cysteine has been researched along with Cell Transformation, Neoplastic in 68 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (13.24) | 18.7374 |
1990's | 20 (29.41) | 18.2507 |
2000's | 19 (27.94) | 29.6817 |
2010's | 17 (25.00) | 24.3611 |
2020's | 3 (4.41) | 2.80 |
Authors | Studies |
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Gureeva, TA; Kugaevskaya, EV; Solovyova, NI; Timoshenko, OS | 1 |
Amieva, MR; Bak, DW; Cover, TL; Fung, C; Gordon, EM; Hatzios, SK; Kovalyova, Y; Shuman, JHB; Weerapana, E | 1 |
Browne, CM; Buratowski, S; Chun, Y; Daitchman, D; Dhe-Paganon, S; Doctor, ZM; Ficarro, SB; Geffken, EA; Gray, NS; Kibe, S; Kozono, S; Lian, X; London, N; Lu, KP; Manz, TD; Marto, JA; Mohardt, ML; Nabet, B; Pinch, BJ; Seo, HS; Tan, L; Vangos, NE; Yeoh, ZC; Zaidman, D; Zhou, XZ | 1 |
Chen, J; Chu, P; Del Rosario, G; Dela Cruz-Chuh, J; Fan, F; He, C; He, J; Kozak, KR; Leipold, D; Lewis Phillips, GD; Li, G; Liu, L; Martin, S; Ng, C; O'Donohue, A; Pillow, TH; Sadowsky, JD; Su, D; Wai, J; Wang, Y; Xu, K; Xu, Z; Yan, G; Yao, H; Yu, SF; Zhang, D | 1 |
Abel, R; Batlevi, CL; Berishaj, M; Dogan, A; Ghanakota, P; Green, MR; Mondal, S; Seshan, VE; Wang, S; Wendel, HG; Younes, A; Zhao, C | 1 |
Ascenzi, P; De Simone, G; Messina, S | 1 |
Savari, S; Sjölander, A; Vinnakota, K; Zhang, Y | 1 |
Counter, CM; Huang, L | 1 |
Yakovlev, VA | 1 |
Ansong, E; Diamond, AM; Yang, W; Ying, Q | 1 |
Al Jammaz, I; Okarvi, SM | 1 |
Barletta, F; Clark, T; Dirico, K; Falahaptisheh, H; Gerber, HP; Graziani, EI; Green, M; Han, X; He, H; Koehn, F; Loganzo, F; Lucas, J; Ma, D; Musto, S; O'Donnell, CJ; Puthenveetil, S; Rago, B; Sapra, P; Subramanyam, C; Teske, J; Tumey, LN; Veneziale, R | 1 |
Burchiel, SW; Cooper, KL; Hudson, LG; Huestis, J; Liu, KJ; Xu, H; Zhou, X | 1 |
Alonso, LG; Borkosky, SS; Camporeale, G; de Prat Gay, G; Lorenzo, JR; Risso, MG; Salvatierra, E; Sánchez, IE; Thomas, MG | 1 |
Colburn, NH; Jiang, H; Matthews, CP; Wei, Q | 1 |
Azad, N; Castranova, V; Iyer, AK; Lu, Y; Medan, D; Rojanasakul, Y; Wang, L | 1 |
Carlsson, G; Dahl, N; Fadeel, B; Fröjmark, AS; Grzybowska, E; Jitkaew, S; Lehtiö, J; Nordström, A; Trebinska, A | 1 |
Endalew, A; Hecht, SS; Kassie, F; Luo, X; Melkamu, T; Upadhyaya, P | 1 |
Izumi, H; Kaneko, K; Matsumoto, T; Mitomi, H; Okubo, T; Saito, T; Sato, K; Suehara, Y; Takagi, T; Torigoe, T; Yao, T | 1 |
Altieri, F; Bisetto, E; Comelli, M; D'Ambrosio, C; Delneri, D; Domenis, R; Kelley, MR; Li, M; Mavelli, I; Quadrifoglio, F; Scaloni, A; Tell, G; Vascotto, C; Zeef, LA | 1 |
Evan, G; Hanahan, D; Nozawa, H; Rostker, F; Shchors, K; Swigart-Brown, L; Xu, J | 1 |
Chang, YC; Chen, PL; Hsieh, YH; Hsu, PH; Jeng, YM; Jiang, X; Lee, KF; Lee, WH; Lo, WT; Shew, JY; Su, MI; Tsai, MD; Wang, JM; Wei, PC; Weng, JY | 1 |
Bliss, RL; Hecht, SS; Kenney, PM; McIntee, EJ; Upadhyaya, P; Wang, M | 1 |
Al-Mjeni, F; Carrington, PE; Costa, M; Maroney, MJ; Zoroddu, MA | 1 |
Rabbitts, TH; Tanaka, T | 1 |
Cabrera, W; Dragani, TA; Falvella, FS; Galbiati, F; Galvan, A; Ibanez, O; Mancuso, MT; Manenti, G; Pazzaglia, S; Pignatiello, C; Saran, A; Spinola, M; Zaffaroni, D | 1 |
Bosch, X; Castellsagué, X; García-Closas, R; González, CA | 1 |
Bongarzone, I; Carniti, C; Clarke, S; Cranston, A; Hodgson, S; Hooks, Y; Leyland, J; Martin, S; Mondellini, P; Pierotti, M; Ponder, BA | 1 |
Amin, SG; Das, A; Desai, DH; El-Bayoumy, K; Kleinman, W; Pinto, JT; Richie, JP | 1 |
Dekant, W; Everitt, JI; Mally, A; Vamvakas, S; Walker, CL | 1 |
Giles, GI | 1 |
Campos, AC; Carneiro, CR; Correa, M; D'Almeida, V; Galdieri, LC; Jasiulionis, MG; Melo, FH; Molognoni, F | 1 |
Hubbert, NL; Lowy, DR; Norris, K; Papageorge, AG; Willumsen, BM | 1 |
Choi, BC; Ford-Hutchinson, AW; Richold, M; Slack, JA | 1 |
Long, CW; Snead, RM; Suk, WR | 1 |
Bell, RM; Brtva, TR; Campbell-Burk, S; Der, CJ; Drugan, JK; Ghosh, S; Terrell, RS | 1 |
Anderson, ME; Mann, K; Parks, D; Rainwater, R; Tegtmeyer, P | 1 |
Buss, JE; Cox, AD; Der, CJ; Graham, SM; Solski, PA | 1 |
Campbell, SL; Der, CJ; Drugan, JK; Hwang, YW; Khosravi-Far, R; Sung, YJ; White, MA | 1 |
Hirai, H; Hirano, N; Kurokawa, M; Mitani, K; Ogawa, S; Tanaka, K; Tanaka, T; Yazaki, Y | 1 |
Muller, WJ; Siegel, PM | 1 |
Buss, JE; Cox, AD; Der, CJ; Solski, PA; Willumsen, BM | 1 |
Berggren, M; Briehl, MM; Gallegos, A; Gasdaska, JR; Gasdaska, PY; Goodman, D; Paine-Murrieta, GD; Powis, G; Taylor, CW | 1 |
Fischer, S; Romero, F | 1 |
Bongarzone, I; Ceccherini, I; Gullo, M; Matera, I; Mondellini, P; Pacini, F; Pasini, B; Pierotti, MA; Pinchera, A; Romei, C; Romeo, G; Santamaria, G; Scopsi, L | 1 |
Campbell, SL; Carpenter, JW; Clark, GJ; Der, CJ; Drugan, JK; Fu, H; Rogers-Graham, K; Rossman, KL | 1 |
Burke, CL; Stern, DF | 1 |
Attié, T; Billaud, M; Chappuis-Flament, S; De Vita, G; Fusco, A; Lenoir, GM; Pasini, A; Santoro, M; Ségouffin-Cariou, C | 1 |
Alberti, L; Bongarzone, I; Borrello, MG; Mondellini, P; Pasini, B; Pierotti, MA; Uggeri, M; Vigano, E | 1 |
Ganther, HE; Ip, C; Thompson, HJ | 1 |
Enomoto, T; Hashimoto, Y; Kamohara, M; Masuko, T; Shishido, T; Tsuneoka-Suzuki, T; Uno, S | 1 |
Adarichev, V; Behn, H; Offermanns, S; Ponimaskin, E; Schmidt, MF; Voyno-Yasenetskaya, TA | 1 |
Chen, XG; Han, R; Li, LN; Li, Y; Yan, CH | 1 |
Bergemann, J; Brandenburg, G; Hannemann, J; Meyer, J; Ostertag, W; Prassolov, V; Stocking, C | 1 |
Bansho, Y; Inoue, S; Ito, K; Kawanishi, S; Midorikawa, K; Murata, M; Ohnishi, S | 1 |
Maruyama, H; Maruyama, IN; Moriki, T | 1 |
Froese, G; Linford, JH | 1 |
Noonan, KD; Noonan, NE | 1 |
Leuchtenberger, C; Leuchtenberger, R | 1 |
Buss, JE; Cox, AD; Der, CJ; Hisaka, MM | 1 |
Grässer, FA; LaMontagne, K; Lipsick, JS; Stohr, S; Whittaker, L | 1 |
Goldstein, DJ; Schlegel, R | 1 |
Barbosa, MS; Lowy, DR; Schiller, JT; Vass, WC | 1 |
Backer, JM; McCleary, WR; Miller, RA; Poenie, M; Rao, A; Stock, JB; Volker, C | 1 |
Almond, N; Crawford, L; Osborn, K; Storey, A | 1 |
Buss, JE; Sefton, BM | 1 |
Beilharz, MW; Hertzog, PJ; Linnane, AW; Nisbet, IT; Tymms, MJ | 1 |
Evans, VJ; Hursey, ML; Richter, A; Sanford, KK; Taylor, WG | 1 |
8 review(s) available for cysteine and Cell Transformation, Neoplastic
Article | Year |
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[Cysteine cathepsins: structure, physiological functions and their role in carcinogenesis].
Topics: Carcinogenesis; Cathepsins; Cell Transformation, Neoplastic; Cysteine; Humans; Neoplasms | 2021 |
Cysteine-based regulation of redox-sensitive Ras small GTPases.
Topics: Animals; Cell Transformation, Neoplastic; Cysteine; Gene Expression Regulation; Humans; Oxidation-Reduction; Protein Isoforms; Protein Processing, Post-Translational; ras Proteins; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Structure-Activity Relationship | 2019 |
Cysteinyl leukotrienes and their receptors: bridging inflammation and colorectal cancer.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biomarkers, Tumor; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cysteine; Enteritis; Humans; Inflammation; Inflammation Mediators; Intestine, Large; Leukotriene Antagonists; Leukotrienes; Prognosis; Receptors, Leukotriene; Risk Factors; Signal Transduction | 2014 |
Role of nitric oxide in the radiation-induced bystander effect.
Topics: Bystander Effect; Cell Transformation, Neoplastic; Cysteine; DNA Damage; Eukaryotic Cells; Gamma Rays; Genomic Instability; Humans; Mutagenesis; Neoplasm Proteins; Nitric Oxide; Protein Processing, Post-Translational; Reactive Nitrogen Species; Signal Transduction; Tyrosine | 2015 |
Use of XAS for the elucidation of metal structure and function: applications to nickel biochemistry, molecular toxicology, and carcinogenesis.
Topics: Absorptiometry, Photon; Cell Transformation, Neoplastic; Cysteine; Histones; Humans; Ligands; Nickel; Oxidation-Reduction; Structure-Activity Relationship | 2002 |
The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence.
Topics: Carotenoids; Cell Transformation, Neoplastic; Cysteine; Diet; Female; Folic Acid; Homocysteine; Humans; Methionine; Nutritional Physiological Phenomena; Uterine Cervical Neoplasms; Vitamins | 2005 |
The redox regulation of thiol dependent signaling pathways in cancer.
Topics: Animals; Antioxidants; Apoptosis; Cell Membrane; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine; Cytosol; Humans; Neoplasms; Oxidation-Reduction; Oxidative Stress; Phosphoric Monoester Hydrolases; Protein Kinases; Protein Processing, Post-Translational; Proteins; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Sulfhydryl Compounds; Transcription Factors | 2006 |
Structure and function of vav.
Topics: Amino Acid Sequence; Animals; Blood Proteins; Calcium-Binding Proteins; Calponins; Cell Cycle Proteins; Cell Transformation, Neoplastic; Cysteine; Hematopoietic System; Humans; Leucine Zippers; Mice; Mice, Knockout; Microfilament Proteins; Molecular Structure; Phosphoproteins; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Proto-Oncogenes; Signal Transduction; src Homology Domains | 1996 |
60 other study(ies) available for cysteine and Cell Transformation, Neoplastic
Article | Year |
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An infection-induced oxidation site regulates legumain processing and tumor growth.
Topics: Cell Transformation, Neoplastic; Cysteine; Cysteine Endopeptidases; Helicobacter Infections; Helicobacter pylori; Humans; Oxidation-Reduction; Stomach Neoplasms | 2022 |
Identification of a potent and selective covalent Pin1 inhibitor.
Topics: Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Crystallography, X-Ray; Cysteine; Drug Design; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Mice; NIH 3T3 Cells; NIMA-Interacting Peptidylprolyl Isomerase; Pancreatic Neoplasms; Protein Conformation; Proto-Oncogene Proteins p21(ras) | 2020 |
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cysteine; Disulfides; Humans; Immunoconjugates; Mice; Peptides; Protein Engineering | 2017 |
Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Cysteine; Enzyme Inhibitors; HEK293 Cells; Humans; Mice; Mutagenesis; Protein Domains; Structure-Activity Relationship | 2019 |
Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S.
Topics: Amino Acid Substitution; Animals; Cell Line; Cell Transformation, Neoplastic; Cysteine; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Gene Knock-In Techniques; GTP Phosphohydrolases; HEK293 Cells; Humans; Membrane Proteins; Mice; Mice, SCID; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Proto-Oncogene Proteins p21(ras); Serine; Signal Transduction; Transplantation, Heterologous | 2015 |
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1.
Topics: Antineoplastic Agents; Cell Survival; Cell Transformation, Neoplastic; Codon; Cysteine; Gene Expression; Glutathione Peroxidase; HCT116 Cells; Humans; Mitochondria; Protein Binding; Proteolysis; Selenium; Selenium-Binding Proteins; Signal Transduction | 2015 |
Preparation and evaluation of the tumor-specific antigen-derived synthetic mucin 1 peptide: A potential candidate for the targeting of breast carcinoma.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Cysteine; Drug Stability; Half-Life; Humans; MCF-7 Cells; Mice; Mucin-1; Peptide Fragments; Protein Transport; Technetium; Tissue Distribution | 2016 |
Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Carboxylic Acids; Cell Line, Tumor; Cell Transformation, Neoplastic; Cysteine; Humans; Immunoconjugates; Lysine; Maleimides; Mice; Pyrans; Tissue Distribution | 2016 |
S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite.
Topics: Arsenites; Cell Line; Cell Transformation, Neoplastic; Cysteine; DNA Damage; DNA Repair; Free Radical Scavengers; Humans; Keratinocytes; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrosation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Protein Processing, Post-Translational; Sodium Compounds; Time Factors; Ultraviolet Rays; Zinc; Zinc Fingers | 2016 |
Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein.
Topics: Cell Nucleolus; Cell Transformation, Neoplastic; Cysteine; Cytoplasm; Disulfides; Neoplasms; Oxidation-Reduction; Oxidative Stress; Papillomavirus E7 Proteins; Protein Transport; Virus Replication | 2017 |
Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Cysteine; Epidermis; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Peptide Fragments; Peroxides; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Skin Neoplasms; Transcription Factor AP-1 | 2008 |
Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.
Topics: Apoptosis; Caspase 9; Cell Line; Cell Transformation, Neoplastic; Chromium; Cysteine; Epithelial Cells; Humans; Lung; Mutant Proteins; Mutation; Nitric Oxide; Nitroso Compounds; Protein Stability; Proto-Oncogene Proteins c-bcl-2; Superoxides | 2010 |
N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Antioxidants; Apoptosis; B-Lymphocytes; Baculoviral IAP Repeat-Containing 3 Protein; Caspases; Cell Line, Transformed; Cell Transformation, Neoplastic; Coumarins; Cysteine; Dose-Response Relationship, Drug; Down-Regulation; Fluorescent Dyes; Herpesvirus 4, Human; Humans; Inhibitor of Apoptosis Proteins; Jurkat Cells; Mitochondria; NF-kappa B; Oligopeptides; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tosylphenylalanyl Chloromethyl Ketone; Transcription, Genetic; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzo(a)pyrene; Bronchi; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; Epithelial Cells; Female; Humans; Indoles; Inositol; Lung Neoplasms; Mice; Mice, Inbred A; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Proto-Oncogene Proteins c-akt; Signal Transduction; Smoke; Thiocarbamates; Vitamin B Complex | 2010 |
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up.
Topics: Adenocarcinoma; Arthrography; Base Sequence; Cell Transformation, Neoplastic; Cysteine; Femur; Fibrosarcoma; Follow-Up Studies; Genes, p53; Genes, Recessive; Giant Cell Tumor of Bone; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Molecular Sequence Data; Mutation; Neoplasm Recurrence, Local; Rectal Neoplasms; Thymine; Tomography, X-Ray Computed; Tumor Suppressor Protein p53 | 2011 |
Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.
Topics: Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine; Cytoplasm; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gene Knock-In Techniques; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Precursor Protein Import Complex Proteins; Mutation; Oxidation-Reduction; Oxidative Stress; Propionates; Protein Binding; Protein Folding; Protein Transport; Signal Transduction | 2011 |
Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis.
Topics: Animals; bcl-X Protein; Cathepsin B; CD11b Antigen; Cell Transformation, Neoplastic; Cysteine; Disease Models, Animal; GTPase-Activating Proteins; Inflammation; Interleukin-1beta; Leukocytes; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Neovascularization, Pathologic; Neuroendocrine Tumors; Pancreatic Neoplasms; Proto-Oncogene Proteins c-myc | 2013 |
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cysteine; Disulfides; DNA Damage; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fibroblasts; Glutathione Peroxidase; Heat-Shock Proteins; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis, Site-Directed; Mutation; Oxidants; Oxidation-Reduction; Oxidative Stress; Peroxidases; Protein Binding; Protein Folding; Proteostasis Deficiencies; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection | 2012 |
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.
Topics: Animals; Antineoplastic Agents; Carcinogenicity Tests; Cell Transformation, Neoplastic; Cysteine; Disease Models, Animal; Female; Inositol; Isothiocyanates; Lung Neoplasms; Mice; Thiocarbamates | 2002 |
Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibody Affinity; Antibody Specificity; Cell Transformation, Neoplastic; COS Cells; Cysteine; Humans; Immunoglobulin Variable Region; Immunosorbent Techniques; Mice; Molecular Sequence Data; Protein Binding; ras Proteins; Sequence Alignment; Surface Plasmon Resonance | 2003 |
Met proto-oncogene juxtamembrane rare variations in mouse and humans: differential effects of Arg and Cys alleles on mouse lung tumorigenesis.
Topics: Adenocarcinoma; Alleles; Amino Acid Sequence; Animals; Arginine; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Cysteine; Disease Models, Animal; DNA Mutational Analysis; Genetic Linkage; Genetic Predisposition to Disease; Germ-Line Mutation; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Molecular Sequence Data; Multifactorial Inheritance; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Receptors, Growth Factor; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
A novel activating mutation in the RET tyrosine kinase domain mediates neoplastic transformation.
Topics: Animals; Cell Transformation, Neoplastic; Cysteine; Dimerization; Female; Gene Expression Regulation; Humans; Mice; Middle Aged; Mutation, Missense; Neoplasm Invasiveness; NIH 3T3 Cells; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-ret; Up-Regulation | 2006 |
The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung.
Topics: Animal Feed; Animals; Antioxidants; Ascorbic Acid; Cell Transformation, Neoplastic; Cysteine; Disulfides; Female; Glutathione; Lung Neoplasms; Mice; Molecular Structure; Nitrosamines; Organoselenium Compounds; Selenium; Sulfhydryl Compounds; Time Factors; Yeasts | 2006 |
Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Renal Cell; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine; DNA; DNA Mutational Analysis; Gene Expression Regulation, Neoplastic; Kidney; Kidney Cortex; Kidney Diseases; Kidney Neoplasms; Loss of Heterozygosity; Male; Precancerous Conditions; Rats; Rats, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; Solvents; Trichloroethylene | 2006 |
Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation.
Topics: Acetylcysteine; Animals; Anoikis; Cell Adhesion; Cell Culture Techniques; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; DNA Methylation; Gene Expression Regulation; Glutathione; Homocysteine; Lipid Peroxidation; Melanocytes; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Sepharose; Superoxides; Trypsin | 2007 |
Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; Genes, Viral; Harvey murine sarcoma virus; Mice; Mice, Inbred Strains; Mutation; Neoplasm Proteins; Nucleic Acid Hybridization; Oncogenes; Plasmids; Proto-Oncogene Proteins p21(ras); Sarcoma Viruses, Murine; Species Specificity; Transfection | 1984 |
Some biochemical and pharmacological properties of an epoxide metabolite of alclofenac.
Topics: Alcohol Oxidoreductases; Analgesics; Animals; Anti-Inflammatory Agents; Cell Transformation, Neoplastic; Cricetinae; Cysteine; Dermatitis, Contact; Drug Hypersensitivity; Female; Guinea Pigs; Hypersensitivity, Delayed; In Vitro Techniques; Lymphocytes; Mice; Mutagens; Phenylacetates; Rats | 1981 |
Amino acid analogs inhibit murine xenotropic retrovirus expression and cell cycle progression.
Topics: Amino Acids; Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; DNA Replication; Kinetics; Kirsten murine sarcoma virus; Mice; Mice, Inbred BALB C; p-Fluorophenylalanine; Protein Biosynthesis; Sarcoma Viruses, Murine; Transcription, Genetic; Valine | 1984 |
Two distinct Raf domains mediate interaction with Ras.
Topics: 3T3 Cells; Animals; Catalysis; Cell Transformation, Neoplastic; Cysteine; Guanosine Triphosphate; Mice; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction; Xenopus laevis | 1995 |
Role of cysteine residues in regulation of p53 function.
Topics: Adenovirus E1A Proteins; Alkylation; Animals; Base Sequence; Cell Transformation, Neoplastic; Cysteine; DNA Mutational Analysis; Mice; Molecular Sequence Data; Oxidation-Reduction; Protein Binding; Protein Conformation; ras Proteins; Structure-Activity Relationship; Sulfhydryl Compounds; Suppression, Genetic; Transcriptional Activation; Tumor Suppressor Protein p53; Zinc | 1995 |
The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cysteine; Genes, ras; GTP-Binding Proteins; Methionine; Mevalonic Acid; Mice; Molecular Sequence Data; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rab5 GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Transfection; Tritium | 1993 |
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cysteine; Mice; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Tryptophan | 1996 |
A conserved cysteine residue in the runt homology domain of AML1 is required for the DNA binding ability and the transforming activity on fibroblasts.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Conserved Sequence; Core Binding Factor Alpha 2 Subunit; Cysteine; Diamide; DNA-Binding Proteins; Ethylmaleimide; Fibroblasts; Mice; Mutagenesis, Site-Directed; Neoplasm Proteins; Oxidation-Reduction; Protein Binding; Proto-Oncogene Proteins; Serine; Transcription Factor AP-2; Transcription Factors; Transcriptional Activation | 1996 |
Mutations affecting conserved cysteine residues within the extracellular domain of Neu promote receptor dimerization and activation.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Conserved Sequence; Cysteine; Disulfides; ErbB Receptors; Molecular Sequence Data; Mutation; Protein Binding; Protein Conformation; Rats; Receptor, ErbB-2; Sequence Deletion | 1996 |
Novel determinants of H-Ras plasma membrane localization and transformation.
Topics: Animals; Binding Sites; Cell Membrane; Cell Transformation, Neoplastic; Cysteine; Farnesol; Genes, ras; Mice; Mutation; Myristic Acids; Palmitates; ras Proteins; Sensitivity and Specificity | 1996 |
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.
Topics: 3T3 Cells; Animals; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cysteine; Genetic Vectors; Humans; Mice; Mutation; Neoplasm Proteins; Peptide Fragments; Phenotype; Serine; Thioredoxins; Transfection; Tumor Cells, Cultured | 1996 |
Somatic in frame deletions not involving juxtamembranous cysteine residues strongly activate the RET proto-oncogene.
Topics: 3T3 Cells; Adult; Animals; Carcinoma, Medullary; Cell Transformation, Neoplastic; Cysteine; Drosophila Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Sequence Deletion; Thyroid Neoplasms; Transfection | 1997 |
14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cysteine; Mice; Mutagenesis; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship; Tyrosine 3-Monooxygenase | 1997 |
Activation of Neu (ErbB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface.
Topics: 3T3 Cells; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cell Transformation, Neoplastic; COS Cells; Cysteine; Dimerization; Disulfides; DNA Primers; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Structure, Secondary; Rats; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Recombinant Proteins; Sequence Alignment | 1998 |
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Cell Transformation, Neoplastic; Cysteine; Dimerization; Disulfides; Drosophila Proteins; Glycosylation; Hirschsprung Disease; Humans; Membrane Proteins; Mice; Models, Biological; Multiple Endocrine Neoplasia Type 2a; PC12 Cells; Phosphotyrosine; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Transcriptional Activation | 1998 |
The Glu632-Leu633 deletion in cysteine rich domain of Ret induces constitutive dimerization and alters the processing of the receptor protein.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Membrane; Cell Transformation, Neoplastic; Cysteine; Dimerization; Drosophila Proteins; Endoplasmic Reticulum; Glutamic Acid; Leucine; Mercaptoethanol; Mice; Phosphorylation; Polysaccharides; Precipitin Tests; Protein Precursors; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Sequence Deletion; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 | 1999 |
Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland.
Topics: Animals; Anticarcinogenic Agents; Antimetabolites; Antineoplastic Agents; Biomarkers; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Chemoprevention; Coloring Agents; Cyclin D; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Cysteine; Enzyme Inhibitors; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Microtubule-Associated Proteins; Organoselenium Compounds; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Selenocysteine; Tumor Suppressor Proteins | 2000 |
Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity.
Topics: Amino Acid Substitution; Animals; Antigens, CD; Carrier Proteins; Cell Transformation, Neoplastic; Contact Inhibition; Cysteine; Cystine; Dimerization; DNA, Complementary; Fibroblasts; Fusion Regulatory Protein-1; Gene Expression Regulation, Neoplastic; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation, Missense; Neoplasm Transplantation; Rats; Recombinant Fusion Proteins; Transfection; Tumor Stem Cell Assay | 2000 |
Acylation of Galpha(13) is important for its interaction with thrombin receptor, transforming activity and actin stress fiber formation.
Topics: Actins; Acylation; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cysteine; Cytoskeleton; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Mice; Molecular Sequence Data; Mutation; Palmitic Acid; Protein Binding; Rats; Receptor, PAR-1; Receptors, Thrombin; rho GTP-Binding Proteins; Signal Transduction; Transfection; Tumor Stem Cell Assay | 2000 |
Cancer chemopreventive activities of S-3-1, a synthetic derivative of danshinone.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Benzofurans; Bepridil; Biphenyl Compounds; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Croton Oil; Cysteine; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epithelial Cells; Fibroblasts; Free Radical Scavengers; Hypoxanthine; In Vitro Techniques; Iron; Lipid Peroxidation; Lung; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Microsomes, Liver; Molecular Structure; Mutagens; Ornithine; Ornithine Decarboxylase; Papilloma; Pentetic Acid; Phenanthrenes; Picrates; Plants, Medicinal; Rats; Salmonella; Skin; Skin Neoplasms; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Xanthine Oxidase | 2001 |
Functional identification of secondary mutations inducing autonomous growth in synergy with a truncated interleukin-3 receptor: implications for multi-step oncogenesis.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cysteine; Dimerization; DNA-Binding Proteins; Genetic Vectors; Interleukin-3; Mice; Milk Proteins; Mutagenesis, Site-Directed; Plasmacytoma; Receptors, Interleukin-3; Recombinant Proteins; Retroviridae; Sequence Deletion; STAT5 Transcription Factor; Trans-Activators; Transfection; Tumor Cells, Cultured | 2001 |
Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate.
Topics: Animals; Antineoplastic Agents; Bromates; Carcinogens; Cell Transformation, Neoplastic; Cysteine; Deuterium; DNA Damage; Food Additives; Free Radicals; Genes, p53; Genes, ras; Glutathione; Guanine; HL-60 Cells; Humans; Kidney Neoplasms; Rats; Spin Trapping | 2001 |
Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding Sites; Cell Line, Transformed; Cell Transformation, Neoplastic; Cysteine; Dimerization; Disulfides; Enzyme Activation; ErbB Receptors; Humans; Kinetics; Ligands; Mice; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutation; Phosphorylation; Pliability; Protein Structure, Tertiary; Proteins; Rotation; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Thermodynamics | 2001 |
Comparisons of the chemical and biologic properties of triaziquone and triaziquone-protein conjugates.
Topics: Bucladesine; Cell Membrane; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chemical Phenomena; Chemistry; Cysteine; gamma-Globulins; Lymphoma; Neoplasms, Experimental; Oxidation-Reduction; Polyomavirus; Triaziquone | 1978 |
The effect of TLCK on transcription and its role in modifying cell growth.
Topics: Amino Acid Chloromethyl Ketones; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Cysteine; Depression, Chemical; Glutathione; Mice; RNA; RNA, Neoplasm; Tosyllysine Chloromethyl Ketone; Transcription, Genetic | 1977 |
Protection of hamster lung cultures by L-cysteine or vitamin C against carcinogenic effects of fresh smoke from tobacco or marihuana cigarettes.
Topics: Animals; Ascorbic Acid; Cannabis; Cell Transformation, Neoplastic; Cricetinae; Culture Media; Cysteine; DNA; Lung; Lysosomes; Nicotiana; Organ Culture Techniques; Plants, Toxic; Smoke | 1977 |
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cysteine; Diterpenes; Farnesol; GTP-Binding Proteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Proto-Oncogene Proteins pp60(c-src); rap GTP-Binding Proteins; Structure-Activity Relationship | 1992 |
A highly conserved cysteine in the v-Myb DNA-binding domain is essential for transformation and transcriptional trans-activation.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Chickens; Chromosome Mapping; Cysteine; DNA; DNA-Binding Proteins; Escherichia coli; Gene Expression Regulation, Viral; Molecular Sequence Data; Mutagenesis, Site-Directed; Oncogene Proteins v-myb; Retroviridae Proteins, Oncogenic; TATA Box; Transcription, Genetic; Transcriptional Activation | 1992 |
The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular protein.
Topics: Animals; Base Sequence; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cysteine; Epitopes; Gene Expression; Genetic Vectors; Golgi Apparatus; Haplorhini; Immunosorbent Techniques; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutation; Oncogene Proteins, Viral; Papillomaviridae; Phosphates; Plasmids; Proteins; Recombinant Fusion Proteins | 1990 |
In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cloning, Molecular; Cysteine; Genes, Viral; Genetic Complementation Test; Genetic Variation; Harvey murine sarcoma virus; Humans; Keratinocytes; Male; Mice; Moloney murine sarcoma virus; Open Reading Frames; Papillomaviridae; Repetitive Sequences, Nucleic Acid; Restriction Mapping; Skin; Transfection; Viral Proteins | 1991 |
Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction.
Topics: Alkyl and Aryl Transferases; Animals; Cell Line; Cell Transformation, Neoplastic; Chemotaxis; Cysteine; GTP-Binding Proteins; Macromolecular Substances; Macrophages; Male; Mice; Mice, Inbred BALB C; Models, Biological; Organ Specificity; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Structure-Activity Relationship; Substrate Specificity; Transferases | 1991 |
Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cysteine; DNA Mutational Analysis; Humans; Mutation; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus E7 Proteins; Phosphorylation; Precipitin Tests; Rats; Serine; Specific Pathogen-Free Organisms; Transcriptional Activation; Transfection | 1990 |
Direct identification of palmitic acid as the lipid attached to p21ras.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; Harvey murine sarcoma virus; Mice; Myristic Acid; Myristic Acids; Oncogene Protein p21(ras); Oncogene Proteins, Viral; Palmitic Acid; Palmitic Acids; Sarcoma Viruses, Murine | 1986 |
Antiviral and antiproliferative activities of interferon-alpha 1: the role of cysteine residues.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromatography, Gel; Cysteine; Humans; Interferon Type I; Mice; Protein Conformation; Structure-Activity Relationship | 1986 |
Effect of reducing agents and oxygen on plating efficiency of some mammalian cells in culture.
Topics: Animals; Benzopyrenes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine; Hydrogen-Ion Concentration; Mice; Mice, Inbred C3H; Oxygen; Thioglycolates | 1974 |