cyproheptadine has been researched along with Nelson Syndrome in 12 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Nelson Syndrome: A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an attempt to delineate the mechanism and the site of action of cyproheptadine and dopaminergic agonists as well as hormones including thyrotropin-releasing hormone (TRH) and hydrocortisone, the effects of these substances on ACTH secretion from corticotroph adenoma cells in culture were examined." | 7.66 | Direct effects of thyrotropin-releasing hormone, cyproheptadine, and dopamine on adrenocorticotropin secretion from human corticotroph adenoma cells in vitro. ( Ishibashi, M; Yamaji, T, 1981) |
| "In an attempt to delineate the mechanism and the site of action of cyproheptadine and dopaminergic agonists as well as hormones including thyrotropin-releasing hormone (TRH) and hydrocortisone, the effects of these substances on ACTH secretion from corticotroph adenoma cells in culture were examined." | 3.66 | Direct effects of thyrotropin-releasing hormone, cyproheptadine, and dopamine on adrenocorticotropin secretion from human corticotroph adenoma cells in vitro. ( Ishibashi, M; Yamaji, T, 1981) |
| "When cabergoline was reintroduced there was a clinical improvement and normalization of ACTH plasma levels (64 pg/ml)." | 1.32 | Nelson's syndrome: complete remission with cabergoline but not with bromocriptine or cyproheptadine treatment. ( Casulari, LA; Mello, PA; Naves, LA; Papadia, C; Pereira Neto, A, 2004) |
| "Cyproheptadine treatment resulted in a marked lowering of plasma ACTH concentrations (221-320 pg/ml)." | 1.26 | Cortisol and androgen secretion in a case of Nelson's syndrome with paratesticular tumors: response to cyproheptadine therapy. ( Bardin, CW; Krieger, DT; Samojlik, E, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (75.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casulari, LA | 1 |
| Naves, LA | 1 |
| Mello, PA | 1 |
| Pereira Neto, A | 1 |
| Papadia, C | 1 |
| Garcia, C | 1 |
| Bordier, L | 1 |
| Garcia-Hejl, C | 1 |
| Ceppa, F | 1 |
| Mayaudon, H | 1 |
| Dupuy, O | 1 |
| Bauduceau, B | 1 |
| Hirata, Y | 1 |
| Nakashima, H | 1 |
| Uchihashi, M | 1 |
| Tomita, M | 1 |
| Fujita, T | 1 |
| Ikeda, M | 1 |
| Aronin, N | 1 |
| Krieger, DT | 3 |
| Ishibashi, M | 1 |
| Yamaji, T | 1 |
| Lamberts, SW | 1 |
| Verleun, T | 1 |
| Bons, EG | 1 |
| Uitterlinden, P | 1 |
| Oosterom, R | 1 |
| Jialal, I | 1 |
| Pillay, NL | 1 |
| Mercado-Asis, LB | 1 |
| Yanovski, JA | 1 |
| Tracer, HL | 1 |
| Chik, CL | 1 |
| Cutler, GB | 1 |
| Cassar, J | 1 |
| Mashiter, K | 1 |
| Joplin, GF | 1 |
| Rees, LH | 1 |
| Gilkes, JJ | 1 |
| Condon, EM | 1 |
| Samojlik, E | 1 |
| Bardin, CW | 1 |
1 trial available for cyproheptadine and Nelson Syndrome
| Article | Year |
|---|---|
Acute effects of bromocriptine, cyproheptadine, and valproic acid on plasma adrenocorticotropin secretion in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Bromocriptine; Cyproheptadine; Drug Combinations; Drug Synergism | 1997 |
11 other studies available for cyproheptadine and Nelson Syndrome
| Article | Year |
|---|---|
Nelson's syndrome: complete remission with cabergoline but not with bromocriptine or cyproheptadine treatment.
Topics: Adenoma; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Bromocriptine; Cabergoline; Cyproheptadi | 2004 |
[Nelson's syndrome management: current knowledge].
Topics: Adolescent; Adrenalectomy; Adrenocorticotropic Hormone; Cushing Syndrome; Cyproheptadine; Diagnosis, | 2007 |
Effects of bromocriptine and cyproheptadine on basal and corticotropin-releasing factor (CRF)-induced ACTH release in a patient with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Basal Metabolism; beta-Endorphin; Bromocriptine; Corticotropin-R | 1984 |
Sustained remission of Nelson's syndrome after stopping cyproheptadine treatment.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Cushing Syndrome; Cyproheptadin | 1980 |
Direct effects of thyrotropin-releasing hormone, cyproheptadine, and dopamine on adrenocorticotropin secretion from human corticotroph adenoma cells in vitro.
Topics: Adenoma; Adrenocorticotropic Hormone; Cells, Cultured; Cushing Syndrome; Cyproheptadine; Dopamine; H | 1981 |
Defect in ACTH control after hypophysectomy in Cushing's disease.
Topics: Adrenocorticotropic Hormone; Animals; Cushing Syndrome; Cyproheptadine; Feedback; Humans; Hydrocorti | 1982 |
Effect of cyproheptadine, desmethylcyproheptadine, gamma-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Cyproheptadine; Female; gamma-Aminobutyric Acid; Humans; Nelson Syndrom | 1983 |
Cyproheptadine therapy in Cushing's disease and Nelson's syndrome.
Topics: Adult; Blood Pressure; Body Weight; Cushing Syndrome; Cyproheptadine; Female; Humans; Nelson Syndrom | 1980 |
Cyproheptadine in Nelson's syndrome.
Topics: Administration, Oral; Cyproheptadine; Drug Evaluation; Humans; Nelson Syndrome; Pituitary Neoplasms | 1976 |
Cyproheptadine treatment of Nelson's syndrome: restoration of plasma ACTH circadian periodicity and reversal of response to TRF.
Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Cyproheptadine; Female; Humans; Nelson Syndrom | 1978 |
Cortisol and androgen secretion in a case of Nelson's syndrome with paratesticular tumors: response to cyproheptadine therapy.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Androgens; Cushing Syndrome; Cyproheptadine; Huma | 1978 |