cyproterone and Skin-Diseases

Several antiandrogens compounds are available in the treatment of acne and hirsutism in women. Cyproterone acetate is the most effective antiandrogen. Its use must prevent the occurrence of amenorrhea with the prescription of an appropriate estrogen. Spironolactone, less effective, is better tolerated on a long-term basis, if precaution is taken to combine it sequentially with a progesterone or a norprogesterone, in order to avoid the occurrence of short cycles. This is the treatment of choice of moderate hirsutism or acne, in young patients. The association of spironolactone with an estroprogestative without nortestosterone is easy to use and well tolerated, and gives good results on acne and hirsutism.

Topics: Androgen Antagonists; Androgens; Cyproterone; Cyproterone Acetate; Endocrine System Diseases; Female; Humans; Skin Diseases; Spironolactone

Antiandrogens, substances that prevent androgens from expressing their activity at target cells, play an important role in the treatment of prostate cancer. The most frequently used substances have either a steroidal structure (cyproterone acetate) or a non-steroidal structure (Flutamide or Anandron). Antiandrogens have been tested both alone and in combination with treatments aimed at inhibiting testicular secretion (castration, LH-RH analogs), thereby producing complete blockade of androgen secretion and action. Patients treated by such combination protocols have often shown an improvement in the percentage of remissions and, less often, improvement in survival. Administration of antiandrogens improves the clinical symptoms of patients with benign prostatic hypertrophy, but the exact mechanism of their action requires further investigation. Cutaneous manifestations due to hyperandrogenicity (hirsutism, alopecia, acne) have also been improved by cyproterone acetate, which is often given together with estrogens (reversed sequential regime), by spironolactone or topically applied products. Finally, antiandrogens have been successfully used to treat breast cancer in men, early puberty, hypersexuality and sexual deviations.

Topics: Androgen Antagonists; Breast Neoplasms; Cyproterone; Cyproterone Acetate; Female; Flutamide; Humans; Imidazoles; Imidazolidines; Male; Prostatic Hyperplasia; Prostatic Neoplasms; Puberty, Precocious; Skin Diseases; Spironolactone

This article describes impending advances in drug treatment of skin diseases. We have included the following categories: (1) interesting new drugs for which there are reasonable prospects of eventual licensing for skin indications, (2) important novel compounds whose progress through licensing procedures, although incomplete at the time of writing, is advanced, and (3) new indications or improved regimens that have recently emerged for established drugs.

Topics: Azathioprine; Cyproterone; Cyproterone Acetate; Furocoumarins; Gonadotropin-Releasing Hormone; Humans; Nifedipine; Skin Diseases

Topics: Administration, Topical; Androgen Antagonists; Cyproterone; Dihydrotestosterone; Female; Humans; Male; Skin Diseases; Testosterone

Topics: Acne Vulgaris; Adolescent; Adult; Androgens; Clinical Trials as Topic; Cyproterone; Cyproterone Acetate; Dermatitis, Seborrheic; Drug Combinations; Ethinyl Estradiol; Female; Humans; Male; Middle Aged; Skin Diseases

Topics: Acne Vulgaris; Androgen Antagonists; Chlormadinone Acetate; Clinical Trials as Topic; Cyproterone; Dermatitis, Seborrheic; Drug Combinations; Ethinyl Estradiol; Hirsutism; Humans; Mestranol; Skin Diseases

Modes of action of antiandrogens, their side effects as well as indications for their application to androgen-dependent skin conditions. Particular attention is paid to the possibilities for topical medication with antiandrogenic active substances.

Topics: Acne Vulgaris; Alopecia; Androgen Antagonists; Chlormadinone Acetate; Cyproterone; Cyproterone Acetate; Dermatitis, Seborrheic; Drug Therapy, Combination; Female; Hirsutism; Humans; Male; Skin Diseases; Spironolactone

Topics: Androgen Antagonists; Cyproterone; Cyproterone Acetate; Drug Combinations; Ethinyl Estradiol; Female; Humans; Skin Diseases

The cyclical use of cyproterone acetate and ethinyl estradiol successfully prevented attacks of abdominal pain in a 30-year-old woman suffering from porphyria variegata. Blistering still appeared following light exposure, but possibly to a lesser degree.

Topics: Abdomen; Adult; Cyproterone; Cyproterone Acetate; Drug Combinations; Ethinyl Estradiol; Female; Humans; Pain; Porphyrias; Skin Diseases

Topics: Adult; Androgen Antagonists; Candidiasis, Vulvovaginal; Cyproterone; Cyproterone Acetate; Female; Humans; Skin Diseases

Topics: Acne Vulgaris; Adolescent; Adult; Alopecia; Child; Chlormadinone Acetate; Cyproterone; Dermatitis, Seborrheic; Female; Fertility; Hirsutism; Humans; Menstruation; Puberty, Precocious; Skin Diseases