cyproheptadine has been researched along with Pituitary Neoplasms in 31 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic efficacy of the combination of cyproheptadine and bromocriptine was studied in 15 patients with active acromegaly showing incomplete GH suppression in response to bromocriptine therapy alone." | 7.67 | The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly. ( Hanew, K; Ishii, K; Saitoh, T; Sasaki, A; Saso, S; Sato, S; Shimizu, Y; Sugawara, A; Tazawa, S; Yoshinaga, K, 1989) |
| "The effect of cyproheptadine on growth hormone (GH) and prolactin (Prl) secretion from cultured pituitary adenoma cells of acromegaly and pituitary gigantism was studied." | 7.67 | Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. ( Fukushima, T; Ishibashi, M; Yamaji, T, 1985) |
| "A 44-year-old female with Cushing's disease associated with a pituitary macroadenoma was treated with cyproheptadine, 24 mg per day, after partial surgical resection of the tumor." | 7.67 | Rebound elevation of cortisol following cyproheptadine withdrawal in Cushing's disease from a pituitary macroadenoma. ( Ooi, TC; Twum-Barima, Y, 1987) |
| "In an attempt to delineate the mechanism and the site of action of cyproheptadine and dopaminergic agonists as well as hormones including thyrotropin-releasing hormone (TRH) and hydrocortisone, the effects of these substances on ACTH secretion from corticotroph adenoma cells in culture were examined." | 7.66 | Direct effects of thyrotropin-releasing hormone, cyproheptadine, and dopamine on adrenocorticotropin secretion from human corticotroph adenoma cells in vitro. ( Ishibashi, M; Yamaji, T, 1981) |
| "Twenty patients affected by hyperprolactinemic amenorrhea-galactorrhea have been treated with one or more of the following serotonin antagonists: metergoline, methysergide, and cyproheptadine." | 7.66 | Antiserotonin treatment of hyperprolactinemic amenorrhea: long-term follow-up with metergoline, methysergide, and cyproheptadine. ( Caccamo, A; Crosignani, PG; D'Alberton, A; Lombroso, GC; Mattei, A; Peracchi, M; Reschini, E, 1978) |
| "The therapeutic efficacy of the combination of cyproheptadine and bromocriptine was studied in 15 patients with active acromegaly showing incomplete GH suppression in response to bromocriptine therapy alone." | 3.67 | The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly. ( Hanew, K; Ishii, K; Saitoh, T; Sasaki, A; Saso, S; Sato, S; Shimizu, Y; Sugawara, A; Tazawa, S; Yoshinaga, K, 1989) |
| "The effect of cyproheptadine on growth hormone (GH) and prolactin (Prl) secretion from cultured pituitary adenoma cells of acromegaly and pituitary gigantism was studied." | 3.67 | Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. ( Fukushima, T; Ishibashi, M; Yamaji, T, 1985) |
| "A 44-year-old female with Cushing's disease associated with a pituitary macroadenoma was treated with cyproheptadine, 24 mg per day, after partial surgical resection of the tumor." | 3.67 | Rebound elevation of cortisol following cyproheptadine withdrawal in Cushing's disease from a pituitary macroadenoma. ( Ooi, TC; Twum-Barima, Y, 1987) |
| "In an attempt to delineate the mechanism and the site of action of cyproheptadine and dopaminergic agonists as well as hormones including thyrotropin-releasing hormone (TRH) and hydrocortisone, the effects of these substances on ACTH secretion from corticotroph adenoma cells in culture were examined." | 3.66 | Direct effects of thyrotropin-releasing hormone, cyproheptadine, and dopamine on adrenocorticotropin secretion from human corticotroph adenoma cells in vitro. ( Ishibashi, M; Yamaji, T, 1981) |
| "Twenty patients affected by hyperprolactinemic amenorrhea-galactorrhea have been treated with one or more of the following serotonin antagonists: metergoline, methysergide, and cyproheptadine." | 3.66 | Antiserotonin treatment of hyperprolactinemic amenorrhea: long-term follow-up with metergoline, methysergide, and cyproheptadine. ( Caccamo, A; Crosignani, PG; D'Alberton, A; Lombroso, GC; Mattei, A; Peracchi, M; Reschini, E, 1978) |
| "When cabergoline was reintroduced there was a clinical improvement and normalization of ACTH plasma levels (64 pg/ml)." | 1.32 | Nelson's syndrome: complete remission with cabergoline but not with bromocriptine or cyproheptadine treatment. ( Casulari, LA; Mello, PA; Naves, LA; Papadia, C; Pereira Neto, A, 2004) |
| " Remission was achieved with cyproheptadine up to a dosage of 24 mg/day." | 1.29 | Cyproheptadine treatment in Cushing's disease. ( Alagöl, F; Azizlerli, H; Berker, F; Sandalci, O; Tanakol, R; Terzioğlu, T, 1996) |
| "189 patients with secretory pituitary adenomas underwent medical therapy for the hypersecretory state." | 1.27 | The medical treatment of the hypersecreting pituitary gland. ( Corenblum, B, 1985) |
| "Ectopic secretion of GH by the carcinoid hepatic metastases was documented by both RIA and immunohistochemical techniques." | 1.26 | Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor. ( Buckley, PJ; Daughaday, WH; Deschryver, K; Greider, MH; Jaffe, BM; Leveston, SA; McKeel, DW, 1981) |
| "Cyproheptadine is a potent antagonist of serotonin and has been used successfully in some patients with Cushing's disease, although, generally, in women without radiological evidence of pituitary tumors." | 1.26 | Cyproheptadine-induced remission of Cushing's disease due to pituitary basophil adenoma. ( Bellido, C; Jaimez, L; Jimenez-Alonso, J; Jiménez-Perepérez, JA; Munoz-Avila, J; Pérez-Jimenez, F, 1982) |
| "Cyproheptadine treatment resulted in a marked lowering of plasma ACTH concentrations (221-320 pg/ml)." | 1.26 | Cortisol and androgen secretion in a case of Nelson's syndrome with paratesticular tumors: response to cyproheptadine therapy. ( Bardin, CW; Krieger, DT; Samojlik, E, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (80.65) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 1 (3.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casulari, LA | 1 |
| Naves, LA | 1 |
| Mello, PA | 1 |
| Pereira Neto, A | 1 |
| Papadia, C | 1 |
| Hirata, Y | 1 |
| Nakashima, H | 1 |
| Uchihashi, M | 1 |
| Tomita, M | 1 |
| Fujita, T | 1 |
| Ikeda, M | 1 |
| Vigneri, R | 1 |
| Goldfine, ID | 1 |
| Krieger, DT | 4 |
| Calderón Gualda, MD | 1 |
| Martínez de Osaba, MJ | 1 |
| Palacín, A | 1 |
| Vilardell, E | 1 |
| Aronin, N | 1 |
| Leveston, SA | 1 |
| McKeel, DW | 1 |
| Buckley, PJ | 1 |
| Deschryver, K | 1 |
| Greider, MH | 1 |
| Jaffe, BM | 1 |
| Daughaday, WH | 1 |
| Ishibashi, M | 2 |
| Yamaji, T | 3 |
| Lankford, HV | 1 |
| Tucker, HS | 1 |
| Blackard, WG | 1 |
| Weiss, MH | 1 |
| Jimenez-Alonso, J | 1 |
| Munoz-Avila, J | 1 |
| Jaimez, L | 1 |
| Pérez-Jimenez, F | 1 |
| Bellido, C | 1 |
| Jiménez-Perepérez, JA | 1 |
| Lamberts, SW | 2 |
| Verleun, T | 1 |
| Bons, EG | 1 |
| Uitterlinden, P | 1 |
| Oosterom, R | 1 |
| Jialal, I | 1 |
| Pillay, NL | 1 |
| van Waveren Hogervorst, CO | 1 |
| Koppeschaar, HP | 1 |
| Zelissen, PM | 1 |
| Lips, CJ | 1 |
| Garcia, BM | 1 |
| Tanakol, R | 1 |
| Alagöl, F | 1 |
| Azizlerli, H | 1 |
| Sandalci, O | 1 |
| Terzioğlu, T | 1 |
| Berker, F | 1 |
| Cassar, J | 1 |
| Mashiter, K | 1 |
| Joplin, GF | 1 |
| Rees, LH | 1 |
| Gilkes, JJ | 1 |
| Condon, EM | 1 |
| Samojlik, E | 1 |
| Bardin, CW | 1 |
| Crosignani, PG | 1 |
| Peracchi, M | 1 |
| Lombroso, GC | 1 |
| Reschini, E | 1 |
| Mattei, A | 1 |
| Caccamo, A | 1 |
| D'Alberton, A | 1 |
| MacLeod, RM | 1 |
| Gerasimov, G | 1 |
| Chernova, T | 1 |
| Goncharov, N | 1 |
| Kato, Y | 2 |
| Fanghanel, G | 1 |
| Larraza, O | 1 |
| Villalobos, M | 1 |
| Fanghanel, L | 1 |
| Velasco, M | 1 |
| Velasco, F | 1 |
| Hanew, K | 1 |
| Sugawara, A | 1 |
| Shimizu, Y | 1 |
| Sato, S | 1 |
| Sasaki, A | 1 |
| Tazawa, S | 1 |
| Ishii, K | 1 |
| Saitoh, T | 1 |
| Saso, S | 1 |
| Yoshinaga, K | 1 |
| Fukushima, T | 1 |
| Corenblum, B | 1 |
| Yoshida, H | 1 |
| Takeda, F | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| Ooi, TC | 1 |
| Twum-Barima, Y | 1 |
| Burch, WM | 1 |
5 reviews available for cyproheptadine and Pituitary Neoplasms
| Article | Year |
|---|---|
Pharmacologic therapy of patients with pituitary tumors secreting prolactin, growth hormone and adrenocorticotropin.
Topics: Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Amenorrhea; Antineoplastic Agents; Bromoc | 1980 |
Physiopathology of Cushing's disease.
Topics: Adenoma; Biomechanical Phenomena; Bromocriptine; Circadian Rhythm; Cushing Syndrome; Cyproheptadine; | 1983 |
[Drug therapy of pituitary tumors].
Topics: Bromocriptine; Cushing Syndrome; Cyproheptadine; Female; Humans; Male; Metyrapone; Octreotide; Pitui | 1991 |
[Drug and radiotherapy of pituitary tumors].
Topics: Acromegaly; Adenoma; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; G | 1986 |
Cushing's disease. A review.
Topics: Adenoma; Adolescent; Adrenalectomy; Adult; Animals; Bromocriptine; Child; Combined Modality Therapy; | 1985 |
26 other studies available for cyproheptadine and Pituitary Neoplasms
| Article | Year |
|---|---|
Nelson's syndrome: complete remission with cabergoline but not with bromocriptine or cyproheptadine treatment.
Topics: Adenoma; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Bromocriptine; Cabergoline; Cyproheptadi | 2004 |
Effects of bromocriptine and cyproheptadine on basal and corticotropin-releasing factor (CRF)-induced ACTH release in a patient with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Basal Metabolism; beta-Endorphin; Bromocriptine; Corticotropin-R | 1984 |
[An ACTH-secreting pituitary macroadenoma: inhibitory effect of cyproheptadine and somatostatin].
Topics: Adenoma; Cushing Syndrome; Cyproheptadine; Female; Humans; Middle Aged; Pituitary Neoplasms; Somatos | 1984 |
Sustained remission of Nelson's syndrome after stopping cyproheptadine treatment.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Cushing Syndrome; Cyproheptadin | 1980 |
Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor.
Topics: Abdominal Neoplasms; Acromegaly; Adolescent; Adrenocorticotropic Hormone; Carcinoid Tumor; Cushing S | 1981 |
Direct effects of thyrotropin-releasing hormone, cyproheptadine, and dopamine on adrenocorticotropin secretion from human corticotroph adenoma cells in vitro.
Topics: Adenoma; Adrenocorticotropic Hormone; Cells, Cultured; Cushing Syndrome; Cyproheptadine; Dopamine; H | 1981 |
A cyproheptadine-reversible defect in ACTH control persisting after removal of the pituitary tumor in Cushing's disease.
Topics: Adenoma; Adrenalectomy; Adrenocorticotropic Hormone; Cushing Syndrome; Cyproheptadine; Feedback; Hum | 1981 |
Medical and surgical management of functional pituitary tumors.
Topics: Acromegaly; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; Growth Hor | 1981 |
Cyproheptadine-induced remission of Cushing's disease due to pituitary basophil adenoma.
Topics: Adenoma, Basophil; Adrenocorticotropic Hormone; Cushing Syndrome; Cyproheptadine; Humans; Male; Midd | 1982 |
Effect of cyproheptadine, desmethylcyproheptadine, gamma-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Cyproheptadine; Female; gamma-Aminobutyric Acid; Humans; Nelson Syndrom | 1983 |
[Medical treatment of functioning pituitary adenomas (author's transl)].
Topics: Acromegaly; Adenoma; Adult; Bromocriptine; Cyproheptadine; Dopamine; Female; Humans; Hypotension; Ma | 1981 |
Cyproheptadine therapy in Cushing's disease and Nelson's syndrome.
Topics: Adult; Blood Pressure; Body Weight; Cushing Syndrome; Cyproheptadine; Female; Humans; Nelson Syndrom | 1980 |
Cortisol secretory patterns in Cushing's disease and response to cyproheptadine treatment.
Topics: Adenoma; Adult; Cushing Syndrome; Cyproheptadine; Female; Humans; Hydrocortisone; Male; Middle Aged; | 1996 |
Cyproheptadine treatment in Cushing's disease.
Topics: Adenoma; Adolescent; Cushing Syndrome; Cyproheptadine; Female; Follow-Up Studies; Humans; Pituitary | 1996 |
Cyproheptadine in Nelson's syndrome.
Topics: Administration, Oral; Cyproheptadine; Drug Evaluation; Humans; Nelson Syndrome; Pituitary Neoplasms | 1976 |
Cyproheptadine treatment of Nelson's syndrome: restoration of plasma ACTH circadian periodicity and reversal of response to TRF.
Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Cyproheptadine; Female; Humans; Nelson Syndrom | 1978 |
Cortisol and androgen secretion in a case of Nelson's syndrome with paratesticular tumors: response to cyproheptadine therapy.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Androgens; Cushing Syndrome; Cyproheptadine; Huma | 1978 |
Antiserotonin treatment of hyperprolactinemic amenorrhea: long-term follow-up with metergoline, methysergide, and cyproheptadine.
Topics: Amenorrhea; Cyproheptadine; Female; Galactorrhea; Humans; Metergoline; Methysergide; Pituitary Neopl | 1978 |
Effects of cyproheptadine on prolactin synthesis and release by normal and suppressed pituitary glands and by dispersed pituitary tumor cells.
Topics: Animals; Cyproheptadine; Female; Haloperidol; Male; Methysergide; Perphenazine; Pimozide; Pituitary | 1978 |
Monoamine regulation of prolactin and TSH secretion in hypothyroidism.
Topics: Adenoma; Adult; Cyproheptadine; Dopamine; Female; Humans; Hyperprolactinemia; Hypothyroidism; Metocl | 1992 |
Differential response to aminergic stimuli and biological behavior of growth hormone secreting pituitary adenomas.
Topics: Acromegaly; Adenoma; Adolescent; Adult; Bromocriptine; Cyproheptadine; Diazepam; Female; Growth Horm | 1990 |
The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly.
Topics: Acromegaly; Adenoma; Adult; Aged; Bromocriptine; Cyproheptadine; Drug Therapy, Combination; Female; | 1989 |
[Drug therapy of pituitary neoplasms].
Topics: Adrenocorticotropic Hormone; Bromocriptine; Cyproheptadine; Delayed-Action Preparations; Female; Gro | 1987 |
Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture.
Topics: Acromegaly; Adenoma, Acidophil; Adenoma, Chromophobe; Adult; Cells, Cultured; Child; Cyproheptadine; | 1985 |
The medical treatment of the hypersecreting pituitary gland.
Topics: Adenoma; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Bromocriptine; Cyproheptadine; Ergoli | 1985 |
Rebound elevation of cortisol following cyproheptadine withdrawal in Cushing's disease from a pituitary macroadenoma.
Topics: Adenoma; Adult; Cushing Syndrome; Cyproheptadine; Female; Humans; Hydrocortisone; Pituitary Neoplasm | 1987 |