cyproheptadine has been researched along with Local Neoplasm Recurrence in 1 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 9.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| "Cyproheptadine hydrochloride (CH), an appetite stimulant, was administered to children with cancer-associated cachexia to prevent further weight loss." | 5.13 | The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. ( Couluris, M; Freyer, DR; Krischer, JP; Mayer, JL; Sandler, E; Xu, P, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Couluris, M | 1 |
| Mayer, JL | 1 |
| Freyer, DR | 1 |
| Sandler, E | 1 |
| Xu, P | 1 |
| Krischer, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment Related Cachexia[NCT00066248] | Phase 2 | 70 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders[NCT02568007] | Phase 4 | 4 participants (Actual) | Interventional | 2015-12-31 | Terminated (stopped due to Unable to enroll adequate participants) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for cyproheptadine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |
The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia.
Topics: Adolescent; Adult; Appetite Stimulants; Cachexia; Child; Child, Preschool; Cyproheptadine; Female; G | 2008 |