cyproterone and Infertility--Female

To report the case of an infertile female patient with cystic fibrosis who was diagnosed with endocervical metaplasia of the endometrium at diagnostic hysteroscopy and successfully treated with an oral estroprogestinic formulation.. Case report.. University hospital.. A 27-year-old infertile female patient with cystic fibrosis.. Hysteroscopy with multiple random biopsies was performed at the time of the first visit and after a 10-month cycle with an oral estroprogestinic formulation.. Hysteroscopic evaluation with target biopsy; histological examinations of endometrial specimens.. Our patient benefited from a 10-month cycle with an oral estroprogestinic formulation. At the control visit we noticed a significant improvement in the hysteroscopic appearance of her endometrium, and the histological examination confirmed the complete reversion of the metaplastic alterations previously observed.. The present report suggests a novel histological alteration possibly involved in affecting fertility in women with cystic fibrosis. In addition, the positive response to the estroprogestinic treatment observed in our patient poses new questions regarding the relationship between ovarian hormones and cystic fibrosis transmembrane conductance regulator protein regulation, offering interesting perspectives for a hormonal therapy in the treatment of subfertility in women with cystic fibrosis.

Topics: Administration, Oral; Adult; Androgen Antagonists; Cervix Uteri; Cyproterone; Cystic Fibrosis; Drug Combinations; Endometrium; Estrogens; Ethinyl Estradiol; Female; Humans; Hysteroscopy; Infertility, Female; Menstruation Disturbances; Metaplasia; Treatment Outcome

Topics: Adrenal Hyperplasia, Congenital; Androgen Antagonists; Androgens; Cyproterone; Cyproterone Acetate; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Drug Combinations; Ethinyl Estradiol; Female; Humans; Infertility, Female; Testosterone

Topics: Androgen Antagonists; Animals; Cyproterone; Female; Humans; Infertility, Female; Libido; Male; Prostatic Hyperplasia; Puberty, Precocious; Rats; Spermatogenesis

Experiments with female rats designed to determine the mechanism of sex steroid-induced hypothalamic sterility are described and discussed. When rats were injected with 30 mcg testosterone propionate on Day 5 after birth and then injected with an antiandrogen, cyproterone acetate or barbiturates, at different intervals thereafter, it was found that the antiandrogen or barbiturates could inhibit androgen action only when given concurrently or shortly after the testosterone. The dosage of the hormone, the time of the neonatal period, and differences in the animal strain, are considered influencing factors on this effect. These androgen/antiandrogen treated rats also showed prolonged and even persistent vaginal estrus after puberty--a reaction comparable to the delayed anovulation syndrome (DAS). Histological examination of similarly treated ovariectomized rats prompted the conclusion that the hypothalamic sex center of the DAS rats is much more liable to ovarian hormonal influence than that of the normal female because of an incomplete feedback mechanism in the latter. This effect may be explained by a premature aging of the sex center caused by neonatal sex steroid treatment. Electrochemical experiments with female rats were conducted to compare pharmacological reactions of persistent estrous rats and persistent diestrous rats. It is concluded that the derangement of the regulatory centers of the pituitary gonadotrophic function of the diestrus rats is much wider than that of the estrus rats, but the syndromes do not appear to be entirely independent phenomena and are highly dependent on dosage, time of injection, and length of the injection period.

Topics: Androgens; Animals; Castration; Corpus Luteum; Cyproterone; Electric Stimulation; Estrogens; Estrus; Female; Hypothalamus; Infertility, Female; Ovary; Pentobarbital; Phenobarbital; Pregnancy; Rats; Stimulation, Chemical; Testosterone; Time Factors