Page last updated: 2024-10-25

cyproheptadine and Pruritus

cyproheptadine has been researched along with Pruritus in 36 studies

Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.

Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.

Research Excerpts

ExcerptRelevanceReference
"Efficacy and safety of rupatadine were evaluated in 66 AD patients, including 50 patients with dose escalation by post hoc analysis of the phase III trial of rupatadine for Japanese patients with pruritus associated with skin diseases."9.34[USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS]. ( Aoki, H; Hide, M; Hirata, K; Komorita, N; Kubo, H; Suzuki, T; Tanaka, A, 2020)
"To investigate the long-term efficacy and safety of rupatadine in the management of pruritus, and the clinical effect of updosing to 20mg in Japanese adult and adolescent patients."9.30Long-term safety and efficacy of rupatadine in Japanese patients with itching due to chronic spontaneous urticaria, dermatitis, or pruritus: A 12-month, multicenter, open-label clinical trial. ( Aoki, H; Hide, M; Suzuki, T; Tanaka, A, 2019)
"After rupatadine treatment, 11 (52%) of 21 patients exhibited a complete response (ie, no urticaria lesions after ice cube provocation)."9.14Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. ( Ferrán, M; Giménez-Arnau, A; Izquierdo, I; Maurer, M; Metz, M; Scholz, E, 2010)
"Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients."9.08The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995)
"A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects."9.04Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975)
"In the search for natural compounds useful against pruritus, alpha,beta-amyrins, the pentacyclic triterpenes isolated from the resin of popular medicinal plant Protium heptaphyllum were examined on scratching behavior induced by dextran T40 and compound 48/80 in mice."7.72Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. ( Almeida, FR; Chaves, MH; Cordeiro, WM; Lima-Junior, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM; Vieira-Júnior, GM, 2004)
"Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available."5.46Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017)
"Efficacy and safety of rupatadine were evaluated in 66 AD patients, including 50 patients with dose escalation by post hoc analysis of the phase III trial of rupatadine for Japanese patients with pruritus associated with skin diseases."5.34[USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS]. ( Aoki, H; Hide, M; Hirata, K; Komorita, N; Kubo, H; Suzuki, T; Tanaka, A, 2020)
"To investigate the long-term efficacy and safety of rupatadine in the management of pruritus, and the clinical effect of updosing to 20mg in Japanese adult and adolescent patients."5.30Long-term safety and efficacy of rupatadine in Japanese patients with itching due to chronic spontaneous urticaria, dermatitis, or pruritus: A 12-month, multicenter, open-label clinical trial. ( Aoki, H; Hide, M; Suzuki, T; Tanaka, A, 2019)
"The present placebo-controlled study in mosquito-bite-sensitive adults shows that rupatadine 10 mg prophylactically given is an effective treatment for the mosquito-bite wealing and skin pruritus."5.16Rupatadine 10 mg in the treatment of immediate mosquito-bite allergy. ( Brummer-Korvenkontio, H; Izquierdo, I; Karppinen, A; Reunala, T, 2012)
"To measure the reduction in nasal obstruction using acoustic rhinometry in patients with allergic rhinitis treated with rupatadine."5.14Reduction of nasal volume after allergen-induced rhinitis in patients treated with rupatadine: a randomized, cross-over, double-blind, placebo-controlled study. ( Bartrá, J; Izquierdo, I; Mullol, J; Muñoz-Cano, R; Picado, C; Serrano, C; Valero, A, 2009)
"After rupatadine treatment, 11 (52%) of 21 patients exhibited a complete response (ie, no urticaria lesions after ice cube provocation)."5.14Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. ( Ferrán, M; Giménez-Arnau, A; Izquierdo, I; Maurer, M; Metz, M; Scholz, E, 2010)
"Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients."5.08The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995)
"A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects."5.04Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975)
"In the search for natural compounds useful against pruritus, alpha,beta-amyrins, the pentacyclic triterpenes isolated from the resin of popular medicinal plant Protium heptaphyllum were examined on scratching behavior induced by dextran T40 and compound 48/80 in mice."3.72Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. ( Almeida, FR; Chaves, MH; Cordeiro, WM; Lima-Junior, RC; Oliveira, FA; Rao, VS; Santos, FA; Silva, RM; Vieira-Júnior, GM, 2004)
"Cyproheptadine hydrochloride was administered to 20 presumed or proven allergic cats to determine its efficacy in controlling pruritus."3.70Observations on the use of cyproheptadine hydrochloride as an antipruritic agent in allergic cats. ( Beningo, KE; Miller, WH; Rothstein, E; Scott, DW, 1998)
"Cyproheptadine hydrochloride was administered orally at 0."2.67Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs: results of a double-blinded, placebo-controlled study. ( Cayatte, SM; Decker, GA; Miller, WH; Scott, DW, 1992)
"Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available."1.46Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system. ( Carcasona, C; Eichhorn, P; Gavaldà, A; Godessart, N; Pérez, B; Tarrasón, G, 2017)
" Flares were induced before dosing and up to 96 h afterwards by intradermal PAF and histamine."1.36Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. ( Church, MK, 2010)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199017 (47.22)18.7374
1990's6 (16.67)18.2507
2000's6 (16.67)29.6817
2010's6 (16.67)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Hide, M2
Hirata, K1
Komorita, N1
Kubo, H1
Suzuki, T2
Tanaka, A2
Aoki, H2
Tarrasón, G1
Carcasona, C1
Eichhorn, P1
Pérez, B1
Gavaldà, A1
Godessart, N1
Valero, A1
Serrano, C1
Bartrá, J1
Izquierdo, I3
Muñoz-Cano, R1
Mullol, J1
Picado, C1
Metz, M1
Scholz, E1
Ferrán, M1
Giménez-Arnau, A1
Maurer, M1
Church, MK1
Karppinen, A1
Brummer-Korvenkontio, H1
Reunala, T1
SPERBER, PA2
MILLER, J1
KITAMURA, K1
TAKASE, Y1
MEGURIGAMI, T1
ABE, Y1
MAEDA, Y1
GOULD, AH1
NEARY, ER1
KAHIL, ME1
BROWN, H1
FRED, HL1
Takano, N1
Arai, I1
Hashimoto, Y1
Kurachi, M1
Oliveira, FA1
Lima-Junior, RC1
Cordeiro, WM1
Vieira-Júnior, GM1
Chaves, MH1
Almeida, FR1
Silva, RM1
Santos, FA1
Rao, VS1
Jiang, S1
Tsumuro, T1
Takubo, M1
Fujii, Y1
Kamei, C1
Yamashita, H1
Makino, T1
Mizukami, H1
Nose, M1
Saveika, JA1
Shelton, JE1
Garafalo, J1
Kaplan, AP1
Kuhn, W1
Awadzi, K1
Orme, ML1
Breckenridge, AM1
Gilles, HM1
Klein, GL1
Galant, SP1
Osifo, NG1
Scott, DW2
Rothstein, E1
Beningo, KE1
Miller, WH2
Tindall, JP1
Rhoades, RB1
Leifer, KN1
Cohan, R1
Wittig, HJ1
Tarnick, M1
Henry, DA1
Lowe, JM1
Donnelly, T1
Baraf, CS1
Abu Shareeah, AM1
Decker, GA1
Cayatte, SM1
Frølund, L1
Paul, E1
Fischer, RW1
Gilbert, HS1
Warner, RR1
Wasserman, LR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nasal Ocular Reflexes Contribute to Eye Symptoms in Patients With Allergic Rhinitis[NCT00117832]20 participants Interventional2005-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for cyproheptadine and Pruritus

ArticleYear
NEWER DEVELOPMENTS IN ORAL ANTIPRURITICS.
    The Medical clinics of North America, 1964, Volume: 48

    Topics: Adrenal Cortex Hormones; Antipruritics; Betamethasone; Cyproheptadine; Dimethindene; Histamine H1 An

1964

Trials

15 trials available for cyproheptadine and Pruritus

ArticleYear
[USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS].
    Arerugi = [Allergy], 2020, Volume: 69, Issue:3

    Topics: Cyproheptadine; Dermatitis, Atopic; Humans; Japan; Pruritus

2020
Long-term safety and efficacy of rupatadine in Japanese patients with itching due to chronic spontaneous urticaria, dermatitis, or pruritus: A 12-month, multicenter, open-label clinical trial.
    Journal of dermatological science, 2019, Volume: 94, Issue:3

    Topics: Adolescent; Adult; Child; Chronic Urticaria; Cyproheptadine; Dose-Response Relationship, Drug; Eczem

2019
Reduction of nasal volume after allergen-induced rhinitis in patients treated with rupatadine: a randomized, cross-over, double-blind, placebo-controlled study.
    Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:6

    Topics: Administration, Intranasal; Adolescent; Adult; Anti-Allergic Agents; Cyproheptadine; Disease Progres

2009
Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2010, Volume: 104, Issue:1

    Topics: Adult; Cold Temperature; Cyproheptadine; Double-Blind Method; Environmental Exposure; Female; Histam

2010
Rupatadine 10 mg in the treatment of immediate mosquito-bite allergy.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2012, Volume: 26, Issue:7

    Topics: Adult; Aedes; Animals; Cross-Over Studies; Cyproheptadine; Double-Blind Method; Histamine H1 Antagon

2012
The chemotherapy of onchocerciasis VI. The effect of indomethacin and cyproheptadine on the Mazzotti reaction.
    Annals of tropical medicine and parasitology, 1982, Volume: 76, Issue:3

    Topics: Adult; Clinical Trials as Topic; Cyproheptadine; Diethylcarbamazine; Double-Blind Method; Humans; Hy

1982
A comparison of the antipruritic efficacy of hydroxyzine and cyproheptadine in children with atopic dermatitis.
    Annals of allergy, 1980, Volume: 44, Issue:3

    Topics: Adolescent; Antipruritics; Child; Child, Preschool; Cyproheptadine; Dermatitis, Atopic; Dermatologic

1980
The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria.
    African journal of medicine and medical sciences, 1995, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Antimalarials; Antipruritics; Chloroquine; Chlorpheniramine; Cyproheptadine; Derm

1995
Suppression of histamine-induced pruritus by three antihistaminic drugs.
    The Journal of allergy and clinical immunology, 1975, Volume: 55, Issue:3

    Topics: Adolescent; Adult; Clinical Trials as Topic; Cyproheptadine; Differential Threshold; Diphenhydramine

1975
Treatment of pruritus in allergic dermatoses: an evaluation of the relative efficacy of cyproheptadine and hydroxyzine.
    Current therapeutic research, clinical and experimental, 1976, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Cyproheptadine; Dermatitis, Atopic; Dermatitis, C

1976
Comparative efficacy of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.
    International journal of dermatology, 1992, Volume: 31, Issue:5

    Topics: Adult; Chronic Disease; Cyproheptadine; Female; Histamine Antagonists; Humans; Loratadine; Male; Pru

1992
Failure of cyproheptadine hydrochloride as an antipruritic agent in allergic dogs: results of a double-blinded, placebo-controlled study.
    The Cornell veterinarian, 1992, Volume: 82, Issue:3

    Topics: Animals; Cyproheptadine; Dog Diseases; Dogs; Double-Blind Method; Female; Hyperphagia; Hypersensitiv

1992
Efficacy of an oral antihistamine, loratadine, as compared with a nasal steroid spray, beclomethasone dipropionate, in seasonal allergic rhinitis.
    Clinical otolaryngology and allied sciences, 1991, Volume: 16, Issue:6

    Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Beclomethasone; Cyproheptadine; Doubl

1991
[Treatment of pruritic skin diseases with loratadine. Results of an open multicenter study].
    Fortschritte der Medizin, 1991, Mar-10, Volume: 109, Issue:7

    Topics: Adolescent; Adult; Aged; Cyproheptadine; Drug Evaluation; Female; Histamine Antagonists; Humans; Lor

1991
Comparison of antipruritic agents administered orally. A double-blind study.
    JAMA, 1968, Feb-05, Volume: 203, Issue:6

    Topics: Analysis of Variance; Clinical Trials as Topic; Cyproheptadine; Humans; Placebos; Pruritus; Trimepra

1968

Other Studies

20 other studies available for cyproheptadine and Pruritus

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.
    Experimental dermatology, 2017, Volume: 26, Issue:11

    Topics: Administration, Oral; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricy

2017
Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males.
    The British journal of dermatology, 2010, Volume: 163, Issue:6

    Topics: Administration, Oral; Adult; Area Under Curve; Cyproheptadine; Histamine; Histamine H1 Antagonists;

2010
Cyproheptadine-dexamethasone combination in the treatment of pruritus.
    Current therapeutic research, clinical and experimental, 1962, Volume: 4

    Topics: Anti-Allergic Agents; Cyproheptadine; Dexamethasone; Histamine H1 Antagonists; Pruritus; Serotonin;

1962
Treatment of pruritus with a new drug, cyproheptadine.
    The Journal of the Florida Medical Association. Florida Medical Association, 1962, Volume: 48

    Topics: Cyproheptadine; Humans; Pruritus; Serotonin; Serotonin Antagonists

1962
A SEROTONIN ANTAGONIST, CYPROHEPTADINE. II. THE TREATMENT OF VASCULAR-TYPE HEADACHE AND PRURITUS.
    Annals of allergy, 1963, Volume: 21

    Topics: Cyproheptadine; Headache; Humans; Migraine Disorders; Pruritus; Serotonin Antagonists; Vascular Head

1963
[EFFECTIVENESS OF SEROTONIN INHIBITORS IN VARIOUS SKIN DISEASES].
    Arerugi = [Allergy], 1964, Volume: 13

    Topics: Adolescent; Child; Cyproheptadine; Dermatology; Eczema; Erythema; Exanthema; Humans; Infant; Mouth;

1964
THE CARCINOID CRISIS.
    Archives of internal medicine, 1964, Volume: 114

    Topics: Cyproheptadine; Drug Therapy; Humans; Hyperesthesia; Hypotension; Malignant Carcinoid Syndrome; Meth

1964
Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice.
    European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3

    Topics: Alprostadil; Animals; Antipruritics; Behavior, Animal; Capsaicin; Chlorpheniramine; Cyproheptadine;

2004
Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 78, Issue:4

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cell Degranulation; Cyproheptadine; Dextrans; Endorph

2004
Antipruritic and antierythema effects of ascomycete Bulgaria inquinans extract in ICR Mice.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:12

    Topics: Administration, Oral; Animals; Ascomycota; Behavior, Animal; Capillary Permeability; Complex Mixture

2005
Pharmacological characterization of a chronic pruritus model induced by multiple application of 2,4,6-trinitrochlorobenzene in NC mice.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Animals; Antipruritics; Cell Degranulation; Chronic Disease; Cromolyn Sodium; Cyproheptadine; Dermat

2007
Cyproheptadine for pediatric intrathecal baclofen withdrawal: a case report.
    American journal of physical medicine & rehabilitation, 2007, Volume: 86, Issue:12

    Topics: Adolescent; Age Factors; Baclofen; Cerebral Palsy; Child; Cyproheptadine; Equipment Failure; Female;

2007
Histamine release and therapy of severe dermatographism.
    The Journal of allergy and clinical immunology, 1981, Volume: 68, Issue:2

    Topics: Adolescent; Animals; Cyproheptadine; Diphenhydramine; Female; Histamine; Histamine Release; Humans;

1981
[Malignant acanthosis nigricans].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1983, Jun-07, Volume: 72, Issue:23

    Topics: Acanthosis Nigricans; Adenocarcinoma, Mucinous; Cyproheptadine; Humans; Male; Middle Aged; Pruritus;

1983
Observations on the use of cyproheptadine hydrochloride as an antipruritic agent in allergic cats.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1998, Volume: 39, Issue:10

    Topics: Administration, Oral; Animals; Antipruritics; Cat Diseases; Cats; Cyproheptadine; Female; Hypersensi

1998
Relieving localized and generalized pruritus.
    Geriatrics, 1975, Volume: 30, Issue:3

    Topics: Aged; Bandages; Chlorpromazine; Cyproheptadine; Dermatitis; Dermatitis, Seborrheic; Female; Humans;

1975
[Results of the treatment in cases of cold urticaria, cold pruritus and cold rhinitis with peritol (zyproheptadinhydrochlorid) (author's transl)].
    Dermatologische Monatschrift, 1979, Volume: 165, Issue:4

    Topics: Cold Temperature; Cyproheptadine; Humans; Pruritus; Rhinitis, Allergic, Seasonal; Urticaria

1979
Jaundice during cyproheptadine treatment.
    British medical journal, 1978, Mar-25, Volume: 1, Issue:6115

    Topics: Adult; Cholestasis; Cyproheptadine; Female; Humans; Jaundice; Pruritus

1978
A study of histamine in myeloproliferative disease.
    Blood, 1966, Volume: 28, Issue:6

    Topics: Bone Marrow Diseases; Cyproheptadine; Histamine; Humans; Myeloproliferative Disorders; Polycythemia;

1966