cyproheptadine has been researched along with Inflammation in 31 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rupatadine is a potent histamine receptor 1 (H1R) and platelet-activating factor (PAF) blocker." | 5.72 | Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation. ( Khalaf, HM; Mohamed, MZ; Mohammed, HH, 2022) |
| "The econazole pleurisy development is monophasic and its peak value occurs between 8 and 12 hr after econazole injection." | 5.27 | Some characteristics of econazole-induced pleurisy in rats. ( Hanada, S; Hirano, MT; Oga, S, 1985) |
| "To compare the effects of an orally administered corticosteroid (prednisone), an inhaled corticosteroid (flunisolide), a leukotriene-receptor antagonist (zafirlukast), an antiserotonergic drug (cyproheptadine), and a control substance on the asthmatic phenotype in cats with experimentally induced asthma." | 5.11 | Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma. ( Berghaus, LJ; Berghaus, RD; Byerly, JR; Decile, KC; Gershwin, LJ; Hyde, DM; Reinero, CR; Schelegle, ES; Walby, WE, 2005) |
| "L-cysteine or sodium hydrogen sulphide (NaHS) was injected into the mouse hind paw and oedema formation was evaluated for 60 min." | 3.76 | Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. ( Bucci, M; Cirino, G; Coletta, C; De Dominicis, G; di Villa Bianca, Rd; Mitidieri, E; Rossi, A; Sautebin, L; Sorrentino, R, 2010) |
| " 2 The aim of the present study was to evaluate the anti-oedematogenic and analgesic effect of the bradykinin antagonist, bradyzide (BDZ) and the opioidergic analgesic, morphine (Mor) against inflammatory hyperalgesia induced by the dried latex (DL) of C." | 3.74 | Calotropis procera latex-induced inflammatory hyperalgesia - effect of bradyzide and morphine. ( Kumar, VL; Sehgal, R, 2007) |
| "In order to assess the role of inflammation and its components in spontaneous cure of Strongyloides ratti infestation, rats were treated with non-steroid anti-inflammatory agents (indometacin; sodium salicylate) or with antagonists of certain mediators (dexchlorpheniramin; cyproheptadin, promethazin)." | 3.67 | [The role of inflammation in the spontaneous elimination of Strongyloides ratti infestation]. ( Bailenger, J; Lacassie, A, 1986) |
| "Rupatadine is a potent histamine receptor 1 (H1R) and platelet-activating factor (PAF) blocker." | 1.72 | Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation. ( Khalaf, HM; Mohamed, MZ; Mohammed, HH, 2022) |
| "Local inflammation is a prominent characteristic of snakebite wound, and snake-venom phospholipase A2s (PLA2s) are some of the main component that contribute to accumulation of inflammatory cells." | 1.39 | Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. ( He, S; Mo, YZ; Wei, JF; Wei, XL; Yang, H, 2013) |
| "The edema was produced in a dose- and time-dependent manner." | 1.39 | Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms. ( Laraba-Djebari, F; Sebia-Amrane, F, 2013) |
| "Pretreatment with cyproheptadine (5 mg/kg), an inhibitor of both histamine and serotonin, significantly suppressed pleural fluid accumulation and the exudation rate at 0." | 1.28 | Involvement of platelet-activating factor in zymosan-induced rat pleurisy. ( Hayashi, M; Imai, Y; Oh-ishi, S, 1991) |
| "The econazole pleurisy development is monophasic and its peak value occurs between 8 and 12 hr after econazole injection." | 1.27 | Some characteristics of econazole-induced pleurisy in rats. ( Hanada, S; Hirano, MT; Oga, S, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (48.39) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 3 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Lou, Y | 1 |
| Owens, TD | 1 |
| Kuglstatter, A | 1 |
| Kondru, RK | 1 |
| Goldstein, DM | 1 |
| Mohamed, MZ | 1 |
| Mohammed, HH | 1 |
| Khalaf, HM | 1 |
| Sharma, N | 1 |
| Sankrityayan, H | 1 |
| Kale, A | 1 |
| Gaikwad, AB | 1 |
| Demopoulos, C | 1 |
| Antonopoulou, S | 1 |
| Theoharides, TC | 1 |
| de Araujo Isaias Muller, J | 1 |
| Mortari, MR | 1 |
| Moslaves, ISB | 1 |
| Toffoli-Kadri, MC | 1 |
| Wei, JF | 1 |
| Wei, XL | 1 |
| Mo, YZ | 1 |
| Yang, H | 1 |
| He, S | 1 |
| di Villa Bianca, Rd | 1 |
| Coletta, C | 1 |
| Mitidieri, E | 1 |
| De Dominicis, G | 1 |
| Rossi, A | 1 |
| Sautebin, L | 1 |
| Cirino, G | 2 |
| Bucci, M | 2 |
| Sorrentino, R | 1 |
| Sebia-Amrane, F | 1 |
| Laraba-Djebari, F | 1 |
| VOGIN, EE | 1 |
| ROSSI, GV | 1 |
| FRANK, L | 1 |
| RAPP, Y | 1 |
| BIRO, L | 1 |
| GLICKMAN, FS | 1 |
| GABBIANI, G | 1 |
| NIELSEN, K | 1 |
| Muhuri, D | 1 |
| Dasgupta, SC | 1 |
| Gomes, A | 1 |
| Reinero, CR | 1 |
| Decile, KC | 1 |
| Byerly, JR | 1 |
| Berghaus, RD | 1 |
| Walby, WE | 1 |
| Berghaus, LJ | 1 |
| Hyde, DM | 1 |
| Schelegle, ES | 1 |
| Gershwin, LJ | 1 |
| Kumar, VL | 1 |
| Sehgal, R | 1 |
| Klimenko, NA | 1 |
| Pyshnov, GIu | 1 |
| Cicala, C | 1 |
| Sorrentino, L | 1 |
| Ambrosini, G | 1 |
| DeDominicis, G | 1 |
| Altieri, DC | 1 |
| Giner-Larza, EM | 1 |
| Máñez, S | 1 |
| Giner, RM | 1 |
| Recio, MC | 1 |
| Prieto, JM | 1 |
| Cerdá-Nicolás, M | 1 |
| Ríos, JL | 1 |
| Miyama, K | 1 |
| Takano, K | 1 |
| Atsumi, I | 1 |
| Nakagawa, H | 1 |
| Hirschelmann, R | 1 |
| Bekemeier, H | 1 |
| Metzner, J | 1 |
| Giessler, AJ | 1 |
| Stelzner, A | 1 |
| Vinegar, R | 1 |
| Truax, JF | 1 |
| Selph, JL | 1 |
| Dunn, CJ | 2 |
| Willoughby, DA | 2 |
| Imai, Y | 1 |
| Hayashi, M | 1 |
| Oh-ishi, S | 1 |
| Hambleton, P | 1 |
| Miller, P | 1 |
| Tan, JQ | 1 |
| Xu, KY | 1 |
| Shen, FM | 1 |
| Feng, ZK | 1 |
| Bailenger, J | 1 |
| Lacassie, A | 1 |
| Proud, D | 1 |
| Kagey-Sobotka, A | 1 |
| Naclerio, RM | 1 |
| Lichtenstein, LM | 1 |
| Hanada, S | 1 |
| Oga, S | 1 |
| Hirano, MT | 1 |
| Selye, H | 2 |
| Somogyi, A | 2 |
| Jancsó-Gábor, A | 1 |
| Szolcsányi, J | 1 |
2 reviews available for cyproheptadine and Inflammation
| Article | Year |
|---|---|
Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies.
Topics: Agammaglobulinaemia Tyrosine Kinase; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Catal | 2012 |
COVID-19, microthromboses, inflammation, and platelet activating factor.
Topics: Antiviral Agents; Blood Platelets; COVID-19; Cyproheptadine; Disseminated Intravascular Coagulation; | 2020 |
1 trial available for cyproheptadine and Inflammation
| Article | Year |
|---|---|
Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.
Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Spasm; Bronchoalveolar Lavage F | 2005 |
28 other studies available for cyproheptadine and Inflammation
| Article | Year |
|---|---|
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation.
Topics: Amylases; Animals; Anti-Inflammatory Agents; Arginine; Caspase 3; Cyproheptadine; Gene Expression; H | 2022 |
Role of SET7/9 in the progression of ischemic renal injury in diabetic and non-diabetic rats.
Topics: Animals; Biomarkers; Cyproheptadine; Diabetes Mellitus, Experimental; Disease Progression; Histone-L | 2020 |
Pharmacological Characterization of Mouse Hind Paw Edema Induced by Parachartergus fraternus Venom.
Topics: Animals; Captopril; Cyproheptadine; Edema; Histamine; Inflammation; Mice; NG-Nitroarginine Methyl Es | 2019 |
Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2.
Topics: Animals; Bothrops; Cell Adhesion Molecules; Cyproheptadine; Ginkgolides; Histamine; Histamine Releas | 2013 |
Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.
Topics: Animals; Cyclooxygenase Inhibitors; Cyproheptadine; Cystathionine beta-Synthase; Cystathionine gamma | 2010 |
Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Capil | 2013 |
RADIOMETRIC QUANTITATION OF THE INHIBITION OF 5-HYDROXYTRYPTAMINE- INDUCED EDEMA IN MICE.
Topics: Animals; Ascorbic Acid; Aspirin; Cyproheptadine; Edema; Flavonoids; Inflammation; Mice; Phenylbutazo | 1963 |
INFLAMMATION MEDIATORS AND THE INFLAMMATORY REACTION.
Topics: Anti-Allergic Agents; Bradykinin; Capillary Permeability; Chlorpheniramine; Cyproheptadine; Fluoresc | 1964 |
ANAPHYLACTOID INFLAMMATION AND MASTOPEXIS; THE ROLE OF THE MAST CELL.
Topics: Anaphylaxis; Cyproheptadine; Edema; Inflammation; Iron-Dextran Complex; Mast Cells; Pathology; Pharm | 1964 |
Lethal, oedema, haemorrhagic activity of spotted butterfish (Scatophagus argus, Linn) sting extract and its neutralization by antiserum and pharmacological antagonists.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyproheptadine; Edema; Edetic | 2005 |
Calotropis procera latex-induced inflammatory hyperalgesia - effect of bradyzide and morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bradykinin Receptor Antagonists; Calotropis; Cyprohep | 2007 |
[Mechanisms of the modulating effect of mast cells on the leukocytic response in inflammation].
Topics: Animals; Cyproheptadine; Diphenhydramine; Inflammation; Male; Mast Cells; Monocytes; Neutrophils; Pr | 1993 |
Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Antithrombins; Blood Coagulation; Carrageenan; C | 1997 |
Anti-inflammatory triterpenes from Pistacia terebinthus galls.
Topics: Animals; Anti-Inflammatory Agents; Calcimycin; Cyproheptadine; Dexamethasone; Dose-Response Relation | 2002 |
Identification of C3a and N-truncated C3a as vascular permeability-enhancing factors from the exudate of chronic phase of carrageenan-induced inflammation in rats.
Topics: Amino Acid Sequence; Animals; Capillary Permeability; Carrageenan; Chromatography, High Pressure Liq | 2002 |
[Modification of the adjuvans arthritis by carrageenin, compound 48/80, histamine- and serotonin antagonists, non-steroid antiphlogistics as well as protease inhibitors and their possible relations to inflammation mediators].
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Chlorpromazine; Cyproheptadin | 1975 |
Quantitative studies of the pathway to acute carrageenan inflammation.
Topics: Acute Disease; Animals; Carrageenan; Chemotaxis; Cyproheptadine; Disease Models, Animal; Edema; Indo | 1976 |
The response of the newborn rat to injury. I. Vascular and humoral aspects.
Topics: Age Factors; Albumins; Animals; Animals, Newborn; Bradykinin; Capillary Permeability; Carrageenan; C | 1975 |
The response of the newborn rat to intraleural dextran: vascular and cellular aspects.
Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Dextrans; Edema; Exudates and Transudates; Hindlim | 1975 |
Involvement of platelet-activating factor in zymosan-induced rat pleurisy.
Topics: Animals; Cyproheptadine; Eosinophils; Inflammation; Leukocytes; Male; Mast Cells; Neutrophils; Plate | 1991 |
Pharmacological investigation of acute cellular accumulation in immunological air pouch inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigens; Aprotinin; Bromelai | 1989 |
[Anti-inflammatory effect of cyproheptadine].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cyproheptadine; Female; In | 1989 |
[The role of inflammation in the spontaneous elimination of Strongyloides ratti infestation].
Topics: Animals; Chlorpheniramine; Cyproheptadine; Indomethacin; Inflammation; Male; Nematode Infections; Pr | 1986 |
Pharmacology of upper airways challenge.
Topics: Aspirin; Cyproheptadine; Exocytosis; Humans; Hypersensitivity; Inflammation; Mast Cells; Nasal Mucos | 1987 |
Some characteristics of econazole-induced pleurisy in rats.
Topics: Animals; Carrageenan; Chlorpheniramine; Cyproheptadine; Dexamethasone; Econazole; Imidazoles; Inflam | 1985 |
Effect of cyproheptadine upon acute inflammation produced by various agents.
Topics: Acute Disease; Anaphylaxis; Animals; Cyproheptadine; Edema; Female; Histamine H1 Antagonists; Histam | 1967 |
Tourniquet poditis--an experimental pedal inflammation in the rat.
Topics: Animals; Anti-Bacterial Agents; Chlorpromazine; Cyproheptadine; Depression, Chemical; Dextrans; Dibe | 1969 |
Action of rare earth metal complexes on neurogenic as well as on bradykinin-induced inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Antivenins; Blood Coagulation; Bradykinin; Catech | 1970 |