cyproheptadine has been researched along with Sensitivity and Specificity in 9 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The method was successfully applied to a pharmacokinetic study of RT and its two metabolite DT and 3-OH-DT in healthy volunteers following single (10, 20, 40 mg) and multiple (10 mg) oral doses of rupatadine fumarate tablets." | 1.42 | Development of a highly sensitive LC-MS/MS method for simultaneous determination of rupatadine and its two active metabolites in human plasma: Application to a clinical pharmacokinetic study. ( Ding, L; Gu, P; Li, Q; Liu, B; Pan, L; Sun, C; Wu, C; Zhang, J, 2015) |
| "A stability-indicating MEKC was developed and validated for the analysis of rupatadine in tablet dosage forms, using nimesulide as internal standard." | 1.35 | Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method. ( da Silva Sangoi, M; da Silva, LM; Dalmora, SL; Nogueira, DR; Todeschini, V, 2008) |
| " The method has been successfully applied to a pharmacokinetic study of rupatadine and its major metabolite after oral administration of 10, 20 and 40mg rupatadine tablets to healthy Chinese volunteers." | 1.35 | Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers. ( Fan, G; Hong, Z; Wei, H; Wen, J; Wu, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 1 |
| Wang, Z | 1 |
| Zhou, T | 1 |
| Song, X | 1 |
| Liu, Q | 1 |
| Zhang, Y | 1 |
| He, L | 1 |
| Sun, C | 1 |
| Li, Q | 1 |
| Pan, L | 1 |
| Liu, B | 1 |
| Gu, P | 1 |
| Zhang, J | 2 |
| Ding, L | 1 |
| Wu, C | 1 |
| Nogueira, DR | 1 |
| da Silva Sangoi, M | 1 |
| da Silva, LM | 1 |
| Todeschini, V | 1 |
| Dalmora, SL | 1 |
| Wen, J | 1 |
| Hong, Z | 1 |
| Wu, Y | 2 |
| Wei, H | 1 |
| Fan, G | 1 |
| Fente, CA | 1 |
| Regal, P | 1 |
| Vázquez, BI | 1 |
| Feás, X | 1 |
| Franco, CM | 1 |
| Cepeda, A | 1 |
| Zhu, D | 1 |
| Li, X | 1 |
| Sun, J | 1 |
| You, T | 1 |
| Perkins, GA | 1 |
| Lamb, S | 1 |
| Erb, HN | 1 |
| Schanbacher, B | 1 |
| Nydam, DV | 1 |
| Divers, TJ | 1 |
| Tian, Y | 1 |
| Lin, H | 1 |
| Liang, J | 1 |
| Zhang, Z | 1 |
| Chen, Y | 1 |
| Visitsuntorn, N | 1 |
| Tuchinda, M | 1 |
| Arunyanark, N | 1 |
| Kerdsomnuk, S | 1 |
1 trial available for cyproheptadine and Sensitivity and Specificity
| Article | Year |
|---|---|
High performance liquid chromatography-tandem mass spectrometric determination of rupatadine in human plasma and its pharmacokinetics.
Topics: Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyproheptadine; Drug Stability; Est | 2008 |
8 other studies available for cyproheptadine and Sensitivity and Specificity
| Article | Year |
|---|---|
Determination of cyproheptadine in feeds using molecularly imprinted solid-phase extraction coupled with HPLC.
Topics: Animal Feed; Chromatography, High Pressure Liquid; Cyproheptadine; Linear Models; Molecular Imprinti | 2015 |
Development of a highly sensitive LC-MS/MS method for simultaneous determination of rupatadine and its two active metabolites in human plasma: Application to a clinical pharmacokinetic study.
Topics: Chromatography, Liquid; Cyproheptadine; Female; Formates; Humans; Loratadine; Male; Plasma; Reproduc | 2015 |
Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method.
Topics: Animals; Chromatography, Micellar Electrokinetic Capillary; Cyproheptadine; Drug Stability; L Cells; | 2008 |
Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers.
Topics: Adult; Asian People; Calibration; Chromatography, Liquid; Cyproheptadine; Drug Stability; Female; Fo | 2009 |
Development and validation of an LC-MS/MS confirmatory method for residue analysis of cyproheptadine in urine of food-producing animals.
Topics: Animals; Appetite Stimulants; Cattle; Chromatography, High Pressure Liquid; Cyproheptadine; Meat; Se | 2009 |
Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.
Topics: Buffers; Chlorpheniramine; Cyproheptadine; Diphenhydramine; Doxylamine; Electrochemistry; Electropho | 2012 |
Plasma adrenocorticotropin (ACTH) concentrations and clinical response in horses treated for equine Cushing's disease with cyproheptadine or pergolide.
Topics: Adrenocorticotropic Hormone; Animals; Cushing Syndrome; Cyproheptadine; Drug Monitoring; Female; Hor | 2002 |
Ice cube test in children with cold urticaria.
Topics: Child; Child, Preschool; Chronic Disease; Cold Temperature; Cyproheptadine; False Positive Reactions | 1992 |