cyproheptadine has been researched along with Muscle Contraction in 49 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine was not detected upon TLC analysis of the extract by comparison with an authentic standard." | 1.30 | This histamine-like effects of Phallusia nigra extract: evidences for direct activity at H1 receptors. ( Berlinck, RG; Costa, LV; de Freitas, JC; Malpezzi, EL; Rowan, EG, 1997) |
| "Cyproheptadine was compared with nifedipine, verapamil and diltiazem for calcium entry blocker activity in isolated cardiovascular preparations." | 1.27 | Calcium entry blocker activity of cyproheptadine in isolated cardiovascular preparations. ( Baskin, EP; Bohn, DL; Morgan, G; Siegl, PK; Wallace, AA; Winquist, RJ, 1984) |
| "6 Dose-response curves for the rate of drug-induced relaxation of tonic contractures produced in hypertonic 42." | 1.26 | The calcium antagonistic effects of cyproheptadine on contraction, membrane electrical events and calcium influx in the guinea-pig taenia coli. ( Lowe, DA; Matthews, EK; Richardson, BP, 1981) |
| "Reserpine pre-treatment potentiated lower doses of NA and the threshold dose of NA was significantly decreased." | 1.26 | Comparative studies of the effects of 5-hydroxytryptamine and noradrenaline on the rat anococcygeus muscle. ( Goyal, RK; Patel, NM; Verma, SC, 1981) |
| "Methysergide was a better agonist in the ear artery than in the aorta." | 1.26 | Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta. ( Apperley, E; Humphrey, PP; Levy, GP, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (73.47) | 18.7374 |
| 1990's | 8 (16.33) | 18.2507 |
| 2000's | 2 (4.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Devlin, JP | 1 |
| Bauen, A | 1 |
| Possanza, GJ | 1 |
| Stewart, PB | 1 |
| Goodlich, BI | 1 |
| Horan, SA | 1 |
| Kavanagh, JJ | 2 |
| Aneesha, VA | 1 |
| Gopi, RP | 1 |
| Kumawat, S | 1 |
| Susanth, VS | 1 |
| Vineetha, S | 1 |
| Kumar, D | 1 |
| Thorstensen, JR | 1 |
| Taylor, JL | 1 |
| Enguix, MJ | 1 |
| Sánchez, L | 1 |
| Villazón, M | 1 |
| Brea, J | 1 |
| Tristán, H | 1 |
| Caruncho, HJ | 1 |
| Cadavid, MI | 1 |
| Loza, MI | 1 |
| Katerere, D | 1 |
| Parry, O | 1 |
| Pawłowski, L | 1 |
| Kwiatek, H | 1 |
| Lowe, DA | 2 |
| Matthews, EK | 1 |
| Richardson, BP | 2 |
| Feniuk, W | 1 |
| Maggi, CA | 1 |
| Manzini, S | 1 |
| Meli, A | 1 |
| Senaratne, M | 1 |
| Kappagoda, T | 1 |
| Winquist, RJ | 1 |
| Siegl, PK | 1 |
| Baskin, EP | 1 |
| Bohn, DL | 1 |
| Morgan, G | 1 |
| Wallace, AA | 1 |
| Moulds, RF | 1 |
| Soter, NA | 1 |
| Wasserman, SI | 1 |
| Goyal, RK | 1 |
| Patel, NM | 1 |
| Verma, SC | 1 |
| Liu, X | 1 |
| Lin, KW | 1 |
| Abdullah, NA | 1 |
| Hirata, M | 1 |
| Matsumoto, K | 1 |
| Aizawa, H | 1 |
| Inoue, R | 1 |
| Hamano, S | 1 |
| Ikeda, S | 1 |
| Xie, Z | 1 |
| Hara, N | 1 |
| Ito, Y | 1 |
| Okoro, EO | 1 |
| Marwood, JF | 1 |
| Zhang, MQ | 1 |
| Timmerman, H | 1 |
| Costa, LV | 1 |
| Malpezzi, EL | 1 |
| Berlinck, RG | 1 |
| Rowan, EG | 1 |
| de Freitas, JC | 1 |
| Apperley, E | 1 |
| Humphrey, PP | 1 |
| Levy, GP | 1 |
| Nakamura, M | 1 |
| Fukushima, H | 1 |
| Ganatra, VM | 1 |
| Dhumal, VR | 1 |
| Bhatt, JD | 1 |
| Sachdev, KS | 1 |
| Mottram, DR | 1 |
| Patel, RJ | 1 |
| Müller-Schweinitzer, E | 1 |
| Maj, J | 1 |
| Palider, W | 1 |
| Baran, L | 1 |
| Gilbert, JC | 1 |
| Goldberg, LI | 1 |
| Marzio, L | 1 |
| Blennerhassett, P | 1 |
| Vermillion, D | 1 |
| Chiverton, S | 1 |
| Collins, S | 1 |
| Silvestrini, B | 1 |
| Palmery, M | 1 |
| Basta, F | 1 |
| Valeri, P | 1 |
| López de Pablo, AL | 1 |
| Marco, EJ | 1 |
| Benito, JM | 1 |
| Fraile, ML | 1 |
| Sanz, ML | 1 |
| Moreno, MJ | 1 |
| Conde, MV | 1 |
| Kalkman, HO | 1 |
| Neumann, V | 1 |
| Brauner, V | 1 |
| Yoshida, S | 1 |
| Kuga, T | 1 |
| Saxena, PR | 1 |
| Heiligers, J | 1 |
| Mylecharane, EJ | 1 |
| Tio, R | 1 |
| Klarskov, P | 1 |
| Hørby-Petersen, J | 1 |
| Patten, BM | 1 |
| Oliver, KL | 1 |
| Engel, WK | 1 |
| Frankhuyzen, AL | 1 |
| Bonta, IL | 2 |
| Tozzi, S | 1 |
| Roth, FE | 1 |
| Tabachnick, II | 1 |
| Daniel, EE | 1 |
| Tohya, Y | 1 |
| Sasagawa, S | 1 |
| Trottier, RW | 1 |
| Malone, MH | 1 |
| Benzi, G | 1 |
| Bermudez, E | 1 |
| Arrigoni, E | 1 |
| Friedman, AP | 1 |
| de Oliveira, LF | 1 |
| Sollero, L | 1 |
| Sadovsky, E | 1 |
| Dora, A | 1 |
| Pfeifer, Y | 1 |
| Polishuk, WZ | 1 |
| Rachamimoff, R | 1 |
| Sulman, FG | 1 |
| Frankhuijzen, AL | 1 |
| Chopra, YM | 1 |
| Dandiya, PC | 1 |
| Mitolo-Chieppa, D | 1 |
| Hong, E | 1 |
| Sancilio, LF | 1 |
| Vargas, R | 1 |
| Pardo, EG | 1 |
2 reviews available for cyproheptadine and Muscle Contraction
| Article | Year |
|---|---|
An analysis of 5-hydroxytryptamine receptors mediating contraction of isolated smooth muscle.
Topics: Animals; Binding, Competitive; Cats; Cyproheptadine; Dogs; In Vitro Techniques; Ketanserin; Methoxam | 1984 |
Physical urticaria/angioedema: an experimental model of mast cell activation in humans.
Topics: Angioedema; Body Temperature; Chemotactic Factors; Cyproheptadine; Hot Temperature; Humans; Hydroxyz | 1980 |
2 trials available for cyproheptadine and Muscle Contraction
| Article | Year |
|---|---|
Blockade of 5-HT
Topics: Adult; Central Nervous System; Cyproheptadine; Double-Blind Method; Electromyography; Female; Humans | 2022 |
Human corticospinal-motoneuronal output is reduced with 5-HT
Topics: Adult; Cross-Over Studies; Cyproheptadine; Double-Blind Method; Evoked Potentials, Motor; Female; Hu | 2021 |
45 other studies available for cyproheptadine and Muscle Contraction
| Article | Year |
|---|---|
Antiallergic 9-oxo-11-hydroxy-5H,9H-[2]benzopyrano[4,3-g][1]benzopyrans.
Topics: Anaphylaxis; Animals; Benzopyrans; Guinea Pigs; Hypersensitivity; In Vitro Techniques; Muscle Contra | 1978 |
Histamine receptors mediate contraction of reticular groove smooth muscle of adult goats.
Topics: Animals; Blotting, Western; Cimetidine; Cyproheptadine; Dose-Response Relationship, Drug; Goats; His | 2020 |
Differential regulation of rat peripheral 5-HT(2A) and 5-HT(2B) receptor systems: influence of drug treatment.
Topics: Amphetamines; Animals; Antipsychotic Agents; Aorta, Thoracic; Clozapine; Cyproheptadine; Gastric Fun | 2003 |
Pharmacological actions of Heteromorpha trifoliata ("dombwe") on rat isolated muscle preparations.
Topics: Alcuronium; Animals; Apiaceae; Atropine; Calcium Channel Blockers; Cyproheptadine; Drug Evaluation, | 2000 |
No correlation exists between antidepressant activity and the ability of 5-HT uptake inhibitors to interact with 5-HT receptors of the rat stomach fundus strip.
Topics: Animals; Antidepressive Agents, Tricyclic; Barium; Barium Compounds; Chlorides; Cyproheptadine; In V | 1984 |
The calcium antagonistic effects of cyproheptadine on contraction, membrane electrical events and calcium influx in the guinea-pig taenia coli.
Topics: Animals; Calcium; Cyproheptadine; Female; Guinea Pigs; Hypertonic Solutions; In Vitro Techniques; In | 1981 |
Contribution of cellular and extracellular Ca2+ during 5-hydroxytryptamine-induced contractions of rabbit ear artery.
Topics: Animals; Calcium; Cyproheptadine; Desoxycorticosterone; Ear, External; Extracellular Space; Hydroxyd | 1983 |
Tetrodotoxin-resistant relaxation to transmural nerve stimulation in isolated saphenous vein.
Topics: Aminophylline; Animals; Biomechanical Phenomena; Cimetidine; Cyproheptadine; Dogs; Drug Resistance; | 1984 |
Calcium entry blocker activity of cyproheptadine in isolated cardiovascular preparations.
Topics: Animals; Calcium Channel Blockers; Cyproheptadine; Diltiazem; Female; Heart; Male; Muscle Contractio | 1984 |
Reactivity of isolated digital arteries in hypertension.
Topics: Angiotensin II; Barium; Barium Compounds; Chlorides; Cyproheptadine; Female; Hand; Humans; Hypertens | 1981 |
Comparative studies of the effects of 5-hydroxytryptamine and noradrenaline on the rat anococcygeus muscle.
Topics: Animals; Cyproheptadine; Drug Interactions; Hydroxydopamines; In Vitro Techniques; Male; Muscle Cont | 1981 |
Effects of cyproheptadine, ketotifen and sodium nitroprusside on mechanical activity and calcium uptake in guinea pig taenia coli in vitro.
Topics: Animals; Calcium; Colon; Cyproheptadine; Ferricyanides; Guinea Pigs; Ketotifen; Muscle Contraction; | 1980 |
[Effect and its mechanism of substance P on contractile activity of isolated antral muscle strips of rat].
Topics: Animals; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Hexamethonium; Hexametho | 1994 |
Contraction and depolarization induced by fetal bovine serum in airway smooth muscle.
Topics: Animals; Blood; Bronchi; Cattle; Culture Media; Culture Media, Serum-Free; Cyproheptadine; Dogs; Fem | 1994 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female | 1997 |
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
Topics: Animals; Butyrophenones; Cell Membrane; Chromones; Cyproheptadine; Guinea Pigs; Histamine H1 Antagon | 1997 |
This histamine-like effects of Phallusia nigra extract: evidences for direct activity at H1 receptors.
Topics: Animals; Atropine; Cyproheptadine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Ileum; | 1997 |
Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta.
Topics: Animals; Aorta, Thoracic; Arteries; Cyproheptadine; Ear, External; Female; In Vitro Techniques; Male | 1976 |
Effect of benzodiazepines on central serotonergic neuron systems.
Topics: Animals; Anticonvulsants; Bicuculline; Brain; Cyproheptadine; Diazepam; Drug Interactions; In Vitro | 1977 |
Antagonism of some contractile responses to prostaglandins by cyproheptadine.
Topics: Anesthetics, Local; Animals; Anura; Cyproheptadine; Female; Guinea Pigs; Ileum; In Vitro Techniques; | 1979 |
Peripheral effects of fenfluramine mediated via the release of 5-hydroxytryptamine.
Topics: Animals; Cyproheptadine; Digestive System; Drug Interactions; Fenfluramine; Guinea Pigs; Histamine; | 1979 |
Responsiveness of isolated canine cerebral and peripheral arteries to ergotamine.
Topics: Animals; Arteries; Basilar Artery; Carotid Artery, External; Cerebral Arteries; Cyproheptadine; Dogs | 1976 |
The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anthracenes; Clonidine; Cyproheptadine; Decerebrate State | 1976 |
Characterization by cyproheptadine of the dopamine-induced contraction in canine isolated arteries.
Topics: Animals; Carotid Arteries; Cyproheptadine; Dogs; Dopamine; Drug Interactions; Femoral Artery; In Vit | 1975 |
Distribution of mast cells in intestinal muscle of nematode-sensitized rats.
Topics: Animals; Antigens, Helminth; Cell Count; Colon; Cyproheptadine; Female; Hypersensitivity; In Vitro T | 1992 |
Facilitating effect of amphetamine on the response of rabbit aortic strips to adrenaline, dopamine and serotonin.
Topics: Amphetamine; Animals; Aorta, Thoracic; Cyproheptadine; Dopamine; Drug Synergism; Epinephrine; Female | 1991 |
Response of isolated cat middle cerebral artery to platelets: effect of endothelium removal.
Topics: Animals; Blood Platelets; Cats; Cerebral Arteries; Cyproheptadine; Endothelium, Vascular; Female; In | 1991 |
Supersensitivity of atherosclerotic rabbit aorta to ergometrine is mediated by 5-HT2 receptors.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Body Weight; Cyproheptadine; Ergonovine; In Vitro Techni | 1989 |
Two kinds of modification by 5-methoxy-N,N-dimethyltryptamine of contractile responses to electrical stimulation of isolated guinea-pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Clonidine; Cyproheptadine; Electric S | 1987 |
Excitatory 5-hydroxytryptamine receptors in the cat urinary bladder are of the M- and 5-HT2-type.
Topics: Animals; Atropine; Cats; Cyproheptadine; Dimethylphenylpiperazinium Iodide; Drug Interactions; Femal | 1985 |
Influence of serotonin on lower urinary tract smooth muscle in vitro.
Topics: Animals; Cyproheptadine; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Keta | 1986 |
Serotonin-induced muscle weakness.
Topics: Adenosine Triphosphatases; Alanine Transaminase; Animals; Aspartate Aminotransferases; Creatine Kina | 1974 |
Effect of mianserin, a potent anti-serotonin agent, on the isolated rat stomach fundus preparation.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Binding Sites; Calcium; Chlorpromazine; Cyproh | 1974 |
The pharmacology of azatadine, a potential antiallergy drug.
Topics: Anaphylaxis; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histami | 1974 |
Further studies of the pharmacology of the pyloric region. Analysis of the effects of intra-arterial histamine, serotonin, phenyldiguanide, morphine, and other drugs on the antrum and duodenal bulb.
Topics: Acetylcholine; Animals; Atropine; Cyproheptadine; Dogs; Drug Antagonism; Duodenum; Electrophysiology | 1966 |
Pharmacological properties of the proteolytic products of the liver homogenates of rat by the acidic protease (TE-P), isolated from Trametes sanguinea.
Topics: Acetylcholine; Animals; Atropine; Bradykinin; Colon; Cyproheptadine; Diphenhydramine; Duodenum; Fema | 1968 |
Comparative in vitro evaluation of cryogenine, cyproheptadine, and diphenhydramine as antagonists of furtrethonium, histamine, and serotonin.
Topics: Alkaloids; Animals; Cyproheptadine; Diphenhydramine; Female; Guinea Pigs; Histamine H1 Antagonists; | 1969 |
Action of antibiotics on respiratory tract. I. Ampicillin.
Topics: Acetylcholine; Amino Alcohols; Ampicillin; Animals; Atropine; Barium; Bronchi; Bronchial Spasm; Chlo | 1970 |
Reflections on the treatment of headache.
Topics: Animals; Aspirin; Cyproheptadine; Ergotamine; Haplorhini; Headache; Hormones; Humans; Methysergide; | 1972 |
Interactions of 5-hydroxytryptamine and narcotic analgesics on dog intestine in vivo.
Topics: Acetylcholine; Analgesics; Animals; Atropine; Blood Pressure; Cyproheptadine; Dextromoramide; Dibenz | 1973 |
Effect of the serotonin antagonist cyproheptadine on uterine and duodenal muscle contractions in rats.
Topics: Animals; Cyproheptadine; Depression, Chemical; Dose-Response Relationship, Drug; Duodenum; Estradiol | 1973 |
Receptors involved in the action of 5-HT and tryptamine on the isolated rat stomach fundus preparation.
Topics: Acetylcholine; Animals; Cyproheptadine; Dibenzazepines; Dose-Response Relationship, Drug; In Vitro T | 1974 |
On the mechanism of reversal of reserpine action by pargyline hydrochloride.
Topics: Animals; Atropine; Blood Pressure; Cyproheptadine; Dogs; Epinephrine; Female; Heart Rate; Male; Meth | 1969 |
[Effects of 5-HT and its antagonists on contraction of the anterior tibial muscle in the rat].
Topics: Animals; Chlorpromazine; Cyproheptadine; Methysergide; Muscle Contraction; Phenoxybenzamine; Rats; S | 1968 |
Similarities between the pharmacological actions of quipazine and serotonin.
Topics: Animals; Aorta; Behavior, Animal; Bronchi; Constriction; Cyproheptadine; Edema; Female; Guinea Pigs; | 1969 |