cyproterone and Leiomyosarcoma

cyproterone has been researched along with Leiomyosarcoma* in 1 studies

Other Studies

1 other study(ies) available for cyproterone and Leiomyosarcoma

Article	Year
Characterization of the androgen receptor from a Syrian hamster ductus deferens tumor cell line (DDT1). Science (New York, N.Y.), 1976, May-28, Volume: 192, Issue:4242 The hamster ductus deferens cloned tumor cell line (DDT1) contains a complex steroid receptor protein that binds 3H-labeled 5 alpha-dihydrotestosterone,. Diethylaminoethyl (DEAE) chromatography of cytosol from these cells yields two major receptor peaks of activity. Identification of this steroid binding protein as a cytoplasmic receptor was confirmed by salt dissociation on sucrose gradients, stability of the hormone-receptor complex at 0 degrees C, and the retention patterns on phosphocellulose and DEAE cellulose. Multiple forms of the receptor exist in a single homogeneous cell type. The data support the theory that steroid hormones bind to a cytoplasmic protein receptor composed of dissimilar subunits as the initial step in steroid hormone action. Topics: Carrier Proteins; Cell Fractionation; Cell Line; Centrifugation, Density Gradient; Chromatography, Affinity; Chromatography, Ion Exchange; Cyproterone; Dihydrotestosterone; Estradiol; Leiomyosarcoma; Male; Molecular Weight; Neoplasms, Experimental; Progesterone; Protein Conformation; Receptors, Cell Surface; Vas Deferens	1976

Article

Year

Characterization of the androgen receptor from a Syrian hamster ductus deferens tumor cell line (DDT1).

Science (New York, N.Y.), 1976, May-28, Volume: 192, Issue:4242

The hamster ductus deferens cloned tumor cell line (DDT1) contains a complex steroid receptor protein that binds 3H-labeled 5 alpha-dihydrotestosterone,. Diethylaminoethyl (DEAE) chromatography of cytosol from these cells yields two major receptor peaks of activity. Identification of this steroid binding protein as a cytoplasmic receptor was confirmed by salt dissociation on sucrose gradients, stability of the hormone-receptor complex at 0 degrees C, and the retention patterns on phosphocellulose and DEAE cellulose. Multiple forms of the receptor exist in a single homogeneous cell type. The data support the theory that steroid hormones bind to a cytoplasmic protein receptor composed of dissimilar subunits as the initial step in steroid hormone action.

Topics: Carrier Proteins; Cell Fractionation; Cell Line; Centrifugation, Density Gradient; Chromatography, Affinity; Chromatography, Ion Exchange; Cyproterone; Dihydrotestosterone; Estradiol; Leiomyosarcoma; Male; Molecular Weight; Neoplasms, Experimental; Progesterone; Protein Conformation; Receptors, Cell Surface; Vas Deferens

1976