cyproheptadine has been researched along with Mastocytosis in 2 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Mastocytosis: A rare neoplastic disorder characterized by a clonal proliferation of MAST CELLS, associated with KIT-D816 mutations, and accompanied by aberrant mast cell activation. The abnormal increase of MAST CELLS may occur in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with cimetidine (H2 receptor antagonist) resulted in diarrhea, however, the addition of cyproheptadine (H1 receptor antagonist) was beneficial in amelioration of the cutaneous symptoms of mastocytosis." | 3.68 | Systemic mastocytosis treated with histamine H1 and H2 receptor antagonists. ( Falk, ES; Gasior-Chrzan, B, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KIBEL, MA | 1 |
| KINGSLEY, HJ | 1 |
| Gasior-Chrzan, B | 1 |
| Falk, ES | 1 |
2 other studies available for cyproheptadine and Mastocytosis
| Article | Year |
|---|---|
Mastocytosis; a report on two cases.
Topics: Cyproheptadine; Humans; Mast Cells; Mastocytosis; Prednisolone; Urticaria Pigmentosa | 1963 |
Systemic mastocytosis treated with histamine H1 and H2 receptor antagonists.
Topics: Biopsy; Cimetidine; Colon; Cyproheptadine; Diarrhea; Drug Therapy, Combination; Humans; Liver; Male; | 1992 |