cyproterone and Intellectual-Disability

A minority of people with mental retardation have sexual behaviour which is socially unacceptable or which brings them into conflict with the law. Such behaviour may be the result of ignorance about sexual matters, often best managed by counselling or by a behavioural approach. There are a small number of men with mental retardation and aberrant sexual behaviour who benefit from the prescription of an antilibidinal drug. Treatment with an antilibidinal drug alone reduces the intensity of sexual drive but does not alter its direction; concurrent sexual counselling or psychotherapy is often indicated. The various antilibidinal medications available are reviewed, with particular attention to reports which have described the treatment of people with mental retardation. Of the antilibidinals currently used, medroxyprogesterone acetate and cyproterone acetate are those for which there is most evidence of efficacy. Cyproterone acetate is preferable because it has a specific antiandrogenic action and fewer adverse effects. There is a need for controlled studies of antilibidinal drugs, with clearly defined inclusion criteria and adequate measures of both behavioural and attitudinal change.

Topics: Benperidol; Cyproterone; Cyproterone Acetate; Humans; Intellectual Disability; Medroxyprogesterone; Medroxyprogesterone Acetate; Sex Offenses; Sexual Behavior

Topics: Adolescent; Adult; Androgen Antagonists; Castration; Clinical Trials as Topic; Cyproterone; Estrogens; Germany, West; Gonadotropins; Homosexuality; Humans; Intellectual Disability; Libido; Male; Middle Aged; Neurotic Disorders; Paraphilic Disorders; Personality Disorders; Progestins; Psychiatric Status Rating Scales; Schizophrenia; Sex Offenses

A total of 509 in- and outpatients with oligophrenia have been studied over time. A multiple modality therapy selected with due consideration to the structure and pathogenetic mechanisms of psychopathological symptom formation was found to be essential in the treatment and prophylaxis of decompensatory states in patients. It is emphasized that psychopharmacotherapy is rather likely to cause side effects and complications. The authors, therefore, pay much attention to search for new combinations of psychotropic drugs and to the use of pharmacological preparations of other groups, in particular alpha- and beta-blockers, and libido inhibitors.

Topics: Adolescent; Combined Modality Therapy; Cyproterone; Diuretics; Drug Therapy, Combination; Humans; Intellectual Disability; Mental Disorders; Psychotropic Drugs; Sexual Dysfunctions, Psychological; Sympatholytics