cysteine has been researched along with Parkinson Disease in 131 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.53) | 18.7374 |
| 1990's | 20 (15.27) | 18.2507 |
| 2000's | 55 (41.98) | 29.6817 |
| 2010's | 38 (29.01) | 24.3611 |
| 2020's | 16 (12.21) | 2.80 |
| Authors | Studies |
|---|---|
| Atieh, TB; Baum, J; Hoop, CL; Roth, J; Yang, X | 1 |
| Dey, AK; Kumar, R; Kumari, R; Maiti, TK; Saha, S | 1 |
| Correia, MAS; Gallardo, E; Gonçalves, AM; Oliveira, AE; Oliveira, DM; Passarinha, LA; Pedro, AQ; Queiroz, JA; Romão, MJ; Santos, MFA | 1 |
| Dairou, J; Galardon, E; Le Corre, L; Mathas, N; Padovani, D; Poncet, G | 1 |
| Coen, M; Foster, E; Martins, LM; Michopoulos, F; Popovic, R; Travaglio, M; Yu, Y | 1 |
| Dijkstra, JM; Ito, S; Nagatsu, T; Nakashima, A; Riederer, P; Wakamatsu, K; Watanabe, H; Wulf, M; Youdim, M; Zecca, L; Zucca, FA | 1 |
| Campos-Peña, V; Corona-Trejo, A; Daniel Reyes-Hernández, O; Figueroa-González, G; Gonsebatt, ME; Hernández-Abad, VJ; Quintas-Granados, LI; Silva-Adaya, D; Trejo-Solis, C; Villegas-Vázquez, EY | 1 |
| Aoyama, K; Matsumura, N | 1 |
| Chohan, K; Farzam, A; Hewitt, SJ; Özcelik, D; Park, DS; Pezacki, JP; Strmiskova, M | 1 |
| Galesic, A; Pratt, MR | 1 |
| Goldman, A; Liu, Y; Ribeiro, OC; Robinson, J | 1 |
| Abe, K; Morihara, R; Ohta, Y; Omote, Y; Tadokoro, K; Takemoto, M; Yamashita, T | 1 |
| Belaidi, AA; Lei, P; Li, H; Tuo, QZ; Xu, S; Yan, HF; Zou, T | 1 |
| Baerenfaller, K; Bedacht, J; Biniossek, ML; Fröhlich, K; Gensch, N; Kern, U; Schilling, O; Schmidt, N | 1 |
| Butler, NJM; Fong, R; Ghosh, S; Huynh, A; Manfredsson, FP; Moss, A; Pan, J; Sanchez, J; Swanson, RA; Wang, J; Won, SJ; Wong, C; Wu, L | 1 |
| Gan, Y; Jiang, H; Li, H; Liu, M; Yao, S; Yin, G; Yin, P; Yu, T; Zhang, Y | 1 |
| Ernst, L; Giesert, F; Glasl, L; Hölter, SM; Piccoli, G; Stautner, C; Vogt Weisenhorn, DM; Wurst, W; Zerle, J; Zimprich, A | 1 |
| Saito, Y | 1 |
| Caaveiro, JMM; Hoang, QQ; Liu, D; Matsuda, N; Nagatoishi, S; Nakakido, M; Tamura, Y; Tanabe, A; Tashiro, S; Tsumoto, K | 1 |
| Baizhumanov, T; Khassenov, B; Minor, W; Mussakhmetov, A; Nugmanova, R; Shabalin, IG; Shumilin, IA; Toibazar, D; Utepbergenov, D | 1 |
| Chen, R; Gao, G; He, M; Li, J; Sun, T; Wang, L | 1 |
| Mitchell, SC; Rawlings, L; Steventon, GB; Turton, L | 1 |
| Huffer, KE; Lacy, SM; Lee, JC; McGlinchey, RP; Sidransky, E; Tayebi, N | 1 |
| Joe, EH; Jou, I; Kim, JS; Kim, KS; Park, JY; Park, SM; Suh, YH | 1 |
| Moody, PC; Møller, SG; Odell, M; Patel, NA; Puno, MR; Robinson, CV | 1 |
| Muhlack, S; Müller, T | 2 |
| Godse, RD; Nair, HA; Wasnik, MN | 1 |
| Bisaglia, M; Bubacco, L; Cendron, L; Girotto, S; Mammi, S; Tessari, I; Zanotti, G | 1 |
| Ahmad, F; Durgadoss, L; Nidadavolu, P; Ravindranath, V | 1 |
| Caldwell, GA; Chen, SG; Johnson, WM; Mieyal, JJ; Siedlak, SL; Wang, W; Wilson-Delfosse, AL; Yao, C; Zhu, X | 1 |
| Barthelmes, J; Laffleur, F; Wagner, J | 1 |
| Lee, JC; McGlinchey, RP | 1 |
| Iwawaki, T; Kaneko, Y; Konishi, A; Lipton, SA; Nakamura, T; Nakato, R; Ohkubo, Y; Shibata, M; Uehara, T | 1 |
| Martínez-Banaclocha, M | 1 |
| Berbellini, A; Cozzolino, V; De Michele, G; Gobbato, R; Manca, A; Paci, C; Peluso, S; Pianese, L; Ragno, M; Sanguigni, S | 1 |
| Mueller, BK; Muhlack, S; Müller, T; Trommer, I | 1 |
| Chen, SG; Choe, K; Curran, PL; Golczak, M; Johnson, WM; Lin, J; Mieyal, JJ; Milkovic, NM; Miller, OG; Ravindranath, V; Ray, A; Wang, W; Wilson, MA; Wilson-Delfosse, AL; Yao, C; Zhu, X | 1 |
| Akazawa-Ogawa, Y; Fujimura, H; Hagihara, Y; Hamakubo, T; Hara, Y; Hisahara, S; Itoh, S; Kobayashi, M; Kusunoki, S; Matsumura, A; Mita, Y; Noguchi, N; Saigoh, K; Saito, Y; Shichiri, M; Shimohama, S; Sutou, K; Takamatsu, H; Yoshida, Y | 1 |
| Haining, RL; Hernandez, A; Jones, TM | 1 |
| Capriati, V; Dimiccoli, V; Mandracchia, D; Maqoud, F; Mele, A; Scilimati, A; Tolomeo, A; Trapani, A; Trapani, G; Tricarico, D; Vitale, P | 1 |
| Bardien, S; Carr, J; Keyser, R; Lombard, D; Yako, Y | 1 |
| Hasim, S; Lakshminarasimhan, M; Pozharski, E; Remington, BC; Wilson, MA; Witt, AC | 1 |
| Cannas, A; Corongiu, D; Cuccu, S; Floris, G; Marrosu, F; Marrosu, MG; Murru, MR; Rolesu, M; Sardu, C; Solla, P; Tranquilli, S | 1 |
| Antonini, A; Canesi, M; Cilia, R; De Gaspari, D; Isaias, IU; Marotta, G; Pezzoli, G; Siri, C | 1 |
| Ahmad, R; Blackinton, J; Cookson, MR; Greggio, E; Lakshminarasimhan, M; Raza, AS; Thomas, KJ; Wilson, MA | 1 |
| Ascherio, A; Gao, X; Han, J; Schwarzschild, MA; Simon, KC | 1 |
| Kuhn, W; Müller, T | 1 |
| Cookson, MR; Fredenburg, RA; Grammatopoulos, TN; Lansbury, PT; Liu, Y; Liu, Z; Logan, T; Meray, RK | 1 |
| Cappai, R; Coleman, BM; Han, S; Hatters, DM; Hill, AF; Nisbet, RM | 1 |
| Elahi, E; Farboodi, N; Fazlali, Z; Ghazavi, F; Ghorashi, SA; Parsa, K; Ronaghi, M; Sadeghi, H; Shahidi, GA; Shojaee, S; Sina, F | 1 |
| Clark, L; Logan, T; Ray, SS | 1 |
| Cus, A; Garasević, Z; Jensterle, J; Kramberger, MG; Meglic, NP; Pirtosek, Z; Repovs, G; Stukovnik, V; Tomse, P | 1 |
| Bishop, C; Geddes, TJ; Jaunarajs, KL; Kuhn, DM; Sykes, CE | 1 |
| Andersen, JK; Danielson, SR; Gibson, BW; Held, JM; Oo, M; Riley, R | 1 |
| Chang, JY; Hong, DP; Jiang, C; Xiong, W | 1 |
| Sun, LL; Wang, ST; Yang, H; Yang, HM; Yuan, JF; Zhang, CG; Zhang, H; Zhu, JW | 1 |
| Abe, K; Deguchi, K; Deguchi, S; Ikeda, Y; Kametaka, S; Kurata, T; Manabe, Y; Morimoto, N; Ohta, T; Ohta, Y; Sato, S; Takao, Y | 1 |
| Cho, AR; Cho, JW; Ki, CS; Kim, HT; Kim, JS; Lee, WY; Shin, H | 1 |
| Camargos, ST; Cardoso, F; DiMauro, S; Gurgel-Giannetti, J; Hirano, M | 1 |
| Galván, I; Ghanem, G; Møller, AP | 1 |
| Ariga, H; Iguchi-Ariga, SM; Ishikawa, S; Niki, T; Takahashi-Niki, K; Tanaka, Y | 1 |
| Ariga, H; Iguchi-Ariga, SM; Kato, I; Maita, H; Noguchi, N; Saito, Y; Takahashi-Niki, K | 1 |
| Ariga, H; Iguchi-Ariga, SM; Maita, C; Maita, H | 1 |
| Antonini, A; Benti, R; De Notaris, R; Eidelberg, D; Feigin, A; Fukuda, M; Mentis, MJ; Moeller, JR; Pezzoli, G | 1 |
| Bosman, T; Santens, P; Van Laere, K | 1 |
| Berger, K; Holzmann, C; Krüger, R; Riess, O; Saecker, AM; Schmitt, I; Schöls, L | 1 |
| Collins, JL; Hod, Y; Petsko, GA; Ringe, D; Wilson, MA | 1 |
| Blom, HJ; Bosma, H; Bosmans, E; De Bruijn, C; de Vente, J; Delanghe, J; Lütjohann, D; Maes, M; Rieckmann, P; Steinbusch, HW; Teunissen, CE; van Boxtel, MP; Verbeek, MM; Verhey, F; von Bergmann, K; Vreeling, F; Wauters, A | 1 |
| Beyer, K; Görner, K; Haass, C; Holtorf, E; Kahle, PJ; Nuscher, B; Odoy, S; Regula, JT; Yamamoto, A | 1 |
| Bosman, T; De Reuck, J; Dierckx, R; Mortelmans, L; Santens, P; Van Laere, K | 1 |
| Kawai, M; Ogawa, M; Oishi, K; Oya, Y | 1 |
| Abeliovich, A; Jonason, A; Leete, T; Martinat, C; Shendelman, S | 1 |
| Kaji, R; Kawakami, H; Kuno, S; Nishimura, M | 1 |
| El Fakhri, G; Habert, MO; Kas, A; Kijewski, MF; Lacomblez, L; Maksud, P; Malek, Z | 1 |
| Chung, KK; Dawson, TM; Dawson, VL | 1 |
| Cookson, MR | 1 |
| Geffard, M; Lagroye, I; Salauze, L; van der Velden, C; Veyret, B | 1 |
| Casteels, C; De Ceuninck, L; Dom, R; Maes, A; Mortelmans, L; Van Laere, K; Vanbilloen, B; Vandenberghe, W; Verbruggen, A | 1 |
| Bulman, DE; Grimes, DA; Han, F; Panisset, M; Racacho, L; Westaff, K; Xiao, F; Zou, R | 1 |
| Gu, Z; Lipton, SA; Ma, Y; Masliah, E; Nakamura, T; Nomura, Y; Shi, ZQ; Uehara, T; Yao, D | 1 |
| Dzoljić, E; Kostić, V; Krajinović, M; Mirković, D; Nesić, Z; Novaković, I; Prostran, M; Stojanović, R; Todorović, Z | 1 |
| Ariga, H; Iguchi-Ariga, SM; Ooe, H | 1 |
| Bonini, NM; Ischiropoulos, H; Meulener, MC; Thompson, L; Thomson, L; Xu, K | 1 |
| Derenko, MV; Grzybowski, T; Malyarchuk, BA; Miścicka-Sliwka, D; Stopińska, K | 1 |
| Brockhuis, B; Derejko, M; Dubaniewicz, M; Lass, P; Sławek, J; Wieczorek, D | 1 |
| Eckert, T; Edwards, C; Eidelberg, D; Lewis, DE; Santens, P; Tang, C; Van Laere, K | 1 |
| Decary, A; Gravel, P; Massicotte-Marquez, J; Mazza, S; Michaud, M; Montplaisir, J; Postuma, R; Soucy, JP | 1 |
| Amboni, M; Barone, P; De Michele, G; Filla, A; Nobili, F; Pagani, M; Pappatà, S; Salmaso, D; Salvatore, E; Salvatore, M; Sansone, V; Varrone, A | 1 |
| Chojnacka, K; Dorszewska, J; Florczak, J; Jaroszewska-Kolecka, J; Kempisty, B; Kozubski, W; Rozycka, A; Trzeciak, WH | 1 |
| Andres-Mateos, E; Blanchard-Fillion, B; Dawson, TM; Dawson, VL; Greco, TM; Ischiropoulos, H; Ko, HS; Perier, C; Przedborski, S; Sasaki, M; Thomas, B; Zhang, L | 1 |
| Aleyasin, H; Bland, RJ; Callaghan, S; During, MJ; Kim, RH; Mak, TW; Park, DS; Phillips, M; Rousseaux, MW; Slack, RS | 1 |
| Cho, DH; Fang, J; Gu, Z; Lipton, SA; Nakamura, T | 1 |
| Brot, N; Haenold, R; Hansel, A; Heinemann, SH; Hoshi, T; Wassef, R | 1 |
| Chang, CC; Chang, WN; Chang, YY; Chen, SS; Lee, CH; Liu, JS | 1 |
| Antonini, A; Benti, R; Cilia, R; Gerundini, P; Isaias, IU; Landi, A; Marotta, G; Pezzoli, G; Sganzerla, E; Vergani, F | 1 |
| Chan, DK; Clarke, R; Fang, ZM; Hattori, N; Kwok, JB; Mok, V; Ng, PW; Schofield, PR; Wong, L; Yeung, J | 1 |
| Banerjee, R; Ciborowski, P; Garg, SK; Gendelman, HE; Glanzer, JG; Kadiu, I; Nordgren, T; Reynolds, AD | 1 |
| Aoki, S; Kabuta, T; Kinugawa, A; Mitsui, T; Sakurai, M; Setsuie, R; Uchida, K; Wada, K | 1 |
| Arosio, P; Biasiotto, G; Finazzi, D; Goldwurm, S; Pezzoli, G; Sironi, F; Tunesi, S; Zecchinelli, A | 1 |
| Benecke, R; Berg, D; Bonifati, V; Brown, L; Cras, P; De Deyn, PP; Engelborghs, S; Farrer, MJ; Foroud, T; Gaig, C; Gasser, T; Gibson, JM; Goldwurm, S; Guidi, M; Hagenah, J; Haugarvoll, K; Kachergus, JM; Klein, C; Nichols, WC; Nuytemans, K; Pals, P; Pickut, B; Rademakers, R; Riboldazzi, G; Ross, OA; Samii, A; Tan, EK; Theuns, J; Tolosa, E; Uitti, RJ; Van Broeckhoven, C; Walter, U; Wszolek, ZK; Zabetian, CP | 1 |
| Amend, D; Bell, IR; Kaszniak, AW; Miller, JW; Peterson, JM; Schwartz, GE; Selhub, J; Stini, WA | 1 |
| Ichikawa, Y; Iwahashi, K; Matsuo, Y; Takeuchi, H; Tsuneoka, Y | 1 |
| Dryhurst, G; Zhang, F | 1 |
| Greenberg, JH; Lassen, NA | 1 |
| Di Chiro, G; Miletich, RS; Quarantelli, M | 1 |
| Allain, P; Bagheri, H; Cordillet, E; Le Bouil, A; Le Quay, L; Montastruc, JL | 1 |
| Hastings, TG; Lewis, DA; Zigmond, MJ | 1 |
| Dryhurst, G; Shen, XM | 2 |
| Berger, W; Decristoforo, C; Donnemiller, E; Heilmann, J; Moncayo, R; Poewe, W; Ransmayr, G; Wenning, GK | 1 |
| Amarnath, V; Graham, DG; Montine, TJ; Picklo, MJ; Whetsell, WO | 1 |
| Friedman, MB; Snyder, RD | 1 |
| Daniel, SE; Halliwell, B; Jenner, P; Lees, AJ; Marsden, DC; Spencer, JP | 1 |
| Blom, H; Büttner, T; Kretschmer, A; Kuhn, W; Müller, T; Przuntek, H; Roebroek, R; van Oppenraaij, D; Woitalla, D | 1 |
| Autret, A; Baulieu, JL; Besnard, JC; Chartier, JR; Cottier, JP; Guilloteau, D; Levilion-Prunier, C; Pourcelot, L; Ribeiro, MJ; Tranquart, F | 1 |
| Ananda Inalsingh, V; Cammack, R; Hughes, MN; Shergill, JK | 1 |
| Ballinger, JR; Ichise, M; Ivo, BD; Vines, DC | 1 |
| Cheng, FC; Dryhurst, G; Han, J; Yang, Z | 1 |
| Imon, Y; Kogure, D; Matsuda, H; Ogawa, M; Sunohara, N | 1 |
| Hermida-Ameijeiras, A; Labandeira-Garcia, JL; Méndez-Alvarez, E; Muñoz-Patiño, AM; Soto-Otero, R | 1 |
| Kowa, H; Nakashima, K; Nakaso, K; Takeshima, T; Yasui, K | 1 |
| Hastings, TG; Lewis, DA; Rabinovic, AD | 1 |
| Caemaert, J; Dierckx, R; Ir, PL; Santens, P; van den Abbeele, D; van der Linden, C; van Laere, K; Vandewalle, V | 1 |
| Antonini, A; Benti, R; De Gaspari, D; De Notaris, R; Pezzoli, G | 1 |
| Amarnath, V; Montine, TJ; Olson, SJ; Ou, JJ; Sidell, KR; Zhang, Y | 1 |
| Burgunder, JM; Kinser, JA; Krauss, JK; Pohle, T; Ritter, EP; Wielepp, JP | 1 |
| Kim, JR; Kwon, KS; Lee, SR; Rhee, SG; Yoon, HW | 1 |
| Fearn, S; Heafield, MT; Steventon, GB; Sturman, SG; Waring, RH; Williams, AC | 1 |
| Gerstenbrand, F; Gründig, E; Oberhummer, J; Schedl, R; Simanyi, M; Weiss, J | 1 |
| Gerstenbrand, F; Gründig, E | 1 |
6 review(s) available for cysteine and Parkinson Disease
| Article | Year |
|---|---|
The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease.
Topics: Catecholamines; Cysteine; Dopaminergic Neurons; Humans; Melanins; Norepinephrine; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase | 2023 |
Transsulfuration pathway: a targeting neuromodulator in Parkinson's disease.
Topics: Cystathionine beta-Synthase; Cysteine; Glutathione; Humans; Parkinson Disease; Sulfur | 2023 |
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Acid Transporter 3; Glutathione; Humans; Neuroprotection; Neuroprotective Agents; Parkinson Disease; Purines; Receptor, Adenosine A2A; Theophylline; Uric Acid | 2023 |
Ferroptosis: mechanisms and links with diseases.
Topics: Alzheimer Disease; Apoptosis; Autophagy; Cysteine; Ferroptosis; Humans; Iron; Lipid Metabolism; Lipid Peroxidation; Neoplasms; Parkinson Disease; Reactive Oxygen Species | 2021 |
Cysteine Network (CYSTEINET) Dysregulation in Parkinson's Disease: Role of N-acetylcysteine.
Topics: Acetylcysteine; Aging; Amino Acid Transport System y+; Brain; Cysteine; Energy Metabolism; Glutathione; Homeostasis; Humans; Metabolic Networks and Pathways; Oxidation-Reduction; Parkinson Disease; Protein Processing, Post-Translational; Reactive Oxygen Species | 2016 |
Nitric oxide, S-nitrosylation and neurodegeneration.
Topics: Animals; Cysteine; Hemostasis; Humans; Neurodegenerative Diseases; Nitric Oxide; Nitric Oxide Synthase; Nitroso Compounds; Oxidation-Reduction; Oxidative Stress; Oxygen; Parkinson Disease; S-Nitrosothiols; Signal Transduction | 2005 |
9 trial(s) available for cysteine and Parkinson Disease
| Article | Year |
|---|---|
Levodopa increases oxidative stress and repulsive guidance molecule A levels: a pilot study in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Carbidopa; Chromatography, High Pressure Liquid; Cysteine; Dipeptides; Drug Combinations; Female; GPI-Linked Proteins; Humans; Levodopa; Male; Middle Aged; Nerve Tissue Proteins; Oxidative Stress; Parkinson Disease; Pilot Projects | 2016 |
Cysteine elevation in levodopa-treated patients with Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Antiparkinson Agents; Cohort Studies; Cysteine; Female; Glycine; Humans; Levodopa; Linear Models; Male; Middle Aged; Parkinson Disease; Severity of Illness Index | 2009 |
Anatomically standardised 99mTc-ECD brain perfusion SPET allows accurate differentiation between healthy volunteers, multiple system atrophy and idiopathic Parkinson's disease.
Topics: Brain; Cysteine; Diagnosis, Differential; Discriminant Analysis; Female; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Multiple System Atrophy; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Reference Standards; Reference Values; Subtraction Technique; Tomography, Emission-Computed, Single-Photon | 2003 |
Combination of serum markers related to several mechanisms in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; alpha 1-Antichymotrypsin; Alzheimer Disease; Analysis of Variance; Biomarkers; Chi-Square Distribution; Cholesterol; Cysteine; Female; Follow-Up Studies; Humans; Hydroxycholesterols; Interleukin-6; Logistic Models; Male; Middle Aged; Neurodegenerative Diseases; Parkinson Disease; Reference Values; Serum; Sterols | 2003 |
Statistical parametric mapping of (99m)Tc-ECD SPECT in idiopathic Parkinson's disease and multiple system atrophy with predominant parkinsonian features: correlation with clinical parameters.
Topics: Algorithms; Brain; Cysteine; Diagnosis, Differential; Female; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Multiple System Atrophy; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Tomography, Emission-Computed, Single-Photon | 2004 |
Quantitative simultaneous (99m)Tc-ECD/123I-FP-CIT SPECT in Parkinson's disease and multiple system atrophy.
Topics: Cysteine; Diagnosis, Differential; Feasibility Studies; Female; Humans; Image Enhancement; Male; Middle Aged; Multiple System Atrophy; Organotechnetium Compounds; Parkinson Disease; Radionuclide Imaging; Reproducibility of Results; Sensitivity and Specificity; Tropanes | 2006 |
Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Cysteine; Female; Homocysteine; Humans; Levodopa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Threonine; Time Factors | 2006 |
SPECT image analysis using statistical parametric mapping in patients with Parkinson's disease.
Topics: Adult; Aged; Brain; Brain Mapping; Cerebrovascular Circulation; Cysteine; Female; Humans; Male; Middle Aged; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Regional Blood Flow; Software; Tomography, Emission-Computed, Single-Photon | 1999 |
99Tc(m)-ECD SPET perfusion changes by internal pallidum stimulation in Parkinson's disease.
Topics: Adult; Aged; Brain Mapping; Cerebrovascular Circulation; Cysteine; Electric Stimulation; Electrodes; Female; Globus Pallidus; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon | 2000 |
116 other study(ies) available for cysteine and Parkinson Disease
| Article | Year |
|---|---|
DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein.
Topics: Acetylation; alpha-Synuclein; Cysteine; Glycation End Products, Advanced; Humans; Magnetic Resonance Spectroscopy; Neurons; Parkinson Disease; Protein Aggregation, Pathological; Protein Deglycase DJ-1; Protein Multimerization | 2021 |
S-Nitrosylation of OTUB1 Alters Its Stability and Ubc13 Binding.
Topics: Amyloid; Animals; Cysteine; Cysteine Endopeptidases; Mice; Nitric Oxide; Parkinson Disease; Protein Processing, Post-Translational; Rotenone; Ubiquitin-Conjugating Enzymes | 2022 |
Thermofluor-Based Optimization Strategy for the Stabilization of Recombinant Human Soluble Catechol-
Topics: Carboxy-Lyases; Catechol O-Methyltransferase; Catechols; Cysteine; Dopamine; Estrogens; Glycerol; Humans; Ionic Liquids; Levodopa; Metanephrine; Parkinson Disease; Trehalose | 2022 |
Persulfidation of DJ-1: Mechanism and Consequences.
Topics: Animals; Cysteine; Humans; Hydrogen Peroxide; Mammals; Oncogene Proteins; Oxidation-Reduction; Parkinson Disease; Protein Deglycase DJ-1 | 2022 |
Increased cysteine metabolism in PINK1 models of Parkinson's disease.
Topics: Animals; Cysteine; Drosophila melanogaster; Drosophila Proteins; Humans; Induced Pluripotent Stem Cells; Neural Stem Cells; Neurodegenerative Diseases; Parkinson Disease; Protein Kinases; Protein Serine-Threonine Kinases | 2023 |
A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death.
Topics: Animals; Cell Line; Cell Survival; Cycloaddition Reaction; Cysteine; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Female; Humans; Hydroxydopamines; Male; Mass Spectrometry; Mice; Oxidopamine; Parkinson Disease; Protein Disulfide-Isomerases; Proteomics; Sulfhydryl Compounds | 2020 |
Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein.
Topics: Acetylglucosamine; alpha-Synuclein; Cysteine; Escherichia coli; Esters; Gene Expression; Glycosylation; Humans; Parkinson Disease; Peptide Biosynthesis; Peptides; Plasmids; Protein Engineering; Recombinant Proteins; Solid-Phase Synthesis Techniques; Sulfhydryl Compounds; Threonine | 2020 |
Expression and purification of the extracellular domain of wild-type humanRET and the dimeric oncogenic mutant C634R.
Topics: Animals; Carcinogenesis; Cell Line; Cysteine; Disulfides; HEK293 Cells; Hirschsprung Disease; Humans; Mammals; Multiple Endocrine Neoplasia Type 2a; Mutation; Parkinson Disease; Protein Domains; Proto-Oncogene Proteins c-ret; Recombinant Proteins; Signal Transduction | 2020 |
Cerebral Microbleeds in Patients with Parkinson's Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99 mTc-ECD SPECT Subtraction Imaging.
Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Basal Ganglia; Cerebrovascular Circulation; Cysteine; Female; Glucose; Gyrus Cinguli; Humans; Intracranial Hemorrhages; Lewy Body Disease; Magnetic Resonance Angiography; Male; Mental Status and Dementia Tests; Mesencephalon; Neuropsychological Tests; Occipital Lobe; Organotechnetium Compounds; Parkinson Disease; Prevalence; Tomography, Emission-Computed, Single-Photon | 2021 |
Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells.
Topics: Cysteine; Humans; Lysosomes; Mutation; Neurons; Oxidative Stress; Parkinson Disease; Peptide Hydrolases; Protein Deglycase DJ-1; Proteome | 2021 |
α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.
Topics: alpha-Synuclein; Animals; Cysteine; Dopamine; Dopaminergic Neurons; Mice; Oxidation-Reduction; Parkinson Disease; Substantia Nigra | 2021 |
Direct Quantification and Visualization of Homocysteine, Cysteine, and Glutathione in Alzheimer's and Parkinson's Disease Model Tissues.
Topics: Alzheimer Disease; Animals; Cysteine; Fluorescent Dyes; Glutathione; HeLa Cells; Homocysteine; Humans; Mice; Parkinson Disease | 2021 |
The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Topics: Animals; Arginine; Cysteine; Disease Models, Animal; Exploratory Behavior; Gait; Genotype; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Transgenic; Motor Activity; Parkinson Disease; Point Mutation; Prodromal Symptoms; Recognition, Psychology; Smell; Swimming; Synaptophysin; Synaptotagmin I; Tyrosine 3-Monooxygenase | 2017 |
DJ-1 as a Biomarker of Parkinson's Disease.
Topics: Animals; Biomarkers; Brain; Cysteine; Early Diagnosis; Humans; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Deglycase DJ-1 | 2017 |
Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1.
Topics: Crystallography, X-Ray; Cysteine; Drug Discovery; HEK293 Cells; HeLa Cells; Humans; Molecular Docking Simulation; Parkinson Disease; Protein Conformation; Protein Deglycase DJ-1; Small Molecule Libraries | 2018 |
A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1.
Topics: Catalytic Domain; Chromatography; Cysteine; Humans; Mutation; Parkinson Disease; Protein Binding; Protein Deglycase DJ-1; Protein Domains; Protein Processing, Post-Translational; Temperature | 2018 |
Gold nanoclusters for Parkinson's disease treatment.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Cysteine; Disease Models, Animal; Gold; Male; Mice, Inbred C57BL; Nanoparticles; Parkinson Disease; PC12 Cells; Rats | 2019 |
Drug S-oxidation and phenylalanine hydroxylase: a biomarker for neurodegenerative susceptibility in Parkinson's disease and amyotrophic lateral sclerosis.
Topics: Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Biotransformation; Cysteine; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Parkinson Disease; Phenotype; Phenylalanine Hydroxylase; Polymorphism, Genetic; Young Adult | 2019 |
C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.
Topics: alpha-Synuclein; Amyloid; Animals; Cathepsin B; Cathepsin L; Cysteine; Dopaminergic Neurons; Humans; Lysosomes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Parkinson Disease; Protein Aggregation, Pathological; Rats | 2019 |
DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes.
Topics: Animals; Astrocytes; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cysteine; Endocytosis; Humans; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Lipoylation; Membrane Microdomains; Mice, Knockout; Microtubule-Associated Proteins; Oncogene Proteins; Parkinson Disease; Peroxiredoxins; Protein Deglycase DJ-1; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptors | 2013 |
Structure of Cu(I)-bound DJ-1 reveals a biscysteinate metal binding site at the homodimer interface: insights into mutational inactivation of DJ-1 in Parkinsonism.
Topics: Binding Sites; Copper; Crystallography, X-Ray; Cysteine; Humans; Intracellular Signaling Peptides and Proteins; Mass Spectrometry; Metals; Models, Molecular; Mutation; Oncogene Proteins; Parkinson Disease; Protein Conformation; Protein Deglycase DJ-1; Spectrometry, Mass, Electrospray Ionization; Superoxide Dismutase; Superoxide Dismutase-1 | 2013 |
Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson's disease patients.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase; Catechols; Chromatography, Reverse-Phase; Cysteine; Dipeptides; Drug Delivery Systems; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Nitriles; Parkinson Disease; Time Factors | 2014 |
Development and evaluation of buccoadhesive tablet for selegiline hydrochloride based on thiolated polycarbophil.
Topics: Acrylic Resins; Administration, Buccal; Animals; Antiparkinson Agents; Cell Line; Chemistry, Pharmaceutical; Cysteine; Delayed-Action Preparations; Humans; Mice; Monoamine Oxidase Inhibitors; Oral Mucosal Absorption; Parkinson Disease; Selegiline; Tablets; Tensile Strength | 2014 |
DJ-1 is a copper chaperone acting on SOD1 activation.
Topics: Amyotrophic Lateral Sclerosis; Binding Sites; Copper; Crystallography, X-Ray; Cysteine; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Intracellular Signaling Peptides and Proteins; Models, Molecular; Molecular Chaperones; Oncogene Proteins; Oxidative Stress; Parkinson Disease; Peroxiredoxins; Protein Binding; Protein Conformation; Protein Deglycase DJ-1; Spectrometry, Fluorescence; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases.
Topics: Acetylcysteine; Animals; Calmodulin; Cell Line, Tumor; Cell Survival; Cysteine; Down-Regulation; Glutaredoxins; Humans; Mice; Mutagenesis, Site-Directed; Mutation; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Protein Disulfide Reductase (Glutathione); Protein Phosphatase 2; Proteolysis; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Caenorhabditis elegans; Cell Survival; Cysteine; Disease Models, Animal; Dopaminergic Neurons; Evolution, Molecular; Gene Expression Regulation; Glutaredoxins; Helminth Proteins; Homeostasis; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mesencephalon; Oxidative Stress; Parkinson Disease; Phenotype; Protein Serine-Threonine Kinases; RNA, Messenger; Tyrosine 3-Monooxygenase | 2015 |
A potential tailor-made hyaluronic acid buccal delivery system comprising rotigotine for Parkinson's disease?
Topics: Administration, Buccal; Cell Line; Cysteine; Delayed-Action Preparations; Dopamine Agonists; Humans; Hyaluronic Acid; Parkinson Disease; Sulfhydryl Compounds; Tetrahydronaphthalenes; Thiophenes | 2015 |
Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
Topics: alpha-Synuclein; Animals; Brain; Cathepsin B; Cathepsin D; Cathepsin L; Chromatography, Liquid; Circular Dichroism; Cysteine; Humans; Liver; Lysosomes; Mass Spectrometry; Mice; Neurodegenerative Diseases; Parkinson Disease; Peptide Mapping; Peptides; Phospholipids | 2015 |
Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress.
Topics: Amino Acid Substitution; Animals; Cell Death; Cell Line; Cell Line, Tumor; Cysteine; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Endoribonucleases; Eukaryotic Initiation Factor-2; Fibroblasts; Mice; Models, Biological; Mutagenesis, Site-Directed; Neurons; Nitric Oxide; Parkinson Disease; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Serine; Signal Transduction; Unfolded Protein Response | 2015 |
Parkinsonism in a pair of monozygotic CADASIL twins sharing the R1006C mutation: a transcranial sonography study.
Topics: Aged; Arginine; CADASIL; Cysteine; Humans; Male; Mutation; Parkinson Disease; Receptor, Notch3; Twins, Monozygotic; Ultrasonography, Doppler, Transcranial | 2016 |
Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Cell Line, Tumor; Cysteine; Glutaredoxins; Glutathione; Humans; Mice; Parkinson Disease; Protein Deglycase DJ-1; Protein Processing, Post-Translational | 2016 |
Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients.
Topics: Aged; Animals; Cysteine; Disease Models, Animal; Erythrocytes; Female; Humans; Levodopa; Macaca fascicularis; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Protein Deglycase DJ-1; Protein Multimerization | 2016 |
Saturation Binding of Nicotine to Synthetic Neuromelanin Demonstrated by Fluorescence Spectroscopy.
Topics: Caffeine; Cysteine; Dopamine; Iron; Melanins; Nicotine; Oxidopamine; Parkinson Disease; Polymerization; Spectrometry, Fluorescence | 2016 |
A novel injectable formulation of 6-fluoro-l-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson's disease.
Topics: Animals; beta-Cyclodextrins; Cell Line, Tumor; Chemistry, Pharmaceutical; Cysteine; Dihydroxyphenylalanine; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Neuroblastoma; Neuroendocrine Tumors; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Wistar | 2017 |
Molecular analysis of the parkin gene in South African patients diagnosed with Parkinson's disease.
Topics: Adolescent; Adult; Aged; Arginine; Asparagine; Aspartic Acid; Cysteine; DNA Mutational Analysis; Exons; Female; Gene Frequency; Heterozygote; Humans; Male; Middle Aged; Parkinson Disease; Point Mutation; Sequence Deletion; South Africa; Ubiquitin-Protein Ligases; Young Adult | 2009 |
Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Topics: Crystallization; Cysteine; Databases, Genetic; Glutamic Acid; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Intracellular Signaling Peptides and Proteins; Models, Molecular; Oncogene Proteins; Oxidative Stress; Parkinson Disease; Protein Conformation; Protein Deglycase DJ-1; Recombinant Proteins; X-Ray Diffraction | 2008 |
Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arginine; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glycine; Humans; Italy; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Parkinson Disease; Population Groups; Protein Serine-Threonine Kinases; Serine; Tomography, Emission-Computed, Single-Photon | 2009 |
Functional abnormalities underlying pathological gambling in Parkinson disease.
Topics: Aged; Brain; Brain Mapping; Case-Control Studies; Cysteine; Female; Functional Laterality; Gambling; Humans; Male; Middle Aged; Neuropsychological Tests; Organotechnetium Compounds; Parkinson Disease; Retrospective Studies; Tomography, Emission-Computed, Single-Photon | 2008 |
Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.
Topics: Amino Acid Substitution; Animals; Cell Line, Tumor; Cysteine; Genetic Diseases, Inborn; Glutamic Acid; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mitochondrial Proteins; Mutation; Oncogene Proteins; Oxidation-Reduction; Parkinson Disease; Protein Deglycase DJ-1; Sulfinic Acids | 2009 |
Genetic determinants of hair color and Parkinson's disease risk.
Topics: Adolescent; Age Factors; Arginine; Case-Control Studies; Cysteine; Female; Follow-Up Studies; Genetic Determinism; Genotype; Hair Color; Humans; Male; Parkinson Disease; Polymorphism, Genetic; Receptor, Melanocortin, Type 1; Retrospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Young Adult | 2009 |
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Topics: alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Cell Membrane; Chlorocebus aethiops; COS Cells; Cysteine; Endoplasmic Reticulum; Humans; Intracellular Membranes; Methionine; Mice; Neurons; Parkinson Disease; Prenylation; Proteasome Endopeptidase Complex; Protein Binding; Ubiquitin Thiolesterase | 2009 |
Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence.
Topics: Alzheimer Disease; Animals; Cysteine; Fluoresceins; Fluorescence; Huntington Disease; Luminescent Measurements; Mice; Neurodegenerative Diseases; Organometallic Compounds; Parkinson Disease; Prion Diseases; Protein Folding; Protein Structure, Secondary; PrPC Proteins; Recombinant Proteins | 2009 |
A clinic-based screening of mutations in exons 31, 34, 35, 41, and 48 of LRRK2 in Iranian Parkinson's disease patients.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Arginine; Child; Cysteine; DNA Mutational Analysis; Exons; Female; Genetic Testing; Humans; Iran; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Parkinson Disease; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Young Adult | 2009 |
Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease.
Topics: alpha-Synuclein; Cysteine; Genetic Diseases, Inborn; Humans; Intracellular Signaling Peptides and Proteins; Molecular Chaperones; Mutation; Oncogene Proteins; Parkinson Disease; Protein Deglycase DJ-1; Protein Structure, Tertiary; Proteins | 2010 |
Parkinson's disease dementia: clinical correlates of brain spect perfusion and treatment.
Topics: Aged; Antiparkinson Agents; Atrophy; Brain Mapping; Cerebral Cortex; Cholinesterase Inhibitors; Cysteine; Dementia; Female; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Organotechnetium Compounds; Parkinson Disease; Pilot Projects; Psychometrics; Statistics as Topic; Tomography, Emission-Computed, Single-Photon | 2010 |
Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease.
Topics: Brain; Catalytic Domain; Cross-Linking Reagents; Cysteine; Dementia; Disulfides; HEK293 Cells; Humans; Neurons; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Binding; Protein Folding; Serotonin; Tryptophan Hydroxylase | 2011 |
Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model.
Topics: Alkylation; Animals; Crystallography; Cysteine; Disease Models, Animal; Electron Transport Complex I; Glutathione; Immunoassay; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mitochondria; Nerve Degeneration; Oxidation-Reduction; Parkinson Disease; Protein Structure, Tertiary | 2011 |
The role of the C-terminus of human α-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers.
Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Cysteine; Cystine; Fluorescent Dyes; Humans; Isomerism; Kinetics; Mutagenesis, Site-Directed; Mutant Proteins; Oxidation-Reduction; Parkinson Disease; Protein Denaturation; Protein Folding; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2011 |
Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity.
Topics: Amino Acids, Sulfur; Animals; Butadienes; Cell Line; Cell Line, Tumor; Cysteine; Cystine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Nitriles; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2012 |
PSP as distinguished from CBD, MSA-P and PD by clinical and imaging differences at an early stage.
Topics: 3-Iodobenzylguanidine; Aged; Aged, 80 and over; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulation; Cysteine; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Multiple System Atrophy; Neurodegenerative Diseases; Organotechnetium Compounds; Parkinson Disease; Parkinsonian Disorders; Radiopharmaceuticals; Supranuclear Palsy, Progressive; Tomography, Emission-Computed, Single-Photon | 2011 |
A Korean Parkinson's disease family with the LRRK2 p.Tyr1699Cys mutation showing clinical heterogeneity.
Topics: Age of Onset; Aged; Cysteine; DNA Mutational Analysis; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Parkinson Disease; Protein Serine-Threonine Kinases; Republic of Korea; Tyrosine | 2012 |
POLG1 Arg953Cys mutation: expanded phenotype and recessive inheritance in a Brazilian family.
Topics: Adult; Arginine; Brazil; Cardiomyopathies; Cysteine; Depression; DNA Mutational Analysis; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Electromyography; Female; Gait Disorders, Neurologic; Humans; Male; Muscle, Skeletal; Mutation; Neural Conduction; Ophthalmoplegia, Chronic Progressive External; Parkinson Disease; Phenotype; Succinate Dehydrogenase | 2012 |
Has removal of excess cysteine led to the evolution of pheomelanin? Pheomelanogenesis as an excretory mechanism for cysteine.
Topics: Alzheimer Disease; Cysteine; Cysteine Dioxygenase; Diet; Evolution, Molecular; Glutathione; Humans; Melanins; Melanocytes; Oxidative Stress; Parkinson Disease; Selection, Genetic; Temperature; Ultraviolet Rays | 2012 |
Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.
Topics: Cell Line; Cysteine; Gene Knockdown Techniques; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mutation; Oncogene Proteins; Parkinson Disease; Protein Deglycase DJ-1; RNA, Small Interfering; Synapses; Transcriptional Activation; Vesicular Monoamine Transport Proteins | 2012 |
Cysteine decrease following acute Levodopa intake in patients with Parkinson's disease.
Topics: Administration, Oral; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Cysteine; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease | 2012 |
Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cysteine; Down-Regulation; Dual Specificity Phosphatase 1; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Hydrogen Peroxide; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mice; Oligonucleotide Array Sequence Analysis; Oncogene Proteins; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Promoter Regions, Genetic; Protein Deglycase DJ-1; Real-Time Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2013 |
Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants.
Topics: Amino Acid Substitution; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cysteine; Cytoplasm; Dimerization; Glutamine; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mutation; Oncogene Proteins; Oxidative Stress; Parkinson Disease; Peroxiredoxins; Protein Deglycase DJ-1 | 2013 |
Tc-99m ethylene cysteinate dimer SPECT in the differential diagnosis of parkinsonism.
Topics: Aged; Brain; Cysteine; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Multiple System Atrophy; Nerve Net; Organotechnetium Compounds; Parkinson Disease; Parkinsonian Disorders; Regional Blood Flow; Sensitivity and Specificity; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 2002 |
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.
Topics: Aged; alpha-Synuclein; Cell Culture Techniques; Cysteine; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Genes, Reporter; Glycine; Haplotypes; Humans; Male; Middle Aged; Nerve Tissue Proteins; Neuroblastoma; Parkinson Disease; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Synucleins; Threonine; Transfection | 2003 |
The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.
Topics: Archaeal Proteins; Catalysis; Chromatography, Gel; Crystallography, X-Ray; Cysteine; Dimerization; Endopeptidases; Escherichia coli; Genes, Recessive; Intracellular Signaling Peptides and Proteins; Models, Molecular; Mutation; Oncogene Proteins; Oxidative Stress; Parkinson Disease; Peptide Hydrolases; Protein Conformation; Protein Deglycase DJ-1; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2003 |
Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1.
Topics: Cell Line; Circular Dichroism; Cycloheximide; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Escherichia coli; Gene Deletion; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Mass Spectrometry; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Neurons; Oncogene Proteins; Parkinson Disease; Point Mutation; Proteasome Endopeptidase Complex; Protein Conformation; Protein Deglycase DJ-1; Protein Folding; Protein Structure, Secondary; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Temperature; Time Factors | 2004 |
Whole-brain voxel-based correlation analysis between regional cerebral blood flow and intelligence quotient score in Parkinson's disease.
Topics: Aged; Brain; Brain Mapping; Cerebrovascular Circulation; Cysteine; Female; Functional Laterality; Humans; Image Interpretation, Computer-Assisted; Intelligence; Intelligence Tests; Male; Middle Aged; Neuropsychological Tests; Organotechnetium Compounds; Parkinson Disease; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon | 2004 |
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.
Topics: alpha-Synuclein; Antioxidants; Cell Differentiation; Cell Line, Tumor; Cysteine; Cytoplasm; Dimerization; Dopamine; Genetic Vectors; HeLa Cells; Homozygote; Humans; Intracellular Signaling Peptides and Proteins; Molecular Chaperones; Mutation; Neurons; Oncogene Proteins; Oxidation-Reduction; Oxidative Stress; Oxygen; Parkinson Disease; Protein Deglycase DJ-1; Spectrophotometry; Synucleins | 2004 |
Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cysteine; Female; Genetic Predisposition to Disease; Humans; Japan; Male; Methionine; Middle Aged; Multiple System Atrophy; Parkinson Disease; Polymorphism, Genetic; Threonine; Valine | 2005 |
Neurons inflict self-harm.
Topics: Cysteine; Dopamine; Histidine; Models, Biological; Mutation; Neurons; Neuroprotective Agents; Parkinson Disease; Protein Folding; Protein Structure, Tertiary; Solubility; Substantia Nigra; Ubiquitin-Protein Ligases | 2005 |
Circulating antibodies to cysteinyl catecholamines in amyotrophic lateral sclerosis and Parkinson's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Antibodies; Catecholamines; Cysteine; Female; Humans; Male; Middle Aged; Parkinson Disease | 2005 |
Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of parkinsonism using template-based discriminant analysis.
Topics: Algorithms; Brain; Cysteine; Diagnosis, Differential; Discriminant Analysis; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Male; Organotechnetium Compounds; Parkinson Disease; Pattern Recognition, Automated; Perfusion; Radiopharmaceuticals; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon; Tropanes | 2006 |
Translated mutation in the Nurr1 gene as a cause for Parkinson's disease.
Topics: Aged; Amino Acid Substitution; Chromatography, High Pressure Liquid; Cysteine; DNA Mutational Analysis; DNA-Binding Proteins; Exons; Female; Genetic Carrier Screening; Humans; Introns; Male; Middle Aged; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinson Disease; Polymorphism, Genetic; Protein Biosynthesis; Sequence Analysis; Serine; Transcription Factors | 2006 |
S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration.
Topics: Alzheimer Disease; Animals; Binding Sites; Cell Line; Cysteine; Endoplasmic Reticulum; Humans; Molecular Chaperones; N-Methylaspartate; Neurodegenerative Diseases; Nitric Oxide; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Disulfide-Isomerases; Protein Folding; Receptors, G-Protein-Coupled; Sulfhydryl Compounds; Ubiquitin | 2006 |
Establishment of specific antibodies that recognize C106-oxidized DJ-1.
Topics: Alzheimer Disease; Antibody Specificity; Brain; Cysteine; Humans; Intracellular Signaling Peptides and Proteins; Oncogene Proteins; Parkinson Disease; Protein Deglycase DJ-1 | 2006 |
Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging.
Topics: Aging; Animals; Animals, Genetically Modified; Cysteine; DNA Mutational Analysis; Drosophila melanogaster; Drosophila Proteins; Herbicides; Humans; Mice; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Oxidative Stress; Paraquat; Parkinson Disease; Protein Deglycase DJ-1 | 2006 |
Optimization of the Y831C mutation detection in human DNA polymerase gamma by allelic discrimination assay.
Topics: Cysteine; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Gene Frequency; Genetic Techniques; Humans; Mitochondrial Diseases; Parkinson Disease; Peripheral Nervous System Diseases; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Tyrosine | 2006 |
Regional cerebral blood flow in Parkinson's disease as an indicator of cognitive impairment.
Topics: Aged; Aged, 80 and over; Brain; Cerebrovascular Circulation; Cognition Disorders; Cysteine; Female; Humans; Male; Middle Aged; Organotechnetium Compounds; Parkinson Disease; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon | 2006 |
Quantification of Parkinson's disease-related network expression with ECD SPECT.
Topics: Algorithms; Brain; Cysteine; Female; Humans; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Male; Middle Aged; Multiple System Atrophy; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Signal Transduction; Tomography, Emission-Computed, Single-Photon | 2007 |
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder.
Topics: Aged; Brain; Brain Stem; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatum; Cysteine; Female; Humans; Male; Middle Aged; Neurodegenerative Diseases; Organotechnetium Compounds; Parkinson Disease; Polysomnography; Predictive Value of Tests; Prognosis; REM Sleep Behavior Disorder; Tomography, Emission-Computed, Single-Photon | 2006 |
Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease.
Topics: Cysteine; Diagnosis, Differential; Female; Gyrus Cinguli; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Supranuclear Palsy, Progressive; Tomography, Emission-Computed, Single-Photon | 2007 |
Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer's and Parkinson's diseases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cysteine; Deoxyguanosine; DNA Damage; DNA Mutational Analysis; Female; Homocystine; Humans; Male; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Parkinson Disease; Polymorphism, Genetic; Sulfhydryl Compounds; Tetrahydrofolates | 2007 |
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase.
Topics: Aging; Animals; Cysteine; DNA Mutational Analysis; Exons; Gene Deletion; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Immunohistochemistry; Mass Spectrometry; Mice; Mice, Knockout; Mitochondria; Oncogene Proteins; Oxidation-Reduction; Parkinson Disease; Peroxidase; Peroxidases; Peroxiredoxins; Protein Deglycase DJ-1; Superoxide Dismutase | 2007 |
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.
Topics: Animals; Biomarkers; Brain Ischemia; Cells, Cultured; Cysteine; Male; Mice; Mice, Knockout; Microtubule-Associated Proteins; Models, Biological; Oncogene Proteins; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Peroxiredoxins; Protein Deglycase DJ-1; Rats; Sensitivity and Specificity; Stroke | 2007 |
S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease.
Topics: Antioxidants; Brain; Cell Death; Cell Line; Cysteine; Humans; Models, Biological; Neurons; Nitrogen Oxides; Oxidative Stress; Parkinson Disease; Peroxiredoxins | 2007 |
Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms.
Topics: Animals; Cysteine; Dietary Supplements; Drosophila; Humans; Methionine Sulfoxide Reductases; Motor Activity; Oxidoreductases; Parkinson Disease | 2007 |
(99m)Tc-ethyl cysteinate dimer brain SPECT findings in early stage of dementia with Lewy bodies and Parkinson's disease patients: a correlation with neuropsychological tests.
Topics: Aged; Aged, 80 and over; Brain; Cerebrovascular Circulation; Cognition Disorders; Cysteine; Diagnosis, Differential; Disease Progression; Early Diagnosis; Female; Humans; Lewy Body Disease; Male; Middle Aged; Neuropsychological Tests; Organotechnetium Compounds; Parkinson Disease; Predictive Value of Tests; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon | 2008 |
Cerebral activity modulation by extradural motor cortex stimulation in Parkinson's disease: a perfusion SPECT study.
Topics: Aged; Brain; Cerebrovascular Circulation; Cohort Studies; Cysteine; Electric Stimulation Therapy; Electrodes, Implanted; Female; Humans; Image Processing, Computer-Assisted; Male; Motor Cortex; Neural Pathways; Organotechnetium Compounds; Parkinson Disease; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2008 |
PARK2 mutations and clinical features in a Chinese population with early-onset Parkinson's disease.
Topics: Adult; Age of Onset; Arginine; Asian People; Cysteine; DNA Mutational Analysis; Female; Hong Kong; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Ubiquitin-Protein Ligases | 2008 |
Nitrated alpha-synuclein and microglial neuroregulatory activities.
Topics: alpha-Synuclein; Animals; Cathepsin B; Cells, Cultured; Cystatins; Cysteine; Cytoskeletal Proteins; Dopamine; Gene Expression Regulation; Glutamic Acid; Glutathione; Mice; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; NF-kappa B; Nitrates; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Array Analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2008 |
Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.
Topics: Aldehydes; Animals; Cell Line; Circular Dichroism; Cysteine; Humans; Models, Molecular; Mutation, Missense; Parkinson Disease; Protein Binding; Protein Carbonylation; Protein Processing, Post-Translational; Tubulin; Ubiquitin Thiolesterase | 2008 |
HFE gene mutations in a population of Italian Parkinson's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Hemochromatosis Protein; Histidine; Histocompatibility Antigens Class I; Humans; Italy; Male; Membrane Proteins; Middle Aged; Mutation; Parkinson Disease; Serine | 2008 |
Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Arginine; Cysteine; DNA Mutational Analysis; Female; Glycine; Haplotypes; Humans; Internationality; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Parkinson Disease; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Serine | 2008 |
Trait shyness in the elderly: evidence for an association with Parkinson's disease in family members and biochemical correlates.
Topics: Aged; Aged, 80 and over; Cysteine; Female; Humans; Male; Parkinson Disease; Shyness | 1995 |
A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease.
Topics: Arginine; Base Sequence; Cysteine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Deoxyribonucleases, Type II Site-Specific; Genotype; Homozygote; Humans; Japan; Mixed Function Oxygenases; Molecular Sequence Data; Mutation; Parkinson Disease; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length | 1993 |
Effects of L-cysteine on the oxidation chemistry of dopamine: new reaction pathways of potential relevance to idiopathic Parkinson's disease.
Topics: Animals; Brain; Cysteine; Dopamine; Electrochemistry; gamma-Glutamyltransferase; Glutathione; Hydrogen-Ion Concentration; Male; Melanins; Mice; Neurons; Oxidation-Reduction; Parkinson Disease; Substantia Nigra; Superoxides | 1994 |
Characterization of 99mTc-bicisate as an agent for the measurement of cerebral blood flow with SPECT.
Topics: Alzheimer Disease; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Cysteine; Humans; Organotechnetium Compounds; Parkinson Disease; Tomography, Emission-Computed, Single-Photon | 1994 |
Regional cerebral blood flow imaging with 99mTc-bicisate SPECT in asymmetric Parkinson's disease: studies with and without chronic drug therapy.
Topics: Adult; Antiparkinson Agents; Brain; Cerebrovascular Circulation; Cysteine; Female; Humans; Male; Middle Aged; Organotechnetium Compounds; Parkinson Disease; Reference Values; Tomography, Emission-Computed, Single-Photon | 1994 |
Sulfate and cysteine levels in the plasma of patients with Parkinson's disease.
Topics: Aged; Cysteine; Homocysteine; Humans; Middle Aged; Parkinson Disease; Sulfates | 1995 |
Reactive dopamine metabolites and neurotoxicity: implications for Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechols; Cysteine; Dopamine; Free Radicals; Histocytochemistry; Male; Nervous System Diseases; Oxidation-Reduction; Parkinson Disease; Protein Binding; Quinones; Rats; Rats, Sprague-Dawley | 1996 |
Further insights into the influence of L-cysteine on the oxidation chemistry of dopamine: reaction pathways of potential relevance to Parkinson's disease.
Topics: Animals; Antineoplastic Agents; Brain; Chromatography, High Pressure Liquid; Cysteine; Cysteinyldopa; Dopamine; Electrochemistry; Electrodes; Injections, Intravenous; Lethal Dose 50; Mice; No-Observed-Adverse-Effect Level; Osmolar Concentration; Oxidation-Reduction; Parkinson Disease; Spectrophotometry, Ultraviolet; Thiazines | 1996 |
Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease.
Topics: Aged; Alzheimer Disease; Brain; Carrier Proteins; Case-Control Studies; Cocaine; Cysteine; Dementia; Diagnosis, Differential; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Organotechnetium Compounds; Oximes; Parkinson Disease; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1997 |
Neurotoxicity of endogenous cysteinylcatechols.
Topics: Animals; Brain Chemistry; Carcinoma, Embryonal; Catechols; Cells, Cultured; Culture Media; Cysteine; Dopamine; Electron Transport; Excitatory Amino Acid Antagonists; Hippocampus; Magnetic Resonance Spectroscopy; N-Methylaspartate; NAD(P)H Dehydrogenase (Quinone); Neuroglia; Oxidation-Reduction; Parkinson Disease; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tumor Cells, Cultured | 1997 |
Iron- and manganese-catalyzed autoxidation of dopamine in the presence of L-cysteine: possible insights into iron- and manganese-mediated dopaminergic neurotoxicity.
Topics: Chromatography, High Pressure Liquid; Cysteine; Dopamine; Electrochemistry; Iron; Magnetic Resonance Spectroscopy; Manganese; Oxidation-Reduction; Parkinson Disease; Spectrophotometry, Ultraviolet | 1998 |
Enhancement of cytotoxicity and clastogenicity of l-DOPA and dopamine by manganese and copper.
Topics: Animals; Cell Division; Cell Line; Copper; Cricetinae; Cysteine; Dopamine; Glutathione; Levodopa; Lung; Manganese; Melanins; Micronucleus Tests; Mutagens; Parkinson Disease | 1998 |
Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8,11,14-Eicosatrienoic Acid; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Copper; Cysteine; Dihydroxyphenylalanine; Dopamine; Glutathione; Humans; Hypoxanthine; Iron; Parkinson Disease; Reactive Oxygen Species; Reference Values; Superoxides; Xanthine | 1998 |
Elevated plasma levels of homocysteine in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cysteine; Dipeptides; Female; Homocysteine; Humans; Male; Middle Aged; Parkinson Disease; Risk Factors | 1998 |
Effects of the method of drawing regions of interest on the differential diagnosis of extrapyramidal syndromes using 123I-iodolisuride SPET.
Topics: Adult; Aged; Basal Ganglia Diseases; Brain; Brain Chemistry; Caudate Nucleus; Corpus Striatum; Cysteine; Female; Frontal Lobe; Humans; Iodine Radioisotopes; Lisuride; Male; Occipital Lobe; Organotechnetium Compounds; Parkinson Disease; Perfusion; Radiopharmaceuticals; Receptors, Dopamine D2; Tomography, Emission-Computed, Single-Photon | 1999 |
Applications of electron paramagnetic resonance spectroscopy to study interactions of iron proteins in cells with nitric oxide.
Topics: Animals; Bacteria; Cysteine; Electron Spin Resonance Spectroscopy; Food Preservation; Hemeproteins; Hemoglobins; Mammals; Mitochondria, Liver; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Parkinson Disease; Shock, Septic; Substantia Nigra | 1998 |
External radioactive reference markers in SPECT imaging of the dopamine system.
Topics: Alzheimer Disease; Brain; Carrier Proteins; Case-Control Studies; Cocaine; Cysteine; Dopamine Plasma Membrane Transport Proteins; Humans; Iodine Radioisotopes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Receptors, Dopamine; Reproducibility of Results; Tomography, Emission-Computed, Single-Photon | 1999 |
Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Cysteine; Glutamic Acid; Glutathione; Glycine; Hydrolysis; Hydroxyl Radical; Iron; Kinetics; Male; Microdialysis; Mitochondria; Models, Chemical; Nitro Compounds; Oxygen Consumption; Parkinson Disease; Perfusion; Propionates; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1999 |
Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Cysteine; Female; Free Radical Scavengers; Glutathione; Hydrogen Peroxide; Neurons; Oxidation-Reduction; Oxidopamine; Oxygen Consumption; Parkinson Disease; Rats; Rats, Sprague-Dawley; Sympatholytics | 2000 |
Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Cysteine; Female; Folic Acid; Genotype; Homocysteine; Humans; Levodopa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Parkinson Disease; Point Mutation | 2000 |
Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cysteine; Dopamine; Down-Regulation; Extracellular Space; Glutathione; Male; Neostriatum; Nerve Degeneration; Oxidative Stress; Parkinson Disease; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine 3-Monooxygenase | 2000 |
Perfusion ECD/SPECT in the characterization of cognitive deficits in Parkinson's disease.
Topics: Aged; Brain; Cerebrovascular Circulation; Cognition Disorders; Cysteine; Female; Frontal Lobe; Humans; Male; Middle Aged; Neuropsychological Tests; Organotechnetium Compounds; Parkinson Disease; Radiopharmaceuticals; Temporal Lobe; Tomography, Emission-Computed, Single-Photon | 2001 |
Cysteine and mercapturate conjugates of oxidized dopamine are in human striatum but only the cysteine conjugate impedes dopamine trafficking in vitro and in vivo.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Animals; Brain; Cells, Cultured; Corpus Striatum; Cysteine; Dopamine; Esters; Female; Fetus; Humans; In Vitro Techniques; Male; Mesencephalon; Microdialysis; Nerve Degeneration; Oxidation-Reduction; Parkinson Disease; Rats; Rats, Sprague-Dawley; Synaptosomes | 2001 |
Deactivation of thalamocortical activity is responsible for suppression of parkinsonian tremor by thalamic stimulation: a 99mTc-ECD SPECT study.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cerebral Cortex; Cysteine; Electric Stimulation Therapy; Female; Humans; Male; Middle Aged; Motor Cortex; Neural Pathways; Organotechnetium Compounds; Parkinson Disease; Prefrontal Cortex; Radiopharmaceuticals; Thalamus; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Tremor | 2001 |
Oxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cells.
Topics: Acetylcysteine; Animals; Apoptosis; Catalase; Creatine Kinase; Cysteine; Dopamine; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen Peroxide; Isoenzymes; Nerve Tissue Proteins; Oxidation-Reduction; Parkinson Disease; PC12 Cells; Phospholipase C gamma; Protein Disulfide-Isomerases; Protein Isoforms; Rats; Thioredoxin-Disulfide Reductase; Type C Phospholipases | 2002 |
Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cysteine; Humans; Middle Aged; Motor Neurons; Neuromuscular Diseases; Parkinson Disease; Sulfates | 1990 |
[Biochemical aspects of the effect of L-dopa in patients with Parkinson's disease].
Topics: Cysteine; Cystine; Dihydroxyphenylalanine; Female; Glycine; Humans; Male; Methionine; Parkinson Disease; Serine; Threonine; Time Factors | 1972 |
[Correlation between Parkinsonism symptoms and a disorder in the amino acid metabolism in CNS].
Topics: Amino Acids; Animals; Brain Injuries; Central Nervous System Diseases; Cerebrospinal Fluid; Cysteine; Cystine; Diagnosis, Differential; Glycine; Humans; Parkinson Disease; Parkinson Disease, Postencephalitic; Phenothiazines; Rats; Serine; Threonine; Tremor | 1970 |