cyproheptadine has been researched along with Migraine Disorders in 56 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| " For hemicrania we used cinnarizine, cyproheptadine, clonidine, histamine, pizotifene and reserpine; for cluster headache, cinnarizine, cyproheptadine, clonidine, histamine and reserpine; for tension headache, cyproheptadine; for psychogenic headache, allylpropylmalonylurea." | 5.04 | [Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)]. ( Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G, 1975) |
| " There are four separate strands of evidence for this: the common co-existence of abdominal pain and migraine headaches; the similarity between children with episodic abdominal pain and children with migraine headaches, with respect to social and demographic factors, precipitating and relieving factors, and accompanying gastrointestinal, neurological and vasomotor features; the effectiveness of nonanalgesic migraine therapy (such as pizotifen, propanolol, cyproheptadine and the triptans) in abdominal migraine; and the finding of similar neurophysiological features in both migraine headache and abdominal migraine." | 4.81 | Abdominal migraine: evidence for existence and treatment options. ( Abu-Arafeh, I; Russell, G; Symon, DN, 2002) |
| "Patients with abdominal migraine may benefit from prophylactic treatment with propranolol or cyproheptadine." | 3.70 | Abdominal migraine: prophylactic treatment and follow-up. ( Lichtman, SN; Rhoads, JM; Ulshen, MH; Worawattanakul, M, 1999) |
| "Methysergide 3-6 mg." | 2.63 | Comparative trial of serotonin antagonists in the management of migraine. ( Anthony, M; Lance, JW; Somerville, B, 1970) |
| "The management of pediatric migraine requires a balance of biobehavioral measures coupled with agents for acute treatment and, if needed, daily preventive medicines." | 2.43 | The treatment of pediatric migraine. ( Lewis, DW; Sowell, M; Winner, P; Yonker, M, 2005) |
| "40." | 1.72 | Pediatric vestibular migraine: Diagnosis according to ICHD-3 criteria and the effectiveness of short-term CH prophylaxis. ( Cetin, H; Cokyaman, T, 2022) |
| "Amitriptyline was the most commonly prescribed agent (58%)." | 1.32 | Prophylactic treatment of pediatric migraine. ( Diamond, S; Jones, V; Lewis, DW; Scott, D, 2004) |
| "Slit ventricle syndrome is characterized by chronic or recurring headaches associated with subnormal ventricular volume in patients who have undergone shunt treatment for hydrocephalus." | 1.28 | Antimigraine treatment for slit ventricle syndrome. ( Cogen, PH; Edwards, MS; Obana, WG; Raskin, NH; Szymanski, JA, 1990) |
| "Ophthalmoplegic migraine, headache associated with oculomotor nerve dysfunction, may present early in the pediatric age group." | 1.27 | Ophthalmoplegic migraine in infancy. ( Blaw, ME; Woody, RC, 1986) |
| "A 27-year-old patient with severe migraine developed bilateral disk edema and retinal hemorrhages during a prolonged attack of his illness, lasting at least two months." | 1.26 | Bilateral retinal hemorrhages and disk edema in migraine. ( Victor, DI; Welch, RB, 1977) |
| " The therapeutic cycles were standardized, for each drug, in the way of administration, dosage and total duration of the treatment." | 1.26 | [Therapeutic possibilities in idiopathic headaches. Analysis of about 1000 cases]. ( Agostoni, A; Brandi, G; Cottino, A; Gai, V; Gastaldi, L; Lisino, F; Nattero, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (67.86) | 18.7374 |
| 1990's | 7 (12.50) | 18.2507 |
| 2000's | 9 (16.07) | 29.6817 |
| 2010's | 1 (1.79) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Cokyaman, T | 1 |
| Cetin, H | 1 |
| Hirfanoglu, T | 1 |
| Serdaroglu, A | 1 |
| Gulbahar, O | 1 |
| Cansu, A | 1 |
| Liao, KY | 1 |
| Chang, FY | 1 |
| Wu, LT | 1 |
| Wu, TC | 1 |
| Sugiyama, N | 1 |
| Hamano, S | 1 |
| Tanaka, M | 1 |
| Mochizuki, M | 1 |
| Nara, T | 1 |
| Ruiz, C | 1 |
| Gener, B | 1 |
| Garaizar, C | 1 |
| Prats, JM | 1 |
| MILLER, J | 1 |
| CURRAN, DA | 1 |
| LANCE, JW | 7 |
| Lewis, DW | 2 |
| Diamond, S | 2 |
| Scott, D | 1 |
| Jones, V | 1 |
| Lehrer, JF | 1 |
| Yonker, M | 1 |
| Winner, P | 1 |
| Sowell, M | 1 |
| Peroutka, SJ | 2 |
| Anthony, M | 6 |
| Damasio, H | 1 |
| Allen, GS | 1 |
| Amano, T | 1 |
| Meyer, JS | 1 |
| Raskin, NH | 2 |
| Schwartz, RK | 1 |
| Katerji, MA | 1 |
| Painter, MJ | 1 |
| Worawattanakul, M | 1 |
| Rhoads, JM | 1 |
| Lichtman, SN | 1 |
| Ulshen, MH | 1 |
| Watemberg, NM | 1 |
| Roth, KS | 1 |
| Alehan, FK | 1 |
| Epstein, CE | 1 |
| Boon, F | 1 |
| Rao, BS | 1 |
| Das, DG | 1 |
| Taraknath, VR | 1 |
| Sarma, Y | 1 |
| Russell, G | 1 |
| Abu-Arafeh, I | 1 |
| Symon, DN | 1 |
| Terrón, JA | 1 |
| Fozard, JR | 1 |
| Bille, B | 1 |
| Ludvigsson, J | 1 |
| Sanner, G | 1 |
| Klimek, A | 3 |
| Hardebo, JE | 1 |
| Edvinsson, L | 1 |
| Owman, C | 1 |
| Svendgaard, NA | 1 |
| Hackaday, J | 1 |
| Nattero, G | 3 |
| Agostoni, A | 2 |
| Brandi, G | 2 |
| Cottino, A | 2 |
| Gai, V | 3 |
| Gastaldi, L | 3 |
| Lisino, F | 2 |
| Victor, DI | 1 |
| Welch, RB | 1 |
| Prusiński, A | 1 |
| Lundberg, PO | 1 |
| Perrault, M | 1 |
| Dry, J | 1 |
| Ollat, H | 1 |
| Green, C | 1 |
| Obana, WG | 1 |
| Cogen, PH | 1 |
| Szymanski, JA | 1 |
| Edwards, MS | 1 |
| Frycová, H | 1 |
| Metys, J | 1 |
| Woody, RC | 1 |
| Blaw, ME | 1 |
| Baltes, BJ | 1 |
| Somerville, B | 3 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Friedman, AP | 3 |
| Crill, WE | 1 |
| Salvati, A | 1 |
| Weber, RB | 1 |
| Saxena, PR | 1 |
10 reviews available for cyproheptadine and Migraine Disorders
| Article | Year |
|---|---|
The treatment of pediatric migraine.
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Antidepressive Agents; Antiemetics; Biofeedback, Psych | 2005 |
Serotonin antagonists.
Topics: Cyproheptadine; Depression; Ergotamine; Humans; Hypertension; Ketanserin; Lisuride; Methysergide; Mi | 1984 |
Drug management of adult vascular headaches (migraine and cluster headache): Part II--Prevention and attacks.
Topics: Adult; Amitriptyline; Belladonna Alkaloids; Cluster Headache; Cyproheptadine; Drug Combinations; Erg | 1984 |
Central anticholinergic syndrome on therapeutic doses of cyproheptadine.
Topics: Central Nervous System Diseases; Child; Cholinergic Antagonists; Cyproheptadine; Hallucinations; Hum | 1999 |
Abdominal migraine: evidence for existence and treatment options.
Topics: Abdominal Pain; Child; Cyproheptadine; Diet; Humans; Migraine Disorders; Pizotyline; Propranolol; Se | 2002 |
Is the 5-HT(7) receptor involved in the pathogenesis and prophylactic treatment of migraine?
Topics: Amitriptyline; Animals; Cyproheptadine; Humans; Lisuride; Migraine Disorders; Models, Biological; Re | 2002 |
The animal pharmacology of drugs used in the treatment of migraine.
Topics: Acetaminophen; Adrenergic alpha-Antagonists; Analgesics; Animals; Aspirin; Caffeine; Clonidine; Cypr | 1975 |
[Serotonin agonists and antagonists in migraine].
Topics: Benzoxepins; Contraindications; Cyproheptadine; Dihydroergotamine; Ergotamine; Histamine H1 Antagoni | 1992 |
Current concepts in the pathogenesis and interval treatment of migraine.
Topics: Adrenergic beta-Antagonists; Bradykinin; Clonidine; Cycloheptanes; Cyproheptadine; Ergotamine; Hista | 1972 |
Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.
Topics: Animals; Blood Pressure; Clinical Trials as Topic; Cycloheptanes; Cyproheptadine; Dogs; Ergolines; G | 1972 |
9 trials available for cyproheptadine and Migraine Disorders
| Article | Year |
|---|---|
The pharmacology of calcium channel antagonists: a novel class of anti-migraine agents?
Topics: Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Cyproheptadine; Dil | 1983 |
A double blind controlled study of propranolol and cyproheptadine in migraine prophylaxis.
Topics: Adolescent; Adult; Cyproheptadine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; M | 2000 |
Prophylaxis of migraine in children.
Topics: Adolescent; Child; Clinical Trials as Topic; Cyproheptadine; Humans; Migraine Disorders; Pizotyline; | 1977 |
[Therapeutic possibilities in idiopathic headaches. Analysis of 1000 cases (author's transl)].
Topics: Aspirin; Caffeine; Cinnarizine; Clinical Trials as Topic; Clonidine; Cyproheptadine; Drug Therapy, C | 1975 |
Antiserotonin agents in the treatment of migraine.
Topics: Adult; Clinical Trials as Topic; Cyproheptadine; Female; Humans; Male; Middle Aged; Migraine Disorde | 1975 |
Comparative trial of serotonin antagonists in the management of migraine.
Topics: Clinical Trials as Topic; Cyproheptadine; Ergolines; Female; Histamine H1 Antagonists; Humans; Male; | 1970 |
Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches.
Topics: Animals; Blood Pressure; Clinical Trials as Topic; Cycloheptanes; Cyproheptadine; Dogs; Ergolines; G | 1972 |
Thermographic, hormonal and clinical studies in migraine.
Topics: Amides; Body Temperature; Clinical Trials as Topic; Cyproheptadine; Ergolines; Female; Humans; Male; | 1970 |
A comparative trial of serotonin antagonists in the management of migraine.
Topics: Clinical Trials as Topic; Cyproheptadine; Ergolines; Humans; Methysergide; Migraine Disorders; Pheno | 1970 |
38 other studies available for cyproheptadine and Migraine Disorders
| Article | Year |
|---|---|
Pediatric vestibular migraine: Diagnosis according to ICHD-3 criteria and the effectiveness of short-term CH prophylaxis.
Topics: Benign Paroxysmal Positional Vertigo; Child; Cyproheptadine; Epilepsy; Headache; Humans; Migraine Di | 2022 |
Prophylactic drugs and cytokine and leptin levels in children with migraine.
Topics: Adolescent; Amitriptyline; Central Nervous System Agents; Child; Cyproheptadine; Cytokines; Female; | 2009 |
Cyclic vomiting syndrome in Taiwanese children.
Topics: Adolescent; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Age of Onset; Amitriptyline; | 2011 |
[MRI findings and effectiveness of cyproheptadine in two patients with ophthalmoplegic migraine].
Topics: Child; Child, Preschool; Cyproheptadine; Female; Histamine H1 Antagonists; Humans; Magnetic Resonanc | 2002 |
Episodic spontaneous hypothermia: a periodic childhood syndrome.
Topics: Abdominal Pain; Body Temperature; Bradycardia; Child; Child, Preschool; Consciousness Disorders; Cyp | 2003 |
A SEROTONIN ANTAGONIST, CYPROHEPTADINE. II. THE TREATMENT OF VASCULAR-TYPE HEADACHE AND PRURITUS.
Topics: Cyproheptadine; Headache; Humans; Migraine Disorders; Pruritus; Serotonin Antagonists; Vascular Head | 1963 |
CLINICAL TRIAL OF METHYSERGIDE AND OTHER PREPARATIONS IN THE MANAGEMENT OF MIGRAINE.
Topics: Biomedical Research; Cyproheptadine; Disease Management; Drug Therapy; Ergotamine; Methysergide; Mig | 1964 |
Prophylactic treatment of pediatric migraine.
Topics: Adolescent; Age Factors; Amitriptyline; Analgesics, Non-Narcotic; Child; Child, Preschool; Cyprohept | 2004 |
Cyproheptadine's antiserotonin effects are responsible for its antimigraine activity.
Topics: Child; Cyproheptadine; Humans; Migraine Disorders; Serotonin Antagonists | 2004 |
The calcium antagonist properties of cyproheptadine: implications for antimigraine action.
Topics: Animals; Basilar Artery; Calcium Channel Blockers; Calcium Chloride; Cyproheptadine; Dogs; Female; M | 1984 |
Cerebrovascular changes in patients with headache during antiserotoninergic treatment.
Topics: Adult; Cerebrovascular Circulation; Cyproheptadine; Female; Headache; Humans; Male; Methysergide; Mi | 1982 |
Interval therapy of migraine: long-term results.
Topics: Adolescent; Adult; Aged; Amitriptyline; Cyproheptadine; Ergonovine; Ergotamine; Humans; Middle Aged; | 1980 |
Infantile migraine presenting as colic.
Topics: Colic; Cyproheptadine; Diagnosis, Differential; Failure to Thrive; Humans; Infant; Male; Migraine Di | 1994 |
Abdominal migraine: prophylactic treatment and follow-up.
Topics: Abdominal Pain; Adolescent; Child; Child, Preschool; Cyproheptadine; Female; Gastrointestinal Agents | 1999 |
Cyproheptadine and SSRIs.
Topics: Adolescent; Cyproheptadine; Depressive Disorder; Drug Administration Schedule; Drug Interactions; Fe | 1999 |
Cyproheptadine (Peritol) in the treatment of migraine and related headache.
Topics: Adolescent; Adult; Cluster Headache; Cyproheptadine; Female; Headache; Humans; Male; Middle Aged; Mi | 1979 |
Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Possible implications in migraine.
Topics: Animals; Arteries; Cats; Cerebral Arteries; Cyproheptadine; Dihydroergotamine; Drug Synergism; Ergot | 1978 |
Migraine. Prophylactic drugs.
Topics: Anticonvulsants; Clonidine; Cyproheptadine; Dihydroergotamine; Humans; Methysergide; Migraine Disord | 1977 |
Bilateral retinal hemorrhages and disk edema in migraine.
Topics: Adult; Belladonna Alkaloids; Child; Cyproheptadine; Dihydroergotamine; Female; Fluorescein Angiograp | 1977 |
[Therapeutic possibilities in idiopathic headaches. Analysis of about 1000 cases].
Topics: Cinnarizine; Clonidine; Cyproheptadine; Headache; Histamine; Humans; Methysergide; Migraine Disorder | 1976 |
Abdominal migraine--diagnosis and therapy.
Topics: Abdomen; Adult; Aged; Cyproheptadine; Female; Humans; Lynestrenol; Male; Middle Aged; Migraine Disor | 1975 |
[Anti-amine treatment of migraines].
Topics: Biogenic Amines; Cyproheptadine; Humans; Methysergide; Migraine Disorders; Phenothiazines; Pizotylin | 1975 |
Sumatriptan and other drugs used in migraine treatment.
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricycl | 1992 |
Antimigraine treatment for slit ventricle syndrome.
Topics: Adult; Cerebral Ventricles; Cerebral Ventriculography; Cerebrospinal Fluid Shunts; Child, Preschool; | 1990 |
[Anti-allergic properties of pipethiaden--a new preventive agent for migraine].
Topics: Anaphylaxis; Animals; Cyproheptadine; Female; Guinea Pigs; Mice; Migraine Disorders; Passive Cutaneo | 1989 |
Ophthalmoplegic migraine in infancy.
Topics: Autonomic Agents; Cyproheptadine; Female; Humans; Infant; Male; Migraine Disorders; Oculomotor Nerve | 1986 |
Management of headache by the family physician.
Topics: Adjustment Disorders; Adrenocorticotropic Hormone; Antidepressive Agents; Cyproheptadine; Ergotamine | 1972 |
[Use of cyproheptadine in the treatment of headaches].
Topics: Adolescent; Adult; Cyproheptadine; Drug Evaluation; Female; Headache; Humans; Male; Middle Aged; Mig | 1974 |
Reflections on the treatment of headache.
Topics: Animals; Aspirin; Cyproheptadine; Ergotamine; Haplorhini; Headache; Hormones; Humans; Methysergide; | 1972 |
Drug therapy of migraine.
Topics: Administration, Intranasal; Administration, Oral; Aerosols; Cyproheptadine; Diagnosis, Differential; | 1972 |
Migraine headaches.
Topics: Caffeine; Contraceptives, Oral; Cyproheptadine; Diagnosis, Differential; Diuretics; Drug Combination | 1972 |
[Drugs which may be used for prevention and therapy. Opinion of Prof. Adriano Marino].
Topics: Carbamazepine; Cyproheptadine; Drug Therapy; Drug Tolerance; Ergot Alkaloids; Ergotamine; Humans; Mi | 1973 |
Prophylaxis of migraine.
Topics: Antidepressive Agents; Cyproheptadine; Humans; Methysergide; Migraine Disorders; Monoamine Oxidase I | 1973 |
Rational treatment of migraine.
Topics: Cyproheptadine; Ergotamine; Humans; Methysergide; Migraine Disorders; Monoamine Oxidase Inhibitors; | 1972 |
The effects of antimigraine drugs on the vascular responses by-5-hydroxytryptamine and related biogenic substances on the external carotid bed of dogs: possible pharmacological implications to their antimigraine action.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Bradykinin; Carotid Arteries; Carotid Artery, External | 1972 |
Thermographic, hormonal, and clinical studies in migraine.
Topics: Body Temperature; Cycloheptanes; Cyproheptadine; Ergolines; Female; Humans; Menstruation; Methysergi | 1970 |
[On the incidence of ocular disorders in severe migraine, common migraine and migraine states. Evaluation of the results obtained with medical and oculistic therapy].
Topics: Adolescent; Adult; Astigmatism; Cyproheptadine; Eye Diseases; Female; Glaucoma; Humans; Hyperopia; M | 1968 |
Studies in migraine.
Topics: Cyproheptadine; Ergotamine; Humans; Hydroxyindoleacetic Acid; Methysergide; Migraine Disorders; Phen | 1966 |