cytarabine and Encephalopathy, Toxic

cytarabine has been researched along with Encephalopathy, Toxic in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's0 (0.00)18.2507
2000's10 (40.00)29.6817
2010's12 (48.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Huitema, ADR; Otten, HM; Verkerk, K1
Khodadoost, A; Kiani, A; Nik, SH; Pourahmad, J; Salimi, A1
Englander, EW; Gorgun, MF; Zhuo, M1
Dotson, JL; Jamil, MO1
Chen, J; Ngo, D; Rosenthal, J1
Morgensztern, D; Peddi, PF; Peddi, S; Santos, ES1
Ambrosetti, A; Balzarotti, M; Binder, M; Cavalli, F; Cwynarski, K; Deckert, M; Fabbri, A; Ferrari, A; Ferreri, AJ; Finke, J; Fox, CP; Gørløv, JS; Hemmaway, C; Hertenstein, B; Hess, G; Illerhaus, G; Johnson, P; Keller, U; Krause, SW; Levis, A; Linton, KM; Panse, J; Pisani, F; Politi, LS; Ponzoni, M; Pukrop, T; Pulczynski, E; Reni, M; Rosée, PL; Roth, A; Rudà, R; Schmoll, HJ; Schorb, E; Stilgenbauer, S; Torri, V; Tucci, A; Zucca, E1
Abrahamsson, J; Åsberg, A; Grell, K; Harila-Saari, A; Heldrup, J; Jonsson, OG; Levinsen, M; Risteli, J; Schmiegelow, K; Taskinen, M; Vettenranta, K1
Bajwa, RPS; Gerhardt, CA; Hagedoorn, M; Keim, MC; Lehmann, V; Olshefski, RS; Tuinman, MA; Winning, AM1
Ehninger, G; Hiddemann, W; Illmer, T; Karsch, C; Kiani, A; Lindner, LH; Ostermann, H; Platzbecker, U; Schleyer, E; Würfel, M1
Cain, M; Cull, GM; Hackett, LP; Ilett, KF; Radeski, D1
Dürken, M; Karremann, M; Neumaier-Probst, E; von Komorowski, G1
Braunagel, D; Dransfeld, CL; Ehninger, G; Kramer, M; Mahlknecht, U; Schaich, M1
Chary, NR; Jena, G; Patel, RS; Rachamalla, M; Shera, FY; Tikoo, K1
Chamberlain, MC1
Dorgeret, S; Duval, M; Legrand, F; Saizou, C; Vilmer, E1
Jain, S; Kumari, S; Lal, V; Mahi, S; Malhotra, P; Varma, S1
Brevet, M; Damaj, G; Garidi, R; Gruson, B; Royer, B; Vaida, I1
Donadio, A; Dossa, D; Jean, R; Margueritte, G; Montoya, F; Navarro, M; Rieu, D1
Ito, M; Kamijo, A; Maruta, I; Mizuno, Y; Onishi, H; Onose, M; Saito, H; Yamada, T1
Hattori, N; Kawakami, K; Nakamaki, T; Nakashima, H; Saito, B; Tomoyasu, S; Usui, T1
Becker, A; Bode, U; Jaehde, U; Linnebank, M; Pels, H; Schlegel, U; Vezmar, S1
Hensley, ML; Larson, RA; Peterson, B; Schiffer, CA; Silver, RT; Szatrowski, TP1
Dastidar, P; Frey, H; Hietaharju, A; Honkaniemi, J; Kähärä, V; Kellokumpu-Lehtinen, P; Keskinen, L; Latvala, M; Ollikainen, J; Salonen, T; Vähämäki, L1
Brant, J; Nielsen, E1

Reviews

2 review(s) available for cytarabine and Encephalopathy, Toxic

ArticleYear
Central nervous system toxicities of chemotherapeutic agents.
    Expert review of anticancer therapy, 2014, Volume: 14, Issue:7

    Topics: Antineoplastic Agents; Central Nervous System Diseases; Cisplatin; Cytarabine; Fluorouracil; Humans; Ifosfamide; Methotrexate; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome; Vidarabine; Vincristine

2014
Chemotherapy-induced neurotoxicity: assessment and interventions for patients at risk.
    The American journal of nursing, 2002, Volume: 102 Suppl 4

    Topics: Antineoplastic Agents; Cisplatin; Cytarabine; Humans; Ifosfamide; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Nursing Assessment; Oncology Nursing; Paclitaxel; Vinca Alkaloids

2002

Trials

5 trial(s) available for cytarabine and Encephalopathy, Toxic

ArticleYear
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
    The Lancet. Haematology, 2016, Volume: 3, Issue:5

    Topics: Acute Kidney Injury; Anemia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy; Comparative Effectiveness Research; Cytarabine; Death, Sudden; Denmark; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Gastrointestinal Diseases; Germany; Heart Injuries; Hematopoietic Stem Cell Transplantation; Humans; Hyperglycemia; Induction Chemotherapy; Infections; Intraocular Lymphoma; Italy; Kaplan-Meier Estimate; Lymphoma, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Mucositis; Neurotoxicity Syndromes; Neutropenia; Optic Nerve Neoplasms; Poisoning; Radiotherapy, Adjuvant; Remission Induction; Rituximab; Stroke; Switzerland; Thiotepa; Thrombocytopenia; Thrombosis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; United Kingdom

2016
Efficacy and Toxicity of Intrathecal Liposomal Cytarabine in First-line Therapy of Childhood Acute Lymphoblastic Leukemia.
    Journal of pediatric hematology/oncology, 2016, Volume: 38, Issue:8

    Topics: Adolescent; Child; Child, Preschool; Cytarabine; Dexamethasone; Disease-Free Survival; Female; Humans; Infant; Injections, Spinal; Liposomes; Maintenance Chemotherapy; Male; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Scandinavian and Nordic Countries

2016
The T_T genotype within the NME1 promoter single nucleotide polymorphism -835 C/T is associated with an increased risk of cytarabine induced neurotoxicity in patients with acute myeloid leukemia.
    Leukemia & lymphoma, 2012, Volume: 53, Issue:5

    Topics: Acetylcysteine; Adolescent; Adult; Aged; Apoptosis; Cytarabine; Female; Genotype; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neurons; Neurotoxicity Syndromes; NM23 Nucleoside Diphosphate Kinases; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Retrospective Studies; Survival Rate; Young Adult

2012
First-line autologous stem cell transplantation in primary CNS lymphoma.
    European journal of haematology, 2005, Volume: 75, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Immunocompetence; Lymphoma; Male; Melphalan; Middle Aged; Neurotoxicity Syndromes; Radiotherapy, Adjuvant; Recurrence; Remission Induction; Survival Rate; Transplantation, Autologous

2005
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
    International journal of clinical pharmacology and therapeutics, 2007, Volume: 45, Issue:9

    Topics: Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Brain Chemistry; Central Nervous System Neoplasms; Cytarabine; Excitatory Amino Acids; Female; Homocysteine; Humans; Injections, Intravenous; Injections, Intraventricular; Lymphoma; Male; Methotrexate; Middle Aged; Neurotoxicity Syndromes; Pilot Projects; S-Adenosylmethionine; Statistics, Nonparametric; Time Factors

2007

Other Studies

18 other study(ies) available for cytarabine and Encephalopathy, Toxic

ArticleYear
Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment.
    Cancer chemotherapy and pharmacology, 2022, Volume: 90, Issue:5

    Topics: Antineoplastic Agents; Asparaginase; Brain Diseases; Cisplatin; Cytarabine; Deoxycytidine; Fluorouracil; Gemcitabine; Humans; Hyperammonemia; Neurotoxicity Syndromes

2022
Trifluoperazine an Antipsychotic Drug and Inhibitor of Mitochondrial Permeability Transition Protects Cytarabine and Ifosfamide-Induced Neurotoxicity.
    Drug research, 2020, Volume: 70, Issue:6

    Topics: Animals; Antineoplastic Agents; Brain; Cells, Cultured; Cytarabine; Disease Models, Animal; Humans; Ifosfamide; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Primary Cell Culture; Rats; Rats, Wistar; Reactive Oxygen Species; Trifluoperazine

2020
Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function.
    Free radical biology & medicine, 2018, Volume: 121

    Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Cytarabine; DNA Damage; DNA, Mitochondrial; Ganglia, Spinal; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurotoxicity Syndromes; Signal Transduction

2018
Successful treatment of cytarabine-related neurotoxicity with corticosteroids, a case series.
    International journal of hematology, 2018, Volume: 108, Issue:5

    Topics: Adrenal Cortex Hormones; Adult; Aged; Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Neurotoxicity Syndromes

2018
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:8

    Topics: Adult; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Cytarabine; Humans; Hydrocortisone; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2019
Psychosexual development and satisfaction in long-term survivors of childhood cancer: Neurotoxic treatment intensity as a risk indicator.
    Cancer, 2017, 05-15, Volume: 123, Issue:10

    Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Case-Control Studies; Cranial Irradiation; Cytarabine; Female; Humans; Injections, Spinal; Leukemia; Lymphoma; Male; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Orgasm; Personal Satisfaction; Psychosexual Development; Reproductive Health; Risk Factors; Sexual Partners; Surveys and Questionnaires; Survivors; Thiotepa; Young Adult

2017
AraU accumulation in patients with renal insufficiency as a potential mechanism for cytarabine neurotoxicity.
    International journal of hematology, 2008, Volume: 88, Issue:4

    Topics: Aged; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Cytarabine; Female; Half-Life; Humans; Kidney Failure, Chronic; Leukemia, Myeloid, Acute; Male; Middle Aged; Neurotoxicity Syndromes

2008
Effective clearance of Ara-U the major metabolite of cytosine arabinoside (Ara-C) by hemodialysis in a patient with lymphoma and end-stage renal failure.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:4

    Topics: Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Chromatography, High Pressure Liquid; Cytarabine; Female; Humans; Kidney Failure, Chronic; Lymphoma, Mantle-Cell; Middle Aged; Neurotoxicity Syndromes; Renal Dialysis

2011
[Hemiparesis in acute lymphoblastic leukemia].
    Der Radiologe, 2010, Volume: 50, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Cytarabine; Diffusion Magnetic Resonance Imaging; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Injections, Spinal; Methotrexate; Neurologic Examination; Neurotoxicity Syndromes; Paresis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

2010
Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations.
    Toxicology, 2012, Mar-11, Volume: 293, Issue:1-3

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Behavior, Animal; Calbindins; Caspase 3; Cerebellum; Cytarabine; DNA Damage; Dose-Response Relationship, Drug; Histones; Male; Nerve Tissue Proteins; Neurotoxicity Syndromes; Organ Size; Oxidative Stress; Psychomotor Performance; Purkinje Cells; Random Allocation; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Tumor Suppressor Protein p53

2012
Neurotoxicity of intra-CSF liposomal cytarabine (DepoCyt) administered for the treatment of leptomeningeal metastases: a retrospective case series.
    Journal of neuro-oncology, 2012, Volume: 109, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Cytarabine; Disease Progression; Female; Follow-Up Studies; Humans; Injections, Spinal; Liposomes; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Middle Aged; Neoplasm Staging; Neoplasms; Neurotoxicity Syndromes; Prognosis; Prospective Studies; Retrospective Studies

2012
Cerebellar herniation after intrathecal chemotherapy including cytosine arabinoside in a boy with T acute lymphoblastic leukemia.
    Leukemia, 2002, Volume: 16, Issue:12

    Topics: Antineoplastic Agents; Child; Cytarabine; Encephalocele; Humans; Injections, Spinal; Leukemia-Lymphoma, Adult T-Cell; Male; Neurotoxicity Syndromes; Radiography

2002
Cytarabine-induced neurotoxicity responding to methyl prednisolone.
    American journal of hematology, 2004, Volume: 77, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Cytarabine; Fatal Outcome; Female; Humans; Injections, Intravenous; Leukemia, Myeloid, Acute; Methylprednisolone; Neurotoxicity Syndromes

2004
[Subacute encephalopathy of early onset during treatment of relapse of lymphoblastosis in a young infant].
    Annales de pediatrie, 1977, Volume: 24, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Atrophy; Brain; Cerebellum; Cerebral Ventricles; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Epilepsy; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Neurotoxicity Syndromes; Paraventricular Hypothalamic Nucleus; Recurrence; Remission Induction

1977
Conversion disorder with convulsion and motor deficit mimicking the adverse effects of high-dose Ara-C treatment in a posttransplant acute myeloid leukemia patient: a case report and review of the literature.
    Palliative & supportive care, 2004, Volume: 2, Issue:1

    Topics: Acute Disease; Adult; Antimetabolites, Antineoplastic; Bone Marrow Transplantation; Conversion Disorder; Cytarabine; Diagnosis, Differential; Female; Humans; Leukemia, Myeloid; Neurotoxicity Syndromes; Psychomotor Performance; Seizures

2004
Reversible posterior leukoencephalopathy syndrome after repeat intermediate-dose cytarabine chemotherapy in a patient with acute myeloid leukemia.
    American journal of hematology, 2007, Volume: 82, Issue:4

    Topics: Antimetabolites, Antineoplastic; Brain Diseases; Cytarabine; Drug Hypersensitivity; Humans; Leukemia, Monocytic, Acute; Male; Middle Aged; Neurotoxicity Syndromes; Syndrome

2007
Risk factors for severe neuropsychiatric toxicity in patients receiving interferon alfa-2b and low-dose cytarabine for chronic myelogenous leukemia: analysis of Cancer and Leukemia Group B 9013.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Cohort Studies; Cytarabine; Female; Humans; Interferon alpha-2; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Logistic Models; Male; Mental Disorders; Middle Aged; Multivariate Analysis; Neurotoxicity Syndromes; Recombinant Proteins; Regression Analysis; Risk Factors

2000
Reversible posterior leukoencephalopathy after combination chemotherapy.
    Neuroradiology, 2000, Volume: 42, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Injections, Spinal; Leukocytes; Magnetic Resonance Imaging; Neurotoxicity Syndromes; Steroids

2000