cysteinylglycine and Myocardial-Ischemia

Oxidative stress plays a role in the progression of chronic heart failure (CHF), but whether and how ischaemic heart disease (IHD) or non-IHD aetiology may account for differential redox alterations is currently unclear. We assessed the relation between thiol redox state and lipid peroxidation, as a marker of oxidative stress, in patients with CHF of ischaemic or non-ischaemic origin.. Blood reduced glutathione, plasma total and reduced cysteine, cysteinylglycine, homocysteine, glutathione, plasma alpha-tocopherol, ascorbic acid, and free malondialdehyde were assessed in 43 CHF heart transplant candidates (24 IHD and 19 non-IHD) and 30 controls matched for age, gender and number of atherosclerotic risk factors.. Reduced cysteine was increased in CHF patients compared with controls. The highest levels were found in IHD versus non-IHD patients versus controls. Malondialdehyde levels were significantly higher in IHD patients than in controls, whereas antioxidant vitamins did not differ among the three groups.. Specific abnormalities in the thiol pattern are associated with heart failure aetiology in CHF patients. Our findings point to the possible role of reduced cysteine in the progression of chronic IHD to heart failure status, as an additional pro-oxidant stimulus for worsening oxidative stress.

Topics: Aged; alpha-Tocopherol; Ascorbic Acid; Biomarkers; Case-Control Studies; Chronic Disease; Cysteine; Dipeptides; Disease Progression; Female; Glutathione; Heart Failure; Homocysteine; Humans; Lipid Peroxidation; Male; Malondialdehyde; Middle Aged; Myocardial Ischemia; Oxidation-Reduction; Oxidative Stress; Research Design; Sulfhydryl Compounds

The objective of this study was to examine the relation between hyperhomocysteinaemia and ischemic heart disease in a cohort of Sri Lankan patients with ischemic heart disease.. Serum homocysteine, cysteine and cysteinylglyceine were measured in 54 patients with a definite diagnosis of ischemic heart disease and compared with those of an age and sex matched control group.. Patients with coronary ischaemia had significantly higher mean concentrations of homocysteine and its metabolite cysteine (P<0.01). Of the 54 patients with ischemic heart disease 14 (35%) had fasting homocysteine concentrations above the 90th percentile of the controls (odds ratio 3.2, 95% CL 1.0-11.3).. Hyperhomocysteinaemia is associated with a three fold increase in coronary risk.

Topics: Adult; Aged; Causality; Cohort Studies; Cysteine; Dipeptides; Female; Homocysteine; Humans; Male; Middle Aged; Myocardial Ischemia; Odds Ratio; Reference Values; Risk Factors; Sri Lanka