cyproheptadine has been researched along with Inappropriate GH Secretion Syndrome (Acromegaly) in 12 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic efficacy of the combination of cyproheptadine and bromocriptine was studied in 15 patients with active acromegaly showing incomplete GH suppression in response to bromocriptine therapy alone." | 7.67 | The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly. ( Hanew, K; Ishii, K; Saitoh, T; Sasaki, A; Saso, S; Sato, S; Shimizu, Y; Sugawara, A; Tazawa, S; Yoshinaga, K, 1989) |
| "The effect of cyproheptadine on growth hormone (GH) and prolactin (Prl) secretion from cultured pituitary adenoma cells of acromegaly and pituitary gigantism was studied." | 7.67 | Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. ( Fukushima, T; Ishibashi, M; Yamaji, T, 1985) |
| "We evaluated the effect of the serotonin antagonists cyproheptadine (Cypro) and methysergide (Methy) on growth hormone secretion in six patients with acromegaly." | 5.04 | Inhibitory effect of serotonin antagonists on growth hormone release in acromegalic patients. ( Bivens, CH; Feldman, JM; Plonk, JW, 1976) |
| "The therapeutic efficacy of the combination of cyproheptadine and bromocriptine was studied in 15 patients with active acromegaly showing incomplete GH suppression in response to bromocriptine therapy alone." | 3.67 | The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly. ( Hanew, K; Ishii, K; Saitoh, T; Sasaki, A; Saso, S; Sato, S; Shimizu, Y; Sugawara, A; Tazawa, S; Yoshinaga, K, 1989) |
| "The effect of cyproheptadine on growth hormone (GH) and prolactin (Prl) secretion from cultured pituitary adenoma cells of acromegaly and pituitary gigantism was studied." | 3.67 | Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture. ( Fukushima, T; Ishibashi, M; Yamaji, T, 1985) |
| "Ectopic secretion of GH by the carcinoid hepatic metastases was documented by both RIA and immunohistochemical techniques." | 1.26 | Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor. ( Buckley, PJ; Daughaday, WH; Deschryver, K; Greider, MH; Jaffe, BM; Leveston, SA; McKeel, DW, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (91.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leveston, SA | 1 |
| McKeel, DW | 1 |
| Buckley, PJ | 1 |
| Deschryver, K | 1 |
| Greider, MH | 1 |
| Jaffe, BM | 1 |
| Daughaday, WH | 1 |
| Weiss, MH | 1 |
| Yamaji, T | 2 |
| Feldman, JM | 2 |
| Plonk, JW | 1 |
| Bivens, CH | 2 |
| Chiodini, PG | 1 |
| Liuzzi, A | 1 |
| Muller, EE | 1 |
| Botalla, L | 1 |
| Cremascoli, G | 1 |
| Oppizzi, G | 1 |
| Verde, G | 1 |
| Silvestrini, F | 1 |
| Skyler, JS | 1 |
| Lebovitz, HE | 1 |
| Fanghanel, G | 1 |
| Larraza, O | 1 |
| Villalobos, M | 1 |
| Fanghanel, L | 1 |
| Velasco, M | 1 |
| Velasco, F | 1 |
| Hanew, K | 1 |
| Sugawara, A | 1 |
| Shimizu, Y | 1 |
| Sato, S | 1 |
| Sasaki, A | 1 |
| Tazawa, S | 1 |
| Ishii, K | 1 |
| Saitoh, T | 1 |
| Saso, S | 1 |
| Yoshinaga, K | 1 |
| Dash, RJ | 1 |
| Ahmad, J | 1 |
| Sethi, BK | 1 |
| Sialy, R | 1 |
| Ishibashi, M | 1 |
| Fukushima, T | 1 |
| Yoshida, H | 1 |
| Takeda, F | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
1 review available for cyproheptadine and Inappropriate GH Secretion Syndrome (Acromegaly)
| Article | Year |
|---|---|
[Drug and radiotherapy of pituitary tumors].
Topics: Acromegaly; Adenoma; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; G | 1986 |
2 trials available for cyproheptadine and Inappropriate GH Secretion Syndrome (Acromegaly)
| Article | Year |
|---|---|
Inhibitory effect of serotonin antagonists on growth hormone release in acromegalic patients.
Topics: Acromegaly; Clinical Trials as Topic; Cyproheptadine; Depression, Chemical; Female; Glucose Toleranc | 1976 |
Effect of cyproheptadine administration on insulin secretion in acromegalic, diabetic and normal subjects.
Topics: Acromegaly; Adult; Blood Glucose; Cyproheptadine; Diabetes Mellitus; Female; Glucose; Glucose Tolera | 1975 |
9 other studies available for cyproheptadine and Inappropriate GH Secretion Syndrome (Acromegaly)
| Article | Year |
|---|---|
Acromegaly and Cushing's syndrome associated with a foregut carcinoid tumor.
Topics: Abdominal Neoplasms; Acromegaly; Adolescent; Adrenocorticotropic Hormone; Carcinoid Tumor; Cushing S | 1981 |
Medical and surgical management of functional pituitary tumors.
Topics: Acromegaly; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; Growth Hor | 1981 |
[Medical treatment of functioning pituitary adenomas (author's transl)].
Topics: Acromegaly; Adenoma; Adult; Bromocriptine; Cyproheptadine; Dopamine; Female; Humans; Hypotension; Ma | 1981 |
Inhibitory effect of an ergoline derivative, methergoline, on growth hormone and prolactin levels in acromegalic patients.
Topics: Acromegaly; Adult; Aged; Bromocriptine; Cyproheptadine; Ergolines; Female; Growth Hormone; Humans; M | 1976 |
Differential response to aminergic stimuli and biological behavior of growth hormone secreting pituitary adenomas.
Topics: Acromegaly; Adenoma; Adolescent; Adult; Bromocriptine; Cyproheptadine; Diazepam; Female; Growth Horm | 1990 |
The combination therapy with bromocriptine and cyproheptadine in patients with acromegaly.
Topics: Acromegaly; Adenoma; Adult; Aged; Bromocriptine; Cyproheptadine; Drug Therapy, Combination; Female; | 1989 |
Failure of long-term cyproheptadine therapy in lowering growth hormone levels in acromegaly.
Topics: Acromegaly; Adult; Cyproheptadine; Female; Glucose; Growth Hormone; Humans; Male; Middle Aged; Time | 1989 |
Cyproheptadine-mediated inhibition of growth hormone and prolactin release from pituitary adenoma cells of acromegaly and gigantism in culture.
Topics: Acromegaly; Adenoma, Acidophil; Adenoma, Chromophobe; Adult; Cells, Cultured; Child; Cyproheptadine; | 1985 |
Growth hormone and serotonin antagonist.
Topics: Acromegaly; Aluminum Hydroxide; Cyproheptadine; Female; Growth Hormone; Humans; Methysergide; Middle | 1973 |