cyproheptadine has been researched along with Malignant Carcinoid Syndrome in 22 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Malignant Carcinoid Syndrome: A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixteen patients with metastatic neuroendocrine tumors and the malignant carcinoid syndrome were treated with cyproheptadine (Periactin, Merck, Sharp & Dohme, West Point, PA) at maximum tolerable doses that ranged from 12 to 48 mg daily." | 9.07 | A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome. ( Kvols, LK; Moertel, CG; Rubin, J, 1991) |
| "Sixteen patients with metastatic neuroendocrine tumors and the malignant carcinoid syndrome were treated with cyproheptadine (Periactin, Merck, Sharp & Dohme, West Point, PA) at maximum tolerable doses that ranged from 12 to 48 mg daily." | 5.07 | A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome. ( Kvols, LK; Moertel, CG; Rubin, J, 1991) |
| "Malignant carcinoid tumors are remarkably varied in their biologic behavior." | 2.66 | Metastatic carcinoid tumors and the carcinoid syndrome. A selective review of chemotherapy and hormonal therapy. ( Kvols, LK, 1986) |
| "Both groups of carcinoid patients had a comparable decrease in their insulinogenic index." | 1.25 | Glucose intolerance in the carcinoid syndrome. ( Bivens, CH; Feldman, JM; Lebovitz, HE; Plonk, JW, 1975) |
| "Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power." | 1.25 | Carcinoid myopathy and treatment with cyproheptadine (Periactin). ( Berry, EM; Maunder, C; Wilson, M, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (90.91) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| JULIAR, B | 1 |
| KAHIL, ME | 1 |
| BROWN, H | 1 |
| FRED, HL | 1 |
| SJOERDSMA, A | 1 |
| MELMON, KL | 1 |
| Rasenack, U | 1 |
| Caspary, W | 1 |
| Modlin, IM | 1 |
| Kvols, LK | 3 |
| Feldman, JM | 2 |
| Plonk, JW | 2 |
| Bivens, CH | 1 |
| Lebovitz, HE | 1 |
| Siklos, P | 1 |
| Mason, RA | 1 |
| Steane, PA | 1 |
| May, B | 1 |
| Moertel, CG | 1 |
| Rubin, J | 1 |
| Leitner, SP | 1 |
| Greenberg, P | 1 |
| Danieu, LA | 1 |
| Michaelson, RA | 1 |
| Padfield, NL | 1 |
| Solares, G | 1 |
| Blanco, E | 1 |
| Pulgar, S | 1 |
| Diago, C | 1 |
| Ramos, F | 1 |
| Berry, EM | 1 |
| Maunder, C | 1 |
| Wilson, M | 1 |
| Gillett, DJ | 1 |
| Smith, RC | 1 |
| Salomon, MI | 1 |
| Bivens, CE | 1 |
| Mengel, CE | 1 |
| Lotito, CA | 1 |
| Martin, RG | 1 |
| Loong, SC | 1 |
| Lance, JW | 1 |
| Rawle, KC | 1 |
2 reviews available for cyproheptadine and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
Metastatic carcinoid tumors and the malignant carcinoid syndrome.
Topics: Biomarkers, Tumor; Carcinoid Heart Disease; Carcinoid Tumor; Cisplatin; Combined Modality Therapy; C | 1994 |
[Carcinoid: diagnosis and therapy].
Topics: Aprotinin; Bradykinin; Carcinoid Heart Disease; Carcinoid Tumor; Cyproheptadine; Diagnosis, Differen | 1975 |
3 trials available for cyproheptadine and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome.
Topics: Adult; Aged; Carcinoid Tumor; Cyproheptadine; Endocrine System Diseases; Female; Humans; Male; Malig | 1991 |
Metastatic carcinoid tumors and the carcinoid syndrome. A selective review of chemotherapy and hormonal therapy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Clinical Tri | 1986 |
A new antiserotonin in the carcinoid syndrome.
Topics: Adult; Aged; Anilides; Chlorpromazine; Cinnamates; Clinical Trials as Topic; Cyproheptadine; Female; | 1968 |
17 other studies available for cyproheptadine and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
CARCINOID SYNDROME: REPORT OF CASE.
Topics: Carcinoid Tumor; Chlorpromazine; Cyproheptadine; Geriatrics; Humans; Hydroxyindoleacetic Acid; Malig | 1963 |
THE CARCINOID CRISIS.
Topics: Cyproheptadine; Drug Therapy; Humans; Hyperesthesia; Hypotension; Malignant Carcinoid Syndrome; Meth | 1964 |
THE CARCINOID SPECTRUM.
Topics: 5-Hydroxytryptophan; Angiotensins; Antineoplastic Agents; Bronchial Neoplasms; Carcinoid Tumor; Chlo | 1964 |
[Therapy of carcinoid and the carcinoid syndrome].
Topics: Aminocaproic Acid; Aprotinin; Carcinoma, Squamous Cell; Cyproheptadine; Doxorubicin; Embolization, T | 1983 |
Carcinoid syndrome.
Topics: Antineoplastic Agents; Apudoma; Carcinoid Tumor; Cyproheptadine; Fenclonine; Gastrointestinal Motili | 1980 |
Glucose intolerance in the carcinoid syndrome.
Topics: Adult; Aged; Carcinoid Tumor; Cyproheptadine; Diabetes Mellitus; Female; Fenclonine; Glucose; Glucos | 1975 |
Surgical approaches and drug treatment in the carcinoid syndrome.
Topics: Antineoplastic Agents; Cyproheptadine; Humans; Malignant Carcinoid Syndrome | 1978 |
Anaesthesia for a patient with carcinoid syndrome.
Topics: Anesthesia, Endotracheal; Anesthesia, General; Cyproheptadine; Female; Humans; Malignant Carcinoid S | 1976 |
Partial remission of carcinoid tumor in response to cyproheptadine.
Topics: Aged; Aged, 80 and over; Carcinoid Tumor; Cyproheptadine; Female; Humans; Hydroxyindoleacetic Acid; | 1989 |
Carcinoid syndrome: comparison of pretreatment regimes in the same patient.
Topics: Blood Pressure; Cyproheptadine; Embolization, Therapeutic; Fenclonine; Hepatic Artery; Humans; Ketan | 1987 |
Carcinoid syndrome and intravenous cyproheptadine.
Topics: Aged; Anesthesia, General; Carcinoid Tumor; Cyproheptadine; Humans; Hypertension; Intraoperative Com | 1987 |
Carcinoid myopathy and treatment with cyproheptadine (Periactin).
Topics: Acid Phosphatase; Cyproheptadine; Diarrhea; Feces; Female; Fenclonine; Humans; Hydroxyindoleacetic A | 1974 |
Treatment of the carcinoid syndrome by hemihepatectomy and radical excision of the primary lesion.
Topics: Aged; Cyproheptadine; Diarrhea; Fenclonine; Heart Valve Diseases; Hepatectomy; Humans; Hydroxyindole | 1974 |
Letter: Vasomotor-like paroxysms.
Topics: Cyproheptadine; Diagnosis, Differential; Humans; Hypertension; Male; Malignant Carcinoid Syndrome; P | 1974 |
Alterations of pituitary-gonadal function in the carcinoid syndrome.
Topics: Aged; Bronchial Neoplasms; Carcinoid Tumor; Cyproheptadine; Erectile Dysfunction; Female; Genitalia, | 1974 |
Management of carcinoid tumors.
Topics: Carcinoid Tumor; Cyproheptadine; Female; Humans; Male; Malignant Carcinoid Syndrome; Methysergide; N | 1970 |
The control of flushing and diarrhoea in carcinoid syndrome by an antiserotonin agent, BC105.
Topics: Blood Circulation; Chloramphenicol; Cyproheptadine; Diarrhea; Face; Humans; Hyperemia; Ileum; Liver | 1968 |