Compounds > cysteine

cysteine and Lung Neoplasms

cysteine has been researched along with Lung Neoplasms in 88 studies

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-199015 (17.05)18.7374
1990's7 (7.95)18.2507
2000's26 (29.55)29.6817
2010's30 (34.09)24.3611
2020's10 (11.36)2.80

Authors

AuthorsStudies
Ačkar, L; Andreas, A; Bartkowiak, K; Brüning, T; Casjens, S; Geffken, M; Johnen, G; Kollmeier, J; Pantel, K; Peine, S; Raiko, I; Weber, DG1
Biswal, BK; Panda, M1
Chen, J; Chen, X; Du, W; Feng, Y; Li, M; Liu, P; Liu, R; Shi, M; Xu, J; Zhao, L; Zhao, Y1
Han, W; Hong, M; Liu, C; Sun, P; Wu, J; Zhang, X; Zhao, F1
Dabhade, PS; Mokale, SN; Rathod, LS1
Chen, B; Frank, DA; Hata, AN; Jarugumilli, GK; Mino-Kenudson, M; Niu, J; Sun, Y; Walker, SR; Wu, X; Zheng, B1
Chen, S; Huang, W; Jin, H; Li, Y; Sui, Y; Zheng, Y1
Chen, Z; Du, Y; Fu, C; Guo, W; Meng, X; Ren, J; Ren, X; Tan, L; Wu, Q1
Arif, M; Jafri, A; Khan, F; Kumar, A; Mazumder, R; Mishra, R; Pandey, P1
Arrieta, O; Aschner, M; Barrios-Bernal, P; Colín-González, AL; Hernández-Pedro, NY; Orozco-Morales, M; Ruiz-Godoy, LM; Santamaría, A1
Hwang, GW; Inose-Maruyama, A; Irokawa, H; Iwai, K; Kato, S; Kuge, S; Numasaki, S; Ohdate, T; Toyama, T; Watanabe, T1
Gill, BS; Kumar, S1
Eitel, A; Esckilsen, D; Evans, HG; Garvey, J; Guthrie, JW; Hendrickson, N; Heyl, DL; Jujjavarapu, M; Newman, R; Park, Y1
Backus, KM; Bar-Peled, L; Chang, MW; Cravatt, BF; Dix, MM; Hayward, MM; Horning, BD; Ichu, TA; Ihle, NT; Jiang, P; Kemper, EK; Kok, BP; Olucha, J; Paul, TA; Saez, E; Shaw, RJ; Suciu, RM; Svensson, RU; Vinogradova, EV; Zhu, Z1
Adams, S; Alvarez, SW; Birsoy, K; Moreira, AL; Papagiannakopoulos, T; Possemato, R; Sabatini, DM; Sviderskiy, VO; Terzi, EM1
Gong, Y; Li, C; Li, Z; Lin, X; Liu, X; Luo, Y; Ma, S; Miao, H; Quan, H; Sun, Y; Tang, F; Tian, X; Wang, F; Wang, H; Xiao, Y; Xie, C; Yang, C; You, C; Yu, H; Zhang, J; Zhang, L1
Choi, J; Choi, M; Churchill, DG; Jon, S; Kim, Y; Lee, DY; Lee, Y; Mulay, SV1
Alfieri, R; Bonelli, M; Bozza, N; Callegari, D; Castelli, R; Cavazzoni, A; Digiacomo, G; Ferlenghi, F; Fumarola, C; Lodola, A; Mor, M; Petronini, PG; Rivara, S; Silva, C; Vacondio, F1
Gao, M; Gao, P; Li, W; Lu, X; Mu, Y; Wang, Q; Wang, Y; Xu, G; Zhao, Y; Zhou, L; Zhou, Y1
Fan, J; Jin, Y; Wu, F; Xu, J; Yang, G; Yang, L; Yin, Z1
Choi, ALM; Ge, AY; Gilbert, LA; Gordan, JD; Hann, B; Hwang, YC; Lou, K; Mitchell, DC; Shkedi, AR; Shokat, KM; Steri, V; Swaney, DL; Yogodzinski, CH1
Benita, S; Borlak, J; Karra, N; Nassar, T; Ripin, AN; Schwob, O1
Ostrem, JM; Peters, U; Shokat, KM; Sos, ML; Wells, JA1
Chen, H; Sang, S; Soroka, DN; Warin, RF; Zhu, Y1
Arnér, ES; Cebula, M; Holmgren, A; Johansson, K; Lundberg, JO; Pader, I; Sengupta, R; Xu, J1
Carroll, KS; Lin, J; Lo Conte, M; Wilson, MA1
Behrens, CR; Bermudez, A; Bowers, S; Chinn, LL; Fitch-Bruhns, M; Flory, MR; Ha, EH; Halcomb, RL; Houser, D; Jackson, DY; Levashova, Z; Liao-Chan, S; Melnick, J; Migone, TS; Monteon, J; Probst, G; Sauer, P; Theunissen, JW; Valdiosera, A; van der Horst, EH; Venstrom, K; Wong, T1
Hansen, R; Li, LS; Lito, P; Rosen, N; Solomon, M1
Cai, J; Cao, J; Li, S; Liu, G; Luan, Y; Qi, Q; Wang, K; Wang, Y; Zhang, F; Zhang, Y; Zhao, Z; Zhu, X1
Ballard, P; Cantarini, MV; Collier, J; Dickinson, PA; Frewer, P; Martin, S; Pickup, K1
Broggini, M; Brunelli, L; Caiola, E; Lupi, M; Marabese, M; Pastorelli, R1
Ben-Lulu, S; Benhar, M; Weisman-Shomer, P; Ziv, T1
Hu, Y; Li, G; Lin, Z; Tang, Z1
Cramer, SL; Crighton, T; Labuschagne, C; Lamb, RF; Mason, D; Pardo, OE; Poursaitidis, I; Rowlinson, SW; Roy, R; Seckl, MJ; Stone, E; Triplett, K; Wang, X1
Borghi, M; Castellani, P; Ceccarelli, J; Delfino, L; Ferrini, S; Rubartelli, A; Tosetti, F; Zappia, E1
Chung, AS; Jung, JY; Kim, A; Lee, SH; Lim, JS; Son, M1
Chung, FL; Mi, L1
Hecht, SS; Kassie, F; Lahti, D; Matise, I; Negia, M; Pan, Y; Scherber, R; Upadhyaya, P1
Hatsukami, DK; Hecht, SS; Kassie, F1
Hida, T; Hosono, S; Ito, H; Kawase, T; Matsuo, K; Mitsudomi, T; Okasaka, T; Suzuki, T; Tajima, K; Tanaka, H; Watanabe, M; Yatabe, Y; Yokoi, K1
Endalew, A; Hecht, SS; Kassie, F; Luo, X; Melkamu, T; Upadhyaya, P1
Chiang, EP; Pai, MH; Tang, FY1
Izumi, H; Kaneko, K; Matsumoto, T; Mitomi, H; Okubo, T; Saito, T; Sato, K; Suehara, Y; Takagi, T; Torigoe, T; Yao, T1
Abdelmelek, MF; Blumenschein, GR; Byers, LA; Chen, L; Coombes, KR; Diao, L; Herbst, RS; Heymach, JV; Hong, WK; Ihle, NT; Kim, ES; Larsen, JE; Lee, JJ; Lippman, SM; Liu, S; Minna, JD; Papadimitrakopoulou, V; Powis, G; Saintigny, P; Tang, X; Tsao, A; Wang, J; Wistuba, II; Zhang, S1
Chung, FL; Mi, L; Veenstra, TD; Xiao, Z1
Good, JA; Kaan, HY; Kozielski, F; MacKay, SP; Podgórski, D; Rath, O; Talapatra, SK; Wang, F1
Bliss, RL; Hecht, SS; Kenney, PM; McIntee, EJ; Upadhyaya, P; Wang, M1
Azhdarinia, A; Bryant, JL; Kim, CG; Kim, EE; Oh, CS; Podoloff, DA; Schechter, NR; Won, JJ; Yang, DJ; Yu, DF1
Bello, S; Bernal, ML; Fanlo, A; Isla, D; Mayayo, E; Rubio, E; Sinués, B1
Bäck, M; Brink, C; Dahlén, SE; Gascard, JP; Norel, X; Walch, L1
Ahmad, A; Allen, RH; Panayiotidis, MI; Stabler, SP; White, CW1
Kelsey, KT; Liu, M; McMillan, A; Miike, R; Quesenberry, C; Sison, JD; Wiencke, JK; Wrensch, MR1
Cabrera, W; Dragani, TA; Falvella, FS; Galbiati, F; Galvan, A; Ibanez, O; Mancuso, MT; Manenti, G; Pazzaglia, S; Pignatiello, C; Saran, A; Spinola, M; Zaffaroni, D1
Bencko, V; Boffetta, P; Borel, S; Brennan, P; Canzian, F; Chabrier, A; Fabianova, E; Foretova, L; Hall, J; Hung, RJ; Janout, V; Lissowska, J; Mates, D; Rudnai, P; Szeszenia-Dabrowska, N; Zaridze, D1
Chung, FL; Conaway, CC; Halicka, HD; Jhanwar-Uniyal, M; Schwartz, J; Traganos, F; Yang, YM1
Anton, M; Gansbacher, B; Kopitz, C; Krüger, A1
Amin, SG; Das, A; Desai, DH; El-Bayoumy, K; Kleinman, W; Pinto, JT; Richie, JP1
Chae, HZ; Ip, C; Kim, YJ; Lee, WS; Park, EM; Park, YM1
Hansen, RD; Overvad, K; Raaschou-Nielsen, O; Sørensen, M; Tjønneland, A; Vogel, U1
Hatt, L; Loft, S; Møller, P; Overvad, K; Raaschou-Nielsen, O; Risom, L; Sørensen, M; Tjønneland, A; Vogel, U1
Bounous, G; Dröge, W; Ducruet, T; Falconer, W; Karabadjian, A; Molson, JH; Tai, P; Tozer, RG1
Andjelković, T; Banković, J; Marković, ID; Pesić, M; Rakić, L; Ruzdijić, S1
Bonker, GJ; Braven, J; Fenner, ML; Tonge, BL1
Ishibashi, M; Kondo, Y; Yamada, N; Yamaji, T1
Bussaka, Y; Fukurono, K; Jingu, K; Kawahira, K; Matsuoka, J; Matsuura, K; Morita, K; Nakagawa, E; Ohtake, H; Sakuma, A; Sasaki, K; Tanaka, M; Tomita, N; Yano, K; Yoshihara, H1
Baas, F; Beijnen, J; Borst, P; Dekker, H; Lankelma, J; Oude Elferink, RP; Paulusma, C; van Tellingen, O; Zaman, GJ1
Cermák, J; Kárová, B; Krepela, E; Procházka, J; Roubková, H1
Kasai, H; Kim, SR; Kohno, T; Nohmi, T; Shinmura, K; Sugimura, H; Tani, M; Tosaka, M; Yokota, J1
Baba, S; Gao, C; Genka, K; Igarashi, H; Iwamasa, T; Kohno, T; Li, Z; Lum, JK; Martinson, JJ; Morris, BJ; Nagura, K; Ohno, Y; Sawaguchi, T; Shinmura, K; Sugimura, H; Tajima, K; Takezaki, T; Tsugane, S; Varga, T; Wakai, K; Wang, J; Yokota, J1
Forth, W; Mückter, H; Walther, SC; Walther, UI; Wilhelm, B1
Oonishi, I; Sui, O; Yasuda, H1
Donlon, T; Le Marchand, L; Lum-Jones, A; Seifried, A; Wilkens, LR1
Pantopoulos, K; Wang, J1
Agrup, G; Falck, B; Kennedy, BM; Rorsman, H; Rosengren, AM; Rosengren, E1
Agrup, G; Andersson, T; Falck, B; Persson, K; Rorsman, H; Rosengren, AM; Rosengren, E1
Grainger, JM; Husain, OA1
Stekar, J1
Alexandrova, N; Horowitz, JM; Kaye, FJ; Kratzke, RA; Lin, AY; Otterson, GA; Shimizu, E; Zajac-Kaye, M1
He, R1
Brodie, AE; Reed, DJ2
Araki, E; Hoshi, A; Iigo, M; Nakajima, Y1
Berti, F; Crivellari, MT; Folco, GC; Galli, G; Mezzetti, M; Sautebin, L; Viganò, R1
Abe, M; Komuro, C; Nishidai, T; Ono, K; Shibamoto, Y; Shrieve, DC; Takahashi, M; Tsutsui, K1
Keller, DA; Menzel, DB1
Mehrishi, JN1
Aoki, T; Hashinotsume, M; Higashino, K; Kang, KY; Takahashi, Y1
Kaufman, L; Mirvish, SS1

Reviews

2 review(s) available for cysteine and Lung Neoplasms

ArticleYear
Recent progress in targeting KRAS mutant cancers with covalent G12C-specific inhibitors.
    Drug discovery today, 2023, Volume: 28, Issue:5

    Topics: Cysteine; Humans; Lung Neoplasms; Mutation; Proto-Oncogene Proteins p21(ras); United States; United States Food and Drug Administration

2023
Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers.
    Nature reviews. Cancer, 2009, Volume: 9, Issue:7

    Topics: Animals; Anticarcinogenic Agents; Budesonide; Clinical Trials as Topic; Cysteine; Humans; Inositol; Lung Neoplasms; Smoking; Thiocarbamates

2009

Trials

3 trial(s) available for cysteine and Lung Neoplasms

ArticleYear
Blood-based detection of lung cancer using cysteine-rich angiogenic inducer 61 (CYR61) as a circulating protein biomarker: a pilot study.
    Molecular oncology, 2021, Volume: 15, Issue:11

    Topics: Biomarkers; Cysteine; Cysteine-Rich Protein 61; Female; Humans; Lung Neoplasms; Male; Pilot Projects

2021
Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8

    Topics: Acrylamides; Adult; Aged; Aniline Compounds; Animals; Antineoplastic Agents; Binding Sites; Biotransformation; Carcinoma, Non-Small-Cell Lung; Cysteine; Cytochrome P-450 CYP3A; Dogs; Drug Administration Schedule; ErbB Receptors; Feces; Female; Hepatocytes; Humans; Lung Neoplasms; Male; Mice; Middle Aged; Piperazines; Protein Binding; Protein Kinase Inhibitors; Rats, Wistar; Serum Albumin, Human; Tissue Distribution

2016
[Protective effect of L-cysteine on the leukopenic syndrome due to radiotherapy (author's transl)].
    Nihon Gan Chiryo Gakkai shi, 1981, Aug-20, Volume: 16, Issue:4

    Topics: Adult; Aged; Clinical Trials as Topic; Cysteine; Double-Blind Method; Female; Humans; Leukopenia; Lung Neoplasms; Male; Middle Aged; Radiation Injuries; Uterine Cervical Neoplasms

1981

Other Studies

83 other study(ies) available for cysteine and Lung Neoplasms

ArticleYear
Evodiamine inhibits stemness and metastasis by altering the SOX9-β-catenin axis in non-small-cell lung cancer.
    Journal of cellular biochemistry, 2022, Volume: 123, Issue:9

    Topics: Alkaloids; Apoptosis; beta Catenin; Cadherins; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cysteine; Humans; Lung Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species; SOX9 Transcription Factor; Vimentin

2022
COX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism.
    Cell death & disease, 2022, 11-23, Volume: 13, Issue:11

    Topics: Carcinoma, Non-Small-Cell Lung; Cysteine; Cystine; Electron Transport Complex IV; Ferroptosis; Humans; Lung Neoplasms; Mitochondria

2022
[miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2022, Volume: 38, Issue:12

    Topics: A549 Cells; Cell Movement; Cysteine; Endothelial Cells; GPI-Linked Proteins; Humans; Kazal Motifs; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Vascular Endothelial Growth Factor A

2022
Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.
    Nature, 2019, Volume: 573, Issue:7772

    Topics: Acyltransferases; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Conserved Sequence; Cysteine; Disease Models, Animal; Fatty Acids; Heterografts; Humans; Inflammation; Interferon-gamma; Interleukin-6; Lipoylation; Lung Neoplasms; Mice; Mice, SCID; Neoplasm Transplantation; Phosphorylation; Protein Multimerization; Signal Transduction; src Homology Domains; STAT3 Transcription Factor

2019
Tumor-specific design of PEGylated gadolinium-based nanoscale particles: Facile synthesis, characterization, and improved magnetic resonance imaging of metastasis lung cancer.
    Journal of photochemistry and photobiology. B, Biology, 2020, Volume: 202

    Topics: Animals; Biocompatible Materials; Cell Line, Tumor; Cell Survival; Contrast Media; Cysteine; Gadolinium; Hemolysis; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Melanoma, Experimental; Mice; Nanoparticles; Polyethylene Glycols; RAW 264.7 Cells; Transplantation, Homologous

2020
l-Cysteine decorated nanoscale metal-organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy.
    Chemical communications (Cambridge, England), 2020, Apr-07, Volume: 56, Issue:27

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cisplatin; Cysteine; Drug Delivery Systems; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Male; Metal-Organic Frameworks; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Nanoparticles; Polyethylene Glycols; Tumor Burden; Valproic Acid; Vascular Endothelial Growth Factor A; Zirconium

2020
Elucidation of S-Allylcysteine Role in Inducing Apoptosis by Inhibiting PD-L1 Expression in Human Lung Cancer Cells.
    Anti-cancer agents in medicinal chemistry, 2021, Volume: 21, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; B7-H1 Antigen; Cell Proliferation; Cell Survival; Cells, Cultured; Cysteine; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Reactive Oxygen Species

2021
S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-κB, and apoptosis.
    Anti-cancer drugs, 2021, 02-01, Volume: 32, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cysteine; Dose-Response Relationship, Drug; Down-Regulation; Humans; Lipid Metabolism; Lung Neoplasms; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Signal Transduction; Time Factors

2021
Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response.
    The Biochemical journal, 2021, 04-16, Volume: 478, Issue:7

    Topics: Carrier Proteins; Cysteine; Glycolysis; Humans; Liver Neoplasms; Lung Neoplasms; Membrane Proteins; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Sulfhydryl Compounds; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Tumor Cells, Cultured

2021
Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:3

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cysteine; Humans; Lung Neoplasms; Molecular Docking Simulation; NF-E2-Related Factor 2; Protein Conformation; Protein Isoforms; Reactive Oxygen Species; Serine; Signal Transduction; Triterpenes

2017
D-Amino Acid Analogues of the Antimicrobial Peptide CDT Exhibit Anti- Cancer Properties in A549, a Human Lung Adenocarcinoma Cell Line.
    Protein and peptide letters, 2017, Volume: 24, Issue:7

    Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Amino Acid Sequence; Amino Acids; Antimicrobial Cationic Peptides; Apoptosis; Cell Proliferation; Cysteine; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Humans; Lung Neoplasms; MAP Kinase Signaling System; Peptides, Cyclic

2017
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
    Cell, 2017, Oct-19, Volume: 171, Issue:3

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cysteine; DAX-1 Orphan Nuclear Receptor; Gene Regulatory Networks; Humans; Kelch-Like ECH-Associated Protein 1; Ligands; Lung Neoplasms; Proteome; Transcriptome

2017
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.
    Nature, 2017, 11-30, Volume: 551, Issue:7682

    Topics: Animals; Carbon-Sulfur Lyases; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cysteine; Glutathione; Humans; Iron-Sulfur Proteins; Lung Neoplasms; Mice; Neoplasm Metastasis; Oxidative Stress; Oxygen; RNA Interference

2017
FePt-Cys nanoparticles induce ROS-dependent cell toxicity, and enhance chemo-radiation sensitivity of NSCLC cells in vivo and in vitro.
    Cancer letters, 2018, 04-01, Volume: 418

    Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Survival; Chemoradiotherapy; Cisplatin; Cysteine; Humans; Lung Neoplasms; Magnetite Nanoparticles; Platinum; Reactive Oxygen Species; Treatment Outcome

2018
Enhanced Doubly Activated Dual Emission Fluorescent Probes for Selective Imaging of Glutathione or Cysteine in Living Systems.
    Analytical chemistry, 2018, 02-20, Volume: 90, Issue:4

    Topics: Animals; Cell Survival; Cysteine; Density Functional Theory; Female; Fibroblasts; Fluorescent Dyes; Glutathione; Humans; Injections, Intravenous; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Molecular Structure; Neoplasms, Experimental; Optical Imaging; Tumor Cells, Cultured

2018
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR.
    European journal of medicinal chemistry, 2019, Jan-15, Volume: 162

    Topics: A549 Cells; Acetamides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cysteine; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Phosphorylation; Thioacetamide

2019
Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.
    Journal of proteome research, 2019, 05-03, Volume: 18, Issue:5

    Topics: Adult; Aged; Amino Acids; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Cysteine; Diagnosis, Differential; Diglycerides; Early Detection of Cancer; Energy Metabolism; Female; Gas Chromatography-Mass Spectrometry; Humans; Lipid Metabolism; Lung Neoplasms; Metabolome; Middle Aged; Neoplasms; Non-Smokers; Oxidative Stress; Sensitivity and Specificity; Serine

2019
Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma.
    Oncology research, 2019, Sep-23, Volume: 27, Issue:9

    Topics: Animals; Carcinoma, Hepatocellular; Cysteine; Endopeptidases; Humans; Lung Neoplasms; Oxidation-Reduction; Reactive Oxygen Species

2019
KRAS
    Science signaling, 2019, 05-28, Volume: 12, Issue:583

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; CRISPR-Cas Systems; Cysteine; Female; Genomics; HEK293 Cells; Humans; Lung Neoplasms; Mice; Mice, Nude; Mutation; Neoplasm Transplantation; Oncogenes; Pancreatic Neoplasms; Protein Binding; Proteomics; Proto-Oncogene Proteins p21(ras); Sequence Analysis, RNA; Signal Transduction

2019
Antibody conjugated PLGA nanoparticles for targeted delivery of paclitaxel palmitate: efficacy and biofate in a lung cancer mouse model.
    Small (Weinheim an der Bergstrasse, Germany), 2013, Dec-20, Volume: 9, Issue:24

    Topics: Amides; Animals; Antibodies; Antibodies, Monoclonal, Humanized; Area Under Curve; Cell Line, Tumor; Cetuximab; Cysteine; Drug Delivery Systems; ErbB Receptors; Humans; Immunotherapy; Lactic Acid; Lung Neoplasms; Mice; Mice, SCID; Nanoparticles; Nanotechnology; Neoplasm Transplantation; Paclitaxel; Palmitates; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sulfhydryl Compounds; Surface Plasmon Resonance; Surface Properties

2013
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
    Nature, 2013, Nov-28, Volume: 503, Issue:7477

    Topics: Allosteric Regulation; Allosteric Site; Apoptosis; Cell Line, Tumor; Crystallography, X-Ray; Cysteine; Drug Discovery; Genes, ras; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Lung Neoplasms; Models, Molecular; Mutant Proteins; Oncogene Protein p21(ras); raf Kinases; Static Electricity; Substrate Specificity

2013
Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2.
    Journal of agricultural and food chemistry, 2014, Feb-12, Volume: 62, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Catechols; Cell Line, Tumor; Cell Proliferation; Cysteine; Glutathione; Humans; Lung Neoplasms; Mice; Mice, Nude; Oxidative Stress; Signal Transduction; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2014
Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, May-13, Volume: 111, Issue:19

    Topics: Carcinoma, Squamous Cell; Cysteine; Cystine; Enzyme Activation; Glutathione; HEK293 Cells; HT29 Cells; Humans; Hydrogen Peroxide; Lung Neoplasms; NADH, NADPH Oxidoreductases; NADP; Nitric Oxide; Oxidants; Oxidation-Reduction; Oxidative Stress; Substrate Specificity; Sulfur; Thioredoxin Reductase 1; Thioredoxins

2014
A Chemical Approach for the Detection of Protein Sulfinylation.
    ACS chemical biology, 2015, Aug-21, Volume: 10, Issue:8

    Topics: Cysteine; HeLa Cells; Humans; Indicators and Reagents; Lung; Lung Neoplasms; Nitroso Compounds; Oxidation-Reduction; Oxidative Stress; Proteins; Proteomics; Staining and Labeling; Sulfinic Acids

2015
Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs.
    Molecular pharmaceutics, 2015, Nov-02, Volume: 12, Issue:11

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Cross-Linking Reagents; Cysteine; Female; Flow Cytometry; Fluorescent Antibody Technique; Fusion Regulatory Protein-1; Humans; Immunoconjugates; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Mice, SCID; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Trastuzumab; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2015
Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism.
    Science (New York, N.Y.), 2016, Feb-05, Volume: 351, Issue:6273

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Alleles; Antineoplastic Agents; Azetidines; Cell Line, Tumor; Cysteine; Cytidine Diphosphate; Enzyme Inhibitors; Glycine; Guanosine Triphosphate; HEK293 Cells; Humans; Lung Neoplasms; Molecular Targeted Therapy; Mutation; Piperazines; Protein Conformation; Proto-Oncogene Proteins p21(ras); Time Factors

2016
Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells.
    International immunopharmacology, 2016, Volume: 34

    Topics: A549 Cells; Benzo(a)pyrene; Carcinogenesis; Cell Cycle; Cell Proliferation; Cysteine; Garlic; Humans; Lung; Lung Neoplasms; NF-kappa B; Precancerous Conditions; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase

2016
Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS.
    Oncotarget, 2016, Aug-09, Volume: 7, Issue:32

    Topics: Amino Acid Substitution; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; Cysteine; Glycine; Humans; Imidazoles; Lung Neoplasms; Mutation, Missense; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Quinolines; Signal Transduction

2016
Nitrosothiol-Trapping-Based Proteomic Analysis of S-Nitrosylation in Human Lung Carcinoma Cells.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: A549 Cells; Cell Cycle; Cysteine; Cytokines; Humans; Inflammation; Lung Neoplasms; Neoplasm Proteins; Proteomics; S-Nitrosothiols; Signal Transduction; Staining and Labeling

2017
Amino Nitrogen Quantum Dots-Based Nanoprobe for Fluorescence Detection and Imaging of Cysteine in Biological Samples.
    Analytical chemistry, 2017, 04-04, Volume: 89, Issue:7

    Topics: Adenocarcinoma of Lung; Biosensing Techniques; Cell Line, Tumor; Cell Survival; Cysteine; Fluorescent Dyes; Humans; Lung Neoplasms; Nanoparticles; Nitrogen; Particle Size; Quantum Dots; Spectrometry, Fluorescence; Surface Properties

2017
Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine.
    Cell reports, 2017, 03-14, Volume: 18, Issue:11

    Topics: Amino Acids; Animals; Breast; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Survival; Cysteine; Cystine; Down-Regulation; Epithelial Cells; ErbB Receptors; Female; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Iron; Lung Neoplasms; MAP Kinase Signaling System; Mice, SCID; Mutation; Oncogenes; Phospholipid Hydroperoxide Glutathione Peroxidase

2017
The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants.
    International journal of cancer, 2008, Oct-15, Volume: 123, Issue:8

    Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Carcinoma, Non-Small-Cell Lung; Cysteine; Disease Progression; Glutathione; HCT116 Cells; Humans; Intramolecular Oxidoreductases; Jurkat Cells; Lung Neoplasms; Macrophage Migration-Inhibitory Factors; Mice; Mice, SCID; Oxidation-Reduction; Oxides; Sulfhydryl Compounds; Thioredoxins

2008
Long exposure of non-cytotoxic concentrations of methylselenol suppresses the invasive potential of B16F10 melanoma.
    Oncology reports, 2008, Volume: 20, Issue:3

    Topics: Animals; Cell Adhesion; Cell Movement; Cell Survival; Cysteine; Dietary Supplements; Female; Fibronectins; Flow Cytometry; Gelatinases; Humans; Integrin alphaVbeta3; Integrins; Lung Neoplasms; Melanoma, Experimental; Methanol; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Organoselenium Compounds; Selenocysteine; Sodium Selenite; Survival Rate; Tumor Cells, Cultured; Vitronectin; Wound Healing

2008
Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.
    Nutrition and cancer, 2008, Volume: 60 Suppl 1

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine; DNA Damage; Humans; Isothiocyanates; Lung Neoplasms; Oxidative Stress; Protein Binding; Protein Carbonylation; Sulfoxides; Thiocyanates; Tubulin

2008
Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice.
    Cancer prevention research (Philadelphia, Pa.), 2008, Volume: 1, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; bcl-Associated Death Protein; Carcinogens; Cell Proliferation; Cysteine; Drug Evaluation, Preclinical; Female; Inositol; Lung Neoplasms; Mice; Models, Biological; Oncogene Protein v-akt; Phosphorylation; Poly(ADP-ribose) Polymerases; Random Allocation; Smoking; Thiocarbamates

2008
hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type.
    Journal of human genetics, 2009, Volume: 54, Issue:12

    Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; DNA Glycosylases; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms; Male; Meta-Analysis as Topic; Middle Aged; Multivariate Analysis; Mutation, Missense; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Serine; Smoking

2009
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
    Carcinogenesis, 2010, Volume: 31, Issue:9

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Bronchi; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; Epithelial Cells; Female; Humans; Indoles; Inositol; Lung Neoplasms; Mice; Mice, Inbred A; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Proto-Oncogene Proteins c-akt; Signal Transduction; Smoke; Thiocarbamates; Vitamin B Complex

2010
Consumption of S-allylcysteine inhibits the growth of human non-small-cell lung carcinoma in a mouse xenograft model.
    Journal of agricultural and food chemistry, 2010, Oct-27, Volume: 58, Issue:20

    Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cysteine; Female; Garlic; Growth Inhibitors; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays

2010
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up.
    Human pathology, 2011, Volume: 42, Issue:5

    Topics: Adenocarcinoma; Arthrography; Base Sequence; Cell Transformation, Neoplastic; Cysteine; Femur; Fibrosarcoma; Follow-Up Studies; Genes, p53; Genes, Recessive; Giant Cell Tumor of Bone; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Molecular Sequence Data; Mutation; Neoplasm Recurrence, Local; Rectal Neoplasms; Thymine; Tomography, X-Ray Computed; Tumor Suppressor Protein p53

2011
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
    Journal of the National Cancer Institute, 2012, Feb-08, Volume: 104, Issue:3

    Topics: Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Clinical Trials, Phase II as Topic; Cysteine; Disease-Free Survival; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, ras; Genetic Vectors; Glycine; Humans; Immunoblotting; Immunoprecipitation; Kaplan-Meier Estimate; Lentivirus; Lung Neoplasms; Microarray Analysis; Molecular Targeted Therapy; Mutation; Proto-Oncogene Proteins c-akt; Randomized Controlled Trials as Topic; Signal Transduction; TOR Serine-Threonine Kinases; Treatment Outcome; Valine

2012
Proteomic analysis of covalent modifications of tubulins by isothiocyanates.
    The Journal of nutrition, 2012, Volume: 142, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cysteine; Diet; Electrophoresis, Gel, Two-Dimensional; Humans; Isothiocyanates; Lung Neoplasms; Mass Spectrometry; Microtubules; Mitosis; Phytotherapy; Plant Extracts; Protein Binding; Protein Isoforms; Proteomics; Tubulin

2012
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.
    Journal of medicinal chemistry, 2013, Mar-14, Volume: 56, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzamides; Butylamines; Cell Line, Tumor; Chromones; Cysteine; Kinesins; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Structure-Activity Relationship; Transplantation, Heterologous

2013
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.
    Carcinogenesis, 2002, Volume: 23, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cysteine; Disease Models, Animal; Female; Inositol; Isothiocyanates; Lung Neoplasms; Mice; Thiocarbamates

2002
Imaging with 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents.
    Radiology, 2003, Volume: 226, Issue:2

    Topics: Animals; Blood Glucose; Cysteine; Feasibility Studies; Fluorodeoxyglucose F18; Insulin; Lung Neoplasms; Mice; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Rats; Tissue Distribution

2003
MDR-1 C3435T genetic polymorphism and tobacco-related lung cancer.
    Oncology, 2003, Volume: 64, Issue:2

    Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; Genes, MDR; Genotype; Humans; Lung Neoplasms; Male; Polymorphism, Genetic; Risk Assessment; Risk Factors; Smoking; Threonine

2003
The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release.
    Advances in experimental medicine and biology, 2002, Volume: 507

    Topics: Adult; Aged; Cysteine; Humans; Indomethacin; Kinetics; Leukotriene C4; Leukotrienes; Lung Neoplasms; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Artery

2002
Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells.
    Chemico-biological interactions, 2004, Jan-15, Volume: 147, Issue:1

    Topics: Amino Acids, Sulfur; Carcinoma; Cell Line, Tumor; Cell Survival; Cystathionine; Cysteine; DNA; Glutathione; Humans; Lung Neoplasms; Methionine; Nicotiana; S-Adenosylhomocysteine; S-Adenosylmethionine; Smoke; Time Factors

2004
CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans.
    International journal of cancer, 2005, Jan-01, Volume: 113, Issue:1

    Topics: Aged; Alanine; Black or African American; Case-Control Studies; Confounding Factors, Epidemiologic; Cysteine; Cytochrome P-450 CYP1A1; Female; Genotype; Glycine; Hispanic or Latino; Humans; Linkage Disequilibrium; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; San Francisco; Smoking; Threonine

2005
Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis.
    Oncogene, 2005, Feb-03, Volume: 24, Issue:6

    Topics: Adenocarcinoma; Alleles; Amino Acid Sequence; Animals; Arginine; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Cysteine; Disease Models, Animal; DNA Mutational Analysis; Genetic Linkage; Genetic Predisposition to Disease; Germ-Line Mutation; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Molecular Sequence Data; Multifactorial Inheritance; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Receptors, Growth Factor; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction

2005
Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study.
    Journal of the National Cancer Institute, 2005, Apr-20, Volume: 97, Issue:8

    Topics: Adenocarcinoma; Adult; Aged; Arginine; Case-Control Studies; Confounding Factors, Epidemiologic; Cysteine; DNA Repair; Europe, Eastern; Female; Genotype; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Research Design; Risk Assessment; Risk Factors; Selection Bias; Serine; Smoking; Tryptophan

2005
N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.
    Cancer research, 2005, Sep-15, Volume: 65, Issue:18

    Topics: Adenocarcinoma; Animals; Apoptosis; Cell Line, Tumor; Cysteine; Dose-Response Relationship, Drug; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Tetradecanoylphorbol Acetate; Thiocarbamates; Transcription Factor AP-1; Transfection; Tumor Suppressor Protein p53

2005
Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host.
    Cancer research, 2005, Oct-01, Volume: 65, Issue:19

    Topics: Adenoviridae; Animals; Cathepsins; Cystatin C; Cystatins; Cysteine; Fibrosarcoma; Genetic Therapy; Humans; Lung Neoplasms; Mice

2005
The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung.
    Chemico-biological interactions, 2006, Jun-10, Volume: 161, Issue:2

    Topics: Animal Feed; Animals; Antioxidants; Ascorbic Acid; Cell Transformation, Neoplastic; Cysteine; Disulfides; Female; Glutathione; Lung Neoplasms; Mice; Molecular Structure; Nitrosamines; Organoselenium Compounds; Selenium; Sulfhydryl Compounds; Time Factors; Yeasts

2006
Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex.
    Cancer research, 2006, Jul-15, Volume: 66, Issue:14

    Topics: Antioxidants; Apoptosis; Binding Sites; Cysteine; Enzyme Activation; Glutathione S-Transferase pi; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Oxidation-Reduction; Peroxiredoxins; Radiation Tolerance; Signal Transduction

2006
Interactions between the OGG1 Ser326Cys polymorphism and intake of fruit and vegetables in relation to lung cancer.
    Free radical research, 2006, Volume: 40, Issue:8

    Topics: Cysteine; Diet; DNA Glycosylases; Female; Fruit; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Prospective Studies; Serine; Smoking; Vegetables

2006
OGG1 expression and OGG1 Ser326Cys polymorphism and risk of lung cancer in a prospective study.
    Mutation research, 2008, Mar-01, Volume: 639, Issue:1-2

    Topics: Amino Acid Substitution; Case-Control Studies; Cohort Studies; Cysteine; DNA Glycosylases; DNA Repair; Female; Genetic Markers; Humans; Lung Neoplasms; Male; Middle Aged; Oxidative Stress; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; RNA, Messenger; Serine; Smoking

2008
Cysteine-rich protein reverses weight loss in lung cancer patients receiving chemotherapy or radiotherapy.
    Antioxidants & redox signaling, 2008, Volume: 10, Issue:2

    Topics: Aged; Antineoplastic Agents; Cysteine; Dietary Proteins; Female; Humans; Lung Neoplasms; Male; Middle Aged; Muscle, Skeletal; Oxidative Stress; Radiotherapy; Weight Loss

2008
Sulfinosine enhances doxorubicin efficacy through synergism and by reversing multidrug resistance in the human non-small cell lung carcinoma cell line (NCI-H460/R).
    Investigational new drugs, 2009, Volume: 27, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cysteine; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Glutathione; Humans; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Purine Nucleosides

2009
The mechanism of carcinogenesis by tobacco smoke. Some experimental observations and a hypothesis.
    British journal of cancer, 1967, Volume: 21, Issue:3

    Topics: Acetaldehyde; Bronchial Neoplasms; Carcinogens; Chemical Phenomena; Chemistry; Chromatography; Cysteine; Humans; Lung Neoplasms; Mutagens; Respiratory Tract Neoplasms; Smoking

1967
Biosynthesis of the common precursor to vasopressin and neurophysin in vitro in transplantable human oat cell carcinoma of the lung with ectopic vasopressin production.
    Endocrinologia japonica, 1983, Volume: 30, Issue:4

    Topics: Carcinoma, Small Cell; Cysteine; Hormones, Ectopic; Humans; In Vitro Techniques; Inappropriate ADH Syndrome; Isoelectric Focusing; Lung Neoplasms; Male; Middle Aged; Molecular Weight; Neurophysins; Vasopressins

1983
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Aug-15, Volume: 92, Issue:17

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Arsenites; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Carcinoma, Non-Small-Cell Lung; Cell Division; Cysteine; Drug Resistance, Multiple; Glutathione; Humans; Kinetics; Lung Neoplasms; Methionine Sulfoximine; Multidrug Resistance-Associated Proteins; Recombinant Proteins; Transfection; Tumor Cells, Cultured

1995
Cathepsin B, thiols and cysteine protease inhibitors in squamous-cell lung cancer.
    Neoplasma, 1997, Volume: 44, Issue:4

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Cathepsin B; Cysteine; Cysteine Proteinase Inhibitors; Dithiothreitol; Female; gamma-Glutamyltransferase; Glutathione; Humans; Isoelectric Focusing; Lung Neoplasms; Male; Middle Aged; Sulfhydryl Compounds; Temperature; Time Factors

1997
Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.
    Oncogene, 1998, Jun-25, Volume: 16, Issue:25

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alleles; Alternative Splicing; Cell Line; Codon; Cysteine; Deoxyguanosine; DNA; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Gene Frequency; Genes; Genetic Variation; Genotype; Humans; Leukocytes, Mononuclear; Loss of Heterozygosity; Lung Neoplasms; Mutation; N-Glycosyl Hydrolases; Polymorphism, Genetic; Serine; Transcription, Genetic; Tumor Cells, Cultured

1998
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Alleles; Carcinoma, Squamous Cell; Case-Control Studies; Cysteine; DNA Damage; Genetic Predisposition to Disease; Guanine; Humans; Japan; Lung Neoplasms; Male; Middle Aged; N-Glycosyl Hydrolases; Polymorphism, Genetic; Risk Assessment; Serine

1999
Effect of zinc chloride on GSH synthesis rates in various lung cell lines.
    In vitro & molecular toxicology, 2000,Summer, Volume: 13, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Line; Chlorides; Chromatography, Thin Layer; Cysteine; Epithelial Cells; Fibroblasts; Glutathione; Kinetics; Lung; Lung Neoplasms; Oxidation-Reduction; Protein Biosynthesis; Pulmonary Alveoli; Tumor Cells, Cultured; Zinc Compounds

2000
[A case of bone metastases from carcinoma of the lung demonstrating increased uptake of 99mTc-ECD].
    Kaku igaku. The Japanese journal of nuclear medicine, 2000, Volume: 37, Issue:6

    Topics: Brain Neoplasms; Cysteine; Humans; Lung Neoplasms; Male; Middle Aged; Organotechnetium Compounds; Radiopharmaceuticals; Skull Neoplasms; Tomography, Emission-Computed, Single-Photon

2000
Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2002, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Asian People; Case-Control Studies; Cysteine; Diet; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Ethnicity; Genotype; Hawaii; Humans; Lung Neoplasms; Middle Aged; N-Glycosyl Hydrolases; Oxidative Stress; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Risk Factors; Serine; Smoking; Vegetables; White People

2002
Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant.
    Molecular and cellular biology, 2002, Volume: 22, Issue:13

    Topics: Adaptor Proteins, Signal Transducing; Breast Neoplasms; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cells, Cultured; Cysteine; Female; Ferritins; Gene Expression Regulation; Humans; Iron; Iron Regulatory Protein 1; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Lung Neoplasms; Phosphoproteins; Promoter Regions, Genetic; Protein Biosynthesis; Response Elements; RNA-Binding Proteins; RNA, Messenger; Tetracycline; Tumor Cells, Cultured

2002
Formation of cysteinyldopa from glutathionedopa in melanoma.
    Acta dermato-venereologica, 1975, Volume: 55, Issue:1

    Topics: Animals; Cysteine; Depression, Chemical; Dihydroxyphenylalanine; Glutathione; Guinea Pigs; Humans; Kidney; Lung; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasis; Skin Neoplasms; Stimulation, Chemical

1975
5-S-cysteinyldopa in the plasma of melanoma patients and the renal clearance of this amino acid.
    Acta dermato-venereologica, 1975, Volume: 55, Issue:1

    Topics: Adult; Breast Neoplasms; Cysteine; Dihydroxyphenylalanine; Humans; Liver Neoplasms; Lung Neoplasms; Male; Melanoma; Neoplasm Metastasis; Skin Neoplasms

1975
Use of a mucolytic agent (Cytoclair) in the preparation of cell material for the detection of malignant cells in sputum.
    Journal of clinical pathology, 1978, Volume: 31, Issue:6

    Topics: Cysteine; Expectorants; Humans; Lung Neoplasms; Methods; Sputum

1978
Pulmotropic carcinogenic activity of N-methyl-N-nitrosopropionamide.
    European journal of cancer, 1977, Volume: 13, Issue:10

    Topics: Animals; Cysteine; Drug Interactions; Female; Lethal Dose 50; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrogen; Nitroso Compounds; Rats

1977
Functional analysis at the Cys706 residue of the retinoblastoma protein.
    The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36

    Topics: Amino Acid Sequence; Animals; Carcinoma, Small Cell; Codon; Cysteine; Exons; Glutathione Transferase; HeLa Cells; Humans; Lung Neoplasms; Mice; Molecular Sequence Data; Mutation; Phosphorylation; Proto-Oncogene Proteins c-myc; Recombinant Fusion Proteins; Retinoblastoma Protein; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured

1992
[Inhibitory effect of micronutrients and BHA on lung cancer induced in rats].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1990, Volume: 12, Issue:6

    Topics: Animals; Butylated Hydroxyanisole; Carcinoma, Squamous Cell; Cysteine; Food, Fortified; Lung Neoplasms; Male; Methylcholanthrene; Rats; Rats, Inbred Strains; Selenium; Superoxide Dismutase; Vitamin A; Vitamin E

1990
Cellular recovery of glyceraldehyde-3-phosphate dehydrogenase activity and thiol status after exposure to hydroperoxides.
    Archives of biochemistry and biophysics, 1990, Volume: 276, Issue:1

    Topics: Cell Line; Cysteamine; Cysteine; Cystine; Dithiothreitol; Ethacrynic Acid; Ethylmaleimide; Glutathione; Glutathione Disulfide; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hydrogen Peroxide; Kinetics; Lung Neoplasms; Oxidation-Reduction; Peroxides; Sulfhydryl Compounds; tert-Butylhydroperoxide; Ultrasonics

1990
Enhanced antitumor effect of 5'-deoxy-5-fluorouridine by oral administration with L-cysteine.
    Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:2

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cysteine; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Lung Neoplasms; Male; Mice

1989
Control of bioconversion of C6 sulfidopeptide leukotrienes by reduced glutathione and L-cysteine in human lung.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1985, Volume: 15

    Topics: Biotransformation; Calcimycin; Cysteine; Glutathione; Glutathione Disulfide; Humans; Lung; Lung Neoplasms; SRS-A

1985
Combined effect of buthionine sulfoximine and cyclophosphamide upon murine tumours and bone marrow.
    British journal of cancer, 1986, Volume: 54, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Buthionine Sulfoximine; Cell Survival; Colony-Forming Units Assay; Cyclophosphamide; Cysteine; Glutathione; Lung Neoplasms; Male; Methionine Sulfoximine; Mice; Mice, Inbred C3H

1986
Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells.
    Toxicology and applied pharmacology, 1985, Mar-15, Volume: 77, Issue:3

    Topics: Buthionine Sulfoximine; Cell Line; Cysteine; Cystine; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Sulfur Radioisotopes

1985
Picomole analysis of glutathione, glutathione disulfide, glutathione S-sulfonate, and cysteine S-sulfonate by high-performance liquid chromatography.
    Analytical biochemistry, 1985, Volume: 151, Issue:2

    Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Glutathione Disulfide; Humans; Lung; Lung Neoplasms; Microchemistry; Rats; Serum Albumin, Bovine

1985
Smoking, cancer, and coronary heart-disease.
    Lancet (London, England), 1973, Mar-24, Volume: 1, Issue:7804

    Topics: Blood Platelets; Carcinoma, Bronchogenic; Cell Membrane; Coronary Disease; Cysteine; Free Radicals; Humans; Lung Neoplasms; Nicotine; Radiation-Protective Agents; Smoking; Thrombosis

1973
Production of the placental-type alkaline phosphatase isoennzyme by lung cancer tissue.
    Gan, 1972, Volume: 63, Issue:2

    Topics: Adenocarcinoma; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cysteine; Edetic Acid; Electrophoresis; Female; Fluorescent Antibody Technique; Hot Temperature; Humans; Immunodiffusion; Immunoelectrophoresis; Isoenzymes; Isoleucine; L-Lactate Dehydrogenase; Lung Neoplasms; Male; Middle Aged; Placenta; Pregnancy; Urea; Valine

1972
A study of nitrosamines and S-carboxyl derivatives of cysteine as lung carcinogens in adult SWR mice.
    International journal of cancer, 1970, Jul-15, Volume: 6, Issue:1

    Topics: Animals; Cysteine; Female; Injections, Intraperitoneal; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrosamines; Sulfur; Urethane

1970