | 1 |
| Avery, T; Rivera, G; Roberts, DW | 1 |
| Hoshi, A; Iigo, M; Kanzawa, F; Kuretani, K | 1 |
| Kobayashi, T; Sakurai, Y; Tsukagoshi, S | 1 |
| Bremerskov, V; Clemmesen, J; Kristensen, P | 1 |
| Carchman, RA; Harris, LS; Munson, AE | 1 |
| Aoshima, M; Ishida, T; Oh-ishi, J; Sakurai, Y; Tsukagoshi, S | 1 |
| Alabaster, O; Bunnag, B | 1 |
| Mancini, WR | 1 |
| Carter, GL; Cory, JG | 1 |
| Allen, TM; Chin, YC; Hansen, C; Mehra, T | 1 |
| Capizzi, RL; Chandrasekaran, B; Kute, TE | 1 |
| Balázová, E; Novotný, L; Reichelová, V; Ujházy, V | 1 |
| Nagai, T; Onishi, H; Pithayanukul, P | 1 |
| Nagai, T; Onishi, H; Pithayanukul, P; Seno, Y | 1 |
| Balázová, E; Novotný, L; Rauko, P; Reichelová, V | 1 |
| Mattern, J; Pommerenke, EW; Traugott, U; Volm, M | 1 |
| Cao, S; Wu, S; Xue, Y; Zhen, Y | 1 |
| Balázová, E; Benesová, M; Novotný, L; Reichelová, V; Scheithauer, W; Ujházy, V | 1 |
| Berdel, WE; Bernacki, RJ; Hong, CI; Tebbi, CK; West, CR | 1 |
| Balázová, E; Kéry, V; Novotný, L; Sandula, J; Ujházy, V | 1 |
| Grem, JL; Harrison, SD; Hawkins, MJ; Plowman, J; Rubinstein, L | 1 |
| Balázová, E; Haplová, J; Kacuráková, M; Kéry, V; Novotný, L; Sandula, J; Tihlárik, K | 1 |
| Bernacki, RJ; Hong, CI; Hui, SW; Rustum, Y; West, CR | 1 |
| Greco, WR; Park, HS; Rustum, YM | 1 |
| Arakawa, M; Ekimoto, H; Ishii, T; Kusama, K; Nagahata, T; Shibasaki, C; Takahashi, K; Uchida, T | 1 |
| Cory, JG; Matsumoto, M; Rey, DA | 1 |
| Muntz, ID; Valeriote, F; Vietti, TJ | 1 |
| Driscoll, JS; Johns, DG; Plowman, J | 1 |
| Pískala, A; Veselý, J | 1 |
| Colombo, T; D'Incalci, M; Rossi, C | 1 |
| Momparler, LF; Momparler, RL | 1 |
| Manda, T; Masuda, K; Matsumoto, S; Mori, J; Nakamura, T; Oku, T; Shimomura, K | 1 |
| Kodama, K; Kuninaka, A; Morozumi, M; Saitoh, K; Saneyoshi, M; Yoshino, H | 1 |
| Bak, M; Efferth, T; Mattern, J; Volm, M | 1 |
| Higashigawa, M; Hori, H; Kagawa, Y; Kakito, E; Kamiya, H; Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M; Sumida, K | 1 |
| Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M | 1 |
| Hong, F; Mayhew, E | 1 |
| Allen, TM; Mehra, T | 1 |
| Kato, T; Ota, K | 1 |
| Hartmann, HR; Hengartner, H; Rubas, W; Schott, H; Schwendener, RA; Supersaxo, A | 1 |
| FitzGerald, GB; Ratliff, J; Wick, MM | 1 |
| Belt, JA; Noel, LD | 1 |
| Beránek, J | 1 |
| Higashigawa, M; Kagawa, Y; Kakito, E; Kamiya, H; Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M; Sumida, K | 1 |
| Efferth, T; Volm, M | 1 |
| Kamiya, H; Nobori, T | 1 |
| Campbell, J; Mayhew, E; Radel, S; Rustum, YM | 1 |
| Fietkau, R; Maurer-Schultze, B | 1 |
| Howell, SB; Kim, S | 1 |
| Preisler, HD; Riva, C; Rustum, YM | 1 |
| Duc, HN; Nickolls, PM | 1 |
| Avramis, VI; Powell, W | 1 |
| Grindey, GB; Plunkett, W | 1 |
| Kamiya, H; Kawasaki, H; Nobori, T; Ochiai, H; Ohkubo, T; Sakurai, M; Shimizu, N | 1 |
| Kimura, K; Takenaka, T | 1 |
| Balzarini, J | 1 |
| Fang, WD; Warrington, RC | 1 |
| Preisler, HD; Riva, CM; Rustum, YM | 1 |
| Bassukas, I; Fietkau, R; Schäfer, E; Schultze, B | 1 |
| Kraemer, HP; Röthig, HJ; Sedlacek, HH | 1 |
| Hoshino, A; Ito, Y; Machida, S | 1 |
| Kufe, DW; Spriggs, DR | 1 |
| Hartmann, HR; Hengartner, H; Rubas, W; Schott, H; Schwendener, R; Supersaxo, A; Weder, HG | 1 |
| Kamiya, H; Kawasaki, H; Nobori, T; Sakurai, M | 1 |
| Homan-Blok, J; Smets, LA | 1 |
| Hirota, H; Izawa, T; Kamiya, H; Kawasaki, H; Komada, M; Noboru, T; Okubo, T; Sako, T; Sakurai, M; Shimizu, N | 1 |
| Berger, J; Mikeska, J | 1 |
| Dolbeare, F; Gray, JW; Waldman, FM | 1 |
| Hirota, H; Kamiya, H; Kawasaki, H; Komada, M; Nobori, T; Okubo, T; Sako, T; Sakurai, M; Shimizu, N | 1 |
| Fu, NW | 1 |
| Suga, S; Tamura, Z | 1 |
| Oliverio, VT | 1 |
| Gang, M; Kline, I; Sirica, AE; Venditti, JM; Woodman, RJ | 1 |
| Kline, I | 1 |
| Brockman, RW | 1 |
| Mellett, LB | 1 |
| Grindey, GB; Nichol, CA | 1 |
| Buck, M; Cleeland, R; Grunberg, E; Prince, HN | 1 |
| Durham, JP; Ives, DH | 1 |
| Bergsagel, DE | 1 |
| LePage, GA; Nakai, Y | 1 |
| Khwaja, TA; Long, RA; Robins, RK; Sidwell, RW; Simon, LN; Szekeres, GL | 1 |
| Ikegami, K; Imamura, H; Okumoto, T | 1 |
| Kessel, D | 2 |
| Hill, DL; Wingo, R | 1 |
| Avery, TL; Roberts, D | 2 |
| Brugerie, E; Huong, TH; Lheritier, J; Pouillart, R | 1 |
| Atwell, GJ; Cain, BF | 1 |
| Bennett, LR; Byfield, JE; Chan, YM; Lee, YC | 1 |
| Hoshino, A; Ogawa, M | 1 |
| Frei, E; Goldin, A; Schabel, FM | 1 |
| Ichino, M; Kanai, T | 1 |
| Tattersall, MH | 1 |
| Bloch, A; Sharma, RA; Wang, MC | 1 |
| Goldin, A | 2 |
| Bourut, C; Halle-Pannenko, O; Mathé, G | 1 |
| Gutterman, JU; Hersh, EM; Mavligit, GM; Reed, RC | 1 |
| Adamson, RH; Hahn, MA | 1 |
| Hoshi, A; Ichino, M; Kanai, T; Kanzawa, F; Kuretani, K | 2 |
| Artis, EW; Gang, M; Goldin, A; Kline, I; Tyrer, DD; Venditti, JM | 2 |
| Bennett, LR; Byfield, JE; Lee, YC | 1 |
| Kuentzel, SL; Moxley, TE; Neil, GL; Scheidt, LG | 1 |
| Homan, ER; Neil, GL | 1 |
| LePage, GA; White, SC | 1 |
| Bhuyan, BK; Fraser, TJ; Gray, LG; Kuentzel, SL; Neil, GL | 1 |
| Burchenal, JH; Giner-Sorolla, A; Longley-Cook, J; McCravey, M | 1 |
| Goldberg, D; Schein, PS; Young, RC | 1 |
| Laseter, AG; Montgomery, JA | 1 |
| Ho, DH | 1 |
| Halberg, F; Haus, E; Kühl, JF; Najarian, JS; Ratte, J; Shiotsuka, R | 1 |
| Benckhuijsen, C | 1 |
| Perry, S; Skipper, HE | 1 |
| Frei, E; Goldin, A; Henderson, ES; Holland, JF; Newman, JW; Sandberg, JS | 1 |
| Carter, SK; Livingston, RB | 1 |
| Manak, RC; Moxley, TE; Neil, GL | 1 |
| Bhuyan, BK; Buskirk, HH; Kuentzel, SL; Manak, RC; Moxley, TE; Neil, GL | 1 |
| Camiener, GW; Gish, DT; Gray, GD; Kelly, RC; Mickelson, MM; Moxley, TE; Neil, GL; Nichol, FR; Wechter, WJ | 1 |
| Hutchison, DJ; Schmid, FA | 2 |
| Lamerton, LF | 1 |
| Hacker, B | 1 |
| Cardoso, S; Halberg, F; Haus, E; Hwang, DS; Kühl, JF; Pauly, JE; Shiotsuka, RN; Sothern, RB | 1 |
| Neil, GL; Taylor, AJ; Warner, DT; Wechter, WJ | 1 |
| Grindey, GB; Mihich, E; Nichol, CA | 1 |
| Montgomery, JA; Thomas, HJ | 1 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 1 |
| Abbott, BJ; Baratta, MC; Greenberg, NH; Kline, I; Venditti, JM | 1 |
| Russell, DH | 1 |
| Arai, Y; Hoshi, A; Kanazawa, F; Kuretani, K; Saneyoshi, M | 1 |
| Camiener, GW; Gish, DT; Kelly, RC; Wechter, WJ | 1 |
| Kitano, M; Mihich, E | 1 |
| Gish, DT; Neil, GL; Wechter, WJ | 1 |
| Goldin, A; Vadlamudi, S | 1 |
| Zubrod, CG | 1 |
| Robins, RK; Tolman, RL | 1 |
| Bodey, GP; Frei, E; Freireich, E; Hart, J; Whitecar, J | 1 |
| Gang, M; Goldin, A; Hoffman, GS; Kline, I; Mantel, N; Tyrer, DD; Venditti, JM | 1 |
| Humphrey, EW; Mizuno, NS | 1 |
| Laster, WR; Schabel, FM; Skipper, HE; Trader, MW | 1 |
| Schrecker, AW | 1 |
| Fox, JJ; Wilson, DP; Wright, JA | 1 |
| Manak, RC; Moxley, TE; Neil, GL; Wiley, PF | 1 |
| Shackney, SE | 1 |
| Brockman, RW; Lloyd, HH; Mellett, LB; Montgomery, JA; Schabel, FM; Skipper, HE; Wilkoff, LJ | 1 |
| Panzica, RP; Robins, RK; Townsend, LB | 1 |
| Grindey, GB; Kline, I; Saslaw, LD; Waravdekar, VS | 1 |
| Falco, EA; Fox, JJ; Miller, N; Wempen, I | 1 |
| Falco, EA; Fox, JJ | 1 |
| Grindey, GB; Saslaw, LD; Waravdekar, VS | 1 |
| Mihich, E; Mulhern, AI | 1 |
| Shrecker, AW; Urshel, MJ | 1 |
| Goldin, A; Schrecker, AW | 1 |
| Gang, M; Goldin, A; Kline, I; Tyrer, DD; Venditti, JM | 1 |
| Kessel, D; Shurin, SB | 1 |
| Baldini, L; Brambilla, G; Cavanna, M; Parodi, S | 1 |
| Goldenberg, DM; Schricker, KT; Sögtrop, HH; von der Emde, J | 1 |
| Bach, MK | 2 |
| Goldin, A; Kline, I; Mantel, N; Tyrer, DD; Venditti, JM | 1 |
| Mead, JA; Schrecker, AW; Urshel, MJ | 1 |
22 review(s) available for cytarabine and Leukemia L 1210
| Article | Year |
|---|---|
[The mechanism of synergistic interaction between etoposide and cytarabine].
Topics: Animals; Cell Cycle; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Etoposide; Humans; Injections, Intraperitoneal; Leukemia L1210; Mice; Mice, Inbred Strains; Stimulation, Chemical; Time Factors | 2002 |
[Liposomes--carriers of cytostatic preparations].
Topics: Adsorption; Animals; Antineoplastic Agents; Cytarabine; Dactinomycin; Doxorubicin; Leukemia L1210; Lipoproteins; Liposomes; Methotrexate; Mice; Tissue Distribution | 1984 |
Intracellular nucleotide pools and their significance in antimetabolite therapy.
Topics: 3-Deazauridine; Animals; Antimetabolites, Antineoplastic; Cell Cycle; Coformycin; Cricetinae; Cricetulus; Cytarabine; HeLa Cells; Humans; Leukemia L1210; Methotrexate; Nucleic Acids; Pyrimidine Nucleotides | 1980 |
Biochemical pharmacological determinants of drug action in cancer therapeutics.
Topics: Animals; Biotransformation; Cytarabine; Humans; Leukemia L1210; Leukemia, Myeloid, Acute; Methotrexate; Mice; Rats | 1980 |
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Neoplasms; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Uridine | 1981 |
Overview of progress in hematology in 1981 with special reference to leukocyte.
Topics: Aclarubicin; Acute Disease; Adult; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cells, Cultured; Child; Cytarabine; Deoxycytidine Monophosphate; Drug Therapy, Combination; Humans; Kinetics; Leukemia; Leukemia L1210; Leukocytes; Naphthacenes | 1982 |
[Development of antimetabolites, II].
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Humans; Leukemia L1210; Methotrexate; Mice; Trimetrexate | 1993 |
Curative chemotherapy for acute myeloid leukemia: the development of high-dose ara-C from the laboratory to bedside.
Topics: Acute Disease; Animals; Antimetabolites, Antineoplastic; Cytarabine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Leukemia L1210; Leukemia, Myeloid; Mice; Randomized Controlled Trials as Topic | 1996 |
Liposomes in therapeutic and preventive medicine: the development of the drug-carrier concept.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Antineoplastic Agents; beta-Glucosidase; Cytarabine; Gaucher Disease; Glucosidases; Humans; Leukemia L1210; Pharmaceutical Vehicles; Phospholipids | 1978 |
Biorhythms in toxicology and pharmacology. II. infradian biorhythms and general discussion.
Topics: Animals; Biological Clocks; Cytarabine; Humans; Leukemia L1210; Periodicity; Pharmaceutical Preparations; Pharmacology; Seasons | 1975 |
Murine and human leukemias.
Topics: Animals; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred AKR; Prednisone; Vincristine | 1975 |
A study on structure-activity relationships of nucleoside analogues.
Topics: Animals; Cells, Cultured; Cytarabine; DNA, Neoplasm; Escherichia coli; Fluorouracil; In Vitro Techniques; Leukemia L1210; RNA, Neoplasm; Simplexvirus; Structure-Activity Relationship | 1986 |
Biochemical and cellular pharmacology of cytosine arabinoside.
Topics: Animals; Aphidicolin; Arabinofuranosylcytosine Triphosphate; Binding, Competitive; Cell Line; Cell Survival; Centrifugation, Density Gradient; Cytarabine; Diterpenes; DNA; DNA Repair; DNA Replication; Fibroblasts; Granulocytes; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid, Acute; Nucleic Acid Synthesis Inhibitors; Templates, Genetic; Vidarabine | 1985 |
Biochemical aspects of drug combinations.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bleomycin; Camptothecin; Cell Division; Cytarabine; Deferoxamine; Diamines; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Leukemia L1210; Macromolecular Substances; Mice; Neoplasms; Neoplasms, Experimental; Nitrosourea Compounds; Purine Nucleotides; Ribonucleotide Reductases; Thioguanine; Triazoles | 1974 |
An assessment of massive-dose chemotherapy of malignant disease.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Leukemia, Lymphoid; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Mice; Multiple Myeloma; Neoplasms; Nitrogen Mustard Compounds; Prednisone; Pregnancy; Time Factors; Trophoblastic Neoplasms; Vinblastine | 1971 |
The emergence of drug resistance in tumours: a characteristic which may be exploited therapeutically.
Topics: Aminohydrolases; Animals; Cytarabine; Cytidine; DNA; Drug Resistance; Humans; Leukemia; Leukemia L1210; Methotrexate; Neoplasms | 1973 |
Rationale of combination chemotherapy based on preclinical experiments.
Topics: Animals; Antineoplastic Agents; Azaguanine; Carcinoma; Cytarabine; Drug Synergism; Humans; Hydroxyurea; Immunotherapy; Leukemia L1210; Lung Neoplasms; Melanoma; Neoplasms; Thiosemicarbazones; Time Factors | 1973 |
Immunochemotherapy of human cancer.
Topics: Acute Disease; Adjuvants, Immunologic; Adult; Animals; Antineoplastic Agents; BCG Vaccine; Cytarabine; Humans; Immunosuppressive Agents; Immunotherapy; Leukemia L1210; Lymphoma; Melanoma; Mice; Neoplasms; Neoplasms, Experimental; Prednisone; Vincristine | 1974 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; Hydroxyurea; In Vitro Techniques; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitroso Compounds; Prednisone; Thymidine; Time Factors; Tritium; Vinblastine; Vincristine | 1969 |
Kinetics of normal and leukemic leukocyte populations and relevance to chemotherapy.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cytarabine; Hematopoietic System; Humans; Kinetics; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Lymphocytes; Mice; Neoplasm Transplantation; Thymidine; Time Factors; Tritium | 1970 |
Factors pertaining to complete drug-induced remission of tumor in animals and man.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; Nitroso Compounds; Urea | 1969 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
4 trial(s) available for cytarabine and Leukemia L 1210
| Article | Year |
|---|---|
Acute myelocytic leukemia.
Topics: Animals; BCG Vaccine; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Immunotherapy; Leukemia L1210; Leukemia, Myeloid; Mercaptopurine; Mice; Mycobacterium bovis; Neuraminidase; Thioguanine | 1976 |
Aclarubicin: experimental and clinical experience.
Topics: Aclarubicin; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colony-Forming Units Assay; Cytarabine; Daunorubicin; Doxorubicin; Humans; Leukemia L1210; Leukemia, Monocytic, Acute; Naphthacenes | 1985 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
Cytosine arabinoside (NSC-63878)--clinical brochure.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cytarabine; Dogs; Haplorhini; Humans; Leukemia L1210; Mice; Neoplasms; Rats | 1968 |
353 other study(ies) available for cytarabine and Leukemia L 1210
| Article | Year |
|---|---|
Synthesis and antitumor activity of 5-azacytosine arabinoside.
Topics: Animals; Antineoplastic Agents; Azacitidine; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Stereoisomerism | 1979 |
Nucleoside conjugates as potential antitumor agents. 2. Synthesis and biological activity of 1-(beta-D-arabinofuranosyl)cytosine conjugates of prednisolone and prednisone.
Topics: Animals; Antineoplastic Agents; Cell Division; Cytarabine; Female; Haplorhini; Hydrolysis; In Vitro Techniques; Leukemia L1210; Mice; Papio; Prednisolone; Prednisone | 1979 |
Reactions of 2-acyloxyisobutyryl halides with nucleosides. 6. Synthesis and biological evaluation of some 3'-acyl derivatives of 2,2'-anhydro-1-(beta-D-arabinofuranosyl)cytosine hydrochloride.
Topics: Anhydrides; Animals; Butyrates; Cells, Cultured; Cytarabine; HeLa Cells; Leukemia L1210; Measles virus; Mice; Mice, Inbred Strains; Orthomyxoviridae; Simplexvirus; Structure-Activity Relationship; Vaccinia virus | 1976 |
Reactions of 2-acyloxyisobutyryl halides with nucleosides. Synthesis and biological evaluation of some 3"-acyl and 3',5'-diacyl derivatives of 1-beta-D-arabinofuranosylcytosine.
Topics: Anhydrides; Animals; Butyrates; Cells, Cultured; Cytarabine; HeLa Cells; Leukemia L1210; Mice; Simplexvirus; Structure-Activity Relationship; Vaccinia virus | 1976 |
Synthesis and antitumor and antiviral activities of 1-beta-D-arabinofuranosyl-2-amino-1,4(2H)-iminopyrimidine and its derivatives.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinonucleosides; Cytopathogenic Effect, Viral; Female; Herpes Simplex; Leukemia L1210; Methods; Mice; Pyrimidine Nucleosides | 1979 |
Nucleic acids. 16. Orally active derivatives of ara-cytidine.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cytarabine; Encephalomyelitis, Autoimmune, Experimental; Immunosuppressive Agents; Leukemia L1210; Mice; Rats | 1976 |
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Chemical Phenomena; Chemistry; Crystallization; Cytarabine; Deoxycytidine; Female; Humans; Leukemia L1210; Leukemia P388; Leukemia, Lymphoid; Mice; Molecular Structure; Nucleosides; Sarcoma 180; Simplexvirus; Tumor Cells, Cultured; X-Ray Diffraction | 1991 |
Additional nucleotide derivatives of mitosenes. Synthesis and activity against parental and multidrug resistant L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry; Leukemia L1210; Mice; Mitomycin; Mitomycins; Nucleotides | 1991 |
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Arabinonucleosides; Cytidine; Drug Screening Assays, Antitumor; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia L1210; Leukemia P388; Mice; Pyrimidine Nucleosides; Pyrimidinones; Structure-Activity Relationship | 1991 |
Nucleosides and nucleotides. 94. Radical deoxygenation of tert-alcohols in 1-(2-C-alkylpentofuranosyl) pyrimidines: synthesis of (2'S)-2'-deoxy-2'-C-methylcytidine, an antileukemic nucleoside.
Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Neoplasms; Structure-Activity Relationship | 1991 |
Unsaturated and carbocyclic nucleoside analogues: synthesis, antitumor, and antiviral activity.
Topics: Adenosine Deaminase; Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Friend murine leukemia virus; HIV-1; HIV-2; Humans; Indicators and Reagents; Leukemia L1210; Mice; Molecular Structure; Nucleosides; Rauscher Virus; Structure-Activity Relationship | 1991 |
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine.
Topics: Animals; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry; Cytarabine; Leukemia L1210; Leukemia P388; Mice; Pyrimidine Nucleosides; Sarcoma 180; Structure-Activity Relationship; X-Ray Diffraction | 1991 |
Nucleosides and nucleotides. 97. Synthesis of new broad spectrum antineoplastic nucleosides, 2'-deoxy-2'-methylidenecytidine (DMDC) and its derivatives.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Deoxycytidine; Female; Humans; Leukemia L1210; Mice; Structure-Activity Relationship | 1991 |
Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytarabine; Leukemia L1210; Mice; Phospholipid Ethers; Structure-Activity Relationship | 1990 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Topics: Animals; Arabinonucleosides; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Female; Fluorine; Humans; Kinetics; Leukemia L1210; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Conformation; Neoplasms, Experimental; Nucleotides; Sarcoma, Experimental; Tumor Cells, Cultured; Uracil; Viruses | 1989 |
Synthesis and biological activity of 5-phenylselenenyl-substituted pyrimidine nucleosides.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Pyrimidine Nucleosides; Sarcoma 180; Selenium; Simplexvirus; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1986 |
Nucleoside conjugates. 10. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitins.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytarabine; Drug Resistance; Drug Therapy; Leukemia L1210; Mice; Mice, Inbred DBA; Prodrugs; Stereoisomerism; Structure-Activity Relationship | 1988 |
Improved synthesis and antitumor activity of 1-deazaadenosine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Female; HeLa Cells; Humans; Leukemia L1210; Leukemia P388; Mice; Ribonucleosides; Tubercidin; Uterine Cervical Neoplasms | 1987 |
Nucleoside conjugates. 7. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of ether lipids.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cytarabine; Drug Administration Schedule; Humans; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred DBA; Solubility | 1986 |
Synthesis and antitumor activity of fluorine-substituted 4-amino-2(1H)-pyridinones and their nucleosides. 3-Deazacytosines.
Topics: Animals; Antimetabolites, Antineoplastic; Cytosine; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry; Structure-Activity Relationship | 1987 |
Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Antibiotics, Antineoplastic; Guanine; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1987 |
Nucleoside conjugates. 6. Synthesis and comparison of antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of corticosteroids and selected lipophilic alcohols.
Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Agents; Arabinonucleotides; Cytidine Deaminase; Esters; Female; Humans; Leukemia L1210; Male; Mice | 1985 |
2'-O-nitro-1-beta-D-arabinofuranosylcytosine. A new derivative of 1-beta-D-arabinofuranosylcytosine that resists enzymatic deamination and has antileukemic activity.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Drug Evaluation, Preclinical; Female; Leukemia L1210; Mice; Mice, Inbred Strains | 1983 |
Lipophilic 5'-(alkyl phosphate) esters of 1-beta-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugs.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytarabine; Drug Resistance; Esters; Hydrolysis; Leukemia L1210; Melanoma; Mice; Neoplasms, Experimental | 1982 |
Phospholipid-nucleoside conjugates. 3. Syntheses and preliminary biological evaluation of 1-beta-D-arabinofuranosylcytosine 5'-monophosphate-L-1,2-dipalmitin and selected 1-beta-D-arabinofuranosylcytosine 5-diphosphate-L-1,2-diacylglycerols.
Topics: Animals; Antineoplastic Agents; Arabinonucleotides; Cell Division; Chemical Phenomena; Chemistry, Physical; Cytarabine; Diglycerides; Glycerides; Leukemia L1210; Mice; Multiple Myeloma; Neoplasms, Experimental | 1982 |
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.
Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cattle; Humans; Leukemia L1210; Melanoma, Experimental; Mice; Nucleosides; Pyridazines; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Mice; Molecular Structure; Neoplasm Transplantation; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Nucleosides and nucleotides. 123. Synthesis of 1-(2-deoxy-2-isocyano-beta-D-arabinofuranosyl)cytosine and related nucleosides as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; Drug Stability; Humans; Isocyanates; Leukemia L1210; Lung Neoplasms; Mice; Molecular Structure; Mouth Neoplasms; Stomach Neoplasms; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Nucleoside conjugates. 13. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of thioether lipids with improved water solubility.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Cytarabine; Freeze Fracturing; Glycerol; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Micelles; Microscopy, Electron; Molecular Structure; Neoplasm Transplantation; Solubility; Structure-Activity Relationship; Water | 1993 |
Influence of the stage of advancement of leukemia L1210 in mice on the optimal schedule of treatment of cytosine arabinoside (NSC-63878).
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Proliferation; Cyclophosphamide; Cytarabine; Disease Progression; Drug Administration Schedule; Injections, Intraperitoneal; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Time Factors | 1972 |
Synthesis and evaluation of macromolecule-bound derivatives of a peptidyl-1-beta-D-arabinofuranosylcytosine prodrug.
Topics: alpha-Macroglobulins; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cytarabine; Delayed-Action Preparations; Dextrans; Drug Carriers; Drug Screening Assays, Antitumor; Half-Life; Humans; Hydrolysis; Inhibitory Concentration 50; Leukemia L1210; Mice; Prodrugs | 2008 |
Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Dietary Supplements; Docosahexaenoic Acids; Erythrocyte Count; Leukemia L1210; Leukocyte Count; Male; Mice; Organ Size; Platelet Count; Treatment Outcome | 2002 |
SYNERGISM OF THE ANTINEOPLASTIC ACTIVITY OF CYTOSINE ARABINOSIDE BY PORFIROMYCIN.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Body Weight; Cytarabine; Cytosine; Leukemia; Leukemia L1210; Leukemia, Experimental; Mice; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Porfiromycin; Research; Survival | 1964 |
THE EFFECT OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE HYDROCHLORIDE ON MURINE NEOPLASMS.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Antineoplastic Agents; Blood Cells; Carcinoma, Ehrlich Tumor; Cortisone; Cytarabine; Cytosine; Leukemia L1210; Leukemia, Experimental; Lymphoma; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180 | 1964 |
ACTIVITY OF SELECTED COMPOUNDS IN SUBLINE OF LEUKEMIA L1210 RESISTANT TO CYTOSINE ARABINOSIDE (NSC-63878).
Topics: Animals; Antineoplastic Agents; Arabinose; Cytarabine; Cytosine; Leukemia L1210; Mice; Nucleosides; Pharmacology; Research | 1964 |
In vitro and in vivo antileukemic effect of novel dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytarabine; Dimerization; Female; Floxuridine; Inhibitory Concentration 50; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred DBA; Time Factors | 2007 |
Pharmacokinetic characteristics of L-valyl-ara-C and its implication on the oral delivery of ara-C.
Topics: Administration, Oral; Animals; Cell Proliferation; Cytarabine; Drug Delivery Systems; Drug Stability; Hydrogen-Ion Concentration; Leukemia L1210; Male; Prodrugs; Rats; Rats, Sprague-Dawley | 2007 |
Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cytarabine; Drug Synergism; Flavonoids; Leukemia L1210; Mice; Tumor Cells, Cultured | 2007 |
Separate and sequential chemotherapy of mouse leukemia L1210 with 1-beta-D-arabinofuranosylcytosine hydrochloride and 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Cytarabine; Injections; Leukemia L1210; Longevity; Mice; Nitroso Compounds; Urea | 1967 |
Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside.
Topics: Animals; Biological Transport; Chromatography, Paper; Cytarabine; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Mice; Neoplasm Transplantation; Nucleotides; Phosphates | 1967 |
Analogs of 1-beta-D-arabinofuranosylcytosine. Studies on mechanisms of action in Burkitt's cell culture and mouse leukemia, and in vitro deamination studies.
Topics: Animals; Burkitt Lymphoma; Chromatography, Paper; Culture Techniques; Cytarabine; Cytosine Nucleotides; Drug Antagonism; Drug Synergism; Kidney; Leukemia L1210; Liver; Lymphoma; Mice; Nucleosides; Oxidation-Reduction; Thymidine; Uracil Nucleotides | 1967 |
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia.
Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; Leukemia; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Nucleosides; Phosphotransferases; Purines; Vincristine | 1967 |
Experimental evaluation of potential anticancer agents. XXI. Scheduling of arabinosylcytosine to take advantage of its S-phase specificity against leukemia cells.
Topics: Animals; Antimetabolites; Cell Division; Cytarabine; DNA, Neoplasm; Leukemia L1210; Mice; Thymidine; Tritium | 1967 |
Effect of antimetabolites on kinetic behavior of proliferating cultured L1210 leukemia cells.
Topics: Animals; Antimetabolites; Azaserine; Cell Division; Culture Techniques; Cytarabine; Fluorouracil; Kinetics; Leukemia L1210; Mathematics; Methotrexate | 1967 |
Criteria associated with destruction of leukemia and solid tumor cells in animals.
Topics: Animals; Cricetinae; Cyclophosphamide; Cytarabine; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Urea | 1967 |
Comparison of the antileukemic activity of 5-AZA-2'-deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-azacytidine against L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; DNA, Neoplasm; Leukemia L1210; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred DBA | 1984 |
Combination chemotherapy with Clostridium perfringens phospholipase C and cytosine antimetabolites: complementary inhibition directed at membrane lipids.
Topics: Animals; Azacitidine; Cell Line; Choline; Clostridium; Cytarabine; Leukemia L1210; Membrane Lipids; Mice; Microscopy, Electron, Scanning; Sarcoma 180; Type C Phospholipases | 1983 |
Combined interferon--antimetabolite therapy of murine L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Doxorubicin; Interferons; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Prognosis | 1981 |
Chemotherapy of L1210 leukemia with 5-azacytidine in combination with vincristine, adriamycin, or beta-cytosine arabinoside.
Topics: Animals; Azacitidine; Colony-Forming Units Assay; Cytarabine; Doxorubicin; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Vincristine | 1981 |
Biochemical and cytokinetic modulation of L1210 and HL-60 cells by hydroxyurea and effect on 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Cytarabine; Cytidine Triphosphate; DNA; Humans; Hydroxyurea; Kinetics; Leukemia L1210; Leukemia, Myeloid; Mice; RNA | 1983 |
Uptake, initial effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensitive and resistant to vincristine and other chemotherapeutic agents.
Topics: Alkaloids; Animals; Cell Line; Cyclophosphamide; Cytarabine; DNA; Doxorubicin; Fluorouracil; Harringtonines; Leukemia L1210; Mercaptopurine; Mice; Mice, Inbred Strains; Microsomes; Protein Biosynthesis; RNA; Vincristine | 1983 |
Effect of 3-deazauridine on the metabolism, toxicity, and antitumor activity of azacitidine in mice bearing L1210 leukemia sensitive and resistant to cytarabine.
Topics: 3-Deazauridine; Animals; Azacitidine; Chromatography, High Pressure Liquid; Cytarabine; Drug Therapy, Combination; Lethal Dose 50; Leukemia L1210; Mice; Mice, Inbred DBA; Purine Nucleotides; Pyrimidine Nucleotides; Uridine | 1983 |
Antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugated with polyglutamic acid and its derivative.
Topics: Animals; Cell Survival; Cytarabine; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Peptides; Polyglutamic Acid; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1984 |
[Antileukemic activity of liposome forms of cytosine arabinoside and cyclocytidine].
Topics: Ancitabine; Animals; Cytarabine; Leukemia L1210; Liposomes; Mice | 1984 |
Enhancement of the DNA breakage and cytotoxic effects of intercalating agents by treatment with sublethal doses of 1-beta-D-arabinofuranosylcytosine or hydroxyurea in L1210 cells.
Topics: Aminoacridines; Amsacrine; Animals; Bleomycin; Cell Survival; Cytarabine; Daunorubicin; DNA, Neoplasm; Doxorubicin; Drug Synergism; Hydroxyurea; Intercalating Agents; Leukemia L1210; Mice | 1984 |
Antileukemic activity of 5-aza-2'-deoxycytidine and cytarabine against intracerebral L1210 murine leukemia.
Topics: Animals; Azacitidine; Brain Neoplasms; Cytarabine; Decitabine; Dose-Response Relationship, Drug; Kinetics; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1984 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine-5'-diphosphate-prednisolone and -cortisol.
Topics: Animals; Cytarabine; Dose-Response Relationship, Drug; Hydrocortisone; Leukemia L1210; Mice; Phosphoric Diester Hydrolases; Prednisolone; Structure-Activity Relationship | 1980 |
Evaluation of 2,2'-anhydro-1-(3'-Ok-acetyl-beta-D-arabinofuranosyl)-5-iodocytosine hydrochloride and related compounds as antineoplastic and antiviral agents.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Cytarabine; Female; Leukemia L1210; Leukemia L5178; Leukemia P388; Macromolecular Substances; Mice; Nucleic Acid Synthesis Inhibitors; Simplexvirus | 1981 |
Role of deoxycytidine kinase in the inhibitory activity of 5-substituted 2'-deoxycytidines and cytosine arabinosides on tumor cell growth.
Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Cell Division; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; DNA, Neoplasm; Leukemia L1210; Mice; Phosphotransferases; Thymidine Kinase | 1983 |
Combination chemotherapy involving alpha-difluoromethylornithine and 1-beta-D-arabinofuranosylcytosine in murine L1210 leukemia.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cytarabine; Drug Therapy, Combination; Eflornithine; Erythrocyte Count; Female; Leukemia L1210; Leukocyte Count; Longevity; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Ornithine; Polyamines | 1983 |
[Effect of combination chemotherapy of nitrosourea MCNU with various anti-tumor agents].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Cell Line; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Fluorouracil; Leukemia L1210; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitomycin; Mitomycins; Nitrosourea Compounds | 1984 |
Effects of 1-beta-D-arabinofuranosylcytosine incorporation on eukaryotic DNA template function.
Topics: Animals; Aphidicolin; Cell Survival; Cytarabine; Diterpenes; DNA Replication; DNA, Neoplasm; Kinetics; Leukemia L1210; Mice; Templates, Genetic | 1984 |
The effect of inhibitors of DNA synthesis on DNA repair.
Topics: Alkylating Agents; Animals; Aphidicolin; Cytarabine; Diterpenes; DNA Polymerase II; DNA Repair; DNA Replication; DNA, Neoplasm; Hydroxyurea; Kinetics; Leukemia L1210; Mice; Ultraviolet Rays | 1984 |
Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays.
Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cell Division; Cells, Cultured; Cytarabine; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Thymidine | 1980 |
1-beta-D-arabinofuranosylcytosine-phospholipid conjugates as prodrugs of Ara-C.
Topics: Animals; Cytarabine; Drug Evaluation, Preclinical; Isomerism; Leukemia L1210; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Structure-Activity Relationship | 1984 |
Ribo- and deoxyribonucleoside effect on 3'-amino-2',3'-dideoxycytidine-induced cytotoxicity in cultured L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cytarabine; Deamination; Deoxycytidine; Deoxyribonucleosides; DNA, Neoplasm; Leukemia L1210; Ribonucleosides; Zalcitabine | 1983 |
Chronobiology: anatomy in time.
Topics: Animals; Biological Clocks; Biomechanical Phenomena; Circadian Rhythm; Cytarabine; Female; Humans; Leukemia L1210; Periodicity; Rats; Research; Research Design; Time Factors | 1983 |
Assessment of antimetabolite cytotoxicity: a comparison of clonogenic assays and tritiated deoxyuridine incorporation.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyuridine; Dose-Response Relationship, Drug; Fluorouracil; Humans; Leukemia L1210; Melanoma; Methotrexate; Mice; Tritium | 1983 |
Development of optimal drug administration strategies for cancer - chemotherapy in the framework of systems theory.
Topics: Animals; Antineoplastic Agents; Cell Division; Cytarabine; Leukemia L1210; Mathematics; Models, Biological | 1983 |
1-beta-D-arabinofuranosylcytosine conjugates of corticosteroids as potential antitumor agents.
Topics: Animals; Cell Division; Cell Line; Cortisone; Cytarabine; Dose-Response Relationship, Drug; Female; Humans; Hydrocortisone; Leukemia L1210; Lymphocytes; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Peritoneum; Skull | 1983 |
Determinants of Ara-C action: biochemical consideration.
Topics: Animals; Cytarabine; DNA, Neoplasm; Female; Leukemia L1210; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred Strains | 1983 |
Antitumor effects and pharmacology of orally administered N4-palmitoyl-1-beta-D-arabinofuranosylcytosine in mice.
Topics: Adenocarcinoma; Administration, Oral; Animals; Colonic Neoplasms; Cytarabine; Drug Evaluation, Preclinical; Leukemia L1210; Leukemia P388; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neoplasms, Experimental | 1984 |
Cell kinetic studies of the cytostatic and cytocidal effect of 1-beta-D-arabinofuranosylcytosine on the L1210 ascites tumor.
Topics: Animals; Carbon Radioisotopes; Cell Cycle; Cell Survival; Cytarabine; DNA Replication; Female; Kinetics; Leukemia L1210; Mathematics; Mice; Mice, Inbred Strains; Tritium | 1984 |
Modulation of cytarabine uptake and toxicity by dipyridamole.
Topics: Animals; Biological Transport; Body Weight; Cell Line; Cytarabine; Dipyridamole; Drug Evaluation, Preclinical; Drug Interactions; Humans; Kinetics; Leukemia L1210; Mice | 1984 |
Cytotoxic effects of Eleutherococcus senticosus aqueous extracts in combination with N6-(delta 2-isopentenyl)-adenosine and 1-beta-D-arabinofuranosylcytosine against L1210 leukemia cells.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cytarabine; In Vitro Techniques; Isopentenyladenosine; Leukemia L1210; Mice; Plant Extracts | 1984 |
Histidinol-mediated improvement in the specificity of 1-beta-D-arabinofuranosylcytosine and 5-fluorouracil in L 1210 leukemia-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Survival; Clone Cells; Colony-Forming Units Assay; Cytarabine; Fluorouracil; Histidinol; Imidazoles; Leukemia L1210; Male; Mice; Mice, Inbred DBA | 1984 |
Differential cytotoxicity of cytosine arabinoside toward murine leukemia L1210 cells and murine bone marrow progenitor cells inhibited in nucleoside transport by cimicifugoside.
Topics: Animals; Bone Marrow Cells; Cell Survival; Cells, Cultured; Cytarabine; Glycoside Hydrolases; Hematopoietic Stem Cells; Lanosterol; Leukemia L1210; Mice; Nucleosides; Showdomycin; Xylosidases | 1981 |
DNA strand breaks caused by inhibitors of DNA synthesis: 1-beta-D-arabinofuranosylcytosine and aphidicolin.
Topics: Animals; Aphidicolin; Cytarabine; Diterpenes; DNA Polymerase II; DNA Replication; Kinetics; Leukemia L1210; Mice; Nucleic Acid Synthesis Inhibitors | 1982 |
Isolation and characterization of subclones of L1210 murine leukemia with different sensitivities to various cytotoxic agents.
Topics: Animals; Cell Separation; Cell Survival; Clone Cells; Cytarabine; Cytotoxins; Dexamethasone; Leukemia L1210; Mice; Vincristine | 1983 |
Accumulation of leukemic cell DNA strand breaks with adriamycin and cytosine arabinoside.
Topics: Animals; Cells, Cultured; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Doxorubicin; Leukemia L1210; Mice | 1983 |
Labelling of the thymidine and deoxycytidine bases of DNA by [2-14C]deoxycytidine in cultured L1210 cells.
Topics: 3-Deazauridine; Animals; Carbon Radioisotopes; Cytarabine; Cytidine; Deoxycytidine; DNA; Leukemia L1210; Mice; Tetrahydrouridine; Thymidine | 1983 |
Intracellular distribution of N4-behenoyl-1-beta-D-arabinofuranosylcytosine in blood cells.
Topics: Animals; Antineoplastic Agents; Cytarabine; Erythrocytes; Female; Humans; Leukemia L1210; Mice; Mice, Inbred Strains | 1983 |
Chemotherapy of leukemia in mice, rats, and humans relating time of humoral stimulation, tumor growth, and clinical response.
Topics: Animals; Cell Division; Cytarabine; Daunorubicin; DNA, Neoplasm; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Myeloid, Acute; Mice; Rats | 1981 |
Sequential high-dose cytosine arabinoside and asparaginase in refractory acute leukemia.
Topics: Animals; Asparaginase; Cytarabine; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leukemia L1210; Leukemia, Lymphoid; Mice | 1982 |
Clinical use of methotrexate--with emphasis on use of high doses.
Topics: Animals; Asparaginase; Brain Diseases; Child, Preschool; Cisplatin; Cytarabine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Humans; Infant; Injections, Spinal; Leucovorin; Leukemia L1210; Leukemia, Lymphoid; Methotrexate; Mice | 1981 |
Modulation of cell-mediated alloimmunity by BCG. I. Antagonism and potentiation of immunosuppression caused by cytarabine.
Topics: Animals; Antigens, Neoplasm; BCG Vaccine; Cell Line; Cytarabine; Cytotoxicity, Immunologic; Female; Immunity, Cellular; Immunization; Immunosuppression Therapy; Leukemia L1210; Liver Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Sarcoma, Experimental; Spleen; T-Lymphocytes; Time Factors | 1982 |
Activity of 2-fluoro-5-methylarabinofuranosyluracil against mouse leukemias sensitive to and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cells, Cultured; Cytarabine; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Pyrimidine Nucleosides | 1982 |
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Arabinofuranosyluracil; Cell Survival; Cytarabine; Deoxycytidine; DNA Replication; Kinetics; Leukemia L1210; Leukemia, Experimental; Mice; Thymidine; Uridine | 1982 |
[Development of leukemia L-1210 after treatment with the methionine synthetase inhibitor quinoline dibromide].
Topics: Animals; Antineoplastic Agents; Cytarabine; Drug Therapy, Combination; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Quinolinium Compounds | 1982 |
Monitoring the effect of anti-cancer drugs on L1210 cells by a mitochondrial probe, rhodamine-123.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA; Flow Cytometry; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Mitochondria; Rhodamines; Xanthenes | 1982 |
Effect of ARA-C incorporation on deoxyribonucleic acid synthesis in cells.
Topics: Animals; Cells, Cultured; Clone Cells; Cytarabine; DNA; DNA, Neoplasm; Leukemia L1210; RNA, Neoplasm | 1982 |
Drug control of Ara-C-resistant tumor cells.
Topics: 3-Deazauridine; Adenocarcinoma; Animals; Anthraquinones; Antimetabolites, Antineoplastic; Colonic Neoplasms; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Leukemia L1210; Mice; Mitoxantrone; Neoplasms, Experimental | 1982 |
Cellular aspects of the action of cytosine arabinoside.
Topics: Animals; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Cytarabine; DNA Replication; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Leukemia L1210 | 1982 |
Basis of observed resistance of L1210 leukemia in mice: methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, and 1-beta-D-arabinofuranosylcytosine administered in different combinations.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Line; Cytarabine; Drug Evaluation, Preclinical; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Methylthioinosine; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Thioguanine | 1981 |
Inability of liposome encapsulated 1-beta-D-arabinofuranosylcytosine nucleotides to overcome drug resistance in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cells, Cultured; Cytarabine; Cytidine Monophosphate; DNA, Neoplasm; Drug Resistance; Female; Leukemia L1210; Liposomes; Mice; Mice, Inbred DBA | 1981 |
Instability of (ara-C) DNA under alkaline conditions.
Topics: Alkalies; Animals; Carbon Radioisotopes; Cytarabine; DNA, Neoplasm; Leukemia L1210; Tritium | 1982 |
Production of N4-succinyl-1-beta-D-arabinofuranosylcytosine, a novel metabolite of N4-behenoyl-1-beta-D-arabinofuranosylcytosine, in mice and its biological significance.
Topics: Animals; Bile; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytarabine; Injections, Intravenous; Leukemia L1210; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C | 1981 |
Phospholipid derivatives of nucleoside analogs as prodrugs with enhanced catabolic stability.
Topics: Animals; Biotransformation; Cell Division; Cell Line; Cytarabine; Cytidine Diphosphate Diglycerides; Deamination; Delayed-Action Preparations; Injections, Intraperitoneal; Leukemia L1210; Mice; Neoplasm Transplantation; Prognosis; Ribonucleosides; Technology, Pharmaceutical; Tubercidin; Vidarabine | 1981 |
Single versus combination chemotherapy of L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Fluorouracil; Leukemia L1210; Male; Mice | 1980 |
Correlation of thymidine-enhanced incorporation of ara-C in deoxyribonucleic acid with increased cell kill.
Topics: Animals; Cell Survival; Cells, Cultured; Cytarabine; DNA; Kinetics; Leukemia L1210; Mice; Thymidine | 1981 |
Effect and mode of action of N4-behenoyl-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cytarabine; Leukemia L1210; Liposomes; Male; Mice; Mice, Inbred Strains | 1980 |
Enhancement of 1-beta-D-arabinofuranosylcytosine accumulation within L1210 cells and increased cytotoxicity following thymidine exposure.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA, Neoplasm; Leukemia L1210; Mice; RNA, Neoplasm; Thymidine; Time Factors | 1980 |
Synchronization of L1210 leukemia with hydroxyurea infusion and the effect of subsequent pulse dose chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cytarabine; Doxorubicin; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hydroxyurea; Interphase; Leukemia L1210; Male; Methotrexate; Mice; Neoplasm Transplantation; Time Factors; Transplantation, Homologous | 1980 |
Detection of induced resistance to cytosine-arabinoside with a short-term test.
Topics: Animals; Cell Line; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Female; Leukemia L1210; Mice; Time Factors | 1980 |
Correlation of cytotoxicity with incorporation of ara-C into DNA.
Topics: Animals; Cell Survival; Cytarabine; DNA, Neoplasm; Kinetics; Leukemia L1210; Mice | 1980 |
Increased activation of 1-beta-D-arabinofuranosylcytosine by hydroxyurea in L1210 cells.
Topics: Animals; Cell Line; Cytarabine; Deoxycytidine Kinase; Enzyme Activation; Hydroxyurea; Infusions, Parenteral; Leukemia L1210; Mice; Neoplasm Transplantation | 1980 |
Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ARA-C.
Topics: Animals; Cell Cycle; Cell Survival; Cytarabine; DNA, Neoplasm; Fluorometry; Leukemia L1210; Mice | 1980 |
Biochemical and antitumor effects of the combination of thymidine and 1-beta-D-arabinofuranosylcytosine against leukemia L1210.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cells, Cultured; Cytarabine; Cytidine; Drug Therapy, Combination; Leukemia L1210; Mice; Phosphonoacetic Acid; Thymidine | 1981 |
Effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on pools of deoxyribonucleoside triphosphates in L1210 ascites cells.
Topics: Animals; Ascites; Cytarabine; Deoxyribonucleotides; Drug Synergism; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice | 1981 |
Sedimentation of DNA from L1210 cells after treatment with 4'-demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) or 1-beta-D-arabinofuranosylcytosine or both drugs.
Topics: Animals; Antibiotics, Antineoplastic; Centrifugation, Density Gradient; Cytarabine; Dose-Response Relationship, Drug; Drug Interactions; Leukemia L1210; Mice; Podophyllotoxin; Teniposide; Time Factors | 1980 |
Effect of cholesterol content on antitumor activity and toxicity of liposome-encapsulated 1-beta-D-arabinofuranosylcytosine in vivo.
Topics: Animals; Cholesterol; Cytarabine; Dose-Response Relationship, Drug; Leukemia L1210; Liposomes; Mice; Phosphatidylcholines | 1980 |
Enhancement of Ca(2+)-dependent endonuclease activity in L1210 cells during apoptosis induced by 1-beta-D-arabinofuranosylcytosine: possible involvement of activating factor(s).
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Nucleus; Cell Survival; Chromatin; Cytarabine; DNA, Neoplasm; Endodeoxyribonucleases; Leukemia L1210; Mice; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1995 |
Nucleoside conjugates. 14. Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of ether lipids with improved water solubility.
Topics: Animals; Antineoplastic Agents; Cytarabine; Ethers; Leukemia L1210; Lipids; Male; Mice; Mice, Inbred DBA; Solubility; Water | 1995 |
Effects of protein kinase C inhibitor, staurosporine derivative CGP 41 251, on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Cycle; Cytarabine; DNA Replication; DNA, Neoplasm; Drug Resistance, Multiple; Drug Synergism; Female; Humans; Leukemia L1210; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred DBA; Neoplasm Proteins; Ovarian Neoplasms; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1995 |
Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs.
Topics: Adenosine; Adenosine Kinase; Animals; Antineoplastic Agents; Arabinonucleosides; Cell Division; Cytarabine; Deoxyguanosine; Leukemia L1210; Mice; Phosphotransferases (Alcohol Group Acceptor); Substrate Specificity | 1994 |
Modulation of the effect of 1-beta-D-arabinofuranosylcytosine by 6-mercaptopurine in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Biological Transport; Cytarabine; Cytidine Deaminase; DNA, Neoplasm; Drug Synergism; In Vitro Techniques; Leukemia L1210; Mercaptopurine; Mice; Tumor Cells, Cultured | 1994 |
N4-(dialkylamino)methylene derivatives of 2'-deoxycytidine and arabinocytidine: physicochemical studies for potential prodrug applications.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Cytarabine; Deoxycytidine; Drug Stability; Half-Life; Hydrolysis; Kinetics; Leukemia L1210; Lipids; Mice; Prodrugs; Solubility | 1994 |
Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of optical isomers of ether and thioether lipids.
Topics: Animals; Antineoplastic Agents; Cytarabine; Ethers; Glycerol; Leukemia L1210; Male; Mice; Mice, Inbred CBA; Phospholipid Ethers; Stereoisomerism; Sulfides; Survival Analysis | 1993 |
Enhanced incorporation of 1-beta-D-arabinofuranosylcytosine by pretreatment with etoposide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1993 |
Deoxyguanosine-resistant leukemia L1210 cells. Loss of specific deoxyribonucleoside kinase activity.
Topics: Animals; Antineoplastic Agents; Cell Division; Cytarabine; Deoxycytidine; Deoxyguanosine; Drug Resistance; Kinetics; Leukemia L1210; Mice; Nucleosides; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Tumor Cells, Cultured | 1993 |
Characterization of tumor cell heterogeneity of a murine leukemia cell line (L1210) in response to arabinosylcytosine: quantitation using a computerized image analysis system.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Division; Cytarabine; Image Processing, Computer-Assisted; Kinetics; Leukemia L1210; Mice; Tumor Cells, Cultured | 1993 |
Oral antitumour activity in murine L1210 leukaemia and pharmacological properties of liposome formulations of N4-alkyl derivatives of 1-beta-D-arabinofuranosylcytosine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cytarabine; Drug Carriers; Female; Hemolysis; Humans; Leukemia L1210; Liposomes; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Tissue Distribution | 1996 |
Synthesis and structure-activity studies in vivo of liposomal phospholipid-N4-palmitoyl- and N4-hexadecyl-1-beta-D-arabinofuranosylcytosine conjugates.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Drug Carriers; Female; Leukemia L1210; Liposomes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Structure; Phospholipids; Prodrugs; Structure-Activity Relationship | 1996 |
Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells.
Topics: Animals; Cytarabine; Deoxycytidine Kinase; Etoposide; Leukemia L1210; Methotrexate; Mice; Phosphorylation | 1996 |
Lipophilic 1-beta-D-arabinofuranosyl cytosine derivatives in liposomal formulations for oral and parenteral antileukemic therapy in the murine L1210 leukemia model.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cytarabine; Female; Infusions, Parenteral; Leukemia L1210; Liposomes; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Structure-Activity Relationship | 1996 |
Intracellular pharmacodynamics of ara-C and flowcytometric analysis of cell cycle progression in leukemia chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Arabinofuranosylcytosine Triphosphate; Biotransformation; Cell Cycle; Cell Survival; Cytarabine; Daunorubicin; DNA, Neoplasm; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Kinetics; Leukemia L1210; Mercaptopurine; Mice; Tumor Cells, Cultured | 1997 |
Alterations in the properties of mouse leukemia L1210 cell lines selected by different methods for resistance to deoxyguanosine.
Topics: Animals; Cell Division; Cladribine; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Deoxyguanosine; Drug Resistance, Neoplasm; Kinetics; Leukemia L1210; Mice; Phosphotransferases (Alcohol Group Acceptor); Tumor Cells, Cultured | 1997 |
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; DNA; Drug Resistance; Gemcitabine; Leukemia L1210; Mice; Nucleoside Deaminases; Polyphosphates; Rats; Rats, Inbred BN; Substrate Specificity; Thymidine Kinase; Tumor Cells, Cultured | 1999 |
Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Carcinoma; Carrier Proteins; Cytarabine; Disease Models, Animal; Drug Screening Assays, Antitumor; Fatty Acids, Unsaturated; Female; Humans; Leukemia L1210; Leukemia, Experimental; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nucleoside Transport Proteins; Rats; Rats, Nude; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Potential of ribozymes against deoxycytidine kinase to confer drug resistance to cytosine nucleoside analogs.
Topics: Animals; Base Sequence; Clone Cells; Cytarabine; Deoxycytidine Kinase; DNA Primers; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Leukemia L1210; Mice; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides, Antisense; RNA, Catalytic; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2000 |
Antitumor drug-protein interactions. Binding of 1-beta-D-arabinofuranosyl cytosine to albumin and chemically modified albumin.
Topics: Animals; Cattle; Cytarabine; Humans; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Mice; Protein Binding; Serum Albumin; Serum Albumin, Bovine | 1979 |
Deoxycytidine and lethal doses of cytarabine in advanced murine leukaemia.
Topics: Administration, Oral; Animals; Cytarabine; Deoxycytidine; Drug Antagonism; Drug Therapy, Combination; Female; Injections, Intraperitoneal; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mice | 1977 |
Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.
Topics: Ancitabine; Animals; Cells, Cultured; Cisplatin; Cytarabine; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1977 |
The synthesis and antitumor activity of arabinosyl-5-azacytosine.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytarabine; Leukemia L1210; Mice | 1977 |
Cell proliferation kinetics and drug sensitivity of exponential and stationary populations of cultured L1210 cells.
Topics: Amino Acids; Animals; Antineoplastic Agents; Carmustine; Cell Division; Cell Survival; Cells, Cultured; Culture Media; Cytarabine; Dactinomycin; Daunorubicin; DNA, Neoplasm; Doxorubicin; Glucose; Hydroxyurea; Kinetics; Leukemia L1210; Lomustine; Streptozocin; Thymidine; Vincristine | 1977 |
The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine.
Topics: 3-Deazauridine; Adenocarcinoma; Animals; Cell Line; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA, Neoplasm; Drug Resistance; Leukemia L1210; Liver; Mice; Neoplasms, Experimental; Orotic Acid; Phosphotransferases; Pyrimidine Nucleotides; Ribonucleotide Reductases; Ribonucleotides; RNA, Neoplasm; Uracil Nucleotides; Uridine | 1975 |
Reactions of 2-acyloxyisobutyryl halides with nucleosides. 7. Synthesis and biological evaluation of some 2,2'-anhydro-1(3',5'-di-O-acyl-beta-D-arabinofuranosyl)cytosine hydrochlorides.
Topics: Anhydrides; Animals; Butyrates; Cells, Cultured; Cytarabine; HeLa Cells; Leukemia L1210; Mice; Simplexvirus; Structure-Activity Relationship; Vaccinia virus | 1976 |
Inhibition of tumor cell growth in vitro and in vivo by 1-beta-D-arabinofuranosylcytosine entrapped within phospholipid vesicles.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Cytarabine; Leukemia L1210; Male; Membranes, Artificial; Mice; Mice, Inbred DBA; Pharmaceutical Vehicles; Phospholipids; Simian virus 40 | 1976 |
Combination chemotherapy of L1210 leukemia with platinum compounds and cyclophosphamide plus other selected antineoplastic agents.
Topics: Animals; Cell Survival; Cisplatin; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Mesylates; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Organometallic Compounds; Platinum; Propylamines; Vincristine | 1976 |
Metabolism and intracellular retention of 1-beta-D-arabinofuranosylcytosine as predictors of response of animal tumors.
Topics: Animals; Carcinoma, Hepatocellular; Cytarabine; Female; Leukemia L1210; Leukemia, Experimental; Liver Neoplasms; Mice; Mice, Inbred DBA; Neoplasms, Experimental; Tissue Distribution | 1978 |
Phosphorylation of 1-beta-D-arabinofuranosylcytosine by the cell-free extract of rat ascites hepatoma, in relation to the mechanism of natural resistance.
Topics: Animals; Bone Marrow; Cell-Free System; Cytarabine; Leukemia L1210; Liver Neoplasms, Experimental; Phosphorylation; Phosphotransferases; Rats | 1978 |
Formation of 1-beta-D-arabinofuranosylcytosine diphosphate choline in neoplastic and normal cells.
Topics: 3-Deazauridine; Animals; Choline; Cytarabine; Cytidine Diphosphate Choline; Drug Synergism; Female; HeLa Cells; Leukemia L1210; Leukemia, Experimental; Leukemia, Myeloid, Acute; Liver; Lymphocytes; Mice; Mice, Inbred Strains | 1978 |
[Selective treatment of leukemia L1210 with combination of deoxycytidine and lethal doses of cytosine arabinoside].
Topics: Administration, Oral; Animals; Cytarabine; Deoxycytidine; Drug Evaluation; Drug Therapy, Combination; Injections, Intraperitoneal; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice | 1978 |
Novel arabinofuranosyl derivatives of cytosine resistant to enzymatic deamination and possessing potent antitumor activity.
Topics: Animals; Antineoplastic Agents; Cell Line; Cytarabine; Cytidine Deaminase; Deamination; Humans; Leukemia L1210; Leukemia, Lymphoid; Liver; Mice | 1978 |
Enhancement of chemotherapeutic effect by entrapping 1-beta-D-arabinofuranosylcytosine in lipid vesicles and its mode of action.
Topics: Animals; Cytarabine; Dose-Response Relationship, Drug; Drug Synergism; Leukemia L1210; Liposomes; Male; Mice; Mice, Inbred DBA; Pharmaceutical Vehicles; Time Factors | 1978 |
Use of liposomes for the enhancement of the cytotoxic effects of cytosine arabinoside.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Drug Synergism; Female; Leukemia L1210; Liposomes; Mice; Mice, Inbred DBA; Pharmaceutical Vehicles; Phosphatidylcholines; Phosphatidylserines; Pregnancy; Tissue Distribution | 1978 |
Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Survival; Cells, Cultured; Cytarabine; Deoxyribonucleotides; Drug Synergism; Humans; In Vitro Techniques; Leukemia L1210; Leukemia, Myeloid, Acute; Methotrexate; Mice | 1979 |
Dose-dependent cytokinetic changes following 1-beta-D-arabinofuranosylcytosine and hydroxyurea in L1210 and S-180 in vivo.
Topics: Animals; Cytarabine; DNA, Neoplasm; Female; Hydroxyurea; Leukemia L1210; Male; Mice | 1978 |
Role of liposome type and route of administration in the antitumor activity of liposome-entrapped 1-beta-D-arabinofuranosylcytosine against mouse L1210 leukemia.
Topics: Administration, Oral; Animals; Cytarabine; Female; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Leukemia L1210; Liposomes; Mice; Mice, Inbred DBA | 1979 |
Carbocyclic analog of cytarabine.
Topics: Animals; Cytarabine; Leukemia L1210; Mice | 1979 |
Antileukemic activity of 1-beta-D-arabinofuranosyl-2-amino-1,4(2H)-4-iminopyrimidine, a new depot form of 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Biotransformation; Chemical Phenomena; Chemistry; Cytarabine; Deamination; Female; Leukemia L1210; Mice; Mice, Inbred Strains | 1979 |
Studies on biologically active nucleosides and nucleotides. 5. Synthesis and antitumor activity of some 2,2'-anhydro-1-(3',5'-di-O-acyl-beta-D-arabinofuranosyl)cytosine salts and 2,2'-anhydro-1-(3'-O-acyl-beta-D-arabinofuranoxyl)cytosine 5'-phosphates.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Female; Leukemia L1210; Methods; Mice; Structure-Activity Relationship | 1979 |
Synthesis and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugates of cortisol and cortisone.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cells, Cultured; Cortisone; Cytarabine; Hydrocortisone; Leukemia L1210; Mice | 1979 |
Methotrexate-induced changes in the levels of 1-beta-D-arabinofuranosylcytosine triphosphate in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Arabinonucleotides; Cytarabine; Deoxycytidine Kinase; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1979 |
On methods for testing and achieving cancer chronotherapy.
Topics: Animals; Antineoplastic Agents; Circadian Rhythm; Cytarabine; Drug Administration Schedule; Leukemia L1210; Mice | 1979 |
[Detection of development of resistance in the short-term test (author's transl].
Topics: Animals; Cytarabine; Drug Resistance; Leukemia L1210; Mice | 1979 |
2'-Deoxycytidine hydrochloride protection of mice against the lethal toxicity of cytosine arabinoside. Absence of protection of bone marrow lymphocytes.
Topics: Animals; Antibody Formation; Bone Marrow; Bone Marrow Cells; Cytarabine; Deoxycytidine; Female; Immunity, Cellular; Leukemia L1210; Lymphocytes; Male; Mice; Mice, Inbred Strains; Time Factors | 1979 |
Partial synchronization of L1210 cells by 5-fluorouracil and its use in drug combinations.
Topics: Animals; Cell Division; Cell Survival; Cytarabine; Doxorubicin; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Thiosemicarbazones; Vincristine | 1977 |
Nucleosides. 107. Synthesis of 5-(beta-D-arabinofuranosyl)isocytosine and related C-nucleosides.
Topics: Animals; Arabinofuranosyluracil; Cells, Cultured; Cytarabine; Isomerism; Leukemia L1210; Methods | 1978 |
Response of lymphoid leukemia L1210 in mice to implantable sustained release cytosine arabinoside capsules.
Topics: Animals; Cytarabine; Drug Implants; Leukemia L1210; Mice; Time Factors | 1978 |
Mode of action of 5-fluorouridine 5'-phosphate in vivo and in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Cytarabine; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Mice; Nucleic Acid Precursors; Uracil Nucleotides | 1978 |
Influence of continuous infusion of cytosine arabinoside on sequencing with daunorubicin in L1210 leukemia.
Topics: Animals; Cell Survival; Cytarabine; Daunorubicin; Leukemia L1210; Mice; Neoplasm Transplantation; Time Factors; Transplantation, Homologous | 1978 |
Combination chemotherapy in sequence for the treatment of L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Teniposide; Therapeutic Equivalency | 1978 |
Chronochemotherapy of L1210 leukemic mice with cytosine arabinoside or cyclophosphamide.
Topics: Animals; Circadian Rhythm; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Drug Resistance; Leukemia L1210; Light; Male; Mice; Species Specificity | 1978 |
Mechanism of natural resistance of rat ascites hepatomas to 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cytarabine; Leukemia L1210; Liver Neoplasms, Experimental; Male; Mice; Phosphorylation; Rats | 1978 |
A new anti-cancer principle isolated from Gymnosporia rothiana Laws, and its use in attaining cures in L1210 leukaemia in combination with "S" phase sensitive drugs.
Topics: Animals; Antineoplastic Agents; Cytarabine; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hydroxyurea; Interphase; Leukemia L1210; Mice; Plants | 1978 |
Antitumor activity of prolonged-release derivative of cytosine arabinoside, cytosine arabinoside-agarose conjugate.
Topics: Animals; Cytarabine; Delayed-Action Preparations; Leukemia L1210; Male; Mice | 1978 |
Cellular quantitation of in vivo effects of 1-beta-D-arabinofuranosylcytosine on leukemia L1210.
Topics: Animals; Cell Division; Cell Survival; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Infusions, Parenteral; Injections, Intravenous; Kinetics; Leukemia L1210; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Models, Biological | 1977 |
Pharmacology of 5'-esters of 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cytarabine; Female; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms; Swine | 1977 |
N4-Behenoyl-1-beta-D-arabinofuranosylcytosine as a potential new antitumor agent.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cytarabine; Cytidine Deaminase; Female; Hydrolysis; Leukemia L1210; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Solutions; Suspensions; Time Factors | 1977 |
Effects of 2'-deoxycoformycin, 9-beta-D-arabinofuranosyladenine 5'-phosphate, and 1-beta-D-arabinofuranosylcytosine triple combination therapy on intracerebral leukemia 1210.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Azepines; Body Weight; Brain; Brain Neoplasms; Cytarabine; Deoxyribonucleotides; Drug Synergism; Drug Therapy, Combination; Female; In Vitro Techniques; Kinetics; Leukemia L1210; Mice; Mice, Inbred DBA; Vidarabine | 1977 |
Survival and cure of leukemic mice after circadian optimization of treatment with cyclophosphamide and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Circadian Rhythm; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Drug Therapy, Combination; Female; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1977 |
Selective chemotherapy for advanced murine L 1210 leukemia by combination of 2' deoxycytidine and lethal doses of cytosine-arabinoside.
Topics: Animals; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Leukemia L1210; Male; Mice | 1977 |
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Podophyllotoxin; Vincristine | 1976 |
Enhancement of the antitumor activity of arabinofuranosyladenine of 2'-deoxycoformycin.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Azepines; Cytarabine; Deoxyribonucleosides; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Female; Leukemia L1210; Lymphoma, Non-Hodgkin; Mice; Mice, Inbred Strains; Purine Nucleosides; Sarcoma, Experimental; Vidarabine | 1976 |
Electronic volume analysis of L1210 chemotherapy.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Count; Cell Division; Cell Survival; Cyclophosphamide; Cytarabine; Drug Evaluation, Preclinical; Electronics; Female; Leukemia L1210; Methotrexate; Mice; Time Factors; Vincristine | 1976 |
Deveopment of resistance to combinations of six antimetabolites in mice with L1210 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Thioguanine; Thioinosine | 1976 |
Computer simulation of leukemia therapy: combined pharmacokinetics, intracellular enzyme kinetics, and cell kinetics of the treatment of L1210 leukemia by cytosine arabinoside.
Topics: Animals; Cell Division; Cell Survival; Computers; Cytarabine; In Vitro Techniques; Kinetics; Leukemia L1210; Mice; Models, Biological; Time Factors | 1976 |
Resting cells in L1210 and JB-1 ascites tumors with special emphasis on recycling.
Topics: Animals; Cell Division; Cell Survival; Cytarabine; DNA, Neoplasm; Kinetics; Leukemia L1210; Mice; Mitotic Index; Models, Biological; Neoplasm Transplantation; Neoplasms, Experimental; Time Factors | 1976 |
Combined effect of cytosine arabinoside and thiopurines.
Topics: Animals; Bone Marrow Cells; Cell Division; Cell Survival; Cytarabine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Hematopoiesis; Leukemia L1210; Male; Mercaptopurine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Thioguanine; Time Factors | 1976 |
Use of cell-cycle information in the preparation of drug combinations: results with cytosine arabinoside plus actinomycin D1,2.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Cytarabine; Dactinomycin; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Leukemia L1210; RNA, Neoplasm | 1976 |
Plasma half-life of cytosine arabinoside in patients with leukaemia--the effect of uridine.
Topics: Administration, Oral; Aminohydrolases; Animals; Cell Count; Cytarabine; Deoxycytidine; DNA, Neoplasm; Dose-Response Relationship, Drug; Half-Life; Humans; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Mice; Uridine | 1975 |
Experimental and clinical studies on nucleoside analogs as antitumor agents.
Topics: Aged; Animals; Cytarabine; Drug Resistance; Flucytosine; Fluorouracil; Humans; Leukemia L1210; Leukemia, Experimental; Male; Methotrexate; Mice; Nasopharyngeal Neoplasms; Structure-Activity Relationship | 1975 |
Occurrence of deaminated monophosphate nucleotide in extracellular sites after giving arabinofuranosylcytosine or deoxycytidine to mice.
Topics: Animals; Blood Platelets; Cytarabine; Deoxycytidine; Intestine, Small; Leukemia L1210; Leukocytes; Liver; Mice; Myocardium; Nucleosides; Nucleotides; Spleen; Thymus Gland | 1975 |
[Clinical and animal experiment studies on the cell-cycle arrest using cytosine arabinoside in leukemias].
Topics: Animals; Cytarabine; Humans; Leukemia L1210; Leukemia, Monocytic, Acute; Mitosis; Rats | 1975 |
Metabolism and selective effects of 1-beta-D-arabinofuranosylcytosine in L1210 and Host tissues in vivo.
Topics: Animals; Ascitic Fluid; Cytarabine; DNA, Neoplasm; Idoxuridine; Intestine, Small; Leukemia L1210; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Thymidine; Tritium | 1975 |
Combination therapy of mouse leukemia L1210 by 1-beta-D-arabinofuranosylcytosine and 6-[(4-nitrobenzyl)thio]-9-beta-D-ribofuranosylpurine.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cytarabine; Drug Synergism; Drug Therapy, Combination; Female; Half-Life; Inosine; Leukemia L1210; Mice; Nitrobenzenes; Sulfides; Thioinosine | 1975 |
ara-Cytidine acylates. Use of drug design predictors in structure-activity relationship correlation.
Topics: Acylation; Animals; Cytarabine; Esterases; Esters; Female; Hydrolysis; Kinetics; Leukemia L1210; Mice; Mice, Inbred Strains; Solubility; Structure-Activity Relationship; Synovial Fluid | 1975 |
Biochemical profiles of cancer cells: I. Computerized analysis of mouse leukemic cellular RNA on polyacrylamide gels.
Topics: Animals; Computers; Cytarabine; Drug Resistance; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Leukemia L1210; Methods; Mice; RNA, Neoplasm; Spectrophotometry, Ultraviolet | 1975 |
The enhanced cytotoxicity of combinations of 1-beta-D-arabinofuranosylcytosine and methotrexate.
Topics: Animals; Cell Division; Cytarabine; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; In Vitro Techniques; Kinetics; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Spleen; Time Factors | 1975 |
Cytosine arabinoside uptake by tumour cells in vitro.
Topics: Animals; Cytarabine; Deoxycytidine; Diffusion; Female; In Vitro Techniques; Kinetics; Leukemia L1210; Leukemia, Experimental; Neoplasms, Experimental; Rats; Sarcoma, Yoshida | 1975 |
The cryopreservation of mouse leukemic cells. I. Effects on drug resistance and the patterns of nucleic acid metabolism.
Topics: Animals; Blood Preservation; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Drug Resistance; Freezing; Leukemia L1210; Mice; Mice, Inbred Strains; RNA, Neoplasm; Time Factors | 1975 |
R17934-NSC238159: a new antitumor drug--II. Effect on mitotic cycle of L1210 leukemia cells in vivo and synergism with cytosine arabinoside (NSC63878).
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Carbamates; Cytarabine; Drug Synergism; Drug Therapy, Combination; Leukemia L1210; Leukemia, Experimental; Mice; Mitosis | 1975 |
Response of L1210 to combinations of cytosine arabinoside and VM-26 or VP16-213.
Topics: Animals; Cytarabine; Drug Therapy, Combination; Etoposide; Female; Leukemia L1210; Leukemia, Experimental; Mice; Podophyllotoxin; Pyrans; Teniposide | 1975 |
Effect and toxicity of combination treatment including cyclocytidine or cytosine arabinoside in L-1210 and sarcoma-180 systems.
Topics: Animals; Antineoplastic Agents; Cell Line; Cytarabine; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Lethal Dose 50; Leukemia L1210; Mice; Sarcoma 180 | 1975 |
Enhancement of the cancer chemotherapeutic effect of cytosine arabinoside entrapped in liposomes on mouse leukemia L-1210.
Topics: Animals; Cytarabine; Leukemia L1210; Liposomes; Mice | 1975 |
Leukocidin--new antimetabolite: effects on L 1210: preliminary report.
Topics: Animals; Antimetabolites, Antineoplastic; Carmustine; Cytarabine; Leukemia L1210; Leukocidins; Mice | 1975 |
The inhibition of DNA synthesis by cannabinoids.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cannabidiol; Cannabis; Cyclophosphamide; Cytarabine; DNA; DNA, Neoplasm; Dronabinol; Fluorouracil; Idoxuridine; Leukemia L1210; Lung Neoplasms; Mice; Neoplasms, Experimental; Semustine | 1976 |
Antitumor activities of newly synthesized N4-acyl-1-beta-D-arabinofuranosylcytosine.
Topics: Acylation; Animals; Cytarabine; Cytidine Deaminase; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatty Acids; Leukemia L1210; Mice; Stearic Acids; Structure-Activity Relationship | 1976 |
Flow microfluorimetric analysis of sensitive and resistant leukemia L1210 following 1-beta-D-arabinofuranosylcytosine in vivo.
Topics: Animals; Cytarabine; DNA, Neoplasm; Drug Resistance; Fluorometry; Kinetics; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Microchemistry; Mitosis | 1976 |
The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3'-amino-2',3'-dideoxycytidine and cytosine arabinoside.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; HeLa Cells; Humans; Leukemia L1210; Mice; Nucleoside Deaminases; Sensitivity and Specificity; Tumor Cells, Cultured; Zalcitabine | 1992 |
Factors affecting the mRNA levels for the non-heme iron and effector-binding subunits of ribonucleotide reductase.
Topics: Animals; Calcium; Cycloheximide; Cytarabine; Dactinomycin; Deoxyadenosines; Gene Expression Regulation, Neoplastic; Hydroxyurea; Leukemia L1210; Metalloproteins; Nonheme Iron Proteins; Protein Biosynthesis; Pyrazoles; Ribonucleotide Reductases; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Stealth liposomes: an improved sustained release system for 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cytarabine; Drug Carriers; Female; Half-Life; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Liposomes; Male; Mice; Survival Analysis | 1992 |
Deoxypyrimidine-induced inhibition of the cytokinetic effects of 1-beta-D-arabinofuranosyluracil.
Topics: Animals; Arabinofuranosyluracil; Cell Cycle; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Leukemia L1210; Mice; Nucleosides; Pyrimidines; S Phase; Thymidine Kinase | 1992 |
Treatment of L1210 murine leukemia with liposome-incorporated N4-hexadecyl-1-beta-D-arabinofuranosyl cytosine.
Topics: Animals; Cytarabine; Drug Carriers; Drug Screening Assays, Antitumor; Leukemia L1210; Liposomes | 1992 |
Comparison of some biochemical parameters of arabinosylcytosine and cyclocytidine in L1210 murine leukemia cells.
Topics: Ancitabine; Animals; Cytarabine; DNA; Drug Resistance; Drug Stability; Female; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Protein Biosynthesis; RNA; Tumor Cells, Cultured | 1990 |
Antitumor characteristics of the conjugate of N4-(4-carboxybutyryl)-ara-C with ethylenediamine-introduced dextran and its resistance to cytidine deaminase.
Topics: Animals; Antineoplastic Agents; Cytarabine; Cytidine Deaminase; Dextrans; Drug Carriers; Ethylenediamines; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Molecular Weight; Schiff Bases; Spectrophotometry, Ultraviolet | 1990 |
Conjugate of N4-(4-carboxybutyryl)-ara-C and ethylenediamine-introduced dextran. Drug release profiles and further in vivo study of its antitumor effects.
Topics: Animals; Cytarabine; Dextrans; Drug Carriers; Drug Design; Drug Evaluation; In Vitro Techniques; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains | 1991 |
Evaluation of synergism of drugs cis-diamminedichloroplatinum (II) and arabinosylcytosine on the level of chemical interaction with DNA and on the growth of mouse leukemia.
Topics: Animals; Cisplatin; Cytarabine; Cytidine; DNA, Neoplasm; Drug Synergism; Female; Fluorescent Dyes; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Spectrophotometry, Ultraviolet | 1991 |
[Reversal of multidrug resistance with (R)-verapamil in vitro and in vivo].
Topics: Animals; Antineoplastic Agents; Cytarabine; Doxorubicin; Drug Resistance; Female; Leukemia L1210; Mice; Stereoisomerism; Thymidine; Tumor Cells, Cultured; Uridine; Verapamil | 1991 |
Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytarabine; Drug Synergism; Female; Humans; Leukemia L1210; Leukemia P388; Male; Methotrexate; Mice; Mice, Inbred DBA; Plant Extracts; Tea; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1991 |
Biotransformation and in vitro activity of an arabinosylcytosine 5'-chloro-5'-deoxy analog.
Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Biotransformation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Culture Media; Cytarabine; DNA, Neoplasm; Hydrogen-Ion Concentration; Leukemia L1210; Phosphorylation; Pyrimidine Nucleosides; Temperature; Tumor Cells, Cultured | 1991 |
1-beta-D-arabinofuranosylcytosine conjugates of ether and thioether phospholipids. A new class of ara-C prodrug with improved antitumor activity.
Topics: Analysis of Variance; Animals; Colonic Neoplasms; Cytarabine; Female; Leukemia L1210; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Structure; Phospholipid Ethers; Prodrugs; Sarcoma, Experimental; Structure-Activity Relationship | 1991 |
Treatment of leukemia L1210 and P388 by arabinosylcytosine-polysaccharide conjugates.
Topics: Animals; beta-Glucans; Cytarabine; DNA; Female; Glucans; Leukemia L1210; Leukemia P388; Male; Mice; Mice, Inbred DBA; Pectins | 1991 |
Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model.
Topics: 3-Deazauridine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Cytidine; Drug Resistance; Drug Synergism; Female; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Remission Induction; Survival Rate | 1991 |
Preparation, properties and antileukemic activity of arabinosylcytosine polysaccharide conjugates.
Topics: Animals; Antineoplastic Agents; beta-Glucans; Cytarabine; Female; Glucans; Hydrolysis; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Nitrogen; Pectins; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1990 |
Formulation, stability, and antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugate of thioether phospholipid.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Cytarabine; Drug Stability; Female; Freeze Fracturing; Leukemia L1210; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Microscopy, Electron; Molecular Structure; Neoplasms, Experimental; Phospholipid Ethers; Sarcoma, Experimental | 1990 |
Application of a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cisplatin; Cytarabine; Drug Synergism; Kinetics; Leukemia L1210; Mathematics; Mice; Models, Theoretical; Tumor Cells, Cultured | 1990 |
[Antitumor activity of a novel analog of cytarabine, 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone 5'-(sodium octadecyl phosphate) monohydrate (YNK01)].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Arabinonucleotides; Cytarabine; Cytidine Monophosphate; Cytosine Nucleotides; Drug Administration Schedule; Drug Screening Assays, Antitumor; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Male; Mice; Neoplasms, Experimental; Tumor Cells, Cultured | 1990 |
Effects of cytosine arabinoside and hydroxyurea on the synthesis of deoxyribonucleotides and DNA replication in L1210 cells.
Topics: Adenosine; Animals; Cytarabine; Cytidine; Deoxyribonucleotides; DNA Replication; Hydroxyurea; Leukemia L1210; Mice; RNA, Neoplasm; Tumor Cells, Cultured | 1990 |
Survival of L1210 leukemia cells and normal hematopoietic stem cells following in vivo administration of cyclocytidine.
Topics: Ancitabine; Animals; Cell Survival; Colony-Forming Units Assay; Cytarabine; Hematopoietic Stem Cells; Leukemia L1210; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Time Factors | 1985 |
Comparison of the activity of arabinosyl-5-azacytosine, arabinosyl cytosine, and 5-azacytidine against intracerebrally implanted L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Azacitidine; Brain Neoplasms; Carmustine; Cytarabine; Leukemia L1210; Mice; Mice, Inbred Strains; Neoplasm Transplantation | 1985 |
Mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine and its effects in L1210 mouse leukemia cells.
Topics: Animals; Antineoplastic Agents; Azacitidine; Bone Marrow; Bone Marrow Cells; Cell Division; Cell Line; Cell Survival; Cytarabine; Decitabine; Drug Evaluation, Preclinical; Kinetics; Leukemia L1210; Leukocyte Count; Male; Mice; Mice, Inbred DBA; Nucleosides; Phosphorylation; Thymidine | 1986 |
Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cytarabine; Decitabine; Drug Interactions; Leukemia L1210; Male; Mice; Statistics as Topic | 1986 |
Chemotherapy of L1210 and L1210/ARA-C leukemia with 5-aza-2'-deoxycytidine and 3-deazauridine.
Topics: 3-Deazauridine; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Line; Cytarabine; Decitabine; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Leukemia L1210; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Tumor Cells, Cultured | 1989 |
Effect of FK973, a new antitumor antibiotic, on the cell cycle of L1210 cells in vitro.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Cell Division; Cytarabine; DNA, Neoplasm; Flow Cytometry; Leukemia L1210; Mitomycin; Mitomycins; Mitosis; Oxazines; Time Factors; Vinblastine | 1989 |
Antitumor activity and pharmacology of 1-beta-D-arabinofuranosylcytosine-5'-stearylphosphate: an orally active derivative of 1-beta-D-arabinofuranosylcytosine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Arabinonucleotides; Cytarabine; Cytidine Monophosphate; Cytosine Nucleotides; Drug Administration Schedule; Leukemia L1210; Metabolic Clearance Rate; Mice; Solubility; Structure-Activity Relationship | 1989 |
Induced multidrug resistance in murine leukemia L1210 and associated changes in a surface-membrane glycoprotein.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Proteins; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Resistance; Female; Immunoblotting; Leukemia L1210; Membrane Glycoproteins; Mice; Phenotype | 1989 |
Synergistic interaction between etoposide and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cytarabine; DNA Damage; DNA, Neoplasm; Drug Administration Schedule; Drug Synergism; Etoposide; Leukemia L1210; Male; Mice; Time Factors | 1989 |
[Studies on the relationship between therapeutic schedule and antitumor effect of etoposide and cytosine arabinoside in murine L1210 leukemia].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Administration Schedule; Drug Synergism; Etoposide; Leukemia L1210; Mice; Mice, Inbred Strains; Remission Induction; Survival Rate | 1989 |
Therapy of central nervous system leukemia in mice by liposome-entrapped 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Bone Marrow; Brain Neoplasms; Cytarabine; Drug Carriers; Intestine, Small; Leukemia L1210; Liposomes; Mice | 1989 |
Recent advances in sustained release of antineoplastic drugs using liposomes which avoid uptake into the reticuloendothelial system.
Topics: Animals; Antineoplastic Agents; Cytarabine; Delayed-Action Preparations; Leukemia L1210; Liposomes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mononuclear Phagocyte System | 1989 |
[Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cytarabine; Fluorouracil; Leukemia L1210; Mice; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Streptozocin; Tegafur; Uracil | 1987 |
[Liposomes as carriers of lipophilic cytosine arabinoside and fluorodeoxyuridine derivatives. Their cytostatic effect and possibilities of tumor cell specific therapy].
Topics: Animals; Antibodies, Monoclonal; Cytarabine; Drug Therapy; Floxuridine; Humans; Leukemia L1210; Liposomes; Mice; Neoplasms, Experimental; Organ Specificity; Prodrugs | 1987 |
Inhibition of thymidylate synthase in intact L1210 cells by ara-C, daunomycin, hydroxyurea and 3,4-dihydroxybenzylamine.
Topics: Animals; Cytarabine; Daunorubicin; Deoxyuridine; DNA; Dopamine; Floxuridine; Hydroxyurea; Kinetics; Leukemia L1210; Methotrexate; Thymidylate Synthase | 1987 |
Isolation and characterization of a mutant of L1210 murine leukemia deficient in nitrobenzylthioinosine-insensitive nucleoside transport.
Topics: Animals; Biological Transport; Carrier Proteins; Cytarabine; Floxuridine; Inosine; Leukemia L1210; Membrane Proteins; Mice; Mutation; Nucleoside Transport Proteins; Nucleosides; Thioinosine; Thymidine; Tubercidin; Tumor Cells, Cultured; Uridine | 1988 |
Sequence-dependent antitumor effect of VP-16 and 1-beta-D-arabinofuranosylcytosine in L1210 ascites tumor.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dose-Response Relationship, Drug; Etoposide; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1988 |
Rapid detection assays for multidrug resistance.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Colchicine; Cricetinae; Cricetulus; Cytarabine; Dactinomycin; Doxorubicin; Drug Resistance; Female; Leukemia L1210; Rhodamine 123; Rhodamines; Sarcoma 180; Vincristine | 1988 |
[Mechanisms of resistance of anticancer drugs and trials for overcoming their resistance].
Topics: Animals; Cytarabine; Drug Resistance; Extracellular Space; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid; Methotrexate; Mice | 1986 |
Approaches to overcome in vivo anti-cancer drug resistance.
Topics: 3-Deazauridine; Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Cytarabine; Doxorubicin; Drug Resistance; Drug Synergism; Fluorouracil; Leucovorin; Leukemia L1210; Liposomes; Mice; Verapamil | 1986 |
Cell kinetic studies of the effect of a combined therapy with 1-beta D-arabinofuranosylcytosine (Ara-C) and X-irradiation on the L1210 ascites tumour.
Topics: Animals; Autoradiography; Cell Division; Cell Survival; Combined Modality Therapy; Cytarabine; DNA, Neoplasm; Female; Flow Cytometry; Interphase; Kinetics; Leukemia L1210; Mice; Mitosis; Mitotic Index; Necrosis; Whole-Body Irradiation | 1986 |
Multivesicular liposomes containing cytarabine for slow-release Sc administration.
Topics: Animals; Cytarabine; Delayed-Action Preparations; Half-Life; Injections, Subcutaneous; Leukemia L1210; Liposomes; Mice | 1987 |
Pharmacokinetic parameters of 1-beta-D-arabinofuranosylcytosine (ara-C) and their relationship to intracellular metabolism of ara-C, toxicity, and response of patients with acute nonlymphocytic leukemia treated with conventional and high-dose ara-C.
Topics: Acute Disease; Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Cytarabine; Drug Administration Schedule; Humans; Leukemia; Leukemia L1210; Metabolic Clearance Rate; Mice; Uridine Kinase | 1987 |
Multicompartment models of cancer chemotherapy incorporating resistant cell populations.
Topics: Animals; Antineoplastic Agents; Biological Availability; Carmustine; Cytarabine; Drug Resistance; Kinetics; Leukemia L1210; Mice; Models, Biological | 1987 |
Pharmacology of combination chemotherapy of cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) or tetrahydrouridine (THU) against murine leukemia L1210/0 in tumor-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosyluracil; Cytarabine; Deamination; Leukemia L1210; Male; Mice; Tetrahydrouridine; Time Factors; Uridine | 1987 |
Pharmacokinetics of the 5'-triphosphates of arabinosylcytosine and 2',2'-difluorodeoxycytidine in L1210 cells.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Biological Transport; Cytarabine; Cytidine Triphosphate; Cytosine Nucleotides; Leukemia L1210; Mice; Structure-Activity Relationship | 1987 |
1-beta-D-arabinofuranosylcytosine conjugates of thioether phospholipids as a new class of potential antitumor drugs.
Topics: Animals; Antineoplastic Agents; Arabinonucleotides; Cytarabine; Cytidine Monophosphate; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred DBA; Structure-Activity Relationship | 1986 |
Effects of methotrexate on the intracellular nucleotide pools and its role in combination chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Leukemia L1210; Methotrexate; Mice; Nucleotides | 1986 |
[Experimental study on the correlation between the antitumor activity and pharmacokinetics of cytosine arabinoside (Ara-C) and N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC)].
Topics: Animals; Cytarabine; Female; Kinetics; Leukemia L1210; Mice | 1985 |
Role of thymidylate synthetase in the cytostatic activity of pyrimidine nucleoside analogues.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Deoxycytidine; Deoxyuridine; Leukemia L1210; Mice; Pyrimidine Nucleosides; Thymidylate Synthase | 1985 |
Histidinol-mediated enhancement of the specificity of two anticancer drugs in mice bearing leukemic bone marrow disease.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Colony-Forming Units Assay; Cytarabine; Drug Synergism; Femoral Neoplasms; Flow Cytometry; Fluorouracil; Histidinol; Imidazoles; Leukemia L1210; Mice; Mice, Inbred DBA; Time Factors | 1985 |
Pharmacokinetics and cellular determinants of response to 1-beta-arabinofuranosylcytosine (ara-C).
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Bone Marrow; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Humans; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice; Mice, Inbred DBA | 1985 |
Cell kinetic studies of the effect of cytotoxic drugs on survival and proliferation of ascites and solid tumor cells of the mouse.
Topics: Adenocarcinoma; Animals; Ascites; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Survival; Cyclophosphamide; Cytarabine; Interphase; Leukemia L1210; Mice; Necrosis; Neoplasms, Experimental | 1985 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubicin; Female; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Mitomycin; Mitomycins; Nitrosourea Compounds; Thioguanine | 1985 |
Treatment of murine L1210 lymphoid leukemia and melanoma B16 with lipophilic cytosine arabinoside prodrugs incorporated into unilamellar liposomes.
Topics: Animals; Bone Marrow; Cytarabine; Female; Leukemia L1210; Liposomes; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1986 |
[Biochemical modulation in cancer chemotherapy].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Synergism; Fluorouracil; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; Nucleosides; Pyrimidine Nucleosides | 1985 |
S1-phase cells of the leukemic cell cycle sensitive to 1-beta-D-arabinofuranosylcytosine at a high-dose level.
Topics: Animals; Cell Cycle; Cell Separation; Cell Survival; Cells, Cultured; Cytarabine; Dose-Response Relationship, Drug; Leukemia L1210; Mice; Thymine Nucleotides; Tritium | 1985 |
[The effect of methotrexate on intracellular nucleotide pools].
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cytarabine; Drug Synergism; Guanosine Triphosphate; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Nucleotides; Purine Nucleotides; Pyrimidine Nucleotides | 1985 |
[Modern aspects of using chronopharmacology in hematology. II. Biorhythms in drug effects].
Topics: Animals; Circadian Rhythm; Cytarabine; Drug Administration Schedule; Hematopoiesis; Humans; Leukemia L1210; Mice | 1985 |
Detection of cytosine arabinoside resistant cells at low frequency using the bromodeoxyuridine/DNA assay.
Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Cell Cycle; Cytarabine; DNA, Neoplasm; Drug Resistance; Flow Cytometry; Leukemia L1210; Mice | 1985 |
Enhanced production of intracellular ara-CTP after sequential use of methotrexate and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Arabinonucleotides; Cytarabine; Deoxycytosine Nucleotides; Drug Administration Schedule; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains | 1985 |
[Influencing factors in the leakage of liposome and arabinoside cytosine (ARA-C) entrapped in liposomes in treatment of L1210 mouse leukemia].
Topics: Animals; Cytarabine; Female; Leukemia L1210; Liposomes; Mice; Mice, Inbred Strains | 1985 |
Analysis of serum protein changes in patients with advanced gastric cancer with special reference to -globulin fractions.
Topics: Adrenocorticotropic Hormone; Alpha-Globulins; Animals; Blood Protein Electrophoresis; Cytarabine; Drug Combinations; Fluorouracil; Humans; Leukemia L1210; Male; Mitomycins; Rats; Stomach Neoplasms | 1972 |
Second Joint Working Conference: National Cancer Institute Chemotherapy Program. Working session report: pharmacology.
Topics: Alkaloids; Animals; Antimetabolites; Antineoplastic Agents; Autoradiography; Azacitidine; Carbazoles; Carbon Isotopes; Cell Line; Cells, Cultured; Cricetinae; Cytarabine; DNA; DNA Nucleotidyltransferases; Dogs; Half-Life; Humans; Leukemia L1210; Lung; Pyridines; RNA | 1972 |
The enhanced therapeutic effect of cis-platinum (II) diamminodichloride against L1210 leukemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxopiperazine-1-yl)propane or several other antitumor agents.
Topics: Amines; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Carmustine; Chlorides; Cyclophosphamide; Cytarabine; Drug Synergism; Emetine; Fluorouracil; Ketones; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperazines; Platinum; Propane; Time Factors | 1973 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes | 1974 |
Pharmacodynamic and pharmacokinetic measurements of antitumor agents.
Topics: Animals; Antineoplastic Agents; Body Surface Area; Cell Division; Cricetinae; Culture Techniques; Cyclophosphamide; Cytarabine; Dogs; Half-Life; Haplorhini; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid; Methotrexate; Mice; Mice, Inbred Strains; Neoplasms; Rats; Species Specificity; Time Factors | 1974 |
Interaction of drugs inhibiting different steps in the synthesis of DNA.
Topics: Animals; Cells, Cultured; Cytarabine; Depression, Chemical; DNA, Neoplasm; Drug Antagonism; Drug Interactions; Drug Synergism; Feedback; Floxuridine; In Vitro Techniques; Isoquinolines; Leukemia L1210; Methotrexate; Mice; Models, Biological; Thiosemicarbazones | 1972 |
A comparative study of the antitumor and antiviral activity of 1-beta-D-arabinofuranosyl-5-fluorocytosine (FCA) and 1-beta-D-arabinofuranosylcytosine (CA).
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Culture Techniques; Cytarabine; Cytosine; DNA Viruses; Enterovirus; Herpesviridae Infections; Leukemia L1210; Mammary Neoplasms, Experimental; Methods; Mice; Neoplasms, Experimental; Nucleosides; Orthomyxoviridae; Rabbits; Rats; RNA Viruses; Simplexvirus; Vaccinia virus | 1969 |
Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-beta-D-arabinofuranosylcytosine phosphorylation.
Topics: Adenocarcinoma; Animals; Carcinoma, Hepatocellular; Cattle; Chick Embryo; Chromatography, Ion Exchange; Cytarabine; Cytosine Nucleotides; Deoxyuridine; Escherichia coli; Fibrosarcoma; Kinetics; Leukemia L1210; Leukemia, Experimental; Liver Neoplasms; Lymphoid Tissue; Mice; Mitosis; Neoplasms, Experimental; Nucleosides; Nucleotides; Phosphotransferases; Rats; Thymidine; Thymus Gland | 1969 |
Characterization of the kinase(s) involved in the phosphorylation of - and -2'-deoxythioguanosine.
Topics: Adenosine Triphosphate; Animals; Bone Marrow; Carcinoma, Hepatocellular; Cattle; Cell Line; Cell-Free System; Chromatography, DEAE-Cellulose; Cytarabine; Cytidine; Deoxyribonucleosides; Dithiothreitol; Guanosine; Humans; Isoenzymes; Kinetics; Leukemia L1210; Liver Neoplasms; Lymphoma, Non-Hodgkin; Magnesium; Mercaptopurine; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred DBA; Phosphotransferases | 1972 |
Synthesis and antitumor and antiviral activities of 1- -D-arabinofuranosylpyrimidine 3',5'-cyclic phosphates.
Topics: Adenoviridae Infections; Animals; Antineoplastic Agents; Antiviral Agents; Arabinose; Carbodiimides; Cyclic AMP; Cytarabine; Cytosine Nucleotides; Eye Diseases; Herpes Simplex; Kidney; Leukemia L1210; Mice; Myxoma; Nucleotides; Phosphoric Diester Hydrolases; Pseudorabies; Pyrimidine Nucleotides; Rabbits; Uracil Nucleotides; Vaccinia | 1972 |
Synergistic effects of bis(3-methylsulfonyloxypropyl)-amine toluenesulfonate (864-T) with 6-mercaptopurine and other antitumor agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chromomycins; Cyclophosphamide; Cytarabine; Drug Synergism; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Mesylates; Mice; Mitomycins; Nitrogen Mustard Compounds; Prednisolone; Rats; Sarcoma, Yoshida; Tosyl Compounds | 1973 |
Combination therapy: some concepts and results.
Topics: Animals; Antineoplastic Agents; Child; Cyclohexanes; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Imidazoles; Leukemia L1210; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nitrosourea Compounds; Thioguanine; Triazenes; Wilms Tumor | 1974 |
On the characteristics of inhibition of deoxyribonucleic acid synthesis by 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine.
Topics: Anhydrides; Animals; Biological Transport; Carbon Radioisotopes; Cell Line; Chromatography, Thin Layer; Cytarabine; DNA, Neoplasm; Leukemia L1210; Mice; Mice, Inbred Strains; Time Factors; Tritium | 1974 |
Nonspecific inhibition of precursor uptake by alkyl-substituted purines and prednisolone.
Topics: Acetates; Adenine; Adenocarcinoma; Animals; Carbon Radioisotopes; Cell Division; Cell Line; Choline; Cytarabine; DNA, Neoplasm; Ethanolamines; Glucosamine; Glycoproteins; Isotope Labeling; Leukemia L1210; Lipids; Mice; Neoplasm Proteins; Prednisolone; Thymidine; Time Factors; Tritium | 1974 |
Dose-related synergism of cytosine arabinoside and methotrexate against murine leukemia L1210.
Topics: Animals; Cytarabine; Dose-Response Relationship, Drug; Drug Synergism; Female; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Time Factors | 1974 |
Sequential administration of two oncostatic drugs: study of modalities for pharmacodynamic potentiation.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Kinetics; Leukemia L1210; Lomustine; Mathematics; Methotrexate; Mice; Mitomycins; Neoplasm Transplantation; Nitrosourea Compounds; Time Factors; Vincristine | 1974 |
The experimental antitumour properties of three congeners of the acridylmethanesulphonanilide (AMSA) series.
Topics: Acridines; Animals; Anisoles; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Cytarabine; Dose-Response Relationship, Drug; Injections, Intradermal; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Leukemia L1210; Leukemia, Experimental; Mammary Neoplasms, Experimental; Melanoma; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phenylenediamines; Skin Neoplasms; Structure-Activity Relationship; Sulfones | 1974 |
X-ray repair replication in L1210 leukemia cells.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Cytarabine; Daunorubicin; DNA Repair; Dose-Response Relationship, Drug; Doxorubicin; Kinetics; Leukemia L1210; Mice; Radiation Dosage; Radiation Injuries, Experimental; Thymidine; Tritium | 1974 |
DCMP therapy in acute leukemia--the experimental and clinical study.
Topics: Acute Disease; Adult; Animals; Child; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Leukemia; Leukemia L1210; Mercaptopurine; Prednisolone; Time Factors | 1974 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Models, Animal; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Fluorouracil; Hodgkin Disease; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Male; Mechlorethamine; Melphalan; Mice; Mice, Inbred AKR; Multiple Myeloma; Nitrosourea Compounds; Prednisone; Remission, Spontaneous; Vinblastine; Vincristine | 1974 |
Pyrimidine nucleosides. 6. Syntheses and anticancer activities of N4-substituted 2,2'-anhydronucleosides.
Topics: Anhydrides; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cells, Cultured; Chromatography, Thin Layer; Cytarabine; Leukemia L1210; Leukemia, Lymphoid; Mice; Pyrimidine Nucleosides | 1974 |
Studies on the mode of action of 2,2'-anhydro-1- -D-arabinofuranosylcytosine.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Chromatography, Paper; Cytarabine; Deamination; Deoxycytidine; Drug Resistance; Electrophoresis, Paper; Escherichia coli; Female; Hydrogen-Ion Concentration; Hydrolysis; Leukemia L1210; Mice; Mice, Inbred Strains; Oxidative Phosphorylation | 1973 |
Active immunotherapy in spontaneous leukemia of AkR mice.
Topics: AKR murine leukemia virus; Animals; Antibody Formation; BCG Vaccine; Cyclophosphamide; Cytarabine; Female; Immunity, Active; Immunization; Immunosuppression Therapy; Immunotherapy; Leukemia L1210; Male; Mice; Mice, Inbred AKR; Mycobacterium bovis; Neuraminidase; Time Factors | 1973 |
Pharmacology of 3,5-diamino-1,24-triazole (guanazole). 1. Antitumor activity of guanazole.
Topics: Amines; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cyclophosphamide; Cytarabine; Depression, Chemical; Female; Hydroxyurea; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Lymphoma, Large B-Cell, Diffuse; Male; Mast-Cell Sarcoma; Methotrexate; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Plasmacytoma; Structure-Activity Relationship; Triazoles | 1972 |
Pyrimidine nucleosides. 5. Syntheses of carcinostatic halogenocyclonucleosides.
Topics: Animals; Antineoplastic Agents; Cyclization; Cytarabine; Dose-Response Relationship, Drug; Female; Halogens; Leukemia L1210; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Nucleosides; Pyrimidines; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1972 |
Evaluation of antileukemic agents in advanced leukemia L1210 in mice. X.
Topics: Alkylating Agents; Amides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Imidazoles; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Nitrosourea Compounds; Purines; Pyrimidines; Time Factors; Urea | 1972 |
Inhibition of repair of DNA single strand breaks in mouse leukemia cells by actinomycin D.
Topics: Animals; Cell Line; Centrifugation, Density Gradient; Cobalt Isotopes; Cold Temperature; Cytarabine; Dactinomycin; DNA Repair; DNA, Neoplasm; Leukemia L1210; Mice; Radiation Effects; Temperature; Thymidine; Tritium | 1972 |
Effectiveness of antitumor agents administered subcutaneously to L1210 leukemic mice in silicone rubber devices.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Chromatography, Thin Layer; Cytarabine; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Leukemia L1210; Mice; Mice, Inbred Strains; Nitrosourea Compounds; Silicone Elastomers; Time Factors | 1973 |
Combination chemotherapy with cytosine arabinoside, L-asparaginase, and 6-azauridine for transplantable murine leukemias.
Topics: Animals; Asparaginase; Azauridine; Cytarabine; Drug Synergism; Female; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Transplantation, Homologous | 1973 |
The effect of dose interval on the survival of L1210 leukemic mice treated with DNA synthesis inhibitors.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Cell Survival; Cytarabine; DNA, Neoplasm; Formates; Hydroxyurea; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pyridines; Thiosemicarbazones; Thymidine; Time Factors | 1973 |
Scheduling of arabinosylcytosine and 6-thioguanine therapy.
Topics: Animals; Bone Marrow; Cells, Cultured; Chromatography, Paper; Cytarabine; DNA; Female; Half-Life; Leukemia L1210; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nucleotides; Sulfur Isotopes; Thioguanine; Time Factors | 1973 |
Cell-kill kinetics of several S-phase-specific drugs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Division; Cell Line; Cell Survival; Cricetinae; Cytarabine; DNA, Neoplasm; Formates; Hydroxyurea; Kinetics; Leukemia L1210; Lung; Mice; Neoplasms, Experimental; Pyridines; Thiosemicarbazones; Time Factors | 1973 |
Heterocyclic thiosemicarbazones and related derivatives. Synthesis and screening data.
Topics: Animals; Antineoplastic Agents; Cytarabine; Drug Resistance; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Mice; Purines; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiosemicarbazones; Vincristine | 1973 |
Effect of phosphorylated cyclocytidine on deoxyribonucleic acid polymerase.
Topics: Anhydrides; Animals; Antineoplastic Agents; Carbon Radioisotopes; Cytarabine; Cytosine Nucleotides; DNA Nucleotidyltransferases; DNA, Neoplasm; Leukemia L1210; Leukemia, Experimental; Male; Mice; Nucleosides; Phosphotransferases; Thymidine; Tritium | 1973 |
Enhanced antitumor effect of cytosine arabinoside given in a schedule dictated by kinetic studies in vivo.
Topics: Animals; Antineoplastic Agents; Cytarabine; DNA, Neoplasm; Kinetics; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Neoplasm Proteins; Neoplasm Transplantation; Thymidine; Time Factors; Transplantation, Homologous; Tritium | 1973 |
Schedule-dependent synergism for the combination of 1-beta-D-arabinofuranosylcytosine and daunorubicin.
Topics: Animals; Cell Division; Cell Survival; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Leukemia L1210; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Time Factors | 1974 |
The 2'-O-methyl ether of 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cells, Cultured; Cytarabine; Leukemia L1210; Magnetic Resonance Spectroscopy; Methylglycosides; Mice; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1974 |
Biochemical studies of a new antitumor agent, O2,2'-cyclocytidine.
Topics: Anhydrides; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Cell Line; Cells, Cultured; Cytarabine; DNA, Neoplasm; Dogs; Dose-Response Relationship, Drug; Drug Resistance; Humans; Hydrolysis; Leukemia L1210; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Thymidine; Time Factors; Transplantation, Homologous; Tritium; Uridine; Valine | 1974 |
[Chronobiological aspects of experimental leukemia].
Topics: Animals; Biological Clocks; Circadian Rhythm; Cytarabine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Leukemia L1210; Mice; Mice, Inbred Strains | 1974 |
Combined effects of chemotherapy and immunity against leukemia L1210 in DBA-2 mice.
Topics: Animals; Antineoplastic Agents; Cytarabine; Female; Immunity, Maternally-Acquired; Immunization; Immunization, Passive; Leukemia L1210; Mice; Neoplasm Transplantation; Skin Transplantation; Sulfonic Acids; Transplantation Immunology; Transplantation, Homologous | 1969 |
Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carbon Isotopes; Cytarabine; Drug Synergism; Enterococcus faecalis; Female; Furans; Humans; Injections, Intraperitoneal; Leukemia L1210; Mice; Nucleosides; Uridine | 1970 |
Biochemical and pharmacologic studies with 1- -D-arabinofuranosylcytosine 5'-adamantoate (NSC-117614), a depot form of cytarabine.
Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Carcinoma, Squamous Cell; Cell Line; Cells, Cultured; Cycloparaffins; Cytarabine; Deamination; Delayed-Action Preparations; Depression, Chemical; DNA, Neoplasm; Half-Life; Haplorhini; Humans; Hydrolysis; In Vitro Techniques; Leukemia L1210; Mice; Neoplasm Proteins; Physostigmine; Plasma; RNA, Neoplasm; Tritium; Uridine | 1971 |
Immunosuppressive, antiviral and antitumor activities of cytarabine derivatives.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cricetinae; Cytarabine; DNA; Esters; Graft Rejection; Hemagglutination; Herpes Simplex; Humans; Immunosuppressive Agents; In Vitro Techniques; Lectins; Leukemia L1210; Lymphocytes; Male; Mice; Solubility; Structure-Activity Relationship; Thymidine; Tritium | 1972 |
Collateral sensitivity of resistant lines of mouse leukemias L1210 and L5178Y.
Topics: Animals; Antineoplastic Agents; Azirines; Cell Line; Cyclophosphamide; Cytarabine; Cytogenetics; Drug Resistance; Female; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Transplantation, Heterologous; Transplantation, Homologous | 1972 |
Cell proliferation and the differential response of normal and malignant tissues. Silvanus Thompson Memorial Lecture.
Topics: Animals; Blood Vessels; Busulfan; Cell Survival; Cyclophosphamide; Cytarabine; Diffusion; Epithelial Cells; Epithelium; Fibrosarcoma; Hematopoietic Stem Cells; Intestine, Small; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mitosis; Necrosis; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Oxygen; Radiation Effects; Rats | 1972 |
Modulation of transfer RNA-methylating enzyme activities in murine leukemic cells.
Topics: Animals; Asparaginase; Carbon Isotopes; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Resistance; Leukemia L1210; Methods; Methyltransferases; Mice; Proteins; RNA, Transfer; Time Factors; Vincristine | 1972 |
Increased tolerance of leukemic mice to arabinosyl cytosine with schedule adjusted to circadian system.
Topics: Animals; Circadian Rhythm; Cytarabine; Drug Tolerance; Injections, Intraperitoneal; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Time Factors | 1972 |
Nucleic acids. l3. 3'-O- and 2'-O-esters of 1- -D-arabinofuranosylcytosine as antileukemic and immunosuppressive agents.
Topics: Animals; Antineoplastic Agents; Benzoates; Cytarabine; Erythrocytes; Esters; Hemagglutination Tests; Immunosuppressive Agents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Palmitic Acids; Sheep; Stearic Acids; Structure-Activity Relationship | 1972 |
Evaluation of combination chemotherapy in vivo and in culture with l- -D-arabinofuranosylcytosine and 1-formylisoquinoline thiosemicarbazone.
Topics: Animals; Cells, Cultured; Cytarabine; Depression, Chemical; DNA Nucleotidyltransferases; Drug Combinations; Drug Synergism; Female; In Vitro Techniques; Isoquinolines; Leukemia L1210; Mice; Mice, Inbred Strains; Thiosemicarbazones | 1972 |
Acyl derivatives of 1- -D-arabinofuranosylcytosine.
Topics: Acylation; Animals; Antineoplastic Agents; Cells, Cultured; Cytarabine; Infrared Rays; Leukemia L1210; Magnetic Resonance Spectroscopy; Spectrum Analysis; Ultraviolet Rays | 1972 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cyclophosphamide; Cytarabine; Cytidine; Dose-Response Relationship, Drug; Female; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Male; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasms, Experimental; Sarcoma 180 | 1972 |
Effect of different doses of methotrexate (NSC-740), cytosine arabinoside (NSC-63878), and cyclophosphamide (NSC-26271) on drug resistance in mice with L1210 leukemia.
Topics: Animals; Cyclophosphamide; Cytarabine; Drug Resistance; Female; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation | 1972 |
Studies of the L1210 antileukemic activity of O-2,2'-cyclocytidine, monoacetate (anhydro-ara-C; NSC-129220)--comparison with cytosine arabinoside (NSC-63878) with respect to treatment schedule dependency.
Topics: Acetates; Administration, Oral; Animals; Cyclization; Cytarabine; Cytidine; Drug Resistance; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1972 |
Effects of methotrexate and cytosine arabinoside on polyamine metabolism in a mouse L1210 leukemia.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Cytarabine; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Ornithine; Polyamines; Putrescine; Spermidine; Spermine; Spleen | 1972 |
2,2'-O-cyclocytidine, an antitumor cytidine analog resistant to cytidine deaminase.
Topics: Aminohydrolases; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; Injections, Intraperitoneal; Leukemia L1210; Mice | 1971 |
Nucleic acids. 11. Synthesis of 5'-esters of 1-beta-D-arabinofuranosylcytosine possessing antileukemic and immunosuppressive activity.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cytarabine; DNA; Esters; Humans; Immunosuppressive Agents; Injections, Intraperitoneal; Leukemia L1210; Lymphocytes; Mice; Structure-Activity Relationship; Thymidine; Tritium | 1971 |
Differences in the immunogenicity of leukemia L1210 sublines in DBA-2 mice.
Topics: Anilides; Animals; Antigens, Neoplasm; Antineoplastic Agents; Cell Line; Cytarabine; Female; Guanine; Hydrazones; Imidazoles; Leukemia L1210; Mice; Mice, Inbred Strains; Radiation Effects; Urea | 1971 |
Nucleic acids. 12. Synthesis of the L enantiomer of 1- -arabinofuranosylcytosine and of O 2 ,O 2' -anhydro-1- -D-arabinofuranosylcytosine.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinose; Cytarabine; Cytosine; Hemagglutination Tests; Immunosuppressive Agents; Leukemia L1210; Mice; Nucleosides; Stereoisomerism; Structure-Activity Relationship | 1971 |
Influence of mitotic cycle inhibitors on the antileukemic activity of cytosine arabinoside (NSC-63878) in mice bearing leukemia L1210.
Topics: Animals; Colchicine; Cytarabine; Depression, Chemical; DNA, Neoplasm; Drug Combinations; Drug Synergism; Female; Leukemia L1210; Male; Methylamines; Mice; Mice, Inbred Strains; Mitosis; Vinblastine | 1971 |
The treatment of acute lymphocytic leukemia.
Topics: Animals; Antineoplastic Agents; Asparaginase; Blood Platelets; Bone Marrow Cells; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Models, Animal; Drug Synergism; Hemorrhage; Humans; Infections; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Mice; Prednisone; Prognosis; Thrombocytopenia; Vincristine | 1970 |
Synthesis of 1-beta-L-arabinofuranosylcytosine, the enantiomer of cytosine arabinoside.
Topics: Animals; Cytarabine; Furans; Leukemia L1210; Neoplasms, Experimental; Osteosarcoma; Stereoisomerism | 1971 |
Advances in the chemotherapy of acute leukemia.
Topics: Adult; Animals; Blood Platelets; Blood Transfusion; Carbenicillin; Child; Cyclophosphamide; Cytarabine; Folic Acid Antagonists; Glucocorticoids; Humans; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Nitrogen Mustard Compounds; Patient Isolators; Purines; Remission, Spontaneous | 1970 |
Sequential chemotherapy with cyclophosphamide (NSC-26271) and cytosine arabinoside (NSC-63878) in mice with advanced leukemia L1210.
Topics: Animals; Cyclophosphamide; Cytarabine; Leukemia L1210; Male; Mice | 1969 |
Effect of combined therapy with cytosine arabinoside (NSC-63878) and l,3-bis-(2-chloroethyl)-1-nitrosourea (NSC-409962) on sarcoma 180 and L1210 in vivo.
Topics: Animals; Cytarabine; DNA, Neoplasm; Drug Synergism; Female; Leukemia L1210; Mice; Neoplasms, Experimental; Nitroso Compounds; Sarcoma, Experimental; Thymidine; Time Factors; Tritium; Urea | 1969 |
Response to therapy of spontaneous, first passage, and long passage lines of AK leukemia.
Topics: Age Factors; Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Leukemia L1210; Leukemia, Experimental; Lymphoma; Mice; Time Factors; Vincristine | 1969 |
Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: nucleoside and nucleotide kinases in cell-free extracts.
Topics: Animals; Carbon Isotopes; Cell-Free System; Chromatography; Chromatography, Paper; Chromatography, Thin Layer; Cytarabine; Leukemia L1210; Mice; Nucleosides; Nucleotides; Phosphotransferases; Spectrophotometry; Tritium | 1970 |
Nucleosides. LXIV. Fluoro sugar analogs of arabinosyl- and xylosylcytosines.
Topics: Aminohydrolases; Animals; Culture Techniques; Cytarabine; Fluorine; Kidney; Leukemia L1210; Nucleosides; Swine | 1970 |
Antitumor effect of 1-beta-D-arabinofuranosylcytosine 5'-adamantoate (NSC 117614) in L1210 leukemic mice.
Topics: Animals; Chemical Phenomena; Chemistry; Cycloparaffins; Cytarabine; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia L1210; Mice | 1970 |
A computer model for tumor growth and chemotherapy, and its application to L1210 leukemia treated with cytosine arabinoside (NSC-63878).
Topics: Animals; Computers; Cytarabine; Disease Models, Animal; Drug Resistance; Kinetics; Leukemia L1210; Mice; Mitosis; Neoplasm Transplantation | 1970 |
Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Disease Models, Animal; DNA, Neoplasm; Fluorouracil; Half-Life; Hydroxyurea; In Vitro Techniques; Kinetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitrosourea Compounds; Thiosemicarbazones | 1970 |
Synthesis and anticancer activity of cytosine arabinoside 3-N-oxide (ara-C 3-N-oxide).
Topics: Animals; Chemical Phenomena; Chemistry; Cytarabine; Leukemia L1210; Oxides | 1971 |
Evaluation of antileukemic agents in advanced leukemia L1210 in mice. IX.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Leukemia L1210; Mercaptopurine; Methotrexate; Mice | 1971 |
Sparing action of uridine on the activity of arabinosylcytosine with normal and leukemic mice.
Topics: Animals; Chromatography; Cytarabine; Cytosine; Drug Synergism; Leukemia L1210; Male; Mice; Nucleosides; Spleen; Thymidine; Tritium; Uracil Nucleotides; Uridine | 1968 |
Nucleosides. XLVII. Synthesis of some N4-substituted derivarives of 1-beta-D-arabinofuranosylcytosine and -5-fluorocytosine.
Topics: Animals; Cytarabine; Cytosine; Fluorine; Leukemia L1210; Methods; Mice; Nucleosides; Pyrimidines; Spectrophotometry; Thiouracil; Ultraviolet Rays | 1968 |
Nucleosides. 48. Synthesis of 1-(5-deoxy-beta-D-arabinosyl)cytosine and related compounds.
Topics: Animals; Burkitt Lymphoma; Carbonates; Cytarabine; Humans; Leukemia L1210; Methods; Mice; Nucleosides; Sulfur; Thiouracil; Uracil | 1968 |
Effects of uracil derivatives on phosphorylation of arabinosylcytosine.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Cytarabine; Dialysis; In Vitro Techniques; Leukemia L1210; Magnesium; Mice; Nucleosides; Nucleotides; Oxidative Phosphorylation; Spleen; Tritium; Uracil Nucleotides; Uridine | 1968 |
Effects of 4,4'-diacetyl-diphenyl-urea-bis(guanylhydrazone) on leukemia L1210.
Topics: Animals; Antineoplastic Agents; Cytarabine; Drug Synergism; Female; Hydrazines; Injections, Intraperitoneal; Injections, Subcutaneous; Leukemia L1210; Male; Mice; Time Factors; Urea | 1968 |
Metabolism of 1-beta-D-arabinofuranosylcytosine in leukemia L1210: studies with intact cells.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Chromatography, Ion Exchange; Cytarabine; Cytosine Nucleotides; Leukemia L1210; Male; Mice; Nucleosides; Oxidative Phosphorylation; Phosphotransferases; Pyrimidines; Thymidine; Time Factors | 1968 |
Antitumor effect and mode of action of 1-beta-D-arabinofuranosylcytosine 5'-phosphate in leukemia L1210.
Topics: Animals; Antineoplastic Agents; Biological Transport, Active; Carbon Isotopes; Cytarabine; Leukemia L1210; Leukemia, Experimental; Male; Mice; N-Glycosyl Hydrolases | 1968 |
Some observations on the phosphorylation of cytosine arabinoside.
Topics: Animals; Cytarabine; Cytosine Nucleotides; Leukemia L1210; Mice; Nucleotides; Oxidative Phosphorylation; Phosphotransferases | 1968 |
Influence of route of administration on antileukemic activity of cytosine arabinoside (NSC-63878) in advanced leukemia L1210 in mice.
Topics: Animals; Cytarabine; Female; Injections; Leukemia L1210; Male; Mice | 1968 |
Transport of two non-metabolized nucleosides, deoxycytidine and cytosine arabinoside, in a sub-line of the L1210 murine leukemia.
Topics: Animals; Biological Transport; Cytarabine; Kinetics; Leukemia L1210; Mice; Nucleosides; Temperature; Tritium; Uranium | 1968 |
Immunosuppressive activity of methotrexate and arabinosyl cytosine in mice bearing L1210 leukaemia.
Topics: Animals; Cytarabine; Histocompatibility; Leukemia L1210; Methotrexate; Mice | 1968 |
Peroral therapy with cytosine arabinoside. Preliminary laboratory and clinical findings.
Topics: Aged; Animals; Bone Marrow; Colonic Neoplasms; Cricetinae; Cytarabine; Esophageal Neoplasms; Humans; Leukemia L1210; Male; Middle Aged; Neoplasms, Experimental; Rectal Neoplasms; Stomach Neoplasms | 1968 |
Biochemical and genetic studies of a mutant strain of mouse leukemia L1210 resistant to 1-beta-D-arabinofuranosylcytosine (Cytarabine).
Topics: Animals; Culture Techniques; Cytarabine; Leukemia L1210; Mice; Mutation; Nucleosides; Nucleotides; Phosphotransferases; Thymidine; Tritium | 1969 |
Reduction in the frequency of mutation to resistance to cytarabine in L1210 murine leukemic cells by treatment with quinacrine hydrochloride.
Topics: Animals; Cytarabine; Leukemia L1210; Mice; Mutation; Quinacrine | 1969 |
Chemotherapy of leukemia L1210 in mice with 1-beta-D-arabinofuranosylcytosine hydrochloride. II. Effectiveness against intracerebrally and subcutaneously inoculated leukemic cells.
Topics: Animals; Cytarabine; Leukemia L1210; Mice | 1966 |
Chemotherapy of leukemia L1210 in mice with 1-beta-d-arabinofuranosylcytosine hydrochloride. I. Influence of treatment schedules.
Topics: Animals; Antineoplastic Agents; Cytarabine; Leukemia L1210; Methotrexate; Mice | 1966 |
Isolation and antileukemic activity, in mice, of 1-beta-D-arabinofuranosylcytosine 5'-phosphate present in synthetic 5'-cytidylic acid.
Topics: Animals; Borates; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Cytarabine; Cytosine Nucleotides; Leukemia L1210; Male; Mice; Oxidative Phosphorylation | 1966 |