cyproterone and Obesity

Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Anorexia Nervosa; Blood Glucose; Brain Diseases; Catecholamines; Child; Circadian Rhythm; Cyproterone; Dexamethasone; Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Hypothalamus; Infant; Insulin; Metyrapone; Nephrotic Syndrome; Obesity; Pituitary Gland; Prednisone; Vasopressins

We have compared three treatments of congenital adrenal hyperplasia (CAH) for their effect on physical development. Thirteen girls and two boys with CAH due to 21-hydroxylase deficiency were treated with three different treatments, hydrocortisone (HC), dexamethasone (DXM) and cyproterone acetate (CA). The results showed that height growth was better with HC and CA than DXM, and bone excessive maturation was more suppressed with DXM and CA than HC. A dose-dependent relationship was revealed between body weight and dose of HC. Iatrogenic obesity was found in 42.9% and 38.1% of the patients treated with DXM and HC, but none of the patients treated with CA did became obese. Physical growth was better with CA treatment than HC or DXM treatment, but CA may have a suppressive effect on the pituitary-adrenal axis observed carefully, especially on prepubertal and pubertal cases.

Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Body Height; Bone Development; Child, Preschool; Cyproterone; Cyproterone Acetate; Dexamethasone; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Infant; Infant, Newborn; Luteinizing Hormone; Male; Obesity; Pregnanetriol

Sera from 500 female blood donors, aged 18-40 years, were examined by quantitative lipoprotein electrophoresis. 218 women had been taking oral contraceptives for more than 3 months; the remaining 282 not on contraceptives acted as controls. The two groups were similar as to age distribution, weight and smoking habits. There were five sub-groups according to the composition of the contraceptives. It was found that all contraceptives had a favourable influence on the atherogenic beta-lipoprotein fraction. The pure progestogen preparations were less advantageous because they in particular reduced the concentration of potentially anti-atherogenic alpha-lipoproteins.. Sera from 500 female blood donors ages 18-40 were examined by quantitative lipoprotein electrophoresis. 218 women had been taking oral contraceptives (OCs) for more than 3 months; the remaining 282 who were not taking OCs acted as controls. The 2 groups were similar as to age distribution, weight, and smoking habits. There were 5 subgroups according to the composition of OCs. It was found that all OCs had a favorable influence on the atherogenic beta-lipoprotein fraction. The pure progestogen preparations were less advantageous because they reduced the concentration of potentially antiantherogenic alpha-lipoproteins. (author's)

Topics: Adolescent; Adult; Blood Donors; Contraceptives, Oral; Cyproterone; Estrogens; Ethinyl Estradiol; Female; Humans; Lipoproteins; Lipoproteins, LDL; Mestranol; Obesity; Progesterone Congeners; Smoking

The most important therapeutic problems of female puberty and adolescence are discussed, including high stature, amenorrhoea, oligomenorrhea, pubertas tarda, anovulation, anorexia, anisomastia, hypermastia. Indications for treatment are given and the possibilities for a prophylactic medicine in this age group are stressed.

Topics: Acne Vulgaris; Adolescent; Amenorrhea; Anorexia Nervosa; Breast Diseases; Child; Cyproterone; Drug Combinations; Endocrine System Diseases; Estradiol Congeners; Ethinyl Estradiol; Female; Growth Disorders; Hirsutism; Humans; Menstruation Disturbances; Obesity; Oligomenorrhea; Progesterone Congeners; Puberty, Precocious