cyproheptadine has been researched along with Drug Withdrawal Symptoms in 16 studies
Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.
cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a case of serotonin syndrome secondary to clozapine withdrawal and concomitant use of citalopram hydrobromide, a phenomenon that has been rarely reported." | 7.79 | Serotonin syndrome associated with clozapine withdrawal. ( Burns, JD; Green, DM; Schembri, F; Stevenson, E, 2013) |
| "A 44-year-old female with Cushing's disease associated with a pituitary macroadenoma was treated with cyproheptadine, 24 mg per day, after partial surgical resection of the tumor." | 7.67 | Rebound elevation of cortisol following cyproheptadine withdrawal in Cushing's disease from a pituitary macroadenoma. ( Ooi, TC; Twum-Barima, Y, 1987) |
| "The effects of different manipulations of brain serotonin (5-HT) content on the development of morphine dependence were investigated in rats, which were implanted with morphine pellets for 40 days." | 7.65 | Central serotonergic mechanisms and development of morphine dependence. ( Blasig, J; Gramsch, C; Herz, A; Papeschi, R, 1976) |
| "The objective of this study was to report the effect of the slow withdrawal of clozapine from 19 patients with neuroleptic-responsive schizophrenia at the end of a 2-year clinical trial of clozapine and to compare this with the results of naturalistic discontinuation of clozapine treatment in 64 neuroleptic-resistant schizophrenic patients." | 5.08 | Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine. ( Cola, PA; Lee, MA; Mason, EA; Meltzer, HY; Ranjan, R, 1996) |
| "We describe a case of serotonin syndrome secondary to clozapine withdrawal and concomitant use of citalopram hydrobromide, a phenomenon that has been rarely reported." | 3.79 | Serotonin syndrome associated with clozapine withdrawal. ( Burns, JD; Green, DM; Schembri, F; Stevenson, E, 2013) |
| "A 44-year-old female with Cushing's disease associated with a pituitary macroadenoma was treated with cyproheptadine, 24 mg per day, after partial surgical resection of the tumor." | 3.67 | Rebound elevation of cortisol following cyproheptadine withdrawal in Cushing's disease from a pituitary macroadenoma. ( Ooi, TC; Twum-Barima, Y, 1987) |
| "The effects of different manipulations of brain serotonin (5-HT) content on the development of morphine dependence were investigated in rats, which were implanted with morphine pellets for 40 days." | 3.65 | Central serotonergic mechanisms and development of morphine dependence. ( Blasig, J; Gramsch, C; Herz, A; Papeschi, R, 1976) |
| "Cyproheptadine is a cheap, widely available anti-allergy drug with a broad receptor binding profile which resembles that of clozapine." | 1.34 | Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats. ( Cole, JC; Cooper, GD; Goudie, AJ; Sumnall, HR, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Stevenson, E | 1 |
| Schembri, F | 1 |
| Green, DM | 1 |
| Burns, JD | 1 |
| Meythaler, JM | 1 |
| Roper, JF | 1 |
| Brunner, RC | 1 |
| Goudie, AJ | 1 |
| Cooper, GD | 1 |
| Cole, JC | 1 |
| Sumnall, HR | 1 |
| Saveika, JA | 1 |
| Shelton, JE | 1 |
| Alphs, L | 1 |
| Davis, JM | 1 |
| el-Kadi, AO | 1 |
| Sharif, SI | 1 |
| Meltzer, HY | 1 |
| Lee, MA | 1 |
| Ranjan, R | 1 |
| Mason, EA | 1 |
| Cola, PA | 1 |
| Vetulani, J | 1 |
| Bednarczyk, B | 1 |
| Blasig, J | 1 |
| Papeschi, R | 1 |
| Gramsch, C | 1 |
| Herz, A | 1 |
| Drawbaugh, RB | 1 |
| Lal, H | 1 |
| Hirschorn, KA | 1 |
| Greenberg, HS | 1 |
| Ooi, TC | 1 |
| Twum-Barima, Y | 1 |
| Nurimoto, S | 1 |
| Friedman, AP | 1 |
| Opitz, K | 1 |
| Reimann, I | 1 |
1 review available for cyproheptadine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
1 trial available for cyproheptadine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine.
Topics: Adult; Antipsychotic Agents; Clozapine; Cyproheptadine; Female; Humans; Male; Perphenazine; Schizoph | 1996 |
14 other studies available for cyproheptadine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Serotonin syndrome associated with clozapine withdrawal.
Topics: Benzodiazepines; Citalopram; Clozapine; Cyproheptadine; Female; Humans; Middle Aged; Selective Serot | 2013 |
Cyproheptadine for intrathecal baclofen withdrawal.
Topics: Acute Disease; Adult; Baclofen; Cerebral Palsy; Cyproheptadine; Diagnosis, Differential; Female; Fev | 2003 |
Cyproheptadine resembles clozapine in vivo following both acute and chronic administration in rats.
Topics: Animals; Anti-Allergic Agents; Antipsychotic Agents; Clozapine; Conditioning, Operant; Cyproheptadin | 2007 |
Cyproheptadine for pediatric intrathecal baclofen withdrawal: a case report.
Topics: Adolescent; Age Factors; Baclofen; Cerebral Palsy; Child; Cyproheptadine; Equipment Failure; Female; | 2007 |
Noncatecholaminergic treatments of tardive dyskinesia.
Topics: Amantadine; Anti-Anxiety Agents; Benzodiazepines; Cyproheptadine; D-Ala(2),MePhe(4),Met(0)-ol-enkeph | 1982 |
The role of 5-HT in the expression of morphine withdrawal in mice.
Topics: Animals; Cyproheptadine; Male; Methysergide; Mice; Morphine; Naloxone; Oxidopamine; Serotonin; Subst | 1995 |
Depression by clonidine of shaking behaviour elicited by nalorphine in morphine-dependent rats.
Topics: Animals; Clonidine; Cyproheptadine; Humans; Male; Morphine Dependence; Nalorphine; Rats; Substance W | 1977 |
Central serotonergic mechanisms and development of morphine dependence.
Topics: 5,6-Dihydroxytryptamine; Animals; Brain Chemistry; Cyproheptadine; Fenclonine; Humans; Injections, I | 1976 |
Effect of pharmacological interference with various neuropathways on blockade of morphine-withdrawal hypothermia by morphine and by conditional stimulus.
Topics: Animals; Benztropine; Conditioning, Classical; Cyproheptadine; Haloperidol; Humans; Hypothermia; Mal | 1976 |
Successful treatment of levodopa-induced myoclonus and levodopa withdrawal-induced neuroleptic malignant syndrome. A case report.
Topics: Aged; Cyproheptadine; Humans; Levodopa; Male; Methysergide; Myoclonus; Neuroleptic Malignant Syndrom | 1988 |
Rebound elevation of cortisol following cyproheptadine withdrawal in Cushing's disease from a pituitary macroadenoma.
Topics: Adenoma; Adult; Cushing Syndrome; Cyproheptadine; Female; Humans; Hydrocortisone; Pituitary Neoplasm | 1987 |
A simple method for evaluating physical dependence liability in rats.
Topics: Aminopyrine; Animals; Azepines; Body Weight; Codeine; Cyproheptadine; Dextropropoxyphene; Humans; Ma | 1973 |
Migraine headaches.
Topics: Caffeine; Contraceptives, Oral; Cyproheptadine; Diagnosis, Differential; Diuretics; Drug Combination | 1972 |
Suppression of the drug-induced morphine withdrawal syndrome by cyproheptadine.
Topics: Animals; Body Weight; Cyproheptadine; Drug Tolerance; Fenfluramine; Humans; Hypothalamus; Levallorph | 1973 |