cysmethynil has been researched along with Leukemia--Myeloid--Acute* in 1 studies
1 other study(ies) available for cysmethynil and Leukemia--Myeloid--Acute
Article | Year |
---|---|
A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia.
Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the clinical validation of this approach. In this work we report a potent ICMT inhibitor, compound Topics: Alanine; Amides; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Enzyme Inhibitors; Humans; Leukemia, Myeloid, Acute; Mice; Protein Methyltransferases; Xenograft Model Antitumor Assays | 2019 |