cyproheptadine has been researched along with Pruritus in 36 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
Excerpt | Relevance | Reference |
---|---|---|
"Efficacy and safety of rupatadine were evaluated in 66 AD patients, including 50 patients with dose escalation by post hoc analysis of the phase III trial of rupatadine for Japanese patients with pruritus associated with skin diseases." | 9.34 | [USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS]. ( Aoki, H; Hide, M; Hirata, K; Komorita, N; Kubo, H; Suzuki, T; Tanaka, A, 2020) |
"To investigate the long-term efficacy and safety of rupatadine in the management of pruritus, and the clinical effect of updosing to 20mg in Japanese adult and adolescent patients." | 9.30 | Long-term safety and efficacy of rupatadine in Japanese patients with itching due to chronic spontaneous urticaria, dermatitis, or pruritus: A 12-month, multicenter, open-label clinical trial. ( Aoki, H; Hide, M; Suzuki, T; Tanaka, A, 2019) |
"After rupatadine treatment, 11 (52%) of 21 patients exhibited a complete response (ie, no urticaria lesions after ice cube provocation)." | 9.14 | Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. ( Ferrán, M; Giménez-Arnau, A; Izquierdo, I; Maurer, M; Metz, M; Scholz, E, 2010) |
"Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 9.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
"A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects." | 9.04 | Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975) |
"In the search for natural compounds useful against pruritus, alpha,beta-amyrins, the pentacyclic triterpenes isolated from the resin of popular medicinal plant Protium heptaphyllum were examined on scratching behavior induced by dextran T40 and compound 48/80 in mice." | 7.72 | Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. ( Almeida, FR; Chaves, MH; Cordeiro, WM; Lima-Junior, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM; Vieira-Júnior, GM, 2004) |
"Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 5.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
"Efficacy and safety of rupatadine were evaluated in 66 AD patients, including 50 patients with dose escalation by post hoc analysis of the phase III trial of rupatadine for Japanese patients with pruritus associated with skin diseases." | 5.34 | [USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS]. ( Aoki, H; Hide, M; Hirata, K; Komorita, N; Kubo, H; Suzuki, T; Tanaka, A, 2020) |
"To investigate the long-term efficacy and safety of rupatadine in the management of pruritus, and the clinical effect of updosing to 20mg in Japanese adult and adolescent patients." | 5.30 | Long-term safety and efficacy of rupatadine in Japanese patients with itching due to chronic spontaneous urticaria, dermatitis, or pruritus: A 12-month, multicenter, open-label clinical trial. ( Aoki, H; Hide, M; Suzuki, T; Tanaka, A, 2019) |
"The present placebo-controlled study in mosquito-bite-sensitive adults shows that rupatadine 10 mg prophylactically given is an effective treatment for the mosquito-bite wealing and skin pruritus." | 5.16 | Rupatadine 10 mg in the treatment of immediate mosquito-bite allergy. ( Brummer-Korvenkontio, H; Izquierdo, I; Karppinen, A; Reunala, T, 2012) |
"To measure the reduction in nasal obstruction using acoustic rhinometry in patients with allergic rhinitis treated with rupatadine." | 5.14 | Reduction of nasal volume after allergen-induced rhinitis in patients treated with rupatadine: a randomized, cross-over, double-blind, placebo-controlled study. ( Bartrá, J; Izquierdo, I; Mullol, J; Muñoz-Cano, R; Picado, C; Serrano, C; Valero, A, 2009) |
"After rupatadine treatment, 11 (52%) of 21 patients exhibited a complete response (ie, no urticaria lesions after ice cube provocation)." | 5.14 | Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. ( Ferrán, M; Giménez-Arnau, A; Izquierdo, I; Maurer, M; Metz, M; Scholz, E, 2010) |
"Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 5.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
"A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects." | 5.04 | Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975) |
"In the search for natural compounds useful against pruritus, alpha,beta-amyrins, the pentacyclic triterpenes isolated from the resin of popular medicinal plant Protium heptaphyllum were examined on scratching behavior induced by dextran T40 and compound 48/80 in mice." | 3.72 | Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. ( Almeida, FR; Chaves, MH; Cordeiro, WM; Lima-Junior, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM; Vieira-Júnior, GM, 2004) |
"Cyproheptadine hydrochloride was administered to 20 presumed or proven allergic cats to determine its efficacy in controlling pruritus." | 3.70 | Observations on the use of cyproheptadine hydrochloride as an antipruritic agent in allergic cats. ( Beningo, KE; Miller, WH; Rothstein, E; Scott, DW, 1998) |
"Cyproheptadine hydrochloride was administered orally at 0." | 2.67 | Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs: results of a double-blinded, placebo-controlled study. ( Cayatte, SM; Decker, GA; Miller, WH; Scott, DW, 1992) |
"Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available." | 1.46 | Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017) |
" Flares were induced before dosing and up to 96 h afterwards by intradermal PAF and histamine." | 1.36 | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. ( Church, MK, 2010) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (47.22) | 18.7374 |
1990's | 6 (16.67) | 18.2507 |
2000's | 6 (16.67) | 29.6817 |
2010's | 6 (16.67) | 24.3611 |
2020's | 1 (2.78) | 2.80 |
Authors | Studies |
---|---|
Solinski, HJ | 1 |
Dranchak, P | 1 |
Oliphant, E | 1 |
Gu, X | 1 |
Earnest, TW | 1 |
Braisted, J | 1 |
Inglese, J | 1 |
Hoon, MA | 1 |
Hide, M | 2 |
Hirata, K | 1 |
Komorita, N | 1 |
Kubo, H | 1 |
Suzuki, T | 2 |
Tanaka, A | 2 |
Aoki, H | 2 |
Tarrasón, G | 1 |
Carcasona, C | 1 |
Eichhorn, P | 1 |
Pérez, B | 1 |
Gavaldà, A | 1 |
Godessart, N | 1 |
Valero, A | 1 |
Serrano, C | 1 |
Bartrá, J | 1 |
Izquierdo, I | 3 |
Muñoz-Cano, R | 1 |
Mullol, J | 1 |
Picado, C | 1 |
Metz, M | 1 |
Scholz, E | 1 |
Ferrán, M | 1 |
Giménez-Arnau, A | 1 |
Maurer, M | 1 |
Church, MK | 1 |
Karppinen, A | 1 |
Brummer-Korvenkontio, H | 1 |
Reunala, T | 1 |
SPERBER, PA | 2 |
MILLER, J | 1 |
KITAMURA, K | 1 |
TAKASE, Y | 1 |
MEGURIGAMI, T | 1 |
ABE, Y | 1 |
MAEDA, Y | 1 |
GOULD, AH | 1 |
NEARY, ER | 1 |
KAHIL, ME | 1 |
BROWN, H | 1 |
FRED, HL | 1 |
Takano, N | 1 |
Arai, I | 1 |
Hashimoto, Y | 1 |
Kurachi, M | 1 |
Oliveira, FA | 1 |
Lima-Junior, RC | 1 |
Cordeiro, WM | 1 |
Vieira-Júnior, GM | 1 |
Chaves, MH | 1 |
Almeida, FR | 1 |
Silva, RM | 1 |
Santos, FA | 1 |
Rao, VS | 1 |
Jiang, S | 1 |
Tsumuro, T | 1 |
Takubo, M | 1 |
Fujii, Y | 1 |
Kamei, C | 1 |
Yamashita, H | 1 |
Makino, T | 1 |
Mizukami, H | 1 |
Nose, M | 1 |
Saveika, JA | 1 |
Shelton, JE | 1 |
Garafalo, J | 1 |
Kaplan, AP | 1 |
Kuhn, W | 1 |
Awadzi, K | 1 |
Orme, ML | 1 |
Breckenridge, AM | 1 |
Gilles, HM | 1 |
Klein, GL | 1 |
Galant, SP | 1 |
Osifo, NG | 1 |
Scott, DW | 2 |
Rothstein, E | 1 |
Beningo, KE | 1 |
Miller, WH | 2 |
Tindall, JP | 1 |
Rhoades, RB | 1 |
Leifer, KN | 1 |
Cohan, R | 1 |
Wittig, HJ | 1 |
Tarnick, M | 1 |
Henry, DA | 1 |
Lowe, JM | 1 |
Donnelly, T | 1 |
Baraf, CS | 1 |
Abu Shareeah, AM | 1 |
Decker, GA | 1 |
Cayatte, SM | 1 |
Frølund, L | 1 |
Paul, E | 1 |
Fischer, RW | 1 |
Gilbert, HS | 1 |
Warner, RR | 1 |
Wasserman, LR | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Nasal Ocular Reflexes Contribute to Eye Symptoms in Patients With Allergic Rhinitis[NCT00117832] | 20 participants | Interventional | 2005-03-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for cyproheptadine and Pruritus
Article | Year |
---|---|
NEWER DEVELOPMENTS IN ORAL ANTIPRURITICS.
Topics: Adrenal Cortex Hormones; Antipruritics; Betamethasone; Cyproheptadine; Dimethindene; Histamine H1 An | 1964 |
15 trials available for cyproheptadine and Pruritus
Article | Year |
---|---|
[USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS].
Topics: Cyproheptadine; Dermatitis, Atopic; Humans; Japan; Pruritus | 2020 |
Long-term safety and efficacy of rupatadine in Japanese patients with itching due to chronic spontaneous urticaria, dermatitis, or pruritus: A 12-month, multicenter, open-label clinical trial.
Topics: Adolescent; Adult; Child; Chronic Urticaria; Cyproheptadine; Dose-Response Relationship, Drug; Eczem | 2019 |
Reduction of nasal volume after allergen-induced rhinitis in patients treated with rupatadine: a randomized, cross-over, double-blind, placebo-controlled study.
Topics: Administration, Intranasal; Adolescent; Adult; Anti-Allergic Agents; Cyproheptadine; Disease Progres | 2009 |
Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria.
Topics: Adult; Cold Temperature; Cyproheptadine; Double-Blind Method; Environmental Exposure; Female; Histam | 2010 |
Rupatadine 10 mg in the treatment of immediate mosquito-bite allergy.
Topics: Adult; Aedes; Animals; Cross-Over Studies; Cyproheptadine; Double-Blind Method; Histamine H1 Antagon | 2012 |
The chemotherapy of onchocerciasis VI. The effect of indomethacin and cyproheptadine on the Mazzotti reaction.
Topics: Adult; Clinical Trials as Topic; Cyproheptadine; Diethylcarbamazine; Double-Blind Method; Humans; Hy | 1982 |
A comparison of the antipruritic efficacy of hydroxyzine and cyproheptadine in children with atopic dermatitis.
Topics: Adolescent; Antipruritics; Child; Child, Preschool; Cyproheptadine; Dermatitis, Atopic; Dermatologic | 1980 |
The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria.
Topics: Adolescent; Adult; Antimalarials; Antipruritics; Chloroquine; Chlorpheniramine; Cyproheptadine; Derm | 1995 |
Suppression of histamine-induced pruritus by three antihistaminic drugs.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cyproheptadine; Differential Threshold; Diphenhydramine | 1975 |
Treatment of pruritus in allergic dermatoses: an evaluation of the relative efficacy of cyproheptadine and hydroxyzine.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Cyproheptadine; Dermatitis, Atopic; Dermatitis, C | 1976 |
Comparative efficacy of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.
Topics: Adult; Chronic Disease; Cyproheptadine; Female; Histamine Antagonists; Humans; Loratadine; Male; Pru | 1992 |
Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs: results of a double-blinded, placebo-controlled study.
Topics: Animals; Cyproheptadine; Dog Diseases; Dogs; Double-Blind Method; Female; Hyperphagia; Hypersensitiv | 1992 |
Efficacy of an oral antihistamine, loratadine, as compared with a nasal steroid spray, beclomethasone dipropionate, in seasonal allergic rhinitis.
Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Beclomethasone; Cyproheptadine; Doubl | 1991 |
[Treatment of pruritic skin diseases with loratadine. Results of an open multicenter study].
Topics: Adolescent; Adult; Aged; Cyproheptadine; Drug Evaluation; Female; Histamine Antagonists; Humans; Lor | 1991 |
Comparison of antipruritic agents administered orally. A double-blind study.
Topics: Analysis of Variance; Clinical Trials as Topic; Cyproheptadine; Humans; Placebos; Pruritus; Trimepra | 1968 |
20 other studies available for cyproheptadine and Pruritus
Article | Year |
---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricy | 2017 |
Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males.
Topics: Administration, Oral; Adult; Area Under Curve; Cyproheptadine; Histamine; Histamine H1 Antagonists; | 2010 |
Cyproheptadine-dexamethasone combination in the treatment of pruritus.
Topics: Anti-Allergic Agents; Cyproheptadine; Dexamethasone; Histamine H1 Antagonists; Pruritus; Serotonin; | 1962 |
Treatment of pruritus with a new drug, cyproheptadine.
Topics: Cyproheptadine; Humans; Pruritus; Serotonin; Serotonin Antagonists | 1962 |
A SEROTONIN ANTAGONIST, CYPROHEPTADINE. II. THE TREATMENT OF VASCULAR-TYPE HEADACHE AND PRURITUS.
Topics: Cyproheptadine; Headache; Humans; Migraine Disorders; Pruritus; Serotonin Antagonists; Vascular Head | 1963 |
[EFFECTIVENESS OF SEROTONIN INHIBITORS IN VARIOUS SKIN DISEASES].
Topics: Adolescent; Child; Cyproheptadine; Dermatology; Eczema; Erythema; Exanthema; Humans; Infant; Mouth; | 1964 |
THE CARCINOID CRISIS.
Topics: Cyproheptadine; Drug Therapy; Humans; Hyperesthesia; Hypotension; Malignant Carcinoid Syndrome; Meth | 1964 |
Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice.
Topics: Alprostadil; Animals; Antipruritics; Behavior, Animal; Capsaicin; Chlorpheniramine; Cyproheptadine; | 2004 |
Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cell Degranulation; Cyproheptadine; Dextrans; Endorph | 2004 |
Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice.
Topics: Administration, Oral; Animals; Ascomycota; Behavior, Animal; Capillary Permeability; Complex Mixture | 2005 |
Pharmacological characterization of a chronic pruritus model induced by multiple application of 2,4,6-trinitrochlorobenzene in NC mice.
Topics: Animals; Antipruritics; Cell Degranulation; Chronic Disease; Cromolyn Sodium; Cyproheptadine; Dermat | 2007 |
Cyproheptadine for pediatric intrathecal baclofen withdrawal: a case report.
Topics: Adolescent; Age Factors; Baclofen; Cerebral Palsy; Child; Cyproheptadine; Equipment Failure; Female; | 2007 |
Histamine release and therapy of severe dermatographism.
Topics: Adolescent; Animals; Cyproheptadine; Diphenhydramine; Female; Histamine; Histamine Release; Humans; | 1981 |
[Malignant acanthosis nigricans].
Topics: Acanthosis Nigricans; Adenocarcinoma, Mucinous; Cyproheptadine; Humans; Male; Middle Aged; Pruritus; | 1983 |
Observations on the use of cyproheptadine hydrochloride as an antipruritic agent in allergic cats.
Topics: Administration, Oral; Animals; Antipruritics; Cat Diseases; Cats; Cyproheptadine; Female; Hypersensi | 1998 |
Relieving localized and generalized pruritus.
Topics: Aged; Bandages; Chlorpromazine; Cyproheptadine; Dermatitis; Dermatitis, Seborrheic; Female; Humans; | 1975 |
[Results of the treatment in cases of cold urticaria, cold pruritus and cold rhinitis with peritol (zyproheptadinhydrochlorid) (author's transl)].
Topics: Cold Temperature; Cyproheptadine; Humans; Pruritus; Rhinitis, Allergic, Seasonal; Urticaria | 1979 |
Jaundice during cyproheptadine treatment.
Topics: Adult; Cholestasis; Cyproheptadine; Female; Humans; Jaundice; Pruritus | 1978 |
A study of histamine in myeloproliferative disease.
Topics: Bone Marrow Diseases; Cyproheptadine; Histamine; Humans; Myeloproliferative Disorders; Polycythemia; | 1966 |