cyproterone and Breast-Diseases

The authors report the results of an open multicentric study of 136 women treated by a combination of 35 micrograms ethinylestradiol and 2 mg cyproterone acetate for cutaneous manifestation of hyperandrogenism. No pregnancy occurred during the treatment of 12 months. Comparison between the last treated and non treated cycle showed a significant difference (p less than 0.001) in the severity of acne lesions regardless of their sites. General and gynaecological tolerance were excellent.

Topics: Acne Vulgaris; Adolescent; Adult; Androgen Antagonists; Breast Diseases; Cyproterone; Cyproterone Acetate; Drug Therapy, Combination; Ethinyl Estradiol; Female; Humans; Pain; Uterine Hemorrhage; Virilism

We compared the efficacy and safety of cyproterone acetate (Shering AC, Berlin, FRG) at a low (Diane, 2 mg) or a high dose (Androcur, 100 mg) in the treatment of 158 patients with severe hirsutism. At baseline, no difference was observed in mean hirsutism total index (19.5 Diane versus 20.1 Androcur) or distribution (facial, bust, or abdomen). By the end of the study, patient loss in Diane and Androcur groups was 29.1% and 27.8%, respectively, and the mean percent difference in the scoring index was as follows: total, 24.6 Diane versus 30.8 Androcur, P less than 0.05; facial, 30.1 Diane versus 33.0 Androcur, P less than 0.10; bust, 12.1 Diane versus 31.2 Androcur, P less than 0.02; and abdomen, 20.1 Diane versus 31.2 Androcur, P less than 0.02. Except for breast tenderness (Diane greater than Androcur), amenorrhea, and weight gain, (Androcur greater than Diane), the incidence of side effects was comparable in both groups.

Topics: Adolescent; Adult; Amenorrhea; Body Weight; Breast Diseases; Clinical Trials as Topic; Cyproterone; Cyproterone Acetate; Double-Blind Method; Drug Combinations; Ethinyl Estradiol; Female; Hirsutism; Humans; Random Allocation; Time Factors

The most important therapeutic problems of female puberty and adolescence are discussed, including high stature, amenorrhoea, oligomenorrhea, pubertas tarda, anovulation, anorexia, anisomastia, hypermastia. Indications for treatment are given and the possibilities for a prophylactic medicine in this age group are stressed.

Topics: Acne Vulgaris; Adolescent; Amenorrhea; Anorexia Nervosa; Breast Diseases; Child; Cyproterone; Drug Combinations; Endocrine System Diseases; Estradiol Congeners; Ethinyl Estradiol; Female; Growth Disorders; Hirsutism; Humans; Menstruation Disturbances; Obesity; Oligomenorrhea; Progesterone Congeners; Puberty, Precocious

Topics: Acne Vulgaris; Adult; Breast Diseases; Cyproterone; Female; Hirsutism; Humans; Libido