cyproheptadine has been researched along with Serotonin Syndrome in 29 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyproheptadine is a serotonin and histamine antagonist that has been suggested as a treatment for serotonin syndrome in case reports." | 7.91 | An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System. ( Cantrell, LF; Kearney, T; Nguyen, H; Pan, A; Smollin, C, 2019) |
| "Despite the numerous advantages of linezolid therapy, one disadvantage continuing to hinder its use is the risk of serotonin syndrome when coadministered with other serotonergic agents." | 7.83 | Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine. ( Deardorff, OG; Doisy, R; Khan, T; Kulkarni, G; Loehr, C, 2016) |
| "We describe a case of serotonin syndrome secondary to clozapine withdrawal and concomitant use of citalopram hydrobromide, a phenomenon that has been rarely reported." | 7.79 | Serotonin syndrome associated with clozapine withdrawal. ( Burns, JD; Green, DM; Schembri, F; Stevenson, E, 2013) |
| "The authors report the case of a patient who developed a serotonin syndrome after taking sertraline and metoclopramide." | 7.70 | [Serotonin syndrome secondary to the use of sertraline and metoclopramide]. ( Beukinga, I; Nève, P; Vandemergel, X, 2000) |
| "Serotonin syndrome is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system." | 6.72 | Postoperative Serotonin Syndrome Following Methylene Blue Administration for Vasoplegia After Cardiac Surgery: A Case Report and Review of the Literature. ( Basta, MN, 2021) |
| "She had a seizure and required sedation and intubation." | 5.62 | Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. ( Beau, J; Bolton, TA; Carpenter, JE; Kazzi, Z; Kiernan, EA; Murray, BP; Sayers, J; Wolf, MJ; Yeh, M, 2021) |
| "Oral terbutaline was begun for hemodynamic improvement." | 5.56 | Serotonin Syndrome Following Terbutaline Administration in a Heart Transplant Patient on Multiple Inotropic Agents: A Case Report. ( Maxa, JL, 2020) |
| "BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone." | 5.48 | Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018) |
| "Citalopram is a very potent and highly selective inhibitor of neuronal serotonin (5-hydroxytryptamine, or 5-HT)." | 5.34 | First time, low dose citalopram use-related serotonin syndrome. ( Eraydin, I; Gunduz, A; Hos, U; Kalkan, A; Turedi, S, 2007) |
| "Despite the numerous advantages of linezolid therapy, one disadvantage continuing to hinder its use is the risk of serotonin syndrome when coadministered with other serotonergic agents." | 3.83 | Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine. ( Deardorff, OG; Doisy, R; Khan, T; Kulkarni, G; Loehr, C, 2016) |
| "We describe a case of serotonin syndrome secondary to clozapine withdrawal and concomitant use of citalopram hydrobromide, a phenomenon that has been rarely reported." | 3.79 | Serotonin syndrome associated with clozapine withdrawal. ( Burns, JD; Green, DM; Schembri, F; Stevenson, E, 2013) |
| "Cyproheptadine is reported to be effective in treating serotonin syndrome." | 3.72 | A comparison of the pharmacokinetics of oral and sublingual cyproheptadine. ( Collins, M; Graudins, A; Gunja, N, 2004) |
| "The authors report the case of a patient who developed a serotonin syndrome after taking sertraline and metoclopramide." | 3.70 | [Serotonin syndrome secondary to the use of sertraline and metoclopramide]. ( Beukinga, I; Nève, P; Vandemergel, X, 2000) |
| "Serotonin syndrome is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system." | 2.72 | Postoperative Serotonin Syndrome Following Methylene Blue Administration for Vasoplegia After Cardiac Surgery: A Case Report and Review of the Literature. ( Basta, MN, 2021) |
| "She had a seizure and required sedation and intubation." | 1.62 | Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. ( Beau, J; Bolton, TA; Carpenter, JE; Kazzi, Z; Kiernan, EA; Murray, BP; Sayers, J; Wolf, MJ; Yeh, M, 2021) |
| "BACKGROUND Serotonin syndrome is a life-threatening condition that involves overstimulation serotonin receptors, which can be caused by medication overdose, drug-drug interactions, and regular doses of medications." | 1.56 | Underlying Serotonin Syndrome, Masked by Community-Acquired Pneumonia and Myocardial Ischemia. ( Arshad, W; Lim, R, 2020) |
| "Oral terbutaline was begun for hemodynamic improvement." | 1.56 | Serotonin Syndrome Following Terbutaline Administration in a Heart Transplant Patient on Multiple Inotropic Agents: A Case Report. ( Maxa, JL, 2020) |
| "BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone." | 1.48 | Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose. ( Lin, CM; Little, K; Reynolds, PM, 2018) |
| "Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS) are life-threatening adverse reactions caused by serotonergic antidepressants and neuroleptics, respectively." | 1.42 | Serotonin syndrome overlapping with neuroleptic malignant syndrome: A case report and approaches for differentially diagnosing the two syndromes. ( Nisijima, K, 2015) |
| "Seizures were significantly increased in rats receiving 80% and 120% of citalopram MLD versus controls (p<0." | 1.38 | Mechanisms of high-dose citalopram-induced death in a rat model. ( Baud, FJ; Beaune, S; Callebert, J; Juvin, P; Mégarbane, B; Risède, P, 2012) |
| " However, the neural mechanism by which extracellular 5-HT is elevated to a toxic level for the syndrome remains to be determined." | 1.35 | Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. ( Huang, X; Krishnamoorthy, S; Ma, Z; Tao, R; Vukovich, NP; Zhang, G, 2009) |
| "Citalopram is a very potent and highly selective inhibitor of neuronal serotonin (5-hydroxytryptamine, or 5-HT)." | 1.34 | First time, low dose citalopram use-related serotonin syndrome. ( Eraydin, I; Gunduz, A; Hos, U; Kalkan, A; Turedi, S, 2007) |
| "Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent." | 1.31 | Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 12 (41.38) | 24.3611 |
| 2020's | 5 (17.24) | 2.80 |
| Authors | Studies |
|---|---|
| Petroianu, GA | 1 |
| Lim, R | 1 |
| Arshad, W | 1 |
| Maxa, JL | 1 |
| Basta, MN | 1 |
| Murray, BP | 1 |
| Carpenter, JE | 1 |
| Sayers, J | 1 |
| Yeh, M | 1 |
| Beau, J | 1 |
| Kiernan, EA | 1 |
| Wolf, MJ | 1 |
| Bolton, TA | 1 |
| Kazzi, Z | 1 |
| Puig-Comas, G | 1 |
| García-Peláez, M | 1 |
| Gorgas Torner, MQ | 1 |
| Pontes García, C | 1 |
| Little, K | 1 |
| Lin, CM | 1 |
| Reynolds, PM | 1 |
| Nguyen, H | 1 |
| Pan, A | 1 |
| Smollin, C | 1 |
| Cantrell, LF | 1 |
| Kearney, T | 1 |
| Bergamini, E | 1 |
| Peche, S | 1 |
| Ferguson, W | 1 |
| Scalzo, A | 1 |
| Calamur, N | 1 |
| Stevenson, E | 1 |
| Schembri, F | 1 |
| Green, DM | 1 |
| Burns, JD | 1 |
| Nisijima, K | 2 |
| Raguveer, V | 1 |
| Varshney, A | 1 |
| D'Ambrosio, JC | 1 |
| Deardorff, OG | 1 |
| Khan, T | 1 |
| Kulkarni, G | 1 |
| Doisy, R | 1 |
| Loehr, C | 1 |
| Isenberg, D | 1 |
| Wong, SC | 1 |
| Curtis, JA | 1 |
| Zhang, G | 2 |
| Krishnamoorthy, S | 2 |
| Ma, Z | 2 |
| Vukovich, NP | 1 |
| Huang, X | 1 |
| Tao, R | 2 |
| Yacoub, HA | 1 |
| Johnson, WG | 1 |
| Souayah, N | 1 |
| Butler, MC | 1 |
| Di Battista, M | 1 |
| Warden, M | 1 |
| Zand, L | 1 |
| Hoffman, SJ | 1 |
| Nyman, MA | 1 |
| Beaune, S | 1 |
| Callebert, J | 1 |
| Baud, FJ | 1 |
| Risède, P | 1 |
| Juvin, P | 1 |
| Mégarbane, B | 1 |
| Yamawaki, S | 1 |
| Iwamoto, Y | 1 |
| Baigel, GD | 1 |
| Gunja, N | 1 |
| Collins, M | 1 |
| Graudins, A | 1 |
| Turedi, S | 1 |
| Eraydin, I | 1 |
| Gunduz, A | 1 |
| Kalkan, A | 1 |
| Hos, U | 1 |
| Jenney, C | 1 |
| Horowitz, BZ | 2 |
| Mullins, ME | 2 |
| Vandemergel, X | 1 |
| Beukinga, I | 1 |
| Nève, P | 1 |
| Yoshino, T | 1 |
| Yui, K | 1 |
| Katoh, S | 1 |
| Isbister, GK | 1 |
3 reviews available for cyproheptadine and Serotonin Syndrome
| Article | Year |
|---|---|
Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine".
Topics: Animals; Antidotes; Cyproheptadine; Hyperthermia; Hyperthermia, Induced; Hypothermia; Serotonin; Ser | 2022 |
Postoperative Serotonin Syndrome Following Methylene Blue Administration for Vasoplegia After Cardiac Surgery: A Case Report and Review of the Literature.
Topics: Cardiac Surgical Procedures; Cyproheptadine; Enzyme Inhibitors; Humans; Hypnotics and Sedatives; Lor | 2021 |
[Serotonin syndrome].
Topics: Adrenergic Uptake Inhibitors; Animals; Cyclopropanes; Cyproheptadine; Diagnosis, Differential; Fluvo | 2003 |
26 other studies available for cyproheptadine and Serotonin Syndrome
| Article | Year |
|---|---|
Underlying Serotonin Syndrome, Masked by Community-Acquired Pneumonia and Myocardial Ischemia.
Topics: Aged; Community-Acquired Infections; Cyproheptadine; Humans; Intensive Care Units; Male; Myocardial | 2020 |
Serotonin Syndrome Following Terbutaline Administration in a Heart Transplant Patient on Multiple Inotropic Agents: A Case Report.
Topics: Cardiotonic Agents; Cyproheptadine; Drug Interactions; Female; Heart Transplantation; Humans; Middle | 2020 |
Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine.
Topics: Adolescent; Adult; Bupropion; Cyproheptadine; Drug Overdose; Female; Humans; Male; Seizures; Seroton | 2021 |
Serotonin syndrome during a heat wave.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Comorbidity; Cyproheptadine; Diabetes Mellitus, Ty | 2018 |
Delayed Serotonin Syndrome in the Setting of a Mixed Fluoxetine and Serotonin Antagonist Overdose.
Topics: Benzodiazepines; Bupropion; Cyproheptadine; Dopamine Uptake Inhibitors; Drug Overdose; Fluoxetine; H | 2018 |
An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; California; Child; Child, Preschool; Cyproh | 2019 |
Fever and Altered Mental Status in an Adolescent Male With Burkitt Lymphoma.
Topics: Adolescent; Burkitt Lymphoma; Confusion; Cyproheptadine; Fever; Humans; Male; Selective Serotonin Re | 2019 |
Serotonin syndrome associated with clozapine withdrawal.
Topics: Benzodiazepines; Citalopram; Clozapine; Cyproheptadine; Female; Humans; Middle Aged; Selective Serot | 2013 |
Serotonin syndrome overlapping with neuroleptic malignant syndrome: A case report and approaches for differentially diagnosing the two syndromes.
Topics: Antidepressive Agents, Tricyclic; Clinical Decision-Making; Cyproheptadine; Dantrolene; Depressive D | 2015 |
Serotonin Syndrome: Difficult to Diagnose but Critical to Treat.
Topics: Adult; Antipsychotic Agents; Cyproheptadine; Diagnosis, Differential; Female; Fluoxetine; Humans; Pe | 2015 |
Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine.
Topics: Adult; Anti-Bacterial Agents; Cyproheptadine; Drug Interactions; Humans; Linezolid; Male; Osteomyeli | 2016 |
Serotonin syndrome triggered by a single dose of suboxone.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cyproheptadine; Humans; Male; Middle Aged; | 2008 |
Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Body Temperature; Clorgyline; Cyproheptadine; D | 2009 |
Serotonin syndrome after administration of milnacipran for fibromyalgia.
Topics: Aged; Cyclopropanes; Cyproheptadine; Fibromyalgia; Humans; Male; Milnacipran; Selective Serotonin Re | 2010 |
Sertraline-induced serotonin syndrome followed by mirtazapine reaction.
Topics: Adult; Antidepressive Agents; Cyproheptadine; Depressive Disorder, Major; Humans; Male; Mianserin; M | 2010 |
74-year-old woman with new-onset myoclonus.
Topics: Aged; Alzheimer Disease; Cyproheptadine; Diagnosis, Differential; Dopamine Antagonists; Dose-Respons | 2010 |
Mechanisms of high-dose citalopram-induced death in a rat model.
Topics: Animals; Body Temperature; Citalopram; Cyproheptadine; Diazepam; Dose-Response Relationship, Drug; L | 2012 |
Cyproheptadine and the treatment of an unconscious patient with the serotonin syndrome.
Topics: Cyproheptadine; Diagnosis, Differential; Female; Humans; Middle Aged; Serotonin Antagonists; Seroton | 2003 |
A comparison of the pharmacokinetics of oral and sublingual cyproheptadine.
Topics: Administration, Oral; Administration, Sublingual; Adolescent; Adult; Area Under Curve; Chromatograph | 2004 |
First time, low dose citalopram use-related serotonin syndrome.
Topics: Adult; Antidepressive Agents, Second-Generation; Citalopram; Confusion; Cyproheptadine; Fever; Fluid | 2007 |
Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Clorgyline; Cyproheptadine; Dizocilpine Maleate; Dos | 2008 |
Cyproheptadine for serotonin syndrome in an accidental pediatric sertraline ingestion.
Topics: Child, Preschool; Cyproheptadine; Drug Overdose; Female; Humans; Selective Serotonin Reuptake Inhibi | 1999 |
Serotonin syndrome after a single dose of fluvoxamine.
Topics: Adolescent; Anti-Anxiety Agents; Cyproheptadine; Female; Fluvoxamine; Humans; Selective Serotonin Re | 1999 |
[Serotonin syndrome secondary to the use of sertraline and metoclopramide].
Topics: Adult; Antiemetics; Cyproheptadine; Drug Combinations; Humans; Male; Metoclopramide; Selective Serot | 2000 |
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature | 2001 |
Comment: serotonin syndrome, mydriasis, and cyproheptadine.
Topics: Cyproheptadine; Humans; Mydriasis; Reproducibility of Results; Serotonin Antagonists; Serotonin Synd | 2001 |