Page last updated: 2024-08-17

cysteamine and Huntington Disease

cysteamine has been researched along with Huntington Disease in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's0 (0.00)18.2507
2000's6 (50.00)29.6817
2010's5 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Allain, P; Azulay, JP; Bachoud-Lévi, AC; Bonneau, D; Calvas, F; Charles, P; Durr, A; Goizet, C; Krystkowiak, P; Maison, P; Olivier, A; Prundean, A; Reynier, P; Saudou, F; Scherer, C; Simonin, C; Tranchant, C; Verny, C; von Studnitz, E; Youssov, K1
Akimov, S; Arbez, N; Eddings, C; Ren, M; Roby, E; Ross, CA; Wang, X1
Bonneau, D; Humbert, S; Prundean, A; Verny, C; Youssov, K1
Cicchetti, F; Gibrat, C1
Borges-Correia, A; Panayotis, N; Roux, JC; Saudou, F; Villard, L; Zala, D1
Couzin, J1
Cooper, AJ; Hayden, MR; Jeitner, TM; Krasnikov, BF; Leavitt, BR; Pinto, JT; Thaler, HT; Van Raamsdonk, JM1
Dubinsky, R; Gray, C1
Alberch, J; Borrell-Pagès, M; Brouillet, E; Bryson, EA; Canals, JM; Cheetham, ME; Cordelières, FP; Grange, G; Guillermier, M; Hantraye, P; Hirsch, E; Humbert, S; Néri, C; Parker, JA; Pineda, JR; Saudou, F1
Frankish, H1
Humbert, S; Saudou, F1
Barone, P; Chase, TN; Fedio, P; Juncos, J; Mohr, E; Serrati, C; Shults, C; Steardo, L; Tamminga, CA1

Reviews

1 review(s) available for cysteamine and Huntington Disease

ArticleYear
Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Mar-30, Volume: 35, Issue:2

    Topics: Animals; Cystamine; Cysteamine; Disease Models, Animal; Enzyme Inhibitors; Humans; Huntington Disease; Mice; Mice, Transgenic; Molecular Targeted Therapy; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Radiation-Protective Agents

2011

Trials

4 trial(s) available for cysteamine and Huntington Disease

ArticleYear
A randomized, double-blind, placebo-controlled trial evaluating cysteamine in Huntington's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2017, Volume: 32, Issue:6

    Topics: Adult; Aged; Cysteamine; Cystine Depleting Agents; Delayed-Action Preparations; Double-Blind Method; Female; Follow-Up Studies; Humans; Huntington Disease; Male; Middle Aged; Treatment Outcome

2017
A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2015, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Cysteamine; Drug Tolerance; Humans; Huntington Disease; Middle Aged; Treatment Outcome; Young Adult

2015
CYTE-I-HD: phase I dose finding and tolerability study of cysteamine (Cystagon) in Huntington's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:4

    Topics: Adult; Cysteamine; Drug Administration Schedule; Drug Tolerance; Female; Humans; Huntington Disease; Male; Middle Aged; Radiation-Protective Agents; Severity of Illness Index

2006
Huntington's disease: effect of cysteamine, a somatostatin-depleting agent.
    Neurology, 1986, Volume: 36, Issue:8

    Topics: Adult; Cognition; Cysteamine; Female; Humans; Huntington Disease; Male; Middle Aged; Somatostatin

1986

Other Studies

7 other study(ies) available for cysteamine and Huntington Disease

ArticleYear
Cysteamine Protects Neurons from Mutant Huntingtin Toxicity.
    Journal of Huntington's disease, 2019, Volume: 8, Issue:2

    Topics: Animals; Cells, Cultured; Cysteamine; Huntingtin Protein; Huntington Disease; Mice; Mutation; Neurons; Neuroprotective Agents

2019
[Unexpected link between Huntington disease and Rett syndrome].
    Medecine sciences : M/S, 2012, Volume: 28, Issue:1

    Topics: Animals; Axonal Transport; Axons; Biological Transport; Brain Stem; Brain-Derived Neurotrophic Factor; Cysteamine; Drug Evaluation, Preclinical; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Methyl-CpG-Binding Protein 2; Mice; Models, Neurological; Nerve Tissue Proteins; Nuclear Proteins; Rett Syndrome; Transcription, Genetic; Transport Vesicles

2012
Huntington's disease. Unorthodox clinical trials meld science and care.
    Science (New York, N.Y.), 2004, May-07, Volume: 304, Issue:5672

    Topics: Animals; Blueberry Plants; Clinical Trials as Topic; Creatine; Cysteamine; Drug Therapy, Combination; Drug Therapy, Computer-Assisted; Fatty Acids, Omega-3; Humans; Huntington Disease; Mice; Patient Selection; Phytotherapy; Plant Extracts; Software; Trehalose; Ubiquinone

2004
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.
    Journal of neurochemistry, 2005, Volume: 94, Issue:4

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Colorimetry; Cystamine; Cysteamine; Female; Glutathione; Huntington Disease; Male; Mice; Mice, Transgenic; Taurine; Time Factors

2005
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:5

    Topics: Aged; Animals; Brain; Brain-Derived Neurotrophic Factor; Caenorhabditis elegans; Cystamine; Cysteamine; HSP40 Heat-Shock Proteins; Humans; Huntington Disease; Macaca; Mice; Mice, Transgenic; Middle Aged; Molecular Chaperones; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Transglutaminases

2006
Drug shows potential for treatment of Huntington's disease.
    The Lancet. Neurology, 2006, Volume: 5, Issue:6

    Topics: Brain-Derived Neurotrophic Factor; Cell Death; Cystamine; Cysteamine; Enzyme Inhibitors; Humans; Huntington Disease

2006
[Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease].
    Medecine sciences : M/S, 2006, Volume: 22, Issue:11

    Topics: Brain-Derived Neurotrophic Factor; Cysteamine; Humans; Huntington Disease; Transglutaminases

2006