cyproheptadine has been researched along with Injuries, Spinal Cord in 14 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiserotonergic agent cyproheptadine was evaluated in six patients as a medication for the management of spasticity due either to spinal cord trauma or to multiple sclerosis." | 5.05 | Action of cyproheptadine in spastic paraparetic patients. ( Barbeau, H; Bédard, PJ; Richards, CL, 1982) |
| " Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h." | 3.71 | Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002) |
| "Baclofen was associated with minor changes in walking." | 2.69 | Effects of drugs on walking after spinal cord injury. ( Barbeau, H; Norman, KE; Pépin, A, 1998) |
| "In twenty-five SCI subjects, antispasticity effects of three putative antispasticity agents [clonidine (an alpha-2 noradrenergic agonist), cyproheptadine (a 5-HT2 antagonist) and baclofen (a GABA-B agonist)] were tested in terms of changes in leg tone as graded by the Ashworth scale (AS), in terms of the vibratory inhibition of the H-reflex (VII) and in terms of the ability of the knee to swing passively in the pendulum test as quantified by video motion analysis." | 2.67 | A comparison of clonidine, cyproheptadine and baclofen in spastic spinal cord injured patients. ( Nance, PW, 1994) |
| "To evaluate spasticity in a dynamic, voluntary movement such as locomotion, a task-specific approach is essential." | 1.28 | A dynamic EMG profile index to quantify muscular activation disorder in spastic paretic gait. ( Barbeau, H; Fung, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Sławińska, U | 1 |
| Majczyński, H | 1 |
| Kwaśniewska, A | 1 |
| Miazga, K | 1 |
| Cabaj, AM | 1 |
| Bekisz, M | 1 |
| Jordan, LM | 1 |
| Zawadzka, M | 1 |
| Ryu, Y | 1 |
| Ogata, T | 1 |
| Nagao, M | 1 |
| Sawada, Y | 1 |
| Nishimura, R | 1 |
| Fujita, N | 1 |
| Leech, KA | 1 |
| Kinnaird, CR | 1 |
| Hornby, TG | 1 |
| Sharma, HS | 2 |
| Winkler, T | 2 |
| Meythaler, JM | 1 |
| Roper, JF | 1 |
| Brunner, RC | 1 |
| Barbeau, H | 5 |
| Richards, CL | 1 |
| Bédard, PJ | 1 |
| Bastings, E | 1 |
| Rapisarda, G | 1 |
| Pepin, JL | 1 |
| Delwaide, PJ | 1 |
| Nance, PW | 1 |
| Norman, KE | 1 |
| Pépin, A | 1 |
| Salzman, SK | 1 |
| Puniak, MA | 1 |
| Liu, ZJ | 1 |
| Maitland-Heriot, RP | 1 |
| Freeman, GM | 1 |
| Agresta, CA | 1 |
| Stålberg, E | 1 |
| Olsson, Y | 1 |
| Dey, PK | 1 |
| Fung, J | 2 |
| Stewart, JE | 1 |
| Wainberg, M | 1 |
| Gauthier, S | 1 |
1 review available for cyproheptadine and Injuries, Spinal Cord
| Article | Year |
|---|---|
[Current pharmacological approach to the treatment of locomotion disorders due to spinal lesions].
Topics: Clonidine; Cyproheptadine; Humans; Locomotion; Spinal Cord Diseases; Spinal Cord Injuries | 1995 |
6 trials available for cyproheptadine and Injuries, Spinal Cord
| Article | Year |
|---|---|
Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury.
Topics: Adult; Citalopram; Cyproheptadine; Double-Blind Method; Female; Humans; Male; Middle Aged; Motor Act | 2014 |
Action of cyproheptadine in spastic paraparetic patients.
Topics: Adult; Cyproheptadine; Electromyography; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Musc | 1982 |
A comparison of clonidine, cyproheptadine and baclofen in spastic spinal cord injured patients.
Topics: Baclofen; Clonidine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1994 |
Effects of drugs on walking after spinal cord injury.
Topics: Adrenergic alpha-Agonists; Adult; Baclofen; Clonidine; Cyproheptadine; Electromyography; Exercise Te | 1998 |
The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects.
Topics: Adult; Biomechanical Phenomena; Clonidine; Combined Modality Therapy; Cyproheptadine; Double-Blind M | 1990 |
The effects of cyproheptadine on locomotion and on spasticity in patients with spinal cord injuries.
Topics: Adult; Cyproheptadine; Double-Blind Method; Drug Administration Schedule; Electromyography; Exercise | 1990 |
7 other studies available for cyproheptadine and Injuries, Spinal Cord
| Article | Year |
|---|---|
Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HT
Topics: Animals; Cyproheptadine; Electric Stimulation; Electromyography; Forelimb; Hindlimb; Humans; Locomot | 2021 |
Effects of Treadmill Training Combined with Serotonergic Interventions on Spasticity after Contusive Spinal Cord Injury.
Topics: Animals; Cyproheptadine; Female; Fluoxetine; Muscle Spasticity; Physical Conditioning, Animal; Rats; | 2018 |
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I | 2002 |
Cyproheptadine for intrathecal baclofen withdrawal.
Topics: Acute Disease; Adult; Baclofen; Cerebral Palsy; Cyproheptadine; Diagnosis, Differential; Female; Fev | 2003 |
The serotonin antagonist mianserin improves functional recovery following experimental spinal trauma.
Topics: Analysis of Variance; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Ketanserin; Male; M | 1991 |
Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space. An experimental study in the rat.
Topics: Animals; Cyproheptadine; Edema; Epidural Space; Evoked Potentials; Fenclonine; Male; Rats; Rats, Inb | 1991 |
A dynamic EMG profile index to quantify muscular activation disorder in spastic paretic gait.
Topics: Adult; Cyproheptadine; Electromyography; Humans; Leg; Locomotion; Male; Middle Aged; Muscle Spastici | 1989 |