cyproheptadine has been researched along with Schizophrenia in 13 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyproheptadine is a relatively safe compound and may be of therapeutic benefit in treating negative symptoms of schizophrenia in combination with typical neuroleptics." | 9.09 | Cyproheptadine in treatment of chronic schizophrenia: a double-blind, placebo-controlled study. ( Akhondzadeh, S; Amini-Nooshabadi, H; Davari-Ashtiani, R; Mohammadi, MR, 1999) |
| "Cyproheptadine pretreatment was associated with erratic increases or decreases in the hGH response to apomorphine, but did not alter PRL levels or apomorphine-induced PRL suppression." | 5.26 | Neuroendocrine effects of apomorphine: characterization of response patterns and application to schizophrenia research. ( Angrist, B; Branchey, L; Gershon, S; Halpern, F; Oleshansky, M; Paquin, J; Rotrosen, J; Sachar, EJ, 1979) |
| "Cyproheptadine is a relatively safe compound and may be of therapeutic benefit in treating negative symptoms of schizophrenia in combination with typical neuroleptics." | 5.09 | Cyproheptadine in treatment of chronic schizophrenia: a double-blind, placebo-controlled study. ( Akhondzadeh, S; Amini-Nooshabadi, H; Davari-Ashtiani, R; Mohammadi, MR, 1999) |
| "The objective of this study was to report the effect of the slow withdrawal of clozapine from 19 patients with neuroleptic-responsive schizophrenia at the end of a 2-year clinical trial of clozapine and to compare this with the results of naturalistic discontinuation of clozapine treatment in 64 neuroleptic-resistant schizophrenic patients." | 5.08 | Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine. ( Cola, PA; Lee, MA; Mason, EA; Meltzer, HY; Ranjan, R, 1996) |
| "Cyproheptadine pretreatment was associated with erratic increases or decreases in the hGH response to apomorphine, but did not alter PRL levels or apomorphine-induced PRL suppression." | 1.26 | Neuroendocrine effects of apomorphine: characterization of response patterns and application to schizophrenia research. ( Angrist, B; Branchey, L; Gershon, S; Halpern, F; Oleshansky, M; Paquin, J; Rotrosen, J; Sachar, EJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, HS | 1 |
| Song, DH | 1 |
| Kim, JH | 1 |
| Lee, YM | 1 |
| Han, ES | 1 |
| Yoo, KJ | 1 |
| Bacher, NM | 1 |
| Sanzone, MM | 1 |
| Kaup, B | 1 |
| Weiss, D | 1 |
| Aizenberg, D | 1 |
| Hermesh, H | 1 |
| Zemishlany, Z | 1 |
| Munitz, H | 1 |
| Radwan, M | 1 |
| Weizman, A | 1 |
| Meltzer, HY | 1 |
| Lee, MA | 1 |
| Ranjan, R | 1 |
| Mason, EA | 1 |
| Cola, PA | 1 |
| Kapur, S | 1 |
| Zipursky, RB | 1 |
| Akhondzadeh, S | 1 |
| Mohammadi, MR | 1 |
| Amini-Nooshabadi, H | 1 |
| Davari-Ashtiani, R | 1 |
| Chaudhry, IB | 1 |
| Soni, SD | 1 |
| Hellewell, JS | 1 |
| Deakin, JF | 1 |
| Nagao, T | 1 |
| Ohshimo, T | 1 |
| Mitsunobu, K | 1 |
| Sato, M | 1 |
| Otsuki, S | 1 |
| Rotrosen, J | 1 |
| Angrist, B | 1 |
| Gershon, S | 1 |
| Paquin, J | 1 |
| Branchey, L | 1 |
| Oleshansky, M | 1 |
| Halpern, F | 1 |
| Sachar, EJ | 1 |
| Silver, H | 2 |
| Blacker, M | 2 |
| Weller, MP | 2 |
| Lerer, B | 2 |
| Jeffries, JJ | 1 |
| Walker, C | 1 |
| Cowen, PJ | 1 |
| Gadhvi, H | 1 |
| Gosden, B | 1 |
| Kolakowska, T | 1 |
7 trials available for cyproheptadine and Schizophrenia
| Article | Year |
|---|---|
Cyproheptadine augmentation of haloperidol in chronic schizophrenic patients: a double-blind placebo-controlled study.
Topics: Adult; Chronic Disease; Cyproheptadine; Double-Blind Method; Drug Therapy, Combination; Female; Foll | 1995 |
Cyproheptadine treatment in neuroleptic-induced akathisia.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Cyproheptadine; Humans; Neurologic Examination; Psych | 1995 |
Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine.
Topics: Adult; Antipsychotic Agents; Clozapine; Cyproheptadine; Female; Humans; Male; Perphenazine; Schizoph | 1996 |
Cyproheptadine in treatment of chronic schizophrenia: a double-blind, placebo-controlled study.
Topics: Adult; Antipsychotic Agents; Cyproheptadine; Double-Blind Method; Drug Therapy, Combination; Female; | 1999 |
Effects of the 5HT antagonist cyproheptadine on neuropsychological function in chronic schizophrenia.
Topics: Adult; Attention; Chronic Disease; Cross-Over Studies; Cyproheptadine; Discrimination Learning; Doub | 2002 |
Treatment of chronic schizophrenia with cyproheptadine: a double-blind placebo-controlled study.
Topics: Adult; Chronic Disease; Cyproheptadine; Dose-Response Relationship, Drug; Double-Blind Method; Drug | 1991 |
Treatment of chronic schizophrenia with cyproheptadine.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Cyproheptadine; Drug Therapy, Combination; Female; | 1989 |
6 other studies available for cyproheptadine and Schizophrenia
| Article | Year |
|---|---|
Cyproheptadine in treatment-resistant chronic schizophrenics with prior negative response to fluoxetine.
Topics: Adult; Aged; Antipsychotic Agents; Chronic Disease; Cyproheptadine; Depressive Disorder; Drug Therap | 1994 |
Do loxapine plus cyproheptadine make an atypical antipsychotic? PET analysis of their dopamine D2 and serotonin2 receptor occupancy.
Topics: Antipsychotic Agents; Cyproheptadine; Drug Administration Schedule; Drug Therapy, Combination; Human | 1998 |
Cerebrospinal fluid monoamine metabolites and cyclic nucleotides in chronic schizophrenic patients with tardive dyskinesia or drug-induced tremor.
Topics: Adult; Chronic Disease; Cyclic AMP; Cyclic GMP; Cyproheptadine; Dyskinesia, Drug-Induced; Female; Ho | 1979 |
Neuroendocrine effects of apomorphine: characterization of response patterns and application to schizophrenia research.
Topics: Adult; Apomorphine; Cyproheptadine; Growth Hormone; Haloperidol; Humans; Male; Pituitary Gland, Ante | 1979 |
Cyproheptadine and drug-induced anorgasmia.
Topics: Adult; Antipsychotic Agents; Cyproheptadine; Humans; Male; Orgasm; Schizophrenia; Sexual Dysfunction | 1987 |
Responses of prolactin and growth hormone to L-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics.
Topics: Adult; Cyproheptadine; Female; Growth Hormone; Humans; Hypothalamo-Hypophyseal System; Male; Prolact | 1985 |