Page last updated: 2024-10-25

cyproheptadine and Fever

cyproheptadine has been researched along with Fever in 15 studies

Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"Tranylcypromine (TCP), a monoamine oxidase inhibitor, caused a fatal hyperpyrexia in rats pretreated with LiCl once a day for 4 days."7.66Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats. ( Hashimoto, M; Honda, F; Mori, J; Shimomura, K, 1979)
"Citalopram is a very potent and highly selective inhibitor of neuronal serotonin (5-hydroxytryptamine, or 5-HT)."5.34First time, low dose citalopram use-related serotonin syndrome. ( Eraydin, I; Gunduz, A; Hos, U; Kalkan, A; Turedi, S, 2007)
"Cyproheptadine-HCl raised the pain thresholds during hot plat test and writhing test in mice and tail flick test in rats, strengthened the hypnotic action by subthreshold dosage of sodium pentobarbital and chloral hydrate."3.68[Analgesic and antipyretic effects of cyproheptadine]. ( Cui, J; Fan, CK; Tan, JQ; Xu, B, 1990)
"In the rabbit, intracerebroventricular administration of dibutyryl cyclic AMP (DBC) produces fever which is selectively antagonised by phenoxybenzamine."3.66Central effect of dibutyryl cyclic AMP on the temperature in the conscious rabbit. ( Kandasamy, SB, 1980)
"Tranylcypromine (TCP), a monoamine oxidase inhibitor, caused a fatal hyperpyrexia in rats pretreated with LiCl once a day for 4 days."3.66Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats. ( Hashimoto, M; Honda, F; Mori, J; Shimomura, K, 1979)
"Citalopram is a very potent and highly selective inhibitor of neuronal serotonin (5-hydroxytryptamine, or 5-HT)."1.34First time, low dose citalopram use-related serotonin syndrome. ( Eraydin, I; Gunduz, A; Hos, U; Kalkan, A; Turedi, S, 2007)
"Pretreatment with propranolol (10 mg/kg), a 5-HT(1A) receptor antagonist as well as a beta-blocker, and dantrolene (20 mg/kg), a peripheral muscle relaxant, did not prevent the death of the animals, even though these two drugs suppressed the increase in rectal temperature to some extent."1.31Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. ( Katoh, S; Nisijima, K; Yoshino, T; Yui, K, 2001)
"Haloperidol was ineffective as a fenfluramine antagonist."1.26Fenfluramine-induced hyperthermia and stimulation in the rabbit. ( Beal, GA; Quock, RM, 1976)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19909 (60.00)18.7374
1990's1 (6.67)18.2507
2000's3 (20.00)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, MH1
Hu, A1
Lee, YS1
Lai, CC1
Bergamini, E1
Peche, S1
Ferguson, W1
Scalzo, A1
Calamur, N1
Meythaler, JM1
Roper, JF1
Brunner, RC1
FUNCKE, AB1
MULDER, D1
DEJONGE, MC1
TERSTEEGE, HM1
HARMS, AF1
NAUTA, WT1
DONNER, R1
RUEMKE, CL1
Turedi, S1
Eraydin, I1
Gunduz, A1
Kalkan, A1
Hos, U1
Konusova, AV1
Popova, NK1
Kandasamy, SB2
Nisijima, K1
Yoshino, T1
Yui, K1
Katoh, S1
Bantutova, I1
Shimomura, K1
Hashimoto, M1
Mori, J1
Honda, F1
Quock, RM1
Beal, GA1
Tan, JQ1
Fan, CK1
Cui, J1
Xu, B1
Simpson, RK1
Fischer, DK1
Ehni, BL1
Tanaka, K1
Iizuka, Y1

Other Studies

15 other studies available for cyproheptadine and Fever

ArticleYear
Arthus Reaction.
    The Journal of emergency medicine, 2019, Volume: 56, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthus Reaction; Child; Cyproheptadine; Diphtheria-Tetanus-

2019
Fever and Altered Mental Status in an Adolescent Male With Burkitt Lymphoma.
    Clinical pediatrics, 2019, Volume: 58, Issue:8

    Topics: Adolescent; Burkitt Lymphoma; Confusion; Cyproheptadine; Fever; Humans; Male; Selective Serotonin Re

2019
Cyproheptadine for intrathecal baclofen withdrawal.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:5

    Topics: Acute Disease; Adult; Baclofen; Cerebral Palsy; Cyproheptadine; Diagnosis, Differential; Female; Fev

2003
INVESTIGATION OF 3-(10,11-DIHYDRO-5H-DIBENZO (A,D) CYCLOHEPTEN-5-YLOXY) TROPANE CITRATE (DIBENZHEPTROPINE CITRATE, BRONTINE). I. PHARMACOLOGICAL PROPERTIES. II. TOXICOLOGICAL PROPERTIES.
    Archives internationales de pharmacodynamie et de therapie, 1964, Mar-01, Volume: 148

    Topics: Acetylcholine; Albumins; Animals; Asthma; Atropine; Bronchi; Citric Acid; Cyproheptadine; Diphenhydr

1964
First time, low dose citalopram use-related serotonin syndrome.
    Neurotoxicology, 2007, Volume: 28, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Citalopram; Confusion; Cyproheptadine; Fever; Fluid

2007
[Role of central and peripheral serotoninergic mechanisms].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1982, Volume: 68, Issue:10

    Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Cyproheptadine; Fenclonine; Fever; In

1982
Central effect of dibutyryl cyclic AMP on the temperature in the conscious rabbit.
    Pharmacology, 1980, Volume: 20, Issue:6

    Topics: Animals; Body Temperature; Brain; Bucladesine; Cyproheptadine; Drug Interactions; Fever; Hydroxydopa

1980
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
    Brain research, 2001, Jan-26, Volume: 890, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Anterior Hypothalamic Nucleus; Antidepressive Agents; Body Temperature

2001
[Effect of pharmacological agents and coagulation of the n. raphe dorsalis on morphine effects].
    Eksperimentalna meditsina i morfologiia, 1979, Volume: 18, Issue:4

    Topics: Animals; Brain Stem; Catalepsy; Cyproheptadine; Dimenhydrinate; Electrocoagulation; Female; Fencloni

1979
Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats.
    Japanese journal of pharmacology, 1979, Volume: 29, Issue:2

    Topics: Amines; Animals; Body Temperature; Brain Chemistry; Chlorpromazine; Cyproheptadine; Dopamine; Fenclo

1979
Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit.
    Experientia, 1977, Dec-15, Volume: 33, Issue:12

    Topics: Animals; Arachidonic Acids; Body Temperature; Cyproheptadine; Fever; Hydroxydopamines; Indomethacin;

1977
Fenfluramine-induced hyperthermia and stimulation in the rabbit.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 13, Issue:3

    Topics: Animals; Behavior, Animal; Body Temperature; Cinanserin; Cyproheptadine; Dose-Response Relationship,

1976
[Analgesic and antipyretic effects of cyproheptadine].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyproheptadine; Female; Fever; Hypnotics and Sedat

1990
Neurogenic hyperthermia in subarachnoid hemorrhage.
    Southern medical journal, 1989, Volume: 82, Issue:12

    Topics: Adult; Combined Modality Therapy; Cyproheptadine; Fever; Humans; Indomethacin; Ischemic Attack, Tran

1989
[Anti-inflammatory effect of bimetopyrol. I. Suppressive effect on acute inflammation].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1972, Volume: 92, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cyproheptadine; Edema; Erythema; Fever; Flufenamic Acid;

1972