cyproheptadine has been researched along with Weight Gain in 14 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 9.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| " Dosing levels included various combinations of the two compounds, ranging from 0-16 ppm DON and 0-20 ppm CYP." | 5.30 | Effect of the appetite stimulant cyproheptadine on deoxynivalenol-induced reductions in feed consumption and weight gain in the mouse. ( Prelusky, DB; Rotter, BA; Thompson, BK; Trenholm, HL, 1997) |
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 5.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| "A 3-week HFD regimen with cyproheptadine supplementation in female SD rats resulted in a significant increase in body weight and acute metabolic alterations." | 4.12 | Effect of Metaswitch® dietary supplement on anthropometric parameters, serum lipids, glucose level, oxidative stress and in vivo antioxidant properties in high fat diet-induced overweight Sprague Dawley rats. ( Adams, I; Adi-Dako, O; Adinortey, MB; Amponsah, SK; Appiah-Opong, R; Asiedu-Gyekye, IJ; Brown, C; N'guessan, BB; Poakwah, AK; Sarkodie, JA; Twumasi-Ankrah, JS, 2022) |
| " Cyproheptadine, dexamethasone, sildenafil, tramadol, caffeine and acetaminophen were detected in herbal weight gain drugs." | 3.88 | Determination of synthetic pharmaceutical adulterants in herbal weight gain supplements sold in herb shops, Tehran, Iran. ( Akhgari, M; Bahmanabadi, L; Bazmi, E; Mousavi, Z; Saberi, N, 2018) |
| "Anorexia and cachexia are common clinical problems of many patients with advanced cancer." | 3.76 | Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group. ( Burch, PA; Ellison, NM; Goldberg, RM; Loprinzi, CL; Michalak, JC, 1990) |
| " Alternative managements by prescribing cyproheptadine as an appetite stimulant resulted in significant improvement of feeding behaviors and weight gain." | 3.75 | Successful treatment in a child with feeding problems and growth failure. ( Benjasuwantep, B, 2009) |
| "Cyproheptadine is a cheap, widely available anti-allergy drug with a broad receptor binding profile which resembles that of clozapine." | 1.34 | Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats. ( Cole, JC; Cooper, GD; Goudie, AJ; Sumnall, HR, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| N'guessan, BB | 1 |
| Twumasi-Ankrah, JS | 1 |
| Amponsah, SK | 1 |
| Adams, I | 1 |
| Poakwah, AK | 1 |
| Brown, C | 1 |
| Adinortey, MB | 1 |
| Sarkodie, JA | 1 |
| Adi-Dako, O | 1 |
| Asiedu-Gyekye, IJ | 1 |
| Appiah-Opong, R | 1 |
| Saberi, N | 1 |
| Akhgari, M | 1 |
| Bahmanabadi, L | 1 |
| Bazmi, E | 1 |
| Mousavi, Z | 1 |
| Harrison, ME | 1 |
| Norris, ML | 1 |
| Robinson, A | 1 |
| Spettigue, W | 1 |
| Morrissey, M | 1 |
| Isserlin, L | 1 |
| Sant'Anna, AM | 1 |
| Hammes, PS | 1 |
| Porporino, M | 1 |
| Martel, C | 1 |
| Zygmuntowicz, C | 1 |
| Ramsay, M | 1 |
| Couluris, M | 1 |
| Mayer, JL | 1 |
| Freyer, DR | 1 |
| Sandler, E | 1 |
| Xu, P | 1 |
| Krischer, JP | 1 |
| Benjasuwantep, B | 1 |
| LAVENSTEIN, AF | 1 |
| DACANEY, EP | 1 |
| LASAGNA, L | 1 |
| VANMETRE, TE | 1 |
| Goudie, AJ | 1 |
| Cooper, GD | 1 |
| Cole, JC | 1 |
| Sumnall, HR | 1 |
| Lerman-Sagie, T | 1 |
| Mimouni, M | 1 |
| Muranjan, MN | 1 |
| Mordekar, SR | 1 |
| Bava, HS | 1 |
| Alavi, S | 1 |
| Kher, AS | 1 |
| Nadkarni, UB | 1 |
| Kamat, JR | 1 |
| Prelusky, DB | 1 |
| Rotter, BA | 1 |
| Thompson, BK | 1 |
| Trenholm, HL | 1 |
| Thirlby, RC | 1 |
| Kardinal, CG | 1 |
| Loprinzi, CL | 2 |
| Schaid, DJ | 1 |
| Hass, AC | 1 |
| Dose, AM | 1 |
| Athmann, LM | 1 |
| Mailliard, JA | 1 |
| McCormack, GW | 1 |
| Gerstner, JB | 1 |
| Schray, MF | 1 |
| Ellison, NM | 1 |
| Goldberg, RM | 1 |
| Michalak, JC | 1 |
| Burch, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders[NCT02568007] | Phase 4 | 4 participants (Actual) | Interventional | 2015-12-31 | Terminated (stopped due to Unable to enroll adequate participants) | ||
| The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia[NCT00066248] | Phase 2 | 70 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cyproheptadine and Weight Gain
| Article | Year |
|---|---|
Use of cyproheptadine to stimulate appetite and body weight gain: A systematic review.
Topics: Anorexia Nervosa; Appetite; Appetite Stimulants; Cyproheptadine; Humans; Malnutrition; Randomized Co | 2019 |
Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.
Topics: Anorexia; Cachexia; Cyproheptadine; Dexamethasone; Double-Blind Method; Humans; Hydrazines; Neoplasm | 1990 |
3 trials available for cyproheptadine and Weight Gain
| Article | Year |
|---|---|
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
A controlled trial of cyproheptadine in cancer patients with anorexia and/or cachexia.
Topics: Adult; Aged; Aged, 80 and over; Anorexia; Appetite; Cachexia; Cyproheptadine; Double-Blind Method; F | 1990 |
Alleviation of cancer anorexia and cachexia: studies of the Mayo Clinic and the North Central Cancer Treatment Group.
Topics: Anorexia; Cachexia; Cyproheptadine; Dexamethasone; Double-Blind Method; Humans; Hydrazines; Neoplasm | 1990 |
10 other studies available for cyproheptadine and Weight Gain
| Article | Year |
|---|---|
Effect of Metaswitch® dietary supplement on anthropometric parameters, serum lipids, glucose level, oxidative stress and in vivo antioxidant properties in high fat diet-induced overweight Sprague Dawley rats.
Topics: Animals; Antioxidants; Body Weight; Cyproheptadine; Diet, High-Fat; Dietary Supplements; Female; Glu | 2022 |
Determination of synthetic pharmaceutical adulterants in herbal weight gain supplements sold in herb shops, Tehran, Iran.
Topics: Acetaminophen; Caffeine; Cyproheptadine; Dexamethasone; Dietary Supplements; Drug Contamination; Hum | 2018 |
Use of cyproheptadine in young children with feeding difficulties and poor growth in a pediatric feeding program.
Topics: Adult; Appetite Stimulants; Child; Child, Preschool; Cyproheptadine; Feeding Behavior; Female; Growt | 2014 |
Successful treatment in a child with feeding problems and growth failure.
Topics: Anorexia; Child, Preschool; Cyproheptadine; Feeding Behavior; Growth Disorders; Humans; Male; Seroto | 2009 |
Effect of cyproheptadine on asthmatic children. Study of appetite, weight gain, and linear growth.
Topics: Antihypertensive Agents; Appetite; Asthma; Body Weight; Child; Cyproheptadine; Growth; Histamine H1 | 1962 |
Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats.
Topics: Animals; Anti-Allergic Agents; Antipsychotic Agents; Clozapine; Conditioning, Operant; Cyproheptadin | 2007 |
Reversal of anorexia in a child with partial ornithine transcarbamylase deficiency by cyproheptadine therapy.
Topics: Anorexia; Child; Cyproheptadine; Female; Humans; Ornithine Carbamoyltransferase Deficiency Disease; | 1995 |
Cyproheptadine in severe anorexia.
Topics: Anorexia; Child, Preschool; Cyproheptadine; Female; Humans; Tuberculosis, Meningeal; Weight Gain | 1994 |
Effect of the appetite stimulant cyproheptadine on deoxynivalenol-induced reductions in feed consumption and weight gain in the mouse.
Topics: Animals; Appetite Stimulants; Cyproheptadine; Drug Evaluation, Preclinical; Feeding Behavior; Male; | 1997 |
Toward a treatment for anorexia and cachexia in patients with cancer.
Topics: Anorexia; Appetite Regulation; Cachexia; Cyproheptadine; Dexamethasone; Humans; Megestrol; Megestrol | 1991 |