cyproterone and Liver-Neoplasms

Topics: Carcinoma, Hepatocellular; Child; Cyproterone; Female; Humans; Liver Neoplasms

Topics: Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Cyproterone; Cyproterone Acetate; Humans; Liver Neoplasms; Male; Prostatic Neoplasms

The male preponderance in cirrhotic patients with primary hepatocellular carcinoma (HCC) and the presence of androgen receptors in tumour tissue suggest possible benefit from anti-androgenic therapy. Twenty-five cirrhotic patients with irresectable HCC (23 male) were treated with cyproterone acetate (CPA) 300 mg daily. Hepatic ultrasound, alpha-fetoprotein and total and free sex steroid levels were monitored. Five patients had an objective response to therapy with a median duration of 8 weeks and survival in excess of 29 weeks. Median survival for all patients was 14 weeks. Apart from transient paranoia in two cases, side-effects were minimal. Total androgen levels (measured in 13 patients) had fallen significantly at 10 weeks, but free 5 alpha-dihydrotestosterone (DHT) which had fallen by 4.8 pM (median) in five responders, had risen by 5.05 pM in eight non-responders: P less than 0.025. The apparent correlation of response with reduction in free DHT suggests that hormonal manipulation may be effective in HCC if free DHT is reliably reduced. This has been achieved in other conditions by the combination of CPA with low dose oestrogen or with LHRH agonists.

Topics: Adult; Aged; Androgen Antagonists; Antineoplastic Agents; Carcinoma, Hepatocellular; Cyproterone; Cyproterone Acetate; Dihydrotestosterone; Female; Gonadal Steroid Hormones; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasms, Hormone-Dependent

Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cyproterone; Cyproterone Acetate; Humans; Liver Neoplasms

Topics: Aged; Carcinoma, Hepatocellular; Cyproterone; Female; Humans; Liver Neoplasms; Male

Endogenous (estradiol-17 beta; progesterone) and synthetic (ethinyl estradiol; cyproterone acetate; norethindrone acetate; norethynodrel) sex steroids were evaluated for tumor-initiating activity in the rat liver using the Solt-Farber system. All steroids were negative. This provides further evidence that tumor formation in long-term rodent bioassays by these compounds may be due to epigenetic mechanisms.

Topics: Androgen Antagonists; Animals; Carcinogens; Cyproterone; Cyproterone Acetate; Estradiol; Ethinyl Estradiol; Liver Neoplasms; Male; Neoplasms, Experimental; Norethindrone; Norethindrone Acetate; Norethynodrel; Progesterone; Rats; Rats, Inbred F344

Topics: Animals; Carcinogens; Cell Division; Cyproterone; Cyproterone Acetate; Eating; Female; Hexachlorocyclohexane; Liver; Liver Neoplasms; Male; Mitotic Index; Nitrosamines; Precancerous Conditions; Progesterone; Rats; Rats, Inbred Strains

Topics: Animals; Carcinogens; Cell Division; Cyproterone; DNA, Neoplasm; Female; gamma-Glutamyltransferase; Hexachlorocyclohexane; Liver; Liver Neoplasms; Neoplasms, Experimental; Precancerous Conditions; Rats

Topics: Adrenal Insufficiency; Animals; Cyproterone; Liver Neoplasms; Rats

Topics: Animals; Carcinoma, Hepatocellular; Cyproterone; Liver Neoplasms; Rats

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Androgen Antagonists; Bone Neoplasms; Carcinoma; Cyproterone; Estrogens; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pregnadienes; Prostatic Neoplasms