cyproheptadine has been researched along with Malaria in 6 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 9.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "Several compounds in current clinical use as antihistaminic agents, among them cyproheptadine (CYP), have been shown, in experimental models, to reverse resistance of the asexual, intra-erythrocytic stages of rodent or human malarial parasites to chloroquine (CQ)." | 7.70 | The chemotherapy of rodent malaria. LIX. Drug combinations to impede the selection of drug resistance, Part 3: Observations on cyproheptadine, an antihistaminic agent, with chloroquine. ( Butcher, GA; Peters, W; Robinson, BL; Stewart, LB, 2000) |
| "Multiple drug resistance in Plasmodium falciparum is already showing evidence of extending to mefloquine, which at present is one of the few alternative antimalarials for the prevention or treatment of infection with such parasites." | 7.68 | The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium. ( Peters, W; Robinson, BL, 1991) |
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 5.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "The effects of p-chlorophenylalanine, an inhibitor of serotonin synthesis, indomethacin, an inhibitor of prostaglandin synthesis, cyproheptadine, a serotonin, bradykinin and histamine antagonist, were assessed separately and in combination with chloroquine (CQ) in Vom strains of Swiss albino mice (18-22 g) of either sex infected intraperitoneally with 1 x 10(7) Plasmodium yoelii nigeriensis-induced malaria." | 3.72 | Effects of autacoid inhibitors and of an antagonist on malaria infection in mice. ( Agbani, EO; Iwalewa, EO, 2004) |
| "Several compounds in current clinical use as antihistaminic agents, among them cyproheptadine (CYP), have been shown, in experimental models, to reverse resistance of the asexual, intra-erythrocytic stages of rodent or human malarial parasites to chloroquine (CQ)." | 3.70 | The chemotherapy of rodent malaria. LIX. Drug combinations to impede the selection of drug resistance, Part 3: Observations on cyproheptadine, an antihistaminic agent, with chloroquine. ( Butcher, GA; Peters, W; Robinson, BL; Stewart, LB, 2000) |
| "Multiple drug resistance in Plasmodium falciparum is already showing evidence of extending to mefloquine, which at present is one of the few alternative antimalarials for the prevention or treatment of infection with such parasites." | 3.68 | The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium. ( Peters, W; Robinson, BL, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iwalewa, EO | 1 |
| Agbani, EO | 1 |
| Osifo, NG | 1 |
| Singh, N | 1 |
| Puri, SK | 1 |
| Peters, W | 2 |
| Robinson, BL | 2 |
| Stewart, LB | 1 |
| Butcher, GA | 1 |
| Björkman, A | 1 |
| Willcox, M | 1 |
| Kihamia, CM | 1 |
| Mahikwano, LF | 1 |
| Howard, PA | 1 |
| Häkansson, A | 1 |
| Warhurst, D | 1 |
2 trials available for cyproheptadine and Malaria
| Article | Year |
|---|---|
The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria.
Topics: Adolescent; Adult; Antimalarials; Antipruritics; Chloroquine; Chlorpheniramine; Cyproheptadine; Derm | 1995 |
Field study of cyproheptadine/chloroquine synergism in falciparum malaria.
Topics: Adolescent; Animals; Child; Chloroquine; Cyproheptadine; Drug Resistance; Drug Synergism; Drug Thera | 1990 |
4 other studies available for cyproheptadine and Malaria
| Article | Year |
|---|---|
Effects of autacoid inhibitors and of an antagonist on malaria infection in mice.
Topics: Animals; Antimalarials; Autacoids; Chloroquine; Cyproheptadine; Drug Combinations; Fenclonine; Hista | 2004 |
Inhibition of the development of the hepatic stages of Plasmodium yoelii nigeriensis by antihistaminic agents.
Topics: Animals; Antimalarials; Cyproheptadine; Dose-Response Relationship, Drug; Female; Histamine H1 Antag | 1999 |
The chemotherapy of rodent malaria. LIX. Drug combinations to impede the selection of drug resistance, Part 3: Observations on cyproheptadine, an antihistaminic agent, with chloroquine.
Topics: Animals; Antimalarials; Chloroquine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Combinat | 2000 |
The chemotherapy of rodent malaria. XLVI. Reversal of mefloquine resistance in rodent Plasmodium.
Topics: Animals; Antimalarials; Cyproheptadine; Dose-Response Relationship, Drug; Drug Combinations; Drug Re | 1991 |